Amino acid dipepetide frequency for Prevotella sp. 885

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.55AlaAla: 6.55 ± 0.1	1.014AlaCys: 1.014 ± 0.03	5.406AlaAsp: 5.406 ± 0.074	5.081AlaGlu: 5.081 ± 0.075	3.207AlaPhe: 3.207 ± 0.061	4.672AlaGly: 4.672 ± 0.079	1.299AlaHis: 1.299 ± 0.038	4.68AlaIle: 4.68 ± 0.081	4.908AlaLys: 4.908 ± 0.081	6.422AlaLeu: 6.422 ± 0.095	2.313AlaMet: 2.313 ± 0.05	3.528AlaAsn: 3.528 ± 0.066	2.399AlaPro: 2.399 ± 0.051	2.86AlaGln: 2.86 ± 0.055	3.213AlaArg: 3.213 ± 0.068	4.747AlaSer: 4.747 ± 0.07	4.445AlaThr: 4.445 ± 0.079	5.212AlaVal: 5.212 ± 0.094	0.867AlaTrp: 0.867 ± 0.028	3.091AlaTyr: 3.091 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.842CysAla: 0.842 ± 0.028	0.223CysCys: 0.223 ± 0.016	0.845CysAsp: 0.845 ± 0.034	0.75CysGlu: 0.75 ± 0.033	0.593CysPhe: 0.593 ± 0.028	1.116CysGly: 1.116 ± 0.039	0.325CysHis: 0.325 ± 0.02	0.85CysIle: 0.85 ± 0.028	0.773CysLys: 0.773 ± 0.027	1.163CysLeu: 1.163 ± 0.032	0.376CysMet: 0.376 ± 0.02	0.623CysAsn: 0.623 ± 0.027	0.56CysPro: 0.56 ± 0.023	0.464CysGln: 0.464 ± 0.02	0.765CysArg: 0.765 ± 0.028	0.859CysSer: 0.859 ± 0.034	0.667CysThr: 0.667 ± 0.026	0.829CysVal: 0.829 ± 0.029	0.175CysTrp: 0.175 ± 0.015	0.602CysTyr: 0.602 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.69AspAla: 4.69 ± 0.076	0.81AspCys: 0.81 ± 0.027	3.735AspAsp: 3.735 ± 0.07	4.355AspGlu: 4.355 ± 0.071	3.134AspPhe: 3.134 ± 0.054	5.048AspGly: 5.048 ± 0.083	0.999AspHis: 0.999 ± 0.032	4.571AspIle: 4.571 ± 0.072	4.081AspLys: 4.081 ± 0.064	4.463AspLeu: 4.463 ± 0.077	1.838AspMet: 1.838 ± 0.045	3.557AspAsn: 3.557 ± 0.07	1.802AspPro: 1.802 ± 0.035	1.396AspGln: 1.396 ± 0.038	2.779AspArg: 2.779 ± 0.056	3.267AspSer: 3.267 ± 0.052	3.108AspThr: 3.108 ± 0.06	4.289AspVal: 4.289 ± 0.067	0.853AspTrp: 0.853 ± 0.028	2.938AspTyr: 2.938 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.958GluAla: 4.958 ± 0.086	0.757GluCys: 0.757 ± 0.03	3.571GluAsp: 3.571 ± 0.07	4.896GluGlu: 4.896 ± 0.088	2.345GluPhe: 2.345 ± 0.049	4.395GluGly: 4.395 ± 0.066	1.34GluHis: 1.34 ± 0.041	3.874GluIle: 3.874 ± 0.075	4.653GluLys: 4.653 ± 0.078	5.104GluLeu: 5.104 ± 0.08	2.035GluMet: 2.035 ± 0.047	3.229GluAsn: 3.229 ± 0.058	1.823GluPro: 1.823 ± 0.044	2.668GluGln: 2.668 ± 0.054	3.463GluArg: 3.463 ± 0.073	3.073GluSer: 3.073 ± 0.053	3.373GluThr: 3.373 ± 0.057	3.868GluVal: 3.868 ± 0.057	0.891GluTrp: 0.891 ± 0.029	2.754GluTyr: 2.754 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.206PheAla: 3.206 ± 0.056	0.75PheCys: 0.75 ± 0.027	2.932PheAsp: 2.932 ± 0.053	2.328PheGlu: 2.328 ± 0.041	2.023PhePhe: 2.023 ± 0.051	3.162PheGly: 3.162 ± 0.066	0.897PheHis: 0.897 ± 0.033	2.536PheIle: 2.536 ± 0.054	2.333PheLys: 2.333 ± 0.048	3.384PheLeu: 3.384 ± 0.067	1.212PheMet: 1.212 ± 0.033	2.185PheAsn: 2.185 ± 0.053	1.462PhePro: 1.462 ± 0.033	1.093PheGln: 1.093 ± 0.034	2.1PheArg: 2.1 ± 0.044	3.215PheSer: 3.215 ± 0.063	2.769PheThr: 2.769 ± 0.063	3.044PheVal: 3.044 ± 0.057	0.516PheTrp: 0.516 ± 0.026	1.801PheTyr: 1.801 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.576GlyAla: 4.576 ± 0.078	1.01GlyCys: 1.01 ± 0.037	3.87GlyAsp: 3.87 ± 0.066	4.157GlyGlu: 4.157 ± 0.067	2.953GlyPhe: 2.953 ± 0.057	4.806GlyGly: 4.806 ± 0.119	1.257GlyHis: 1.257 ± 0.038	4.785GlyIle: 4.785 ± 0.073	5.454GlyLys: 5.454 ± 0.074	5.276GlyLeu: 5.276 ± 0.078	2.192GlyMet: 2.192 ± 0.052	3.592GlyAsn: 3.592 ± 0.074	1.231GlyPro: 1.231 ± 0.037	2.05GlyGln: 2.05 ± 0.048	3.059GlyArg: 3.059 ± 0.066	4.027GlySer: 4.027 ± 0.077	4.237GlyThr: 4.237 ± 0.071	4.863GlyVal: 4.863 ± 0.068	1.004GlyTrp: 1.004 ± 0.035	3.184GlyTyr: 3.184 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.236HisAla: 1.236 ± 0.035	0.306HisCys: 0.306 ± 0.017	1.216HisAsp: 1.216 ± 0.037	1.059HisGlu: 1.059 ± 0.034	1.001HisPhe: 1.001 ± 0.031	1.314HisGly: 1.314 ± 0.037	0.554HisHis: 0.554 ± 0.031	1.419HisIle: 1.419 ± 0.038	1.169HisLys: 1.169 ± 0.036	1.629HisLeu: 1.629 ± 0.044	0.433HisMet: 0.433 ± 0.019	1.077HisAsn: 1.077 ± 0.034	0.932HisPro: 0.932 ± 0.032	0.57HisGln: 0.57 ± 0.022	0.952HisArg: 0.952 ± 0.03	1.177HisSer: 1.177 ± 0.034	1.059HisThr: 1.059 ± 0.035	1.221HisVal: 1.221 ± 0.037	0.248HisTrp: 0.248 ± 0.016	0.949HisTyr: 0.949 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.044IleAla: 5.044 ± 0.073	0.99IleCys: 0.99 ± 0.034	4.474IleAsp: 4.474 ± 0.066	4.027IleGlu: 4.027 ± 0.064	2.429IlePhe: 2.429 ± 0.05	4.311IleGly: 4.311 ± 0.066	1.216IleHis: 1.216 ± 0.035	4.179IleIle: 4.179 ± 0.08	4.123IleLys: 4.123 ± 0.069	4.733IleLeu: 4.733 ± 0.079	1.59IleMet: 1.59 ± 0.043	3.273IleAsn: 3.273 ± 0.057	2.535IlePro: 2.535 ± 0.054	1.872IleGln: 1.872 ± 0.043	3.045IleArg: 3.045 ± 0.052	4.234IleSer: 4.234 ± 0.063	3.94IleThr: 3.94 ± 0.059	4.474IleVal: 4.474 ± 0.075	0.571IleTrp: 0.571 ± 0.025	2.482IleTyr: 2.482 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	5.384LysAla: 5.384 ± 0.085	0.636LysCys: 0.636 ± 0.025	4.186LysAsp: 4.186 ± 0.062	5.233LysGlu: 5.233 ± 0.089	2.206LysPhe: 2.206 ± 0.049	4.391LysGly: 4.391 ± 0.064	1.318LysHis: 1.318 ± 0.036	3.713LysIle: 3.713 ± 0.063	5.005LysLys: 5.005 ± 0.081	5.106LysLeu: 5.106 ± 0.071	2.253LysMet: 2.253 ± 0.037	3.342LysAsn: 3.342 ± 0.055	2.346LysPro: 2.346 ± 0.056	2.691LysGln: 2.691 ± 0.058	3.318LysArg: 3.318 ± 0.068	3.385LysSer: 3.385 ± 0.055	4.081LysThr: 4.081 ± 0.07	4.319LysVal: 4.319 ± 0.07	0.816LysTrp: 0.816 ± 0.028	2.87LysTyr: 2.87 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	6.432LeuAla: 6.432 ± 0.098	1.304LeuCys: 1.304 ± 0.041	4.723LeuAsp: 4.723 ± 0.08	4.219LeuGlu: 4.219 ± 0.068	3.635LeuPhe: 3.635 ± 0.069	5.294LeuGly: 5.294 ± 0.086	1.796LeuHis: 1.796 ± 0.05	4.476LeuIle: 4.476 ± 0.073	5.626LeuLys: 5.626 ± 0.071	7.514LeuLeu: 7.514 ± 0.107	2.383LeuMet: 2.383 ± 0.049	4.21LeuAsn: 4.21 ± 0.067	3.605LeuPro: 3.605 ± 0.062	3.051LeuGln: 3.051 ± 0.063	4.562LeuArg: 4.562 ± 0.072	6.239LeuSer: 6.239 ± 0.069	5.461LeuThr: 5.461 ± 0.074	4.955LeuVal: 4.955 ± 0.081	0.965LeuTrp: 0.965 ± 0.034	3.355LeuTyr: 3.355 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.544MetAla: 2.544 ± 0.049	0.307MetCys: 0.307 ± 0.017	1.575MetAsp: 1.575 ± 0.041	1.933MetGlu: 1.933 ± 0.046	1.141MetPhe: 1.141 ± 0.04	1.852MetGly: 1.852 ± 0.047	0.511MetHis: 0.511 ± 0.02	1.489MetIle: 1.489 ± 0.043	2.434MetLys: 2.434 ± 0.047	2.729MetLeu: 2.729 ± 0.058	0.955MetMet: 0.955 ± 0.03	1.488MetAsn: 1.488 ± 0.037	1.377MetPro: 1.377 ± 0.035	1.22MetGln: 1.22 ± 0.035	1.539MetArg: 1.539 ± 0.04	1.823MetSer: 1.823 ± 0.041	1.807MetThr: 1.807 ± 0.04	1.701MetVal: 1.701 ± 0.043	0.256MetTrp: 0.256 ± 0.018	0.898MetTyr: 0.898 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.948AsnAla: 3.948 ± 0.066	0.564AsnCys: 0.564 ± 0.024	2.928AsnAsp: 2.928 ± 0.059	2.938AsnGlu: 2.938 ± 0.061	2.019AsnPhe: 2.019 ± 0.05	4.035AsnGly: 4.035 ± 0.08	0.959AsnHis: 0.959 ± 0.03	3.801AsnIle: 3.801 ± 0.063	3.121AsnLys: 3.121 ± 0.059	4.052AsnLeu: 4.052 ± 0.061	1.404AsnMet: 1.404 ± 0.037	2.778AsnAsn: 2.778 ± 0.067	2.26AsnPro: 2.26 ± 0.049	1.413AsnGln: 1.413 ± 0.035	2.306AsnArg: 2.306 ± 0.05	2.794AsnSer: 2.794 ± 0.058	2.846AsnThr: 2.846 ± 0.058	3.678AsnVal: 3.678 ± 0.072	0.598AsnTrp: 0.598 ± 0.028	2.158AsnTyr: 2.158 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.603ProAla: 2.603 ± 0.052	0.397ProCys: 0.397 ± 0.019	2.35ProAsp: 2.35 ± 0.046	2.878ProGlu: 2.878 ± 0.06	1.662ProPhe: 1.662 ± 0.036	2.107ProGly: 2.107 ± 0.049	0.678ProHis: 0.678 ± 0.03	2.076ProIle: 2.076 ± 0.049	2.123ProLys: 2.123 ± 0.046	2.926ProLeu: 2.926 ± 0.048	1.043ProMet: 1.043 ± 0.032	1.684ProAsn: 1.684 ± 0.042	0.704ProPro: 0.704 ± 0.029	1.399ProGln: 1.399 ± 0.033	1.326ProArg: 1.326 ± 0.035	2.332ProSer: 2.332 ± 0.056	2.339ProThr: 2.339 ± 0.05	2.559ProVal: 2.559 ± 0.057	0.444ProTrp: 0.444 ± 0.024	1.667ProTyr: 1.667 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.367GlnAla: 2.367 ± 0.049	0.359GlnCys: 0.359 ± 0.018	1.601GlnAsp: 1.601 ± 0.045	2.022GlnGlu: 2.022 ± 0.056	1.323GlnPhe: 1.323 ± 0.03	1.888GlnGly: 1.888 ± 0.047	0.702GlnHis: 0.702 ± 0.029	2.162GlnIle: 2.162 ± 0.049	2.417GlnLys: 2.417 ± 0.059	3.251GlnLeu: 3.251 ± 0.061	1.163GlnMet: 1.163 ± 0.035	1.788GlnAsn: 1.788 ± 0.045	1.34GlnPro: 1.34 ± 0.037	1.742GlnGln: 1.742 ± 0.053	1.928GlnArg: 1.928 ± 0.056	1.887GlnSer: 1.887 ± 0.041	2.399GlnThr: 2.399 ± 0.048	1.931GlnVal: 1.931 ± 0.045	0.468GlnTrp: 0.468 ± 0.022	1.508GlnTyr: 1.508 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.777ArgAla: 2.777 ± 0.058	0.594ArgCys: 0.594 ± 0.024	2.458ArgAsp: 2.458 ± 0.051	2.852ArgGlu: 2.852 ± 0.065	2.267ArgPhe: 2.267 ± 0.045	2.591ArgGly: 2.591 ± 0.063	1.176ArgHis: 1.176 ± 0.034	3.525ArgIle: 3.525 ± 0.056	3.358ArgLys: 3.358 ± 0.065	4.733ArgLeu: 4.733 ± 0.079	1.718ArgMet: 1.718 ± 0.042	2.502ArgAsn: 2.502 ± 0.047	1.644ArgPro: 1.644 ± 0.038	2.216ArgGln: 2.216 ± 0.05	2.838ArgArg: 2.838 ± 0.061	2.589ArgSer: 2.589 ± 0.052	2.708ArgThr: 2.708 ± 0.053	2.815ArgVal: 2.815 ± 0.056	0.668ArgTrp: 0.668 ± 0.029	2.27ArgTyr: 2.27 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.701SerAla: 4.701 ± 0.068	0.822SerCys: 0.822 ± 0.029	3.825SerAsp: 3.825 ± 0.064	3.55SerGlu: 3.55 ± 0.058	3.055SerPhe: 3.055 ± 0.063	4.228SerGly: 4.228 ± 0.079	1.28SerHis: 1.28 ± 0.038	3.894SerIle: 3.894 ± 0.069	3.644SerLys: 3.644 ± 0.066	5.879SerLeu: 5.879 ± 0.085	1.684SerMet: 1.684 ± 0.037	2.736SerAsn: 2.736 ± 0.056	2.241SerPro: 2.241 ± 0.046	2.103SerGln: 2.103 ± 0.046	2.707SerArg: 2.707 ± 0.054	3.94SerSer: 3.94 ± 0.071	3.359SerThr: 3.359 ± 0.07	4.319SerVal: 4.319 ± 0.072	0.807SerTrp: 0.807 ± 0.032	2.687SerTyr: 2.687 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.753ThrAla: 4.753 ± 0.074	0.673ThrCys: 0.673 ± 0.021	4.072ThrAsp: 4.072 ± 0.075	3.468ThrGlu: 3.468 ± 0.061	2.776ThrPhe: 2.776 ± 0.055	4.091ThrGly: 4.091 ± 0.073	1.025ThrHis: 1.025 ± 0.035	4.219ThrIle: 4.219 ± 0.07	3.325ThrLys: 3.325 ± 0.058	5.485ThrLeu: 5.485 ± 0.081	1.523ThrMet: 1.523 ± 0.037	2.52ThrAsn: 2.52 ± 0.053	2.714ThrPro: 2.714 ± 0.047	1.749ThrGln: 1.749 ± 0.035	2.347ThrArg: 2.347 ± 0.048	3.78ThrSer: 3.78 ± 0.073	3.762ThrThr: 3.762 ± 0.068	4.275ThrVal: 4.275 ± 0.081	0.775ThrTrp: 0.775 ± 0.034	2.602ThrTyr: 2.602 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	5.213ValAla: 5.213 ± 0.081	1.083ValCys: 1.083 ± 0.038	4.143ValAsp: 4.143 ± 0.07	4.267ValGlu: 4.267 ± 0.072	2.892ValPhe: 2.892 ± 0.059	4.35ValGly: 4.35 ± 0.071	1.034ValHis: 1.034 ± 0.034	3.982ValIle: 3.982 ± 0.056	4.648ValLys: 4.648 ± 0.071	5.377ValLeu: 5.377 ± 0.082	1.905ValMet: 1.905 ± 0.045	3.31ValAsn: 3.31 ± 0.058	2.485ValPro: 2.485 ± 0.05	1.773ValGln: 1.773 ± 0.043	3.265ValArg: 3.265 ± 0.058	4.681ValSer: 4.681 ± 0.065	4.107ValThr: 4.107 ± 0.079	4.916ValVal: 4.916 ± 0.088	0.739ValTrp: 0.739 ± 0.024	2.731ValTyr: 2.731 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.832TrpAla: 0.832 ± 0.03	0.189TrpCys: 0.189 ± 0.013	0.702TrpAsp: 0.702 ± 0.029	0.668TrpGlu: 0.668 ± 0.025	0.5TrpPhe: 0.5 ± 0.021	0.888TrpGly: 0.888 ± 0.029	0.321TrpHis: 0.321 ± 0.017	0.698TrpIle: 0.698 ± 0.026	0.813TrpLys: 0.813 ± 0.027	1.189TrpLeu: 1.189 ± 0.039	0.43TrpMet: 0.43 ± 0.019	0.78TrpAsn: 0.78 ± 0.031	0.267TrpPro: 0.267 ± 0.019	0.576TrpGln: 0.576 ± 0.024	0.631TrpArg: 0.631 ± 0.028	0.689TrpSer: 0.689 ± 0.024	0.855TrpThr: 0.855 ± 0.036	0.678TrpVal: 0.678 ± 0.033	0.199TrpTrp: 0.199 ± 0.014	0.506TrpTyr: 0.506 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.259TyrAla: 3.259 ± 0.06	0.612TyrCys: 0.612 ± 0.026	3.099TyrAsp: 3.099 ± 0.065	2.392TyrGlu: 2.392 ± 0.048	1.788TyrPhe: 1.788 ± 0.049	3.045TyrGly: 3.045 ± 0.077	0.834TyrHis: 0.834 ± 0.026	2.613TyrIle: 2.613 ± 0.042	2.589TyrLys: 2.589 ± 0.056	3.387TyrLeu: 3.387 ± 0.065	1.129TyrMet: 1.129 ± 0.035	2.398TyrAsn: 2.398 ± 0.051	1.569TyrPro: 1.569 ± 0.042	1.34TyrGln: 1.34 ± 0.041	2.157TyrArg: 2.157 ± 0.044	2.727TyrSer: 2.727 ± 0.047	2.612TyrThr: 2.612 ± 0.067	2.956TyrVal: 2.956 ± 0.057	0.548TyrTrp: 0.548 ± 0.022	2.132TyrTyr: 2.132 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2874 proteins (1060643 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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