Amino acid dipepetide frequency for Taibaiella sp. KVB11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.412AlaAla: 6.412 ± 0.104	0.739AlaCys: 0.739 ± 0.022	3.996AlaAsp: 3.996 ± 0.06	3.885AlaGlu: 3.885 ± 0.078	3.628AlaPhe: 3.628 ± 0.061	5.7AlaGly: 5.7 ± 0.091	1.223AlaHis: 1.223 ± 0.033	5.513AlaIle: 5.513 ± 0.076	4.337AlaLys: 4.337 ± 0.072	6.671AlaLeu: 6.671 ± 0.084	1.908AlaMet: 1.908 ± 0.043	4.023AlaAsn: 4.023 ± 0.072	2.567AlaPro: 2.567 ± 0.053	2.922AlaGln: 2.922 ± 0.053	2.248AlaArg: 2.248 ± 0.042	4.818AlaSer: 4.818 ± 0.076	4.809AlaThr: 4.809 ± 0.105	4.635AlaVal: 4.635 ± 0.072	0.739AlaTrp: 0.739 ± 0.025	2.805AlaTyr: 2.805 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.682CysAla: 0.682 ± 0.028	0.155CysCys: 0.155 ± 0.011	0.567CysAsp: 0.567 ± 0.034	0.466CysGlu: 0.466 ± 0.02	0.549CysPhe: 0.549 ± 0.022	0.796CysGly: 0.796 ± 0.029	0.185CysHis: 0.185 ± 0.014	0.793CysIle: 0.793 ± 0.025	0.554CysLys: 0.554 ± 0.021	0.806CysLeu: 0.806 ± 0.028	0.211CysMet: 0.211 ± 0.015	0.637CysAsn: 0.637 ± 0.025	0.402CysPro: 0.402 ± 0.02	0.263CysGln: 0.263 ± 0.014	0.309CysArg: 0.309 ± 0.016	0.698CysSer: 0.698 ± 0.024	0.605CysThr: 0.605 ± 0.028	0.561CysVal: 0.561 ± 0.023	0.096CysTrp: 0.096 ± 0.01	0.394CysTyr: 0.394 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.21AspAla: 4.21 ± 0.065	0.488AspCys: 0.488 ± 0.021	2.606AspAsp: 2.606 ± 0.061	3.299AspGlu: 3.299 ± 0.064	3.004AspPhe: 3.004 ± 0.054	3.786AspGly: 3.786 ± 0.073	0.79AspHis: 0.79 ± 0.026	4.292AspIle: 4.292 ± 0.062	3.928AspLys: 3.928 ± 0.071	4.452AspLeu: 4.452 ± 0.066	1.266AspMet: 1.266 ± 0.037	3.193AspAsn: 3.193 ± 0.058	1.759AspPro: 1.759 ± 0.044	1.248AspGln: 1.248 ± 0.032	1.743AspArg: 1.743 ± 0.044	3.453AspSer: 3.453 ± 0.073	3.159AspThr: 3.159 ± 0.07	3.324AspVal: 3.324 ± 0.051	0.744AspTrp: 0.744 ± 0.023	2.677AspTyr: 2.677 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.296GluAla: 4.296 ± 0.079	0.375GluCys: 0.375 ± 0.019	2.908GluAsp: 2.908 ± 0.052	3.799GluGlu: 3.799 ± 0.094	2.125GluPhe: 2.125 ± 0.041	3.359GluGly: 3.359 ± 0.058	1.197GluHis: 1.197 ± 0.037	4.345GluIle: 4.345 ± 0.079	4.587GluLys: 4.587 ± 0.091	5.103GluLeu: 5.103 ± 0.073	1.698GluMet: 1.698 ± 0.048	3.481GluAsn: 3.481 ± 0.053	1.533GluPro: 1.533 ± 0.038	2.568GluGln: 2.568 ± 0.057	2.413GluArg: 2.413 ± 0.062	2.965GluSer: 2.965 ± 0.051	3.049GluThr: 3.049 ± 0.05	3.347GluVal: 3.347 ± 0.069	0.7GluTrp: 0.7 ± 0.025	2.126GluTyr: 2.126 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.284PheAla: 3.284 ± 0.054	0.537PheCys: 0.537 ± 0.023	2.787PheAsp: 2.787 ± 0.052	2.768PheGlu: 2.768 ± 0.055	2.44PhePhe: 2.44 ± 0.06	3.323PheGly: 3.323 ± 0.06	0.943PheHis: 0.943 ± 0.03	3.533PheIle: 3.533 ± 0.059	3.043PheLys: 3.043 ± 0.057	4.233PheLeu: 4.233 ± 0.076	1.131PheMet: 1.131 ± 0.032	3.002PheAsn: 3.002 ± 0.053	1.816PhePro: 1.816 ± 0.045	1.589PheGln: 1.589 ± 0.039	1.793PheArg: 1.793 ± 0.045	3.708PheSer: 3.708 ± 0.055	3.3PheThr: 3.3 ± 0.064	2.97PheVal: 2.97 ± 0.051	0.557PheTrp: 0.557 ± 0.024	2.121PheTyr: 2.121 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.749GlyAla: 4.749 ± 0.089	0.862GlyCys: 0.862 ± 0.035	3.295GlyAsp: 3.295 ± 0.058	2.97GlyGlu: 2.97 ± 0.059	3.508GlyPhe: 3.508 ± 0.063	5.101GlyGly: 5.101 ± 0.106	1.193GlyHis: 1.193 ± 0.034	5.671GlyIle: 5.671 ± 0.076	5.013GlyLys: 5.013 ± 0.067	5.741GlyLeu: 5.741 ± 0.075	1.883GlyMet: 1.883 ± 0.048	4.521GlyAsn: 4.521 ± 0.079	1.568GlyPro: 1.568 ± 0.05	2.22GlyGln: 2.22 ± 0.049	2.266GlyArg: 2.266 ± 0.049	4.626GlySer: 4.626 ± 0.09	4.99GlyThr: 4.99 ± 0.118	4.035GlyVal: 4.035 ± 0.066	0.86GlyTrp: 0.86 ± 0.027	2.957GlyTyr: 2.957 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.211HisAla: 1.211 ± 0.032	0.233HisCys: 0.233 ± 0.013	0.901HisAsp: 0.901 ± 0.026	0.969HisGlu: 0.969 ± 0.029	1.224HisPhe: 1.224 ± 0.037	1.101HisGly: 1.101 ± 0.03	0.522HisHis: 0.522 ± 0.022	1.487HisIle: 1.487 ± 0.036	1.074HisLys: 1.074 ± 0.035	1.848HisLeu: 1.848 ± 0.041	0.36HisMet: 0.36 ± 0.016	0.981HisAsn: 0.981 ± 0.027	1.031HisPro: 1.031 ± 0.034	0.688HisGln: 0.688 ± 0.024	0.687HisArg: 0.687 ± 0.023	1.125HisSer: 1.125 ± 0.029	1.062HisThr: 1.062 ± 0.03	1.015HisVal: 1.015 ± 0.032	0.295HisTrp: 0.295 ± 0.017	0.94HisTyr: 0.94 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.042IleAla: 6.042 ± 0.074	0.915IleCys: 0.915 ± 0.036	4.251IleAsp: 4.251 ± 0.069	4.316IleGlu: 4.316 ± 0.072	3.248IlePhe: 3.248 ± 0.053	4.891IleGly: 4.891 ± 0.072	1.497IleHis: 1.497 ± 0.033	5.486IleIle: 5.486 ± 0.087	4.972IleLys: 4.972 ± 0.081	6.341IleLeu: 6.341 ± 0.09	1.528IleMet: 1.528 ± 0.039	4.486IleAsn: 4.486 ± 0.059	3.325IlePro: 3.325 ± 0.054	2.65IleGln: 2.65 ± 0.049	2.839IleArg: 2.839 ± 0.049	5.19IleSer: 5.19 ± 0.073	4.881IleThr: 4.881 ± 0.082	4.557IleVal: 4.557 ± 0.064	0.734IleTrp: 0.734 ± 0.029	2.818IleTyr: 2.818 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.928LysAla: 4.928 ± 0.084	0.401LysCys: 0.401 ± 0.018	4.226LysAsp: 4.226 ± 0.076	5.137LysGlu: 5.137 ± 0.078	2.4LysPhe: 2.4 ± 0.046	4.406LysGly: 4.406 ± 0.07	1.317LysHis: 1.317 ± 0.037	5.05LysIle: 5.05 ± 0.076	5.18LysLys: 5.18 ± 0.094	5.486LysLeu: 5.486 ± 0.087	2.19LysMet: 2.19 ± 0.053	3.95LysAsn: 3.95 ± 0.066	2.462LysPro: 2.462 ± 0.048	2.703LysGln: 2.703 ± 0.048	2.534LysArg: 2.534 ± 0.045	3.827LysSer: 3.827 ± 0.063	3.912LysThr: 3.912 ± 0.066	4.248LysVal: 4.248 ± 0.062	0.78LysTrp: 0.78 ± 0.028	2.772LysTyr: 2.772 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	5.934LeuAla: 5.934 ± 0.077	0.958LeuCys: 0.958 ± 0.03	4.348LeuAsp: 4.348 ± 0.06	4.819LeuGlu: 4.819 ± 0.076	4.53LeuPhe: 4.53 ± 0.069	5.351LeuGly: 5.351 ± 0.066	1.842LeuHis: 1.842 ± 0.044	6.313LeuIle: 6.313 ± 0.089	6.671LeuLys: 6.671 ± 0.088	8.965LeuLeu: 8.965 ± 0.126	2.336LeuMet: 2.336 ± 0.049	5.665LeuAsn: 5.665 ± 0.077	3.972LeuPro: 3.972 ± 0.067	3.954LeuGln: 3.954 ± 0.067	3.392LeuArg: 3.392 ± 0.056	6.784LeuSer: 6.784 ± 0.078	5.142LeuThr: 5.142 ± 0.074	4.576LeuVal: 4.576 ± 0.063	0.885LeuTrp: 0.885 ± 0.03	3.16LeuTyr: 3.16 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.865MetAla: 1.865 ± 0.039	0.169MetCys: 0.169 ± 0.013	1.425MetAsp: 1.425 ± 0.035	1.619MetGlu: 1.619 ± 0.038	0.888MetPhe: 0.888 ± 0.026	1.537MetGly: 1.537 ± 0.037	0.533MetHis: 0.533 ± 0.024	1.563MetIle: 1.563 ± 0.04	2.188MetLys: 2.188 ± 0.049	2.325MetLeu: 2.325 ± 0.049	0.796MetMet: 0.796 ± 0.029	1.6MetAsn: 1.6 ± 0.038	1.211MetPro: 1.211 ± 0.033	1.221MetGln: 1.221 ± 0.032	1.007MetArg: 1.007 ± 0.034	1.539MetSer: 1.539 ± 0.038	1.3MetThr: 1.3 ± 0.033	1.475MetVal: 1.475 ± 0.039	0.192MetTrp: 0.192 ± 0.014	0.71MetTyr: 0.71 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	4.783AsnAla: 4.783 ± 0.085	0.589AsnCys: 0.589 ± 0.025	3.38AsnAsp: 3.38 ± 0.054	3.265AsnGlu: 3.265 ± 0.055	2.695AsnPhe: 2.695 ± 0.051	4.618AsnGly: 4.618 ± 0.091	1.057AsnHis: 1.057 ± 0.029	4.93AsnIle: 4.93 ± 0.088	3.888AsnLys: 3.888 ± 0.061	4.992AsnLeu: 4.992 ± 0.068	1.315AsnMet: 1.315 ± 0.032	4.299AsnAsn: 4.299 ± 0.09	2.997AsnPro: 2.997 ± 0.06	1.975AsnGln: 1.975 ± 0.039	2.138AsnArg: 2.138 ± 0.05	3.512AsnSer: 3.512 ± 0.059	3.959AsnThr: 3.959 ± 0.085	3.637AsnVal: 3.637 ± 0.062	0.751AsnTrp: 0.751 ± 0.026	2.806AsnTyr: 2.806 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	3.164ProAla: 3.164 ± 0.054	0.31ProCys: 0.31 ± 0.019	2.53ProAsp: 2.53 ± 0.049	2.825ProGlu: 2.825 ± 0.054	2.03ProPhe: 2.03 ± 0.046	2.676ProGly: 2.676 ± 0.059	0.623ProHis: 0.623 ± 0.023	2.194ProIle: 2.194 ± 0.048	2.088ProLys: 2.088 ± 0.044	3.249ProLeu: 3.249 ± 0.055	0.775ProMet: 0.775 ± 0.027	2.239ProAsn: 2.239 ± 0.042	1.154ProPro: 1.154 ± 0.036	1.356ProGln: 1.356 ± 0.034	0.947ProArg: 0.947 ± 0.027	2.352ProSer: 2.352 ± 0.04	2.15ProThr: 2.15 ± 0.059	3.38ProVal: 3.38 ± 0.068	0.364ProTrp: 0.364 ± 0.019	1.651ProTyr: 1.651 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.421GlnAla: 2.421 ± 0.053	0.27GlnCys: 0.27 ± 0.015	1.617GlnAsp: 1.617 ± 0.041	1.968GlnGlu: 1.968 ± 0.041	1.687GlnPhe: 1.687 ± 0.038	1.963GlnGly: 1.963 ± 0.048	0.846GlnHis: 0.846 ± 0.028	2.529GlnIle: 2.529 ± 0.048	2.716GlnLys: 2.716 ± 0.049	3.752GlnLeu: 3.752 ± 0.058	1.1GlnMet: 1.1 ± 0.029	2.201GlnAsn: 2.201 ± 0.053	1.509GlnPro: 1.509 ± 0.034	2.203GlnGln: 2.203 ± 0.077	1.444GlnArg: 1.444 ± 0.038	2.451GlnSer: 2.451 ± 0.045	2.24GlnThr: 2.24 ± 0.046	2.162GlnVal: 2.162 ± 0.045	0.497GlnTrp: 0.497 ± 0.021	1.685GlnTyr: 1.685 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	1.963ArgAla: 1.963 ± 0.042	0.283ArgCys: 0.283 ± 0.015	1.683ArgAsp: 1.683 ± 0.04	1.951ArgGlu: 1.951 ± 0.049	1.929ArgPhe: 1.929 ± 0.037	1.76ArgGly: 1.76 ± 0.043	0.708ArgHis: 0.708 ± 0.023	3.069ArgIle: 3.069 ± 0.06	2.881ArgLys: 2.881 ± 0.057	3.517ArgLeu: 3.517 ± 0.067	1.189ArgMet: 1.189 ± 0.035	2.334ArgAsn: 2.334 ± 0.043	1.223ArgPro: 1.223 ± 0.036	1.457ArgGln: 1.457 ± 0.04	1.421ArgArg: 1.421 ± 0.041	1.972ArgSer: 1.972 ± 0.043	1.851ArgThr: 1.851 ± 0.042	2.018ArgVal: 2.018 ± 0.045	0.429ArgTrp: 0.429 ± 0.021	1.619ArgTyr: 1.619 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.517SerAla: 4.517 ± 0.073	0.702SerCys: 0.702 ± 0.031	3.394SerAsp: 3.394 ± 0.055	3.053SerGlu: 3.053 ± 0.054	3.868SerPhe: 3.868 ± 0.057	5.524SerGly: 5.524 ± 0.099	1.046SerHis: 1.046 ± 0.029	5.144SerIle: 5.144 ± 0.069	3.906SerLys: 3.906 ± 0.064	6.156SerLeu: 6.156 ± 0.075	1.585SerMet: 1.585 ± 0.039	3.947SerAsn: 3.947 ± 0.067	2.276SerPro: 2.276 ± 0.044	2.037SerGln: 2.037 ± 0.047	2.08SerArg: 2.08 ± 0.04	4.234SerSer: 4.234 ± 0.086	3.882SerThr: 3.882 ± 0.085	4.274SerVal: 4.274 ± 0.063	0.708SerTrp: 0.708 ± 0.025	2.848SerTyr: 2.848 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	5.151ThrAla: 5.151 ± 0.11	0.523ThrCys: 0.523 ± 0.021	3.367ThrAsp: 3.367 ± 0.064	3.063ThrGlu: 3.063 ± 0.049	3.125ThrPhe: 3.125 ± 0.059	5.266ThrGly: 5.266 ± 0.114	1.01ThrHis: 1.01 ± 0.029	4.882ThrIle: 4.882 ± 0.075	3.103ThrLys: 3.103 ± 0.054	5.655ThrLeu: 5.655 ± 0.081	1.206ThrMet: 1.206 ± 0.031	3.384ThrAsn: 3.384 ± 0.071	2.853ThrPro: 2.853 ± 0.066	2.022ThrGln: 2.022 ± 0.044	1.644ThrArg: 1.644 ± 0.032	3.96ThrSer: 3.96 ± 0.102	4.288ThrThr: 4.288 ± 0.121	4.333ThrVal: 4.333 ± 0.081	0.657ThrTrp: 0.657 ± 0.025	2.585ThrTyr: 2.585 ± 0.064	0.0ThrXaa: 0.0 ± 0.0
Val	4.563ValAla: 4.563 ± 0.063	0.653ValCys: 0.653 ± 0.023	3.129ValAsp: 3.129 ± 0.051	3.086ValGlu: 3.086 ± 0.059	3.065ValPhe: 3.065 ± 0.057	3.508ValGly: 3.508 ± 0.06	1.121ValHis: 1.121 ± 0.029	4.679ValIle: 4.679 ± 0.069	4.142ValLys: 4.142 ± 0.072	5.449ValLeu: 5.449 ± 0.065	1.491ValMet: 1.491 ± 0.034	3.913ValAsn: 3.913 ± 0.076	2.47ValPro: 2.47 ± 0.049	2.057ValGln: 2.057 ± 0.037	2.175ValArg: 2.175 ± 0.048	4.424ValSer: 4.424 ± 0.065	4.133ValThr: 4.133 ± 0.077	3.888ValVal: 3.888 ± 0.065	0.649ValTrp: 0.649 ± 0.023	2.698ValTyr: 2.698 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.742TrpAla: 0.742 ± 0.024	0.113TrpCys: 0.113 ± 0.01	0.652TrpAsp: 0.652 ± 0.023	0.599TrpGlu: 0.599 ± 0.025	0.571TrpPhe: 0.571 ± 0.022	0.686TrpGly: 0.686 ± 0.024	0.266TrpHis: 0.266 ± 0.014	0.774TrpIle: 0.774 ± 0.029	0.833TrpLys: 0.833 ± 0.03	1.064TrpLeu: 1.064 ± 0.035	0.36TrpMet: 0.36 ± 0.018	0.845TrpAsn: 0.845 ± 0.032	0.264TrpPro: 0.264 ± 0.017	0.525TrpGln: 0.525 ± 0.021	0.419TrpArg: 0.419 ± 0.018	0.703TrpSer: 0.703 ± 0.027	0.626TrpThr: 0.626 ± 0.022	0.673TrpVal: 0.673 ± 0.029	0.172TrpTrp: 0.172 ± 0.012	0.453TrpTyr: 0.453 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.661TyrAla: 2.661 ± 0.049	0.453TyrCys: 0.453 ± 0.02	2.36TyrAsp: 2.36 ± 0.057	2.114TyrGlu: 2.114 ± 0.043	2.363TyrPhe: 2.363 ± 0.051	2.678TyrGly: 2.678 ± 0.062	0.834TyrHis: 0.834 ± 0.032	2.72TyrIle: 2.72 ± 0.049	2.806TyrLys: 2.806 ± 0.053	3.791TyrLeu: 3.791 ± 0.057	0.835TyrMet: 0.835 ± 0.026	2.887TyrAsn: 2.887 ± 0.059	1.663TyrPro: 1.663 ± 0.042	1.605TyrGln: 1.605 ± 0.044	1.758TyrArg: 1.758 ± 0.045	2.842TyrSer: 2.842 ± 0.052	2.74TyrThr: 2.74 ± 0.057	2.186TyrVal: 2.186 ± 0.037	0.53TyrTrp: 0.53 ± 0.023	2.119TyrTyr: 2.119 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3591 proteins (1235045 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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