Amino acid dipepetide frequency for Triplophysa tibetana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.012AlaAla: 5.012 ± 0.029	1.313AlaCys: 1.313 ± 0.011	3.04AlaAsp: 3.04 ± 0.017	4.285AlaGlu: 4.285 ± 0.027	2.351AlaPhe: 2.351 ± 0.015	3.904AlaGly: 3.904 ± 0.027	1.498AlaHis: 1.498 ± 0.012	2.677AlaIle: 2.677 ± 0.019	3.165AlaLys: 3.165 ± 0.022	6.262AlaLeu: 6.262 ± 0.031	1.472AlaMet: 1.472 ± 0.012	2.096AlaAsn: 2.096 ± 0.014	3.101AlaPro: 3.101 ± 0.025	2.771AlaGln: 2.771 ± 0.018	3.028AlaArg: 3.028 ± 0.018	5.136AlaSer: 5.136 ± 0.025	3.238AlaThr: 3.238 ± 0.021	4.808AlaVal: 4.808 ± 0.025	0.603AlaTrp: 0.603 ± 0.007	1.425AlaTyr: 1.425 ± 0.013	0.0AlaXaa: 0.0 ± 0.0
Cys	1.229CysAla: 1.229 ± 0.012	0.653CysCys: 0.653 ± 0.009	1.218CysAsp: 1.218 ± 0.015	1.344CysGlu: 1.344 ± 0.016	0.896CysPhe: 0.896 ± 0.009	1.632CysGly: 1.632 ± 0.02	0.676CysHis: 0.676 ± 0.009	0.986CysIle: 0.986 ± 0.012	1.228CysLys: 1.228 ± 0.013	2.204CysLeu: 2.204 ± 0.019	0.496CysMet: 0.496 ± 0.007	0.874CysAsn: 0.874 ± 0.01	1.293CysPro: 1.293 ± 0.017	1.049CysGln: 1.049 ± 0.014	1.297CysArg: 1.297 ± 0.011	2.164CysSer: 2.164 ± 0.017	1.232CysThr: 1.232 ± 0.012	1.678CysVal: 1.678 ± 0.017	0.299CysTrp: 0.299 ± 0.005	0.616CysTyr: 0.616 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	2.955AspAla: 2.955 ± 0.018	1.178AspCys: 1.178 ± 0.013	3.225AspAsp: 3.225 ± 0.024	4.005AspGlu: 4.005 ± 0.024	2.108AspPhe: 2.108 ± 0.015	3.644AspGly: 3.644 ± 0.029	1.264AspHis: 1.264 ± 0.011	2.861AspIle: 2.861 ± 0.02	2.736AspLys: 2.736 ± 0.019	5.144AspLeu: 5.144 ± 0.027	1.325AspMet: 1.325 ± 0.012	2.001AspAsn: 2.001 ± 0.016	2.782AspPro: 2.782 ± 0.019	2.019AspGln: 2.019 ± 0.016	2.701AspArg: 2.701 ± 0.018	4.538AspSer: 4.538 ± 0.025	2.793AspThr: 2.793 ± 0.017	3.683AspVal: 3.683 ± 0.024	0.664AspTrp: 0.664 ± 0.007	1.509AspTyr: 1.509 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.199GluAla: 4.199 ± 0.026	1.317GluCys: 1.317 ± 0.016	4.49GluAsp: 4.49 ± 0.025	7.211GluGlu: 7.211 ± 0.053	2.063GluPhe: 2.063 ± 0.016	3.89GluGly: 3.89 ± 0.026	1.559GluHis: 1.559 ± 0.013	3.209GluIle: 3.209 ± 0.027	4.942GluLys: 4.942 ± 0.045	5.953GluLeu: 5.953 ± 0.041	1.906GluMet: 1.906 ± 0.018	3.103GluAsn: 3.103 ± 0.018	2.688GluPro: 2.688 ± 0.023	3.01GluGln: 3.01 ± 0.025	4.398GluArg: 4.398 ± 0.03	4.726GluSer: 4.726 ± 0.024	3.736GluThr: 3.736 ± 0.041	4.218GluVal: 4.218 ± 0.024	0.689GluTrp: 0.689 ± 0.008	1.594GluTyr: 1.594 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	1.895PheAla: 1.895 ± 0.014	0.95PheCys: 0.95 ± 0.01	1.794PheAsp: 1.794 ± 0.013	1.976PheGlu: 1.976 ± 0.014	1.567PhePhe: 1.567 ± 0.015	2.212PheGly: 2.212 ± 0.018	1.027PheHis: 1.027 ± 0.01	2.062PheIle: 2.062 ± 0.017	1.955PheLys: 1.955 ± 0.019	3.784PheLeu: 3.784 ± 0.024	0.852PheMet: 0.852 ± 0.009	1.577PheAsn: 1.577 ± 0.015	1.797PhePro: 1.797 ± 0.012	1.658PheGln: 1.658 ± 0.014	1.927PheArg: 1.927 ± 0.019	3.486PheSer: 3.486 ± 0.023	2.405PheThr: 2.405 ± 0.016	2.244PheVal: 2.244 ± 0.017	0.462PheTrp: 0.462 ± 0.006	1.189PheTyr: 1.189 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	3.558GlyAla: 3.558 ± 0.028	1.282GlyCys: 1.282 ± 0.013	3.176GlyAsp: 3.176 ± 0.022	3.941GlyGlu: 3.941 ± 0.026	2.424GlyPhe: 2.424 ± 0.016	4.556GlyGly: 4.556 ± 0.044	1.655GlyHis: 1.655 ± 0.013	2.664GlyIle: 2.664 ± 0.019	3.585GlyLys: 3.585 ± 0.025	5.328GlyLeu: 5.328 ± 0.032	1.437GlyMet: 1.437 ± 0.016	2.514GlyAsn: 2.514 ± 0.017	2.947GlyPro: 2.947 ± 0.036	2.618GlyGln: 2.618 ± 0.02	3.486GlyArg: 3.486 ± 0.021	5.445GlySer: 5.445 ± 0.035	3.387GlyThr: 3.387 ± 0.024	3.942GlyVal: 3.942 ± 0.023	0.746GlyTrp: 0.746 ± 0.01	1.773GlyTyr: 1.773 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.382HisAla: 1.382 ± 0.012	0.77HisCys: 0.77 ± 0.01	1.041HisAsp: 1.041 ± 0.01	1.344HisGlu: 1.344 ± 0.011	1.085HisPhe: 1.085 ± 0.008	1.523HisGly: 1.523 ± 0.012	1.019HisHis: 1.019 ± 0.015	1.38HisIle: 1.38 ± 0.013	1.389HisLys: 1.389 ± 0.019	2.812HisLeu: 2.812 ± 0.021	0.773HisMet: 0.773 ± 0.012	1.098HisAsn: 1.098 ± 0.016	1.55HisPro: 1.55 ± 0.014	1.306HisGln: 1.306 ± 0.013	1.621HisArg: 1.621 ± 0.013	2.431HisSer: 2.431 ± 0.018	1.768HisThr: 1.768 ± 0.019	1.544HisVal: 1.544 ± 0.011	0.33HisTrp: 0.33 ± 0.005	0.84HisTyr: 0.84 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.57IleAla: 2.57 ± 0.018	1.154IleCys: 1.154 ± 0.011	2.252IleAsp: 2.252 ± 0.018	2.647IleGlu: 2.647 ± 0.028	1.885IlePhe: 1.885 ± 0.018	2.381IleGly: 2.381 ± 0.018	1.406IleHis: 1.406 ± 0.015	2.6IleIle: 2.6 ± 0.024	2.763IleLys: 2.763 ± 0.021	4.446IleLeu: 4.446 ± 0.023	1.136IleMet: 1.136 ± 0.012	2.123IleAsn: 2.123 ± 0.015	2.555IlePro: 2.555 ± 0.019	2.314IleGln: 2.314 ± 0.015	2.538IleArg: 2.538 ± 0.017	4.161IleSer: 4.161 ± 0.024	3.054IleThr: 3.054 ± 0.023	2.701IleVal: 2.701 ± 0.023	0.507IleTrp: 0.507 ± 0.007	1.428IleTyr: 1.428 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.597LysAla: 3.597 ± 0.024	1.131LysCys: 1.131 ± 0.012	3.435LysAsp: 3.435 ± 0.028	4.708LysGlu: 4.708 ± 0.036	1.645LysPhe: 1.645 ± 0.017	3.14LysGly: 3.14 ± 0.028	1.567LysHis: 1.567 ± 0.011	2.746LysIle: 2.746 ± 0.018	4.429LysLys: 4.429 ± 0.035	5.029LysLeu: 5.029 ± 0.034	1.524LysMet: 1.524 ± 0.012	2.47LysAsn: 2.47 ± 0.017	2.984LysPro: 2.984 ± 0.026	2.616LysGln: 2.616 ± 0.026	3.63LysArg: 3.63 ± 0.022	4.227LysSer: 4.227 ± 0.029	3.498LysThr: 3.498 ± 0.025	3.474LysVal: 3.474 ± 0.021	0.586LysTrp: 0.586 ± 0.009	1.502LysTyr: 1.502 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	5.631LeuAla: 5.631 ± 0.029	2.233LeuCys: 2.233 ± 0.016	4.861LeuAsp: 4.861 ± 0.025	6.314LeuGlu: 6.314 ± 0.039	3.392LeuPhe: 3.392 ± 0.02	4.862LeuGly: 4.862 ± 0.026	2.722LeuHis: 2.722 ± 0.017	4.044LeuIle: 4.044 ± 0.024	5.896LeuLys: 5.896 ± 0.032	9.555LeuLeu: 9.555 ± 0.05	2.244LeuMet: 2.244 ± 0.016	3.958LeuAsn: 3.958 ± 0.023	5.017LeuPro: 5.017 ± 0.025	5.332LeuGln: 5.332 ± 0.033	5.509LeuArg: 5.509 ± 0.032	8.289LeuSer: 8.289 ± 0.038	5.351LeuThr: 5.351 ± 0.024	5.292LeuVal: 5.292 ± 0.024	1.04LeuTrp: 1.04 ± 0.01	2.592LeuTyr: 2.592 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	1.814MetAla: 1.814 ± 0.013	0.54MetCys: 0.54 ± 0.007	1.475MetAsp: 1.475 ± 0.013	1.989MetGlu: 1.989 ± 0.017	0.934MetPhe: 0.934 ± 0.01	1.422MetGly: 1.422 ± 0.014	0.518MetHis: 0.518 ± 0.006	0.972MetIle: 0.972 ± 0.009	1.561MetLys: 1.561 ± 0.014	2.117MetLeu: 2.117 ± 0.013	0.751MetMet: 0.751 ± 0.009	1.029MetAsn: 1.029 ± 0.012	1.098MetPro: 1.098 ± 0.013	1.01MetGln: 1.01 ± 0.011	1.334MetArg: 1.334 ± 0.013	2.021MetSer: 2.021 ± 0.013	1.357MetThr: 1.357 ± 0.011	1.479MetVal: 1.479 ± 0.012	0.268MetTrp: 0.268 ± 0.005	0.641MetTyr: 0.641 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.28AsnAla: 2.28 ± 0.016	0.922AsnCys: 0.922 ± 0.011	1.865AsnAsp: 1.865 ± 0.015	2.38AsnGlu: 2.38 ± 0.018	1.474AsnPhe: 1.474 ± 0.012	2.848AsnGly: 2.848 ± 0.023	1.059AsnHis: 1.059 ± 0.016	2.421AsnIle: 2.421 ± 0.015	2.374AsnLys: 2.374 ± 0.018	3.77AsnLeu: 3.77 ± 0.021	1.084AsnMet: 1.084 ± 0.011	1.962AsnAsn: 1.962 ± 0.022	2.317AsnPro: 2.317 ± 0.018	1.778AsnGln: 1.778 ± 0.013	2.125AsnArg: 2.125 ± 0.013	3.463AsnSer: 3.463 ± 0.022	2.512AsnThr: 2.512 ± 0.018	2.581AsnVal: 2.581 ± 0.02	0.46AsnTrp: 0.46 ± 0.006	1.17AsnTyr: 1.17 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	3.652ProAla: 3.652 ± 0.025	1.071ProCys: 1.071 ± 0.013	2.833ProAsp: 2.833 ± 0.018	3.648ProGlu: 3.648 ± 0.023	1.832ProPhe: 1.832 ± 0.016	3.59ProGly: 3.59 ± 0.047	1.473ProHis: 1.473 ± 0.016	1.965ProIle: 1.965 ± 0.017	2.601ProLys: 2.601 ± 0.025	4.674ProLeu: 4.674 ± 0.026	1.031ProMet: 1.031 ± 0.01	1.979ProAsn: 1.979 ± 0.017	4.755ProPro: 4.755 ± 0.055	2.525ProGln: 2.525 ± 0.022	2.595ProArg: 2.595 ± 0.016	5.358ProSer: 5.358 ± 0.037	3.018ProThr: 3.018 ± 0.027	3.765ProVal: 3.765 ± 0.025	0.527ProTrp: 0.527 ± 0.007	1.409ProTyr: 1.409 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	2.87GlnAla: 2.87 ± 0.018	1.121GlnCys: 1.121 ± 0.016	2.347GlnAsp: 2.347 ± 0.014	3.409GlnGlu: 3.409 ± 0.024	1.386GlnPhe: 1.386 ± 0.011	2.511GlnGly: 2.511 ± 0.021	1.375GlnHis: 1.375 ± 0.012	2.084GlnIle: 2.084 ± 0.018	2.779GlnLys: 2.779 ± 0.025	4.219GlnLeu: 4.219 ± 0.029	1.223GlnMet: 1.223 ± 0.012	2.048GlnAsn: 2.048 ± 0.016	2.348GlnPro: 2.348 ± 0.02	2.915GlnGln: 2.915 ± 0.036	3.01GlnArg: 3.01 ± 0.019	3.621GlnSer: 3.621 ± 0.022	2.861GlnThr: 2.861 ± 0.024	2.59GlnVal: 2.59 ± 0.015	0.531GlnTrp: 0.531 ± 0.007	1.212GlnTyr: 1.212 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	3.315ArgAla: 3.315 ± 0.017	1.272ArgCys: 1.272 ± 0.014	2.983ArgAsp: 2.983 ± 0.02	3.957ArgGlu: 3.957 ± 0.026	2.028ArgPhe: 2.028 ± 0.015	3.284ArgGly: 3.284 ± 0.024	1.576ArgHis: 1.576 ± 0.011	2.526ArgIle: 2.526 ± 0.015	3.609ArgLys: 3.609 ± 0.02	5.164ArgLeu: 5.164 ± 0.026	1.341ArgMet: 1.341 ± 0.009	2.232ArgAsn: 2.232 ± 0.012	2.873ArgPro: 2.873 ± 0.019	2.594ArgGln: 2.594 ± 0.016	4.289ArgArg: 4.289 ± 0.025	4.663ArgSer: 4.663 ± 0.025	2.987ArgThr: 2.987 ± 0.018	3.375ArgVal: 3.375 ± 0.025	0.681ArgTrp: 0.681 ± 0.008	1.549ArgTyr: 1.549 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	5.402SerAla: 5.402 ± 0.028	1.978SerCys: 1.978 ± 0.017	4.677SerAsp: 4.677 ± 0.027	5.35SerGlu: 5.35 ± 0.04	3.228SerPhe: 3.228 ± 0.019	5.59SerGly: 5.59 ± 0.031	2.318SerHis: 2.318 ± 0.016	3.59SerIle: 3.59 ± 0.016	4.197SerLys: 4.197 ± 0.026	8.207SerLeu: 8.207 ± 0.036	1.869SerMet: 1.869 ± 0.012	3.216SerAsn: 3.216 ± 0.019	5.604SerPro: 5.604 ± 0.041	3.851SerGln: 3.851 ± 0.027	4.533SerArg: 4.533 ± 0.021	9.997SerSer: 9.997 ± 0.075	5.121SerThr: 5.121 ± 0.061	5.797SerVal: 5.797 ± 0.026	0.975SerTrp: 0.975 ± 0.011	2.157SerTyr: 2.157 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	3.968ThrAla: 3.968 ± 0.023	1.452ThrCys: 1.452 ± 0.016	3.175ThrAsp: 3.175 ± 0.019	4.038ThrGlu: 4.038 ± 0.044	2.215ThrPhe: 2.215 ± 0.015	3.839ThrGly: 3.839 ± 0.026	1.591ThrHis: 1.591 ± 0.018	2.575ThrIle: 2.575 ± 0.022	2.72ThrLys: 2.72 ± 0.019	5.547ThrLeu: 5.547 ± 0.023	1.184ThrMet: 1.184 ± 0.011	2.13ThrAsn: 2.13 ± 0.016	3.631ThrPro: 3.631 ± 0.033	2.572ThrGln: 2.572 ± 0.022	2.606ThrArg: 2.606 ± 0.018	5.177ThrSer: 5.177 ± 0.045	3.555ThrThr: 3.555 ± 0.095	4.267ThrVal: 4.267 ± 0.027	0.64ThrTrp: 0.64 ± 0.011	1.457ThrTyr: 1.457 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	3.82ValAla: 3.82 ± 0.021	1.751ValCys: 1.751 ± 0.016	3.228ValAsp: 3.228 ± 0.021	4.07ValGlu: 4.07 ± 0.028	2.666ValPhe: 2.666 ± 0.017	3.366ValGly: 3.366 ± 0.023	1.634ValHis: 1.634 ± 0.012	3.149ValIle: 3.149 ± 0.024	3.771ValLys: 3.771 ± 0.023	6.292ValLeu: 6.292 ± 0.028	1.651ValMet: 1.651 ± 0.012	2.67ValAsn: 2.67 ± 0.018	3.244ValPro: 3.244 ± 0.024	2.862ValGln: 2.862 ± 0.019	3.307ValArg: 3.307 ± 0.018	5.502ValSer: 5.502 ± 0.029	4.079ValThr: 4.079 ± 0.036	4.247ValVal: 4.247 ± 0.033	0.784ValTrp: 0.784 ± 0.009	1.861ValTyr: 1.861 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	0.637TrpAla: 0.637 ± 0.007	0.258TrpCys: 0.258 ± 0.005	0.622TrpAsp: 0.622 ± 0.008	0.7TrpGlu: 0.7 ± 0.01	0.459TrpPhe: 0.459 ± 0.007	0.61TrpGly: 0.61 ± 0.009	0.286TrpHis: 0.286 ± 0.005	0.611TrpIle: 0.611 ± 0.008	0.732TrpLys: 0.732 ± 0.009	1.095TrpLeu: 1.095 ± 0.011	0.349TrpMet: 0.349 ± 0.006	0.523TrpAsn: 0.523 ± 0.007	0.419TrpPro: 0.419 ± 0.006	0.469TrpGln: 0.469 ± 0.005	0.741TrpArg: 0.741 ± 0.008	0.932TrpSer: 0.932 ± 0.01	0.71TrpThr: 0.71 ± 0.011	0.677TrpVal: 0.677 ± 0.009	0.177TrpTrp: 0.177 ± 0.004	0.331TrpTyr: 0.331 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.397TyrAla: 1.397 ± 0.012	0.715TyrCys: 0.715 ± 0.008	1.397TyrAsp: 1.397 ± 0.013	1.585TyrGlu: 1.585 ± 0.014	1.181TyrPhe: 1.181 ± 0.011	1.661TyrGly: 1.661 ± 0.016	0.785TyrHis: 0.785 ± 0.009	1.499TyrIle: 1.499 ± 0.014	1.503TyrLys: 1.503 ± 0.015	2.533TyrLeu: 2.533 ± 0.018	0.682TyrMet: 0.682 ± 0.008	1.244TyrAsn: 1.244 ± 0.015	1.301TyrPro: 1.301 ± 0.012	1.189TyrGln: 1.189 ± 0.012	1.625TyrArg: 1.625 ± 0.014	2.32TyrSer: 2.32 ± 0.016	1.679TyrThr: 1.679 ± 0.016	1.591TyrVal: 1.591 ± 0.013	0.368TyrTrp: 0.368 ± 0.006	0.946TyrTyr: 0.946 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 23866 proteins (13339987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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