Amino acid dipepetide frequency for Devosia geojensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.753AlaAla: 16.753 ± 0.171	0.853AlaCys: 0.853 ± 0.028	7.041AlaAsp: 7.041 ± 0.075	8.311AlaGlu: 8.311 ± 0.101	4.618AlaPhe: 4.618 ± 0.058	11.216AlaGly: 11.216 ± 0.11	2.176AlaHis: 2.176 ± 0.041	6.916AlaIle: 6.916 ± 0.078	3.056AlaLys: 3.056 ± 0.056	13.584AlaLeu: 13.584 ± 0.124	3.675AlaMet: 3.675 ± 0.057	3.019AlaAsn: 3.019 ± 0.052	5.477AlaPro: 5.477 ± 0.08	3.896AlaGln: 3.896 ± 0.056	9.074AlaArg: 9.074 ± 0.096	5.927AlaSer: 5.927 ± 0.073	5.977AlaThr: 5.977 ± 0.07	9.125AlaVal: 9.125 ± 0.099	1.536AlaTrp: 1.536 ± 0.036	2.676AlaTyr: 2.676 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.825CysAla: 0.825 ± 0.028	0.075CysCys: 0.075 ± 0.008	0.435CysAsp: 0.435 ± 0.019	0.387CysGlu: 0.387 ± 0.018	0.268CysPhe: 0.268 ± 0.014	0.743CysGly: 0.743 ± 0.026	0.235CysHis: 0.235 ± 0.014	0.315CysIle: 0.315 ± 0.016	0.125CysLys: 0.125 ± 0.01	0.691CysLeu: 0.691 ± 0.027	0.117CysMet: 0.117 ± 0.009	0.174CysAsn: 0.174 ± 0.012	0.351CysPro: 0.351 ± 0.019	0.189CysGln: 0.189 ± 0.013	0.469CysArg: 0.469 ± 0.021	0.318CysSer: 0.318 ± 0.015	0.327CysThr: 0.327 ± 0.019	0.513CysVal: 0.513 ± 0.022	0.094CysTrp: 0.094 ± 0.008	0.17CysTyr: 0.17 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.65AspAla: 6.65 ± 0.078	0.38AspCys: 0.38 ± 0.019	2.846AspAsp: 2.846 ± 0.052	3.717AspGlu: 3.717 ± 0.061	2.3AspPhe: 2.3 ± 0.044	5.053AspGly: 5.053 ± 0.074	1.209AspHis: 1.209 ± 0.033	3.412AspIle: 3.412 ± 0.053	1.58AspLys: 1.58 ± 0.043	5.919AspLeu: 5.919 ± 0.073	1.337AspMet: 1.337 ± 0.035	1.31AspAsn: 1.31 ± 0.034	3.653AspPro: 3.653 ± 0.051	1.479AspGln: 1.479 ± 0.033	3.895AspArg: 3.895 ± 0.061	1.878AspSer: 1.878 ± 0.047	2.551AspThr: 2.551 ± 0.046	4.12AspVal: 4.12 ± 0.055	1.046AspTrp: 1.046 ± 0.034	1.602AspTyr: 1.602 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.45GluAla: 8.45 ± 0.101	0.272GluCys: 0.272 ± 0.017	2.996GluAsp: 2.996 ± 0.053	3.764GluGlu: 3.764 ± 0.067	1.953GluPhe: 1.953 ± 0.047	4.879GluGly: 4.879 ± 0.072	1.262GluHis: 1.262 ± 0.034	3.549GluIle: 3.549 ± 0.058	2.042GluLys: 2.042 ± 0.05	5.66GluLeu: 5.66 ± 0.066	1.685GluMet: 1.685 ± 0.041	1.638GluAsn: 1.638 ± 0.042	3.131GluPro: 3.131 ± 0.064	1.938GluGln: 1.938 ± 0.041	5.174GluArg: 5.174 ± 0.078	2.331GluSer: 2.331 ± 0.046	3.916GluThr: 3.916 ± 0.053	4.302GluVal: 4.302 ± 0.065	0.812GluTrp: 0.812 ± 0.026	1.087GluTyr: 1.087 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	5.014PheAla: 5.014 ± 0.075	0.346PheCys: 0.346 ± 0.016	2.634PheAsp: 2.634 ± 0.047	2.371PheGlu: 2.371 ± 0.046	1.569PhePhe: 1.569 ± 0.04	3.815PheGly: 3.815 ± 0.061	0.775PheHis: 0.775 ± 0.022	1.86PheIle: 1.86 ± 0.045	0.905PheLys: 0.905 ± 0.027	3.592PheLeu: 3.592 ± 0.058	0.809PheMet: 0.809 ± 0.026	1.124PheAsn: 1.124 ± 0.029	1.646PhePro: 1.646 ± 0.031	0.989PheGln: 0.989 ± 0.026	2.085PheArg: 2.085 ± 0.045	2.297PheSer: 2.297 ± 0.042	2.074PheThr: 2.074 ± 0.041	3.202PheVal: 3.202 ± 0.054	0.628PheTrp: 0.628 ± 0.026	1.044PheTyr: 1.044 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	9.276GlyAla: 9.276 ± 0.099	0.719GlyCys: 0.719 ± 0.026	4.203GlyAsp: 4.203 ± 0.056	5.591GlyGlu: 5.591 ± 0.075	3.734GlyPhe: 3.734 ± 0.055	7.173GlyGly: 7.173 ± 0.109	1.775GlyHis: 1.775 ± 0.036	4.908GlyIle: 4.908 ± 0.067	3.162GlyLys: 3.162 ± 0.052	9.219GlyLeu: 9.219 ± 0.097	2.326GlyMet: 2.326 ± 0.047	2.301GlyAsn: 2.301 ± 0.049	3.618GlyPro: 3.618 ± 0.061	2.886GlyGln: 2.886 ± 0.054	6.12GlyArg: 6.12 ± 0.071	4.411GlySer: 4.411 ± 0.066	4.742GlyThr: 4.742 ± 0.075	6.364GlyVal: 6.364 ± 0.07	1.435GlyTrp: 1.435 ± 0.04	2.403GlyTyr: 2.403 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.196HisAla: 2.196 ± 0.052	0.181HisCys: 0.181 ± 0.013	1.18HisAsp: 1.18 ± 0.034	1.106HisGlu: 1.106 ± 0.026	0.865HisPhe: 0.865 ± 0.025	1.81HisGly: 1.81 ± 0.04	0.562HisHis: 0.562 ± 0.023	1.068HisIle: 1.068 ± 0.024	0.489HisLys: 0.489 ± 0.022	2.092HisLeu: 2.092 ± 0.043	0.509HisMet: 0.509 ± 0.02	0.499HisAsn: 0.499 ± 0.021	1.313HisPro: 1.313 ± 0.039	0.616HisGln: 0.616 ± 0.021	1.376HisArg: 1.376 ± 0.035	0.86HisSer: 0.86 ± 0.024	0.798HisThr: 0.798 ± 0.025	1.485HisVal: 1.485 ± 0.033	0.323HisTrp: 0.323 ± 0.015	0.548HisTyr: 0.548 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.93IleAla: 7.93 ± 0.088	0.445IleCys: 0.445 ± 0.02	3.7IleAsp: 3.7 ± 0.063	4.061IleGlu: 4.061 ± 0.064	1.951IlePhe: 1.951 ± 0.049	5.305IleGly: 5.305 ± 0.084	0.874IleHis: 0.874 ± 0.026	2.425IleIle: 2.425 ± 0.056	1.268IleLys: 1.268 ± 0.038	4.737IleLeu: 4.737 ± 0.07	1.008IleMet: 1.008 ± 0.028	1.445IleAsn: 1.445 ± 0.039	2.422IlePro: 2.422 ± 0.043	1.111IleGln: 1.111 ± 0.031	3.084IleArg: 3.084 ± 0.058	2.875IleSer: 2.875 ± 0.053	2.702IleThr: 2.702 ± 0.05	4.854IleVal: 4.854 ± 0.071	0.643IleTrp: 0.643 ± 0.023	1.304IleTyr: 1.304 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.893LysAla: 3.893 ± 0.062	0.119LysCys: 0.119 ± 0.01	1.475LysAsp: 1.475 ± 0.038	1.316LysGlu: 1.316 ± 0.035	0.824LysPhe: 0.824 ± 0.029	2.327LysGly: 2.327 ± 0.046	0.544LysHis: 0.544 ± 0.022	1.406LysIle: 1.406 ± 0.041	0.908LysLys: 0.908 ± 0.031	2.833LysLeu: 2.833 ± 0.054	0.603LysMet: 0.603 ± 0.021	0.63LysAsn: 0.63 ± 0.025	1.822LysPro: 1.822 ± 0.045	0.775LysGln: 0.775 ± 0.022	2.256LysArg: 2.256 ± 0.046	1.668LysSer: 1.668 ± 0.039	1.68LysThr: 1.68 ± 0.037	2.218LysVal: 2.218 ± 0.045	0.336LysTrp: 0.336 ± 0.017	0.556LysTyr: 0.556 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.375LeuAla: 14.375 ± 0.132	0.719LeuCys: 0.719 ± 0.023	6.211LeuAsp: 6.211 ± 0.084	5.715LeuGlu: 5.715 ± 0.082	3.67LeuPhe: 3.67 ± 0.055	8.392LeuGly: 8.392 ± 0.091	1.774LeuHis: 1.774 ± 0.042	5.224LeuIle: 5.224 ± 0.083	3.357LeuLys: 3.357 ± 0.068	9.17LeuLeu: 9.17 ± 0.129	2.418LeuMet: 2.418 ± 0.048	2.6LeuAsn: 2.6 ± 0.053	5.578LeuPro: 5.578 ± 0.076	2.404LeuGln: 2.404 ± 0.041	6.316LeuArg: 6.316 ± 0.076	6.231LeuSer: 6.231 ± 0.08	5.878LeuThr: 5.878 ± 0.063	8.278LeuVal: 8.278 ± 0.089	1.166LeuTrp: 1.166 ± 0.039	2.167LeuTyr: 2.167 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.157MetAla: 3.157 ± 0.057	0.119MetCys: 0.119 ± 0.009	1.134MetAsp: 1.134 ± 0.031	1.126MetGlu: 1.126 ± 0.032	0.734MetPhe: 0.734 ± 0.026	1.897MetGly: 1.897 ± 0.049	0.451MetHis: 0.451 ± 0.017	1.404MetIle: 1.404 ± 0.038	0.843MetLys: 0.843 ± 0.029	2.506MetLeu: 2.506 ± 0.045	0.624MetMet: 0.624 ± 0.024	0.715MetAsn: 0.715 ± 0.027	1.474MetPro: 1.474 ± 0.038	0.827MetGln: 0.827 ± 0.029	1.914MetArg: 1.914 ± 0.042	1.699MetSer: 1.699 ± 0.036	1.888MetThr: 1.888 ± 0.038	1.874MetVal: 1.874 ± 0.039	0.216MetTrp: 0.216 ± 0.014	0.338MetTyr: 0.338 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.047AsnAla: 3.047 ± 0.052	0.207AsnCys: 0.207 ± 0.014	1.334AsnAsp: 1.334 ± 0.036	1.383AsnGlu: 1.383 ± 0.033	1.048AsnPhe: 1.048 ± 0.029	2.424AsnGly: 2.424 ± 0.043	0.506AsnHis: 0.506 ± 0.019	1.416AsnIle: 1.416 ± 0.035	0.625AsnLys: 0.625 ± 0.023	2.749AsnLeu: 2.749 ± 0.057	0.611AsnMet: 0.611 ± 0.024	0.678AsnAsn: 0.678 ± 0.024	1.892AsnPro: 1.892 ± 0.042	0.759AsnGln: 0.759 ± 0.026	1.76AsnArg: 1.76 ± 0.039	1.199AsnSer: 1.199 ± 0.027	1.311AsnThr: 1.311 ± 0.042	2.024AsnVal: 2.024 ± 0.041	0.449AsnTrp: 0.449 ± 0.018	0.775AsnTyr: 0.775 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.327ProAla: 6.327 ± 0.094	0.242ProCys: 0.242 ± 0.013	3.592ProAsp: 3.592 ± 0.055	3.923ProGlu: 3.923 ± 0.059	2.037ProPhe: 2.037 ± 0.041	4.472ProGly: 4.472 ± 0.066	1.129ProHis: 1.129 ± 0.031	2.419ProIle: 2.419 ± 0.053	1.418ProLys: 1.418 ± 0.033	4.918ProLeu: 4.918 ± 0.072	1.183ProMet: 1.183 ± 0.032	1.406ProAsn: 1.406 ± 0.034	2.453ProPro: 2.453 ± 0.066	1.885ProGln: 1.885 ± 0.04	2.914ProArg: 2.914 ± 0.047	2.548ProSer: 2.548 ± 0.048	2.609ProThr: 2.609 ± 0.05	4.408ProVal: 4.408 ± 0.066	0.724ProTrp: 0.724 ± 0.027	1.33ProTyr: 1.33 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.806GlnAla: 3.806 ± 0.061	0.16GlnCys: 0.16 ± 0.011	1.417GlnAsp: 1.417 ± 0.032	1.399GlnGlu: 1.399 ± 0.03	1.236GlnPhe: 1.236 ± 0.035	2.284GlnGly: 2.284 ± 0.045	0.553GlnHis: 0.553 ± 0.018	1.739GlnIle: 1.739 ± 0.042	0.913GlnLys: 0.913 ± 0.028	2.793GlnLeu: 2.793 ± 0.054	0.934GlnMet: 0.934 ± 0.027	0.851GlnAsn: 0.851 ± 0.024	1.737GlnPro: 1.737 ± 0.041	1.099GlnGln: 1.099 ± 0.035	2.338GlnArg: 2.338 ± 0.047	1.595GlnSer: 1.595 ± 0.037	1.676GlnThr: 1.676 ± 0.04	2.429GlnVal: 2.429 ± 0.04	0.419GlnTrp: 0.419 ± 0.018	0.698GlnTyr: 0.698 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.669ArgAla: 7.669 ± 0.095	0.432ArgCys: 0.432 ± 0.019	3.775ArgAsp: 3.775 ± 0.055	4.439ArgGlu: 4.439 ± 0.067	2.891ArgPhe: 2.891 ± 0.051	4.699ArgGly: 4.699 ± 0.063	1.675ArgHis: 1.675 ± 0.043	4.122ArgIle: 4.122 ± 0.061	2.086ArgLys: 2.086 ± 0.043	7.741ArgLeu: 7.741 ± 0.098	1.889ArgMet: 1.889 ± 0.037	1.89ArgAsn: 1.89 ± 0.038	3.443ArgPro: 3.443 ± 0.062	2.689ArgGln: 2.689 ± 0.044	5.449ArgArg: 5.449 ± 0.082	3.274ArgSer: 3.274 ± 0.052	3.405ArgThr: 3.405 ± 0.057	4.853ArgVal: 4.853 ± 0.059	0.976ArgTrp: 0.976 ± 0.024	1.789ArgTyr: 1.789 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.937SerAla: 5.937 ± 0.074	0.296SerCys: 0.296 ± 0.015	2.648SerAsp: 2.648 ± 0.049	2.629SerGlu: 2.629 ± 0.049	2.185SerPhe: 2.185 ± 0.043	5.379SerGly: 5.379 ± 0.075	1.044SerHis: 1.044 ± 0.031	2.83SerIle: 2.83 ± 0.056	1.234SerLys: 1.234 ± 0.034	5.344SerLeu: 5.344 ± 0.069	1.264SerMet: 1.264 ± 0.031	1.352SerAsn: 1.352 ± 0.034	2.69SerPro: 2.69 ± 0.053	1.641SerGln: 1.641 ± 0.04	3.421SerArg: 3.421 ± 0.058	2.582SerSer: 2.582 ± 0.057	2.473SerThr: 2.473 ± 0.048	4.02SerVal: 4.02 ± 0.054	0.752SerTrp: 0.752 ± 0.025	1.256SerTyr: 1.256 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.074ThrAla: 6.074 ± 0.07	0.342ThrCys: 0.342 ± 0.02	2.863ThrAsp: 2.863 ± 0.05	2.604ThrGlu: 2.604 ± 0.047	2.216ThrPhe: 2.216 ± 0.047	5.226ThrGly: 5.226 ± 0.081	1.152ThrHis: 1.152 ± 0.028	3.202ThrIle: 3.202 ± 0.049	1.155ThrLys: 1.155 ± 0.034	6.092ThrLeu: 6.092 ± 0.078	1.156ThrMet: 1.156 ± 0.031	1.347ThrAsn: 1.347 ± 0.033	3.2ThrPro: 3.2 ± 0.049	1.622ThrGln: 1.622 ± 0.036	3.509ThrArg: 3.509 ± 0.062	2.737ThrSer: 2.737 ± 0.05	2.851ThrThr: 2.851 ± 0.053	4.448ThrVal: 4.448 ± 0.066	0.691ThrTrp: 0.691 ± 0.026	1.354ThrTyr: 1.354 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.571ValAla: 9.571 ± 0.084	0.571ValCys: 0.571 ± 0.023	4.293ValAsp: 4.293 ± 0.068	4.989ValGlu: 4.989 ± 0.065	3.047ValPhe: 3.047 ± 0.049	6.027ValGly: 6.027 ± 0.08	1.405ValHis: 1.405 ± 0.039	4.218ValIle: 4.218 ± 0.076	2.054ValLys: 2.054 ± 0.042	7.975ValLeu: 7.975 ± 0.094	1.952ValMet: 1.952 ± 0.046	2.057ValAsn: 2.057 ± 0.044	4.051ValPro: 4.051 ± 0.066	1.863ValGln: 1.863 ± 0.038	5.034ValArg: 5.034 ± 0.066	4.458ValSer: 4.458 ± 0.062	4.951ValThr: 4.951 ± 0.068	6.467ValVal: 6.467 ± 0.087	0.975ValTrp: 0.975 ± 0.029	1.694ValTyr: 1.694 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.306TrpAla: 1.306 ± 0.032	0.121TrpCys: 0.121 ± 0.009	0.668TrpAsp: 0.668 ± 0.022	0.603TrpGlu: 0.603 ± 0.022	0.584TrpPhe: 0.584 ± 0.02	0.982TrpGly: 0.982 ± 0.029	0.311TrpHis: 0.311 ± 0.015	0.673TrpIle: 0.673 ± 0.024	0.414TrpLys: 0.414 ± 0.018	1.645TrpLeu: 1.645 ± 0.04	0.354TrpMet: 0.354 ± 0.017	0.501TrpAsn: 0.501 ± 0.019	0.725TrpPro: 0.725 ± 0.026	0.669TrpGln: 0.669 ± 0.021	1.151TrpArg: 1.151 ± 0.034	0.902TrpSer: 0.902 ± 0.033	0.842TrpThr: 0.842 ± 0.03	0.875TrpVal: 0.875 ± 0.028	0.274TrpTrp: 0.274 ± 0.016	0.324TrpTyr: 0.324 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.651TyrAla: 2.651 ± 0.048	0.221TyrCys: 0.221 ± 0.014	1.492TyrAsp: 1.492 ± 0.041	1.404TyrGlu: 1.404 ± 0.034	1.047TyrPhe: 1.047 ± 0.033	2.26TyrGly: 2.26 ± 0.045	0.463TyrHis: 0.463 ± 0.021	1.037TyrIle: 1.037 ± 0.027	0.555TyrLys: 0.555 ± 0.025	2.387TyrLeu: 2.387 ± 0.048	0.487TyrMet: 0.487 ± 0.019	0.66TyrAsn: 0.66 ± 0.024	1.263TyrPro: 1.263 ± 0.032	0.741TyrGln: 0.741 ± 0.022	1.849TyrArg: 1.849 ± 0.042	1.186TyrSer: 1.186 ± 0.032	1.189TyrThr: 1.189 ± 0.035	1.79TyrVal: 1.79 ± 0.037	0.431TyrTrp: 0.431 ± 0.019	0.649TyrTyr: 0.649 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3992 proteins (1214804 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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