Amino acid dipepetide frequency for Pseudorhodobacter turbinis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.495AlaAla: 16.495 ± 0.178	1.131AlaCys: 1.131 ± 0.037	6.907AlaAsp: 6.907 ± 0.087	7.774AlaGlu: 7.774 ± 0.102	4.404AlaPhe: 4.404 ± 0.07	10.371AlaGly: 10.371 ± 0.125	2.328AlaHis: 2.328 ± 0.049	6.229AlaIle: 6.229 ± 0.079	4.608AlaLys: 4.608 ± 0.083	13.661AlaLeu: 13.661 ± 0.139	4.021AlaMet: 4.021 ± 0.062	3.097AlaAsn: 3.097 ± 0.064	5.609AlaPro: 5.609 ± 0.085	4.806AlaGln: 4.806 ± 0.073	8.22AlaArg: 8.22 ± 0.105	5.835AlaSer: 5.835 ± 0.092	6.328AlaThr: 6.328 ± 0.083	8.421AlaVal: 8.421 ± 0.096	1.367AlaTrp: 1.367 ± 0.045	2.526AlaTyr: 2.526 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.1CysAla: 1.1 ± 0.032	0.127CysCys: 0.127 ± 0.011	0.634CysAsp: 0.634 ± 0.025	0.41CysGlu: 0.41 ± 0.019	0.363CysPhe: 0.363 ± 0.018	0.892CysGly: 0.892 ± 0.026	0.278CysHis: 0.278 ± 0.015	0.466CysIle: 0.466 ± 0.023	0.262CysLys: 0.262 ± 0.014	0.873CysLeu: 0.873 ± 0.027	0.176CysMet: 0.176 ± 0.012	0.241CysAsn: 0.241 ± 0.014	0.549CysPro: 0.549 ± 0.025	0.252CysGln: 0.252 ± 0.014	0.545CysArg: 0.545 ± 0.023	0.455CysSer: 0.455 ± 0.022	0.474CysThr: 0.474 ± 0.019	0.628CysVal: 0.628 ± 0.026	0.098CysTrp: 0.098 ± 0.01	0.219CysTyr: 0.219 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.196AspAla: 7.196 ± 0.099	0.561AspCys: 0.561 ± 0.022	3.191AspAsp: 3.191 ± 0.076	3.228AspGlu: 3.228 ± 0.06	2.319AspPhe: 2.319 ± 0.041	5.251AspGly: 5.251 ± 0.082	1.319AspHis: 1.319 ± 0.034	3.21AspIle: 3.21 ± 0.06	1.785AspLys: 1.785 ± 0.041	6.416AspLeu: 6.416 ± 0.084	1.719AspMet: 1.719 ± 0.034	1.348AspAsn: 1.348 ± 0.038	3.344AspPro: 3.344 ± 0.054	1.848AspGln: 1.848 ± 0.037	3.913AspArg: 3.913 ± 0.061	2.291AspSer: 2.291 ± 0.048	2.932AspThr: 2.932 ± 0.059	4.169AspVal: 4.169 ± 0.057	1.088AspTrp: 1.088 ± 0.028	1.492AspTyr: 1.492 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.596GluAla: 7.596 ± 0.116	0.383GluCys: 0.383 ± 0.017	2.908GluAsp: 2.908 ± 0.054	2.987GluGlu: 2.987 ± 0.076	1.746GluPhe: 1.746 ± 0.042	4.656GluGly: 4.656 ± 0.07	1.051GluHis: 1.051 ± 0.03	3.36GluIle: 3.36 ± 0.056	2.076GluLys: 2.076 ± 0.049	4.779GluLeu: 4.779 ± 0.073	1.848GluMet: 1.848 ± 0.04	1.667GluAsn: 1.667 ± 0.034	2.222GluPro: 2.222 ± 0.055	1.863GluGln: 1.863 ± 0.044	3.718GluArg: 3.718 ± 0.065	2.191GluSer: 2.191 ± 0.043	3.471GluThr: 3.471 ± 0.056	4.434GluVal: 4.434 ± 0.069	0.749GluTrp: 0.749 ± 0.026	1.071GluTyr: 1.071 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.541PheAla: 4.541 ± 0.066	0.441PheCys: 0.441 ± 0.021	2.839PheAsp: 2.839 ± 0.052	2.092PheGlu: 2.092 ± 0.044	1.499PhePhe: 1.499 ± 0.045	3.767PheGly: 3.767 ± 0.063	0.732PheHis: 0.732 ± 0.026	1.812PheIle: 1.812 ± 0.045	1.06PheLys: 1.06 ± 0.033	3.513PheLeu: 3.513 ± 0.07	0.915PheMet: 0.915 ± 0.028	1.092PheAsn: 1.092 ± 0.031	1.557PhePro: 1.557 ± 0.045	1.058PheGln: 1.058 ± 0.028	2.01PheArg: 2.01 ± 0.038	2.259PheSer: 2.259 ± 0.044	2.2PheThr: 2.2 ± 0.048	2.689PheVal: 2.689 ± 0.046	0.558PheTrp: 0.558 ± 0.023	0.911PheTyr: 0.911 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.952GlyAla: 9.952 ± 0.13	0.804GlyCys: 0.804 ± 0.026	4.57GlyAsp: 4.57 ± 0.08	4.161GlyGlu: 4.161 ± 0.068	3.805GlyPhe: 3.805 ± 0.057	7.277GlyGly: 7.277 ± 0.107	1.929GlyHis: 1.929 ± 0.046	4.74GlyIle: 4.74 ± 0.072	3.484GlyLys: 3.484 ± 0.066	9.249GlyLeu: 9.249 ± 0.105	2.722GlyMet: 2.722 ± 0.053	2.26GlyAsn: 2.26 ± 0.061	3.581GlyPro: 3.581 ± 0.058	3.196GlyGln: 3.196 ± 0.05	5.397GlyArg: 5.397 ± 0.059	4.164GlySer: 4.164 ± 0.075	4.608GlyThr: 4.608 ± 0.074	6.485GlyVal: 6.485 ± 0.068	1.375GlyTrp: 1.375 ± 0.043	2.224GlyTyr: 2.224 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.356HisAla: 2.356 ± 0.048	0.255HisCys: 0.255 ± 0.015	1.277HisAsp: 1.277 ± 0.034	1.043HisGlu: 1.043 ± 0.029	0.843HisPhe: 0.843 ± 0.03	1.825HisGly: 1.825 ± 0.034	0.533HisHis: 0.533 ± 0.024	1.081HisIle: 1.081 ± 0.033	0.564HisLys: 0.564 ± 0.019	2.124HisLeu: 2.124 ± 0.049	0.542HisMet: 0.542 ± 0.021	0.551HisAsn: 0.551 ± 0.022	1.335HisPro: 1.335 ± 0.039	0.628HisGln: 0.628 ± 0.023	1.273HisArg: 1.273 ± 0.037	1.08HisSer: 1.08 ± 0.031	0.843HisThr: 0.843 ± 0.03	1.382HisVal: 1.382 ± 0.036	0.326HisTrp: 0.326 ± 0.016	0.568HisTyr: 0.568 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.311IleAla: 7.311 ± 0.091	0.643IleCys: 0.643 ± 0.025	3.477IleAsp: 3.477 ± 0.056	3.333IleGlu: 3.333 ± 0.052	1.888IlePhe: 1.888 ± 0.044	5.063IleGly: 5.063 ± 0.07	0.955IleHis: 0.955 ± 0.029	2.692IleIle: 2.692 ± 0.06	1.723IleLys: 1.723 ± 0.042	5.072IleLeu: 5.072 ± 0.079	1.203IleMet: 1.203 ± 0.036	1.635IleAsn: 1.635 ± 0.045	2.512IlePro: 2.512 ± 0.045	1.264IleGln: 1.264 ± 0.032	3.098IleArg: 3.098 ± 0.052	3.395IleSer: 3.395 ± 0.057	3.296IleThr: 3.296 ± 0.053	3.67IleVal: 3.67 ± 0.075	0.749IleTrp: 0.749 ± 0.025	1.218IleTyr: 1.218 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.29LysAla: 4.29 ± 0.07	0.213LysCys: 0.213 ± 0.015	1.875LysAsp: 1.875 ± 0.042	1.612LysGlu: 1.612 ± 0.04	1.005LysPhe: 1.005 ± 0.031	3.146LysGly: 3.146 ± 0.064	0.678LysHis: 0.678 ± 0.026	1.901LysIle: 1.901 ± 0.041	1.309LysLys: 1.309 ± 0.041	3.318LysLeu: 3.318 ± 0.058	1.071LysMet: 1.071 ± 0.034	0.97LysAsn: 0.97 ± 0.028	2.012LysPro: 2.012 ± 0.047	0.986LysGln: 0.986 ± 0.032	2.438LysArg: 2.438 ± 0.051	2.044LysSer: 2.044 ± 0.045	2.229LysThr: 2.229 ± 0.046	2.47LysVal: 2.47 ± 0.049	0.419LysTrp: 0.419 ± 0.021	0.684LysTyr: 0.684 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.322LeuAla: 13.322 ± 0.132	1.018LeuCys: 1.018 ± 0.03	5.845LeuAsp: 5.845 ± 0.074	5.159LeuGlu: 5.159 ± 0.067	3.504LeuPhe: 3.504 ± 0.063	8.633LeuGly: 8.633 ± 0.091	2.007LeuHis: 2.007 ± 0.046	5.415LeuIle: 5.415 ± 0.083	3.339LeuLys: 3.339 ± 0.049	9.108LeuLeu: 9.108 ± 0.116	2.814LeuMet: 2.814 ± 0.061	2.699LeuAsn: 2.699 ± 0.047	5.496LeuPro: 5.496 ± 0.077	2.957LeuGln: 2.957 ± 0.054	7.067LeuArg: 7.067 ± 0.1	6.552LeuSer: 6.552 ± 0.079	6.244LeuThr: 6.244 ± 0.078	6.77LeuVal: 6.77 ± 0.084	1.269LeuTrp: 1.269 ± 0.039	1.984LeuTyr: 1.984 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.65MetAla: 3.65 ± 0.057	0.188MetCys: 0.188 ± 0.012	1.429MetAsp: 1.429 ± 0.034	1.48MetGlu: 1.48 ± 0.038	0.871MetPhe: 0.871 ± 0.031	2.431MetGly: 2.431 ± 0.043	0.463MetHis: 0.463 ± 0.022	1.775MetIle: 1.775 ± 0.045	1.146MetLys: 1.146 ± 0.033	2.878MetLeu: 2.878 ± 0.055	0.907MetMet: 0.907 ± 0.031	0.885MetAsn: 0.885 ± 0.023	1.582MetPro: 1.582 ± 0.038	1.024MetGln: 1.024 ± 0.031	1.893MetArg: 1.893 ± 0.036	1.668MetSer: 1.668 ± 0.037	2.296MetThr: 2.296 ± 0.045	1.941MetVal: 1.941 ± 0.044	0.253MetTrp: 0.253 ± 0.012	0.36MetTyr: 0.36 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.335AsnAla: 3.335 ± 0.07	0.246AsnCys: 0.246 ± 0.015	1.524AsnAsp: 1.524 ± 0.044	1.222AsnGlu: 1.222 ± 0.036	1.016AsnPhe: 1.016 ± 0.033	2.509AsnGly: 2.509 ± 0.058	0.58AsnHis: 0.58 ± 0.02	1.585AsnIle: 1.585 ± 0.042	0.801AsnLys: 0.801 ± 0.029	2.756AsnLeu: 2.756 ± 0.046	0.772AsnMet: 0.772 ± 0.025	0.753AsnAsn: 0.753 ± 0.028	2.006AsnPro: 2.006 ± 0.046	0.775AsnGln: 0.775 ± 0.025	1.814AsnArg: 1.814 ± 0.041	1.29AsnSer: 1.29 ± 0.036	1.552AsnThr: 1.552 ± 0.047	1.879AsnVal: 1.879 ± 0.048	0.432AsnTrp: 0.432 ± 0.02	0.624AsnTyr: 0.624 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.552ProAla: 5.552 ± 0.072	0.373ProCys: 0.373 ± 0.018	3.819ProAsp: 3.819 ± 0.068	3.81ProGlu: 3.81 ± 0.063	1.987ProPhe: 1.987 ± 0.043	3.739ProGly: 3.739 ± 0.059	1.059ProHis: 1.059 ± 0.031	2.299ProIle: 2.299 ± 0.048	1.952ProLys: 1.952 ± 0.044	4.677ProLeu: 4.677 ± 0.067	1.377ProMet: 1.377 ± 0.039	1.39ProAsn: 1.39 ± 0.032	2.241ProPro: 2.241 ± 0.048	1.79ProGln: 1.79 ± 0.035	2.62ProArg: 2.62 ± 0.054	2.612ProSer: 2.612 ± 0.046	2.513ProThr: 2.513 ± 0.049	4.066ProVal: 4.066 ± 0.059	0.609ProTrp: 0.609 ± 0.022	1.166ProTyr: 1.166 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.243GlnAla: 4.243 ± 0.07	0.225GlnCys: 0.225 ± 0.015	1.76GlnAsp: 1.76 ± 0.044	1.597GlnGlu: 1.597 ± 0.04	1.091GlnPhe: 1.091 ± 0.036	2.663GlnGly: 2.663 ± 0.054	0.642GlnHis: 0.642 ± 0.024	2.165GlnIle: 2.165 ± 0.041	1.247GlnLys: 1.247 ± 0.033	2.79GlnLeu: 2.79 ± 0.047	1.161GlnMet: 1.161 ± 0.033	1.026GlnAsn: 1.026 ± 0.027	1.552GlnPro: 1.552 ± 0.034	1.098GlnGln: 1.098 ± 0.037	2.213GlnArg: 2.213 ± 0.043	2.047GlnSer: 2.047 ± 0.039	1.987GlnThr: 1.987 ± 0.038	2.356GlnVal: 2.356 ± 0.042	0.39GlnTrp: 0.39 ± 0.02	0.633GlnTyr: 0.633 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.754ArgAla: 7.754 ± 0.095	0.499ArgCys: 0.499 ± 0.02	3.889ArgAsp: 3.889 ± 0.061	3.349ArgGlu: 3.349 ± 0.057	2.609ArgPhe: 2.609 ± 0.048	4.433ArgGly: 4.433 ± 0.064	1.515ArgHis: 1.515 ± 0.036	3.742ArgIle: 3.742 ± 0.057	2.42ArgLys: 2.42 ± 0.047	6.89ArgLeu: 6.89 ± 0.098	2.026ArgMet: 2.026 ± 0.039	1.869ArgAsn: 1.869 ± 0.034	3.075ArgPro: 3.075 ± 0.056	2.226ArgGln: 2.226 ± 0.045	4.415ArgArg: 4.415 ± 0.068	3.105ArgSer: 3.105 ± 0.051	2.895ArgThr: 2.895 ± 0.054	4.474ArgVal: 4.474 ± 0.065	0.87ArgTrp: 0.87 ± 0.027	1.506ArgTyr: 1.506 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.978SerAla: 5.978 ± 0.087	0.462SerCys: 0.462 ± 0.022	3.169SerAsp: 3.169 ± 0.058	2.583SerGlu: 2.583 ± 0.044	2.339SerPhe: 2.339 ± 0.043	5.548SerGly: 5.548 ± 0.083	1.134SerHis: 1.134 ± 0.033	2.768SerIle: 2.768 ± 0.051	1.724SerLys: 1.724 ± 0.044	5.46SerLeu: 5.46 ± 0.074	1.426SerMet: 1.426 ± 0.035	1.432SerAsn: 1.432 ± 0.036	2.453SerPro: 2.453 ± 0.039	1.732SerGln: 1.732 ± 0.037	3.209SerArg: 3.209 ± 0.053	2.775SerSer: 2.775 ± 0.057	2.779SerThr: 2.779 ± 0.055	3.947SerVal: 3.947 ± 0.07	0.679SerTrp: 0.679 ± 0.023	1.341SerTyr: 1.341 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.692ThrAla: 6.692 ± 0.1	0.5ThrCys: 0.5 ± 0.023	3.195ThrAsp: 3.195 ± 0.054	2.911ThrGlu: 2.911 ± 0.051	1.958ThrPhe: 1.958 ± 0.042	5.309ThrGly: 5.309 ± 0.08	1.155ThrHis: 1.155 ± 0.033	2.923ThrIle: 2.923 ± 0.051	1.767ThrLys: 1.767 ± 0.045	6.22ThrLeu: 6.22 ± 0.085	1.311ThrMet: 1.311 ± 0.034	1.491ThrAsn: 1.491 ± 0.037	3.441ThrPro: 3.441 ± 0.06	1.759ThrGln: 1.759 ± 0.042	3.412ThrArg: 3.412 ± 0.057	3.061ThrSer: 3.061 ± 0.068	3.121ThrThr: 3.121 ± 0.073	4.234ThrVal: 4.234 ± 0.076	0.642ThrTrp: 0.642 ± 0.027	1.312ThrTyr: 1.312 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	8.775ValAla: 8.775 ± 0.094	0.617ValCys: 0.617 ± 0.025	4.02ValAsp: 4.02 ± 0.062	4.306ValGlu: 4.306 ± 0.063	2.86ValPhe: 2.86 ± 0.058	5.439ValGly: 5.439 ± 0.075	1.229ValHis: 1.229 ± 0.033	4.356ValIle: 4.356 ± 0.066	2.315ValLys: 2.315 ± 0.057	7.506ValLeu: 7.506 ± 0.088	2.233ValMet: 2.233 ± 0.048	2.007ValAsn: 2.007 ± 0.046	3.332ValPro: 3.332 ± 0.056	2.329ValGln: 2.329 ± 0.043	3.814ValArg: 3.814 ± 0.067	4.164ValSer: 4.164 ± 0.068	4.745ValThr: 4.745 ± 0.073	5.555ValVal: 5.555 ± 0.077	0.897ValTrp: 0.897 ± 0.03	1.434ValTyr: 1.434 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.428TrpAla: 1.428 ± 0.042	0.124TrpCys: 0.124 ± 0.01	0.741TrpAsp: 0.741 ± 0.025	0.605TrpGlu: 0.605 ± 0.023	0.542TrpPhe: 0.542 ± 0.022	0.997TrpGly: 0.997 ± 0.029	0.316TrpHis: 0.316 ± 0.015	0.658TrpIle: 0.658 ± 0.023	0.437TrpLys: 0.437 ± 0.017	1.589TrpLeu: 1.589 ± 0.039	0.369TrpMet: 0.369 ± 0.019	0.395TrpAsn: 0.395 ± 0.019	0.696TrpPro: 0.696 ± 0.024	0.63TrpGln: 0.63 ± 0.024	1.033TrpArg: 1.033 ± 0.036	0.709TrpSer: 0.709 ± 0.025	0.701TrpThr: 0.701 ± 0.026	0.921TrpVal: 0.921 ± 0.032	0.2TrpTrp: 0.2 ± 0.014	0.249TrpTyr: 0.249 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.575TyrAla: 2.575 ± 0.042	0.234TyrCys: 0.234 ± 0.014	1.552TyrAsp: 1.552 ± 0.036	1.114TyrGlu: 1.114 ± 0.032	0.895TyrPhe: 0.895 ± 0.03	2.034TyrGly: 2.034 ± 0.045	0.525TyrHis: 0.525 ± 0.019	1.02TyrIle: 1.02 ± 0.033	0.646TyrLys: 0.646 ± 0.03	2.324TyrLeu: 2.324 ± 0.05	0.505TyrMet: 0.505 ± 0.022	0.664TyrAsn: 0.664 ± 0.025	1.058TyrPro: 1.058 ± 0.028	0.666TyrGln: 0.666 ± 0.022	1.458TyrArg: 1.458 ± 0.034	1.244TyrSer: 1.244 ± 0.036	1.198TyrThr: 1.198 ± 0.031	1.441TyrVal: 1.441 ± 0.035	0.369TyrTrp: 0.369 ± 0.019	0.567TyrTyr: 0.567 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3753 proteins (1189126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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