Amino acid dipepetide frequency for Cottoperca gobio (Frogmouth) (Aphritis gobio)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.558AlaAla: 6.558 ± 0.029	1.206AlaCys: 1.206 ± 0.009	3.229AlaAsp: 3.229 ± 0.012	4.755AlaGlu: 4.755 ± 0.021	2.179AlaPhe: 2.179 ± 0.013	4.435AlaGly: 4.435 ± 0.023	1.494AlaHis: 1.494 ± 0.009	2.587AlaIle: 2.587 ± 0.013	3.446AlaLys: 3.446 ± 0.025	6.232AlaLeu: 6.232 ± 0.025	1.612AlaMet: 1.612 ± 0.01	2.224AlaAsn: 2.224 ± 0.012	3.809AlaPro: 3.809 ± 0.022	3.023AlaGln: 3.023 ± 0.017	3.126AlaArg: 3.126 ± 0.014	5.696AlaSer: 5.696 ± 0.022	3.653AlaThr: 3.653 ± 0.02	4.781AlaVal: 4.781 ± 0.017	0.627AlaTrp: 0.627 ± 0.008	1.43AlaTyr: 1.43 ± 0.009	0.002AlaXaa: 0.002 ± 0.0
Cys	1.127CysAla: 1.127 ± 0.008	0.583CysCys: 0.583 ± 0.008	1.111CysAsp: 1.111 ± 0.011	1.267CysGlu: 1.267 ± 0.012	0.784CysPhe: 0.784 ± 0.006	1.437CysGly: 1.437 ± 0.012	0.61CysHis: 0.61 ± 0.006	0.884CysIle: 0.884 ± 0.008	1.124CysLys: 1.124 ± 0.009	1.986CysLeu: 1.986 ± 0.011	0.444CysMet: 0.444 ± 0.005	0.807CysAsn: 0.807 ± 0.007	1.219CysPro: 1.219 ± 0.013	0.984CysGln: 0.984 ± 0.009	1.219CysArg: 1.219 ± 0.009	2.091CysSer: 2.091 ± 0.015	1.137CysThr: 1.137 ± 0.009	1.441CysVal: 1.441 ± 0.011	0.268CysTrp: 0.268 ± 0.004	0.566CysTyr: 0.566 ± 0.005	0.001CysXaa: 0.001 ± 0.0
Asp	3.008AspAla: 3.008 ± 0.014	1.112AspCys: 1.112 ± 0.01	3.245AspAsp: 3.245 ± 0.023	3.896AspGlu: 3.896 ± 0.019	2.061AspPhe: 2.061 ± 0.012	3.761AspGly: 3.761 ± 0.023	1.182AspHis: 1.182 ± 0.008	2.662AspIle: 2.662 ± 0.019	2.814AspLys: 2.814 ± 0.016	4.932AspLeu: 4.932 ± 0.018	1.346AspMet: 1.346 ± 0.009	1.973AspAsn: 1.973 ± 0.012	2.872AspPro: 2.872 ± 0.013	2.007AspGln: 2.007 ± 0.011	2.793AspArg: 2.793 ± 0.015	4.749AspSer: 4.749 ± 0.018	2.806AspThr: 2.806 ± 0.012	3.352AspVal: 3.352 ± 0.016	0.634AspTrp: 0.634 ± 0.006	1.52AspTyr: 1.52 ± 0.011	0.002AspXaa: 0.002 ± 0.0
Glu	4.77GluAla: 4.77 ± 0.019	1.195GluCys: 1.195 ± 0.011	4.605GluAsp: 4.605 ± 0.02	8.353GluGlu: 8.353 ± 0.051	1.851GluPhe: 1.851 ± 0.011	4.306GluGly: 4.306 ± 0.02	1.492GluHis: 1.492 ± 0.01	2.834GluIle: 2.834 ± 0.019	4.766GluLys: 4.766 ± 0.029	6.125GluLeu: 6.125 ± 0.024	1.807GluMet: 1.807 ± 0.012	2.699GluAsn: 2.699 ± 0.014	2.989GluPro: 2.989 ± 0.018	3.189GluGln: 3.189 ± 0.02	4.503GluArg: 4.503 ± 0.024	4.608GluSer: 4.608 ± 0.017	3.512GluThr: 3.512 ± 0.016	4.467GluVal: 4.467 ± 0.02	0.666GluTrp: 0.666 ± 0.006	1.638GluTyr: 1.638 ± 0.019	0.002GluXaa: 0.002 ± 0.0
Phe	1.744PheAla: 1.744 ± 0.01	0.848PheCys: 0.848 ± 0.007	1.67PheAsp: 1.67 ± 0.009	1.812PheGlu: 1.812 ± 0.013	1.362PhePhe: 1.362 ± 0.011	2.054PheGly: 2.054 ± 0.016	0.943PheHis: 0.943 ± 0.007	1.741PheIle: 1.741 ± 0.012	1.741PheLys: 1.741 ± 0.013	3.422PheLeu: 3.422 ± 0.018	0.768PheMet: 0.768 ± 0.006	1.397PheAsn: 1.397 ± 0.009	1.734PhePro: 1.734 ± 0.012	1.507PheGln: 1.507 ± 0.011	1.83PheArg: 1.83 ± 0.018	3.148PheSer: 3.148 ± 0.014	2.174PheThr: 2.174 ± 0.012	2.028PheVal: 2.028 ± 0.013	0.409PheTrp: 0.409 ± 0.006	1.055PheTyr: 1.055 ± 0.009	0.001PheXaa: 0.001 ± 0.0
Gly	4.041GlyAla: 4.041 ± 0.019	1.203GlyCys: 1.203 ± 0.01	3.274GlyAsp: 3.274 ± 0.019	4.216GlyGlu: 4.216 ± 0.021	2.258GlyPhe: 2.258 ± 0.015	5.762GlyGly: 5.762 ± 0.04	1.696GlyHis: 1.696 ± 0.012	2.45GlyIle: 2.45 ± 0.011	3.537GlyLys: 3.537 ± 0.02	5.384GlyLeu: 5.384 ± 0.022	1.524GlyMet: 1.524 ± 0.011	2.415GlyAsn: 2.415 ± 0.015	3.432GlyPro: 3.432 ± 0.037	2.874GlyGln: 2.874 ± 0.016	3.721GlyArg: 3.721 ± 0.021	6.043GlySer: 6.043 ± 0.023	3.392GlyThr: 3.392 ± 0.016	3.936GlyVal: 3.936 ± 0.016	0.729GlyTrp: 0.729 ± 0.007	1.844GlyTyr: 1.844 ± 0.015	0.003GlyXaa: 0.003 ± 0.0
His	1.369HisAla: 1.369 ± 0.009	0.724HisCys: 0.724 ± 0.007	1.019HisAsp: 1.019 ± 0.008	1.2HisGlu: 1.2 ± 0.01	0.983HisPhe: 0.983 ± 0.008	1.575HisGly: 1.575 ± 0.01	1.172HisHis: 1.172 ± 0.015	1.29HisIle: 1.29 ± 0.009	1.318HisLys: 1.318 ± 0.009	2.637HisLeu: 2.637 ± 0.016	0.7HisMet: 0.7 ± 0.006	1.068HisAsn: 1.068 ± 0.008	1.661HisPro: 1.661 ± 0.015	1.372HisGln: 1.372 ± 0.011	1.666HisArg: 1.666 ± 0.01	2.569HisSer: 2.569 ± 0.015	1.676HisThr: 1.676 ± 0.012	1.461HisVal: 1.461 ± 0.009	0.315HisTrp: 0.315 ± 0.005	0.85HisTyr: 0.85 ± 0.008	0.001HisXaa: 0.001 ± 0.0
Ile	2.397IleAla: 2.397 ± 0.012	0.972IleCys: 0.972 ± 0.008	2.062IleAsp: 2.062 ± 0.012	2.412IleGlu: 2.412 ± 0.02	1.594IlePhe: 1.594 ± 0.011	2.212IleGly: 2.212 ± 0.012	1.23IleHis: 1.23 ± 0.008	2.281IleIle: 2.281 ± 0.016	2.533IleLys: 2.533 ± 0.019	3.99IleLeu: 3.99 ± 0.018	1.037IleMet: 1.037 ± 0.007	1.931IleAsn: 1.931 ± 0.012	2.45IlePro: 2.45 ± 0.012	2.218IleGln: 2.218 ± 0.012	2.357IleArg: 2.357 ± 0.011	3.69IleSer: 3.69 ± 0.016	2.827IleThr: 2.827 ± 0.024	2.493IleVal: 2.493 ± 0.018	0.431IleTrp: 0.431 ± 0.005	1.238IleTyr: 1.238 ± 0.009	0.001IleXaa: 0.001 ± 0.0
Lys	3.783LysAla: 3.783 ± 0.023	0.997LysCys: 0.997 ± 0.009	3.43LysAsp: 3.43 ± 0.023	4.823LysGlu: 4.823 ± 0.029	1.479LysPhe: 1.479 ± 0.012	3.233LysGly: 3.233 ± 0.026	1.428LysHis: 1.428 ± 0.01	2.387LysIle: 2.387 ± 0.016	4.578LysLys: 4.578 ± 0.03	4.883LysLeu: 4.883 ± 0.02	1.506LysMet: 1.506 ± 0.011	2.206LysAsn: 2.206 ± 0.015	3.115LysPro: 3.115 ± 0.023	2.572LysGln: 2.572 ± 0.016	3.518LysArg: 3.518 ± 0.018	3.936LysSer: 3.936 ± 0.017	3.251LysThr: 3.251 ± 0.017	3.569LysVal: 3.569 ± 0.02	0.566LysTrp: 0.566 ± 0.008	1.471LysTyr: 1.471 ± 0.016	0.002LysXaa: 0.002 ± 0.0
Leu	5.86LeuAla: 5.86 ± 0.022	2.053LeuCys: 2.053 ± 0.014	4.852LeuAsp: 4.852 ± 0.019	6.359LeuGlu: 6.359 ± 0.029	3.048LeuPhe: 3.048 ± 0.017	4.897LeuGly: 4.897 ± 0.022	2.712LeuHis: 2.712 ± 0.015	3.565LeuIle: 3.565 ± 0.015	5.484LeuLys: 5.484 ± 0.023	9.534LeuLeu: 9.534 ± 0.043	2.073LeuMet: 2.073 ± 0.012	3.499LeuAsn: 3.499 ± 0.014	5.375LeuPro: 5.375 ± 0.025	5.544LeuGln: 5.544 ± 0.027	5.479LeuArg: 5.479 ± 0.02	8.327LeuSer: 8.327 ± 0.03	5.163LeuThr: 5.163 ± 0.019	5.139LeuVal: 5.139 ± 0.017	0.971LeuTrp: 0.971 ± 0.007	2.428LeuTyr: 2.428 ± 0.014	0.003LeuXaa: 0.003 ± 0.0
Met	1.906MetAla: 1.906 ± 0.01	0.474MetCys: 0.474 ± 0.006	1.492MetAsp: 1.492 ± 0.008	2.044MetGlu: 2.044 ± 0.009	0.8MetPhe: 0.8 ± 0.007	1.47MetGly: 1.47 ± 0.011	0.508MetHis: 0.508 ± 0.005	0.852MetIle: 0.852 ± 0.006	1.514MetLys: 1.514 ± 0.01	2.078MetLeu: 2.078 ± 0.012	0.739MetMet: 0.739 ± 0.008	0.909MetAsn: 0.909 ± 0.007	1.179MetPro: 1.179 ± 0.013	1.061MetGln: 1.061 ± 0.008	1.225MetArg: 1.225 ± 0.009	1.995MetSer: 1.995 ± 0.01	1.31MetThr: 1.31 ± 0.008	1.54MetVal: 1.54 ± 0.008	0.257MetTrp: 0.257 ± 0.003	0.615MetTyr: 0.615 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.151AsnAla: 2.151 ± 0.011	0.816AsnCys: 0.816 ± 0.007	1.696AsnAsp: 1.696 ± 0.01	2.062AsnGlu: 2.062 ± 0.011	1.302AsnPhe: 1.302 ± 0.009	2.747AsnGly: 2.747 ± 0.017	1.011AsnHis: 1.011 ± 0.008	2.113AsnIle: 2.113 ± 0.012	2.261AsnLys: 2.261 ± 0.013	3.48AsnLeu: 3.48 ± 0.015	1.073AsnMet: 1.073 ± 0.008	1.862AsnAsn: 1.862 ± 0.011	2.206AsnPro: 2.206 ± 0.013	1.745AsnGln: 1.745 ± 0.01	1.976AsnArg: 1.976 ± 0.01	3.322AsnSer: 3.322 ± 0.016	2.341AsnThr: 2.341 ± 0.011	2.286AsnVal: 2.286 ± 0.013	0.405AsnTrp: 0.405 ± 0.004	1.111AsnTyr: 1.111 ± 0.01	0.001AsnXaa: 0.001 ± 0.0
Pro	4.503ProAla: 4.503 ± 0.026	1.044ProCys: 1.044 ± 0.01	2.938ProAsp: 2.938 ± 0.016	3.903ProGlu: 3.903 ± 0.02	1.707ProPhe: 1.707 ± 0.011	4.272ProGly: 4.272 ± 0.044	1.603ProHis: 1.603 ± 0.013	1.976ProIle: 1.976 ± 0.014	2.604ProLys: 2.604 ± 0.021	4.901ProLeu: 4.901 ± 0.02	1.097ProMet: 1.097 ± 0.009	1.943ProAsn: 1.943 ± 0.012	5.987ProPro: 5.987 ± 0.045	2.928ProGln: 2.928 ± 0.023	2.808ProArg: 2.808 ± 0.016	6.033ProSer: 6.033 ± 0.031	3.385ProThr: 3.385 ± 0.02	3.879ProVal: 3.879 ± 0.017	0.498ProTrp: 0.498 ± 0.005	1.423ProTyr: 1.423 ± 0.012	0.002ProXaa: 0.002 ± 0.0
Gln	3.297GlnAla: 3.297 ± 0.019	0.934GlnCys: 0.934 ± 0.009	2.359GlnAsp: 2.359 ± 0.011	3.608GlnGlu: 3.608 ± 0.018	1.327GlnPhe: 1.327 ± 0.01	2.85GlnGly: 2.85 ± 0.017	1.507GlnHis: 1.507 ± 0.012	1.919GlnIle: 1.919 ± 0.011	2.578GlnLys: 2.578 ± 0.014	4.543GlnLeu: 4.543 ± 0.024	1.193GlnMet: 1.193 ± 0.008	1.734GlnAsn: 1.734 ± 0.01	2.829GlnPro: 2.829 ± 0.022	4.064GlnGln: 4.064 ± 0.055	3.225GlnArg: 3.225 ± 0.019	3.781GlnSer: 3.781 ± 0.021	2.735GlnThr: 2.735 ± 0.016	2.776GlnVal: 2.776 ± 0.012	0.548GlnTrp: 0.548 ± 0.005	1.236GlnTyr: 1.236 ± 0.009	0.001GlnXaa: 0.001 ± 0.0
Arg	3.452ArgAla: 3.452 ± 0.013	1.19ArgCys: 1.19 ± 0.01	3.016ArgAsp: 3.016 ± 0.014	4.099ArgGlu: 4.099 ± 0.022	1.837ArgPhe: 1.837 ± 0.01	3.563ArgGly: 3.563 ± 0.021	1.592ArgHis: 1.592 ± 0.011	2.305ArgIle: 2.305 ± 0.012	3.566ArgLys: 3.566 ± 0.018	5.206ArgLeu: 5.206 ± 0.02	1.327ArgMet: 1.327 ± 0.009	2.083ArgAsn: 2.083 ± 0.01	3.091ArgPro: 3.091 ± 0.018	2.758ArgGln: 2.758 ± 0.015	4.467ArgArg: 4.467 ± 0.027	4.774ArgSer: 4.774 ± 0.027	2.968ArgThr: 2.968 ± 0.014	3.363ArgVal: 3.363 ± 0.022	0.647ArgTrp: 0.647 ± 0.006	1.494ArgTyr: 1.494 ± 0.009	0.002ArgXaa: 0.002 ± 0.0
Ser	5.915SerAla: 5.915 ± 0.021	1.943SerCys: 1.943 ± 0.013	4.573SerAsp: 4.573 ± 0.018	5.136SerGlu: 5.136 ± 0.019	2.929SerPhe: 2.929 ± 0.012	5.716SerGly: 5.716 ± 0.021	2.334SerHis: 2.334 ± 0.015	3.365SerIle: 3.365 ± 0.014	4.14SerLys: 4.14 ± 0.019	8.328SerLeu: 8.328 ± 0.031	1.951SerMet: 1.951 ± 0.009	3.108SerAsn: 3.108 ± 0.016	6.496SerPro: 6.496 ± 0.038	4.158SerGln: 4.158 ± 0.022	4.754SerArg: 4.754 ± 0.022	11.163SerSer: 11.163 ± 0.061	5.165SerThr: 5.165 ± 0.022	5.465SerVal: 5.465 ± 0.019	0.996SerTrp: 0.996 ± 0.009	2.158SerTyr: 2.158 ± 0.012	0.003SerXaa: 0.003 ± 0.0
Thr	4.205ThrAla: 4.205 ± 0.018	1.298ThrCys: 1.298 ± 0.011	2.973ThrAsp: 2.973 ± 0.014	3.875ThrGlu: 3.875 ± 0.017	1.997ThrPhe: 1.997 ± 0.009	3.742ThrGly: 3.742 ± 0.019	1.463ThrHis: 1.463 ± 0.012	2.416ThrIle: 2.416 ± 0.016	2.826ThrLys: 2.826 ± 0.018	5.405ThrLeu: 5.405 ± 0.017	1.28ThrMet: 1.28 ± 0.008	2.015ThrAsn: 2.015 ± 0.012	3.952ThrPro: 3.952 ± 0.02	2.493ThrGln: 2.493 ± 0.015	2.555ThrArg: 2.555 ± 0.011	5.194ThrSer: 5.194 ± 0.021	3.671ThrThr: 3.671 ± 0.028	4.189ThrVal: 4.189 ± 0.028	0.66ThrTrp: 0.66 ± 0.008	1.38ThrTyr: 1.38 ± 0.009	0.002ThrXaa: 0.002 ± 0.0
Val	4.031ValAla: 4.031 ± 0.019	1.612ValCys: 1.612 ± 0.011	3.213ValAsp: 3.213 ± 0.014	4.239ValGlu: 4.239 ± 0.025	2.383ValPhe: 2.383 ± 0.014	3.474ValGly: 3.474 ± 0.015	1.579ValHis: 1.579 ± 0.009	2.839ValIle: 2.839 ± 0.016	3.748ValLys: 3.748 ± 0.027	5.824ValLeu: 5.824 ± 0.022	1.51ValMet: 1.51 ± 0.008	2.463ValAsn: 2.463 ± 0.014	3.358ValPro: 3.358 ± 0.016	2.833ValGln: 2.833 ± 0.014	3.224ValArg: 3.224 ± 0.014	5.438ValSer: 5.438 ± 0.02	4.096ValThr: 4.096 ± 0.031	4.291ValVal: 4.291 ± 0.02	0.729ValTrp: 0.729 ± 0.006	1.715ValTyr: 1.715 ± 0.01	0.002ValXaa: 0.002 ± 0.0
Trp	0.621TrpAla: 0.621 ± 0.006	0.223TrpCys: 0.223 ± 0.003	0.623TrpAsp: 0.623 ± 0.007	0.734TrpGlu: 0.734 ± 0.008	0.442TrpPhe: 0.442 ± 0.005	0.589TrpGly: 0.589 ± 0.008	0.262TrpHis: 0.262 ± 0.004	0.502TrpIle: 0.502 ± 0.005	0.684TrpLys: 0.684 ± 0.007	1.057TrpLeu: 1.057 ± 0.009	0.327TrpMet: 0.327 ± 0.005	0.476TrpAsn: 0.476 ± 0.005	0.416TrpPro: 0.416 ± 0.005	0.473TrpGln: 0.473 ± 0.005	0.705TrpArg: 0.705 ± 0.007	0.899TrpSer: 0.899 ± 0.009	0.691TrpThr: 0.691 ± 0.009	0.651TrpVal: 0.651 ± 0.007	0.165TrpTrp: 0.165 ± 0.003	0.328TrpTyr: 0.328 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.363TyrAla: 1.363 ± 0.009	0.666TyrCys: 0.666 ± 0.008	1.345TyrAsp: 1.345 ± 0.01	1.582TyrGlu: 1.582 ± 0.012	1.063TyrPhe: 1.063 ± 0.008	1.636TyrGly: 1.636 ± 0.011	0.81TyrHis: 0.81 ± 0.008	1.387TyrIle: 1.387 ± 0.012	1.467TyrLys: 1.467 ± 0.018	2.418TyrLeu: 2.418 ± 0.012	0.654TyrMet: 0.654 ± 0.006	1.154TyrAsn: 1.154 ± 0.009	1.26TyrPro: 1.26 ± 0.011	1.238TyrGln: 1.238 ± 0.008	1.649TyrArg: 1.649 ± 0.013	2.336TyrSer: 2.336 ± 0.013	1.634TyrThr: 1.634 ± 0.012	1.493TyrVal: 1.493 ± 0.012	0.346TyrTrp: 0.346 ± 0.005	0.9TyrTyr: 0.9 ± 0.008	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.003XaaGlu: 0.003 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.003XaaGly: 0.003 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.003XaaPro: 0.003 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.003XaaSer: 0.003 ± 0.0	0.002XaaThr: 0.002 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 32862 proteins (22561719 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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