Amino acid dipepetide frequency for Campylobacter geochelonis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.102AlaAla: 4.102 ± 0.12
0.956AlaCys: 0.956 ± 0.045
2.957AlaAsp: 2.957 ± 0.077
2.406AlaGlu: 2.406 ± 0.066
3.59AlaPhe: 3.59 ± 0.091
4.431AlaGly: 4.431 ± 0.127
1.136AlaHis: 1.136 ± 0.052
6.373AlaIle: 6.373 ± 0.138
7.858AlaLys: 7.858 ± 0.127
7.885AlaLeu: 7.885 ± 0.144
1.993AlaMet: 1.993 ± 0.065
4.151AlaAsn: 4.151 ± 0.102
1.807AlaPro: 1.807 ± 0.06
2.164AlaGln: 2.164 ± 0.075
2.498AlaArg: 2.498 ± 0.072
4.638AlaSer: 4.638 ± 0.094
3.547AlaThr: 3.547 ± 0.095
4.631AlaVal: 4.631 ± 0.097
0.469AlaTrp: 0.469 ± 0.031
2.537AlaTyr: 2.537 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.906CysAla: 0.906 ± 0.045
0.159CysCys: 0.159 ± 0.021
0.908CysAsp: 0.908 ± 0.041
1.015CysGlu: 1.015 ± 0.052
0.623CysPhe: 0.623 ± 0.033
1.015CysGly: 1.015 ± 0.051
0.324CysHis: 0.324 ± 0.043
0.845CysIle: 0.845 ± 0.045
0.877CysLys: 0.877 ± 0.043
0.862CysLeu: 0.862 ± 0.043
0.292CysMet: 0.292 ± 0.022
0.432CysAsn: 0.432 ± 0.03
0.423CysPro: 0.423 ± 0.033
0.256CysGln: 0.256 ± 0.023
0.242CysArg: 0.242 ± 0.02
0.781CysSer: 0.781 ± 0.04
0.423CysThr: 0.423 ± 0.023
0.872CysVal: 0.872 ± 0.038
0.068CysTrp: 0.068 ± 0.011
0.404CysTyr: 0.404 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.447AspAla: 3.447 ± 0.081
0.478AspCys: 0.478 ± 0.032
3.563AspAsp: 3.563 ± 0.126
6.44AspGlu: 6.44 ± 0.14
3.21AspPhe: 3.21 ± 0.085
4.162AspGly: 4.162 ± 0.099
0.427AspHis: 0.427 ± 0.029
5.346AspIle: 5.346 ± 0.126
6.054AspLys: 6.054 ± 0.12
4.38AspLeu: 4.38 ± 0.091
1.471AspMet: 1.471 ± 0.048
2.455AspAsn: 2.455 ± 0.086
1.229AspPro: 1.229 ± 0.055
0.665AspGln: 0.665 ± 0.037
1.816AspArg: 1.816 ± 0.053
3.442AspSer: 3.442 ± 0.106
2.459AspThr: 2.459 ± 0.091
3.585AspVal: 3.585 ± 0.087
0.29AspTrp: 0.29 ± 0.022
1.945AspTyr: 1.945 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.303GluAla: 4.303 ± 0.095
0.771GluCys: 0.771 ± 0.041
2.884GluAsp: 2.884 ± 0.079
3.527GluGlu: 3.527 ± 0.088
4.721GluPhe: 4.721 ± 0.111
2.582GluGly: 2.582 ± 0.071
1.025GluHis: 1.025 ± 0.045
7.016GluIle: 7.016 ± 0.121
6.286GluLys: 6.286 ± 0.12
7.277GluLeu: 7.277 ± 0.136
1.476GluMet: 1.476 ± 0.051
4.752GluAsn: 4.752 ± 0.093
1.65GluPro: 1.65 ± 0.062
1.971GluGln: 1.971 ± 0.066
2.148GluArg: 2.148 ± 0.069
3.148GluSer: 3.148 ± 0.078
1.986GluThr: 1.986 ± 0.065
4.102GluVal: 4.102 ± 0.094
0.49GluTrp: 0.49 ± 0.035
2.539GluTyr: 2.539 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
4.035PheAla: 4.035 ± 0.104
0.819PheCys: 0.819 ± 0.04
3.802PheAsp: 3.802 ± 0.096
3.539PheGlu: 3.539 ± 0.078
3.17PhePhe: 3.17 ± 0.105
4.278PheGly: 4.278 ± 0.084
0.654PheHis: 0.654 ± 0.038
5.156PheIle: 5.156 ± 0.137
4.737PheLys: 4.737 ± 0.103
5.772PheLeu: 5.772 ± 0.143
1.415PheMet: 1.415 ± 0.052
2.773PheAsn: 2.773 ± 0.077
1.077PhePro: 1.077 ± 0.047
0.952PheGln: 0.952 ± 0.048
1.519PheArg: 1.519 ± 0.047
4.764PheSer: 4.764 ± 0.1
2.321PheThr: 2.321 ± 0.067
3.669PheVal: 3.669 ± 0.082
0.51PheTrp: 0.51 ± 0.032
2.442PheTyr: 2.442 ± 0.072
0.0PheXaa: 0.0 ± 0.0
Gly
4.904GlyAla: 4.904 ± 0.113
0.887GlyCys: 0.887 ± 0.034
3.309GlyAsp: 3.309 ± 0.09
4.087GlyGlu: 4.087 ± 0.085
4.039GlyPhe: 4.039 ± 0.094
4.6GlyGly: 4.6 ± 0.114
0.996GlyHis: 0.996 ± 0.043
5.162GlyIle: 5.162 ± 0.096
4.986GlyLys: 4.986 ± 0.099
5.767GlyLeu: 5.767 ± 0.11
1.589GlyMet: 1.589 ± 0.053
2.559GlyAsn: 2.559 ± 0.11
0.812GlyPro: 0.812 ± 0.043
1.269GlyGln: 1.269 ± 0.049
1.954GlyArg: 1.954 ± 0.063
3.873GlySer: 3.873 ± 0.11
2.609GlyThr: 2.609 ± 0.09
5.626GlyVal: 5.626 ± 0.11
0.471GlyTrp: 0.471 ± 0.029
2.763GlyTyr: 2.763 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.072HisAla: 1.072 ± 0.049
0.218HisCys: 0.218 ± 0.021
0.73HisAsp: 0.73 ± 0.033
0.928HisGlu: 0.928 ± 0.048
0.911HisPhe: 0.911 ± 0.037
0.985HisGly: 0.985 ± 0.043
0.338HisHis: 0.338 ± 0.029
1.346HisIle: 1.346 ± 0.05
1.211HisLys: 1.211 ± 0.046
1.386HisLeu: 1.386 ± 0.052
0.357HisMet: 0.357 ± 0.022
0.708HisAsn: 0.708 ± 0.04
0.659HisPro: 0.659 ± 0.038
0.401HisGln: 0.401 ± 0.023
0.454HisArg: 0.454 ± 0.03
1.039HisSer: 1.039 ± 0.049
0.761HisThr: 0.761 ± 0.036
0.674HisVal: 0.674 ± 0.033
0.119HisTrp: 0.119 ± 0.016
0.594HisTyr: 0.594 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.259IleAla: 6.259 ± 0.121
1.234IleCys: 1.234 ± 0.05
4.948IleAsp: 4.948 ± 0.115
4.976IleGlu: 4.976 ± 0.11
4.858IlePhe: 4.858 ± 0.123
4.986IleGly: 4.986 ± 0.122
1.073IleHis: 1.073 ± 0.041
6.475IleIle: 6.475 ± 0.144
7.991IleLys: 7.991 ± 0.137
8.347IleLeu: 8.347 ± 0.16
1.747IleMet: 1.747 ± 0.06
4.962IleAsn: 4.962 ± 0.109
2.379IlePro: 2.379 ± 0.076
1.725IleGln: 1.725 ± 0.061
2.338IleArg: 2.338 ± 0.063
6.494IleSer: 6.494 ± 0.13
4.15IleThr: 4.15 ± 0.087
5.11IleVal: 5.11 ± 0.106
0.614IleTrp: 0.614 ± 0.028
3.74IleTyr: 3.74 ± 0.085
0.0IleXaa: 0.0 ± 0.0
Lys
6.073LysAla: 6.073 ± 0.126
0.752LysCys: 0.752 ± 0.039
6.564LysAsp: 6.564 ± 0.123
7.67LysGlu: 7.67 ± 0.132
6.339LysPhe: 6.339 ± 0.132
4.225LysGly: 4.225 ± 0.094
1.263LysHis: 1.263 ± 0.051
8.139LysIle: 8.139 ± 0.118
8.347LysLys: 8.347 ± 0.142
7.02LysLeu: 7.02 ± 0.121
2.182LysMet: 2.182 ± 0.064
7.226LysAsn: 7.226 ± 0.127
2.524LysPro: 2.524 ± 0.074
2.36LysGln: 2.36 ± 0.065
3.0LysArg: 3.0 ± 0.071
5.742LysSer: 5.742 ± 0.109
4.952LysThr: 4.952 ± 0.104
4.795LysVal: 4.795 ± 0.099
0.507LysTrp: 0.507 ± 0.033
2.832LysTyr: 2.832 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
7.525LeuAla: 7.525 ± 0.132
1.172LeuCys: 1.172 ± 0.05
5.65LeuAsp: 5.65 ± 0.105
6.718LeuGlu: 6.718 ± 0.116
5.114LeuPhe: 5.114 ± 0.129
6.344LeuGly: 6.344 ± 0.131
1.314LeuHis: 1.314 ± 0.051
6.813LeuIle: 6.813 ± 0.137
9.746LeuLys: 9.746 ± 0.147
8.646LeuLeu: 8.646 ± 0.157
2.155LeuMet: 2.155 ± 0.058
6.344LeuAsn: 6.344 ± 0.135
3.09LeuPro: 3.09 ± 0.077
2.336LeuGln: 2.336 ± 0.057
3.109LeuArg: 3.109 ± 0.078
7.762LeuSer: 7.762 ± 0.137
4.126LeuThr: 4.126 ± 0.093
5.982LeuVal: 5.982 ± 0.114
0.594LeuTrp: 0.594 ± 0.038
3.283LeuTyr: 3.283 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
1.797MetAla: 1.797 ± 0.068
0.246MetCys: 0.246 ± 0.021
1.145MetAsp: 1.145 ± 0.047
1.044MetGlu: 1.044 ± 0.039
1.123MetPhe: 1.123 ± 0.049
1.607MetGly: 1.607 ± 0.056
0.372MetHis: 0.372 ± 0.027
1.942MetIle: 1.942 ± 0.063
2.155MetLys: 2.155 ± 0.06
2.478MetLeu: 2.478 ± 0.069
0.643MetMet: 0.643 ± 0.034
0.998MetAsn: 0.998 ± 0.044
1.022MetPro: 1.022 ± 0.043
1.046MetGln: 1.046 ± 0.038
0.863MetArg: 0.863 ± 0.041
1.875MetSer: 1.875 ± 0.056
0.822MetThr: 0.822 ± 0.041
1.525MetVal: 1.525 ± 0.055
0.16MetTrp: 0.16 ± 0.016
0.534MetTyr: 0.534 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
4.052AsnAla: 4.052 ± 0.078
0.488AsnCys: 0.488 ± 0.033
3.162AsnAsp: 3.162 ± 0.132
4.022AsnGlu: 4.022 ± 0.074
3.152AsnPhe: 3.152 ± 0.084
3.578AsnGly: 3.578 ± 0.096
0.869AsnHis: 0.869 ± 0.041
4.701AsnIle: 4.701 ± 0.1
4.162AsnLys: 4.162 ± 0.107
7.881AsnLeu: 7.881 ± 0.133
0.986AsnMet: 0.986 ± 0.042
2.37AsnAsn: 2.37 ± 0.101
2.111AsnPro: 2.111 ± 0.066
1.749AsnGln: 1.749 ± 0.063
1.788AsnArg: 1.788 ± 0.057
4.404AsnSer: 4.404 ± 0.109
2.425AsnThr: 2.425 ± 0.076
2.752AsnVal: 2.752 ± 0.081
0.336AsnTrp: 0.336 ± 0.022
2.191AsnTyr: 2.191 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
1.763ProAla: 1.763 ± 0.061
0.297ProCys: 0.297 ± 0.023
1.328ProAsp: 1.328 ± 0.051
1.508ProGlu: 1.508 ± 0.06
1.728ProPhe: 1.728 ± 0.059
1.24ProGly: 1.24 ± 0.045
0.517ProHis: 0.517 ± 0.03
2.184ProIle: 2.184 ± 0.064
2.674ProLys: 2.674 ± 0.073
2.827ProLeu: 2.827 ± 0.067
0.582ProMet: 0.582 ± 0.035
1.962ProAsn: 1.962 ± 0.05
0.701ProPro: 0.701 ± 0.037
0.92ProGln: 0.92 ± 0.039
0.807ProArg: 0.807 ± 0.037
1.746ProSer: 1.746 ± 0.051
1.682ProThr: 1.682 ± 0.062
1.88ProVal: 1.88 ± 0.064
0.23ProTrp: 0.23 ± 0.022
1.292ProTyr: 1.292 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
1.682GlnAla: 1.682 ± 0.047
0.215GlnCys: 0.215 ± 0.018
1.401GlnAsp: 1.401 ± 0.058
1.759GlnGlu: 1.759 ± 0.059
0.944GlnPhe: 0.944 ± 0.04
1.227GlnGly: 1.227 ± 0.047
0.321GlnHis: 0.321 ± 0.025
3.025GlnIle: 3.025 ± 0.08
2.998GlnLys: 2.998 ± 0.083
1.618GlnLeu: 1.618 ± 0.059
0.589GlnMet: 0.589 ± 0.031
2.691GlnAsn: 2.691 ± 0.08
0.667GlnPro: 0.667 ± 0.036
0.555GlnGln: 0.555 ± 0.045
0.911GlnArg: 0.911 ± 0.04
1.793GlnSer: 1.793 ± 0.057
1.667GlnThr: 1.667 ± 0.055
1.317GlnVal: 1.317 ± 0.052
0.184GlnTrp: 0.184 ± 0.018
0.648GlnTyr: 0.648 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.329ArgAla: 2.329 ± 0.059
0.329ArgCys: 0.329 ± 0.025
1.754ArgAsp: 1.754 ± 0.059
2.228ArgGlu: 2.228 ± 0.066
1.688ArgPhe: 1.688 ± 0.057
1.976ArgGly: 1.976 ± 0.063
0.558ArgHis: 0.558 ± 0.028
2.431ArgIle: 2.431 ± 0.066
2.43ArgLys: 2.43 ± 0.061
3.099ArgLeu: 3.099 ± 0.075
0.778ArgMet: 0.778 ± 0.037
1.64ArgAsn: 1.64 ± 0.057
0.742ArgPro: 0.742 ± 0.04
0.99ArgGln: 0.99 ± 0.039
1.225ArgArg: 1.225 ± 0.056
1.708ArgSer: 1.708 ± 0.058
1.249ArgThr: 1.249 ± 0.058
2.513ArgVal: 2.513 ± 0.073
0.23ArgTrp: 0.23 ± 0.022
1.514ArgTyr: 1.514 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
4.522SerAla: 4.522 ± 0.107
0.836SerCys: 0.836 ± 0.043
3.875SerAsp: 3.875 ± 0.094
3.918SerGlu: 3.918 ± 0.081
4.017SerPhe: 4.017 ± 0.095
4.957SerGly: 4.957 ± 0.112
1.118SerHis: 1.118 ± 0.043
5.17SerIle: 5.17 ± 0.108
6.317SerLys: 6.317 ± 0.126
6.892SerLeu: 6.892 ± 0.14
1.498SerMet: 1.498 ± 0.056
3.486SerAsn: 3.486 ± 0.08
1.792SerPro: 1.792 ± 0.052
2.344SerGln: 2.344 ± 0.074
2.089SerArg: 2.089 ± 0.066
4.928SerSer: 4.928 ± 0.104
2.964SerThr: 2.964 ± 0.08
4.554SerVal: 4.554 ± 0.094
0.507SerTrp: 0.507 ± 0.032
2.687SerTyr: 2.687 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
3.047ThrAla: 3.047 ± 0.095
0.445ThrCys: 0.445 ± 0.028
2.331ThrAsp: 2.331 ± 0.069
1.57ThrGlu: 1.57 ± 0.058
2.14ThrPhe: 2.14 ± 0.063
2.681ThrGly: 2.681 ± 0.079
0.973ThrHis: 0.973 ± 0.043
3.79ThrIle: 3.79 ± 0.108
4.17ThrLys: 4.17 ± 0.089
4.848ThrLeu: 4.848 ± 0.099
0.979ThrMet: 0.979 ± 0.044
2.621ThrAsn: 2.621 ± 0.082
2.176ThrPro: 2.176 ± 0.071
1.727ThrGln: 1.727 ± 0.05
1.435ThrArg: 1.435 ± 0.049
3.242ThrSer: 3.242 ± 0.074
2.629ThrThr: 2.629 ± 0.083
2.314ThrVal: 2.314 ± 0.072
0.29ThrTrp: 0.29 ± 0.021
1.636ThrTyr: 1.636 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
5.143ValAla: 5.143 ± 0.109
0.949ValCys: 0.949 ± 0.045
3.663ValAsp: 3.663 ± 0.088
4.001ValGlu: 4.001 ± 0.079
3.496ValPhe: 3.496 ± 0.087
4.592ValGly: 4.592 ± 0.111
0.802ValHis: 0.802 ± 0.038
4.991ValIle: 4.991 ± 0.108
5.371ValLys: 5.371 ± 0.118
6.544ValLeu: 6.544 ± 0.134
1.66ValMet: 1.66 ± 0.064
2.885ValAsn: 2.885 ± 0.078
1.705ValPro: 1.705 ± 0.058
1.346ValGln: 1.346 ± 0.05
1.822ValArg: 1.822 ± 0.055
4.191ValSer: 4.191 ± 0.096
2.302ValThr: 2.302 ± 0.085
5.261ValVal: 5.261 ± 0.111
0.486ValTrp: 0.486 ± 0.03
2.182ValTyr: 2.182 ± 0.069
0.002ValXaa: 0.002 ± 0.002
Trp
0.486TrpAla: 0.486 ± 0.032
0.101TrpCys: 0.101 ± 0.014
0.41TrpAsp: 0.41 ± 0.025
0.403TrpGlu: 0.403 ± 0.026
0.421TrpPhe: 0.421 ± 0.03
0.495TrpGly: 0.495 ± 0.03
0.159TrpHis: 0.159 ± 0.016
0.558TrpIle: 0.558 ± 0.036
0.381TrpLys: 0.381 ± 0.028
0.812TrpLeu: 0.812 ± 0.041
0.217TrpMet: 0.217 ± 0.024
0.258TrpAsn: 0.258 ± 0.022
0.111TrpPro: 0.111 ± 0.011
0.305TrpGln: 0.305 ± 0.024
0.241TrpArg: 0.241 ± 0.018
0.398TrpSer: 0.398 ± 0.029
0.225TrpThr: 0.225 ± 0.024
0.462TrpVal: 0.462 ± 0.027
0.106TrpTrp: 0.106 ± 0.014
0.309TrpTyr: 0.309 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.682TyrAla: 2.682 ± 0.074
0.375TyrCys: 0.375 ± 0.028
2.479TyrAsp: 2.479 ± 0.071
2.897TyrGlu: 2.897 ± 0.065
2.119TyrPhe: 2.119 ± 0.072
2.302TyrGly: 2.302 ± 0.079
0.654TyrHis: 0.654 ± 0.032
2.942TyrIle: 2.942 ± 0.08
3.761TyrLys: 3.761 ± 0.087
3.484TyrLeu: 3.484 ± 0.081
0.788TyrMet: 0.788 ± 0.036
1.904TyrAsn: 1.904 ± 0.064
1.194TyrPro: 1.194 ± 0.044
1.131TyrGln: 1.131 ± 0.044
1.153TyrArg: 1.153 ± 0.046
2.501TyrSer: 2.501 ± 0.065
1.744TyrThr: 1.744 ± 0.063
1.769TyrVal: 1.769 ± 0.066
0.193TyrTrp: 0.193 ± 0.019
1.42TyrTyr: 1.42 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.002XaaTyr: 0.002 ± 0.002
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1901 proteins (586059 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski