Amino acid dipepetide frequency for Parapusillimonas sp. SGNA-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.811AlaAla: 12.811 ± 0.147
1.087AlaCys: 1.087 ± 0.028
5.743AlaAsp: 5.743 ± 0.058
5.562AlaGlu: 5.562 ± 0.059
3.718AlaPhe: 3.718 ± 0.047
8.881AlaGly: 8.881 ± 0.1
2.228AlaHis: 2.228 ± 0.039
5.639AlaIle: 5.639 ± 0.065
3.761AlaLys: 3.761 ± 0.064
11.672AlaLeu: 11.672 ± 0.111
3.004AlaMet: 3.004 ± 0.046
2.946AlaAsn: 2.946 ± 0.05
4.542AlaPro: 4.542 ± 0.053
4.433AlaGln: 4.433 ± 0.059
6.798AlaArg: 6.798 ± 0.083
6.144AlaSer: 6.144 ± 0.07
5.359AlaThr: 5.359 ± 0.06
7.448AlaVal: 7.448 ± 0.078
1.519AlaTrp: 1.519 ± 0.038
2.823AlaTyr: 2.823 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.937CysAla: 0.937 ± 0.028
0.115CysCys: 0.115 ± 0.011
0.507CysAsp: 0.507 ± 0.019
0.46CysGlu: 0.46 ± 0.019
0.301CysPhe: 0.301 ± 0.012
0.831CysGly: 0.831 ± 0.025
0.258CysHis: 0.258 ± 0.013
0.492CysIle: 0.492 ± 0.018
0.292CysLys: 0.292 ± 0.015
0.824CysLeu: 0.824 ± 0.023
0.228CysMet: 0.228 ± 0.011
0.29CysAsn: 0.29 ± 0.014
0.461CysPro: 0.461 ± 0.017
0.241CysGln: 0.241 ± 0.013
0.523CysArg: 0.523 ± 0.02
0.506CysSer: 0.506 ± 0.016
0.489CysThr: 0.489 ± 0.018
0.664CysVal: 0.664 ± 0.025
0.116CysTrp: 0.116 ± 0.009
0.25CysTyr: 0.25 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.934AspAla: 5.934 ± 0.072
0.464AspCys: 0.464 ± 0.018
2.968AspAsp: 2.968 ± 0.052
3.439AspGlu: 3.439 ± 0.05
2.402AspPhe: 2.402 ± 0.043
4.335AspGly: 4.335 ± 0.054
1.22AspHis: 1.22 ± 0.028
3.552AspIle: 3.552 ± 0.051
2.395AspLys: 2.395 ± 0.046
5.419AspLeu: 5.419 ± 0.061
1.49AspMet: 1.49 ± 0.029
1.74AspAsn: 1.74 ± 0.036
2.906AspPro: 2.906 ± 0.049
1.796AspGln: 1.796 ± 0.038
3.362AspArg: 3.362 ± 0.057
2.452AspSer: 2.452 ± 0.042
2.899AspThr: 2.899 ± 0.043
4.292AspVal: 4.292 ± 0.05
0.872AspTrp: 0.872 ± 0.025
1.897AspTyr: 1.897 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.884GluAla: 5.884 ± 0.068
0.381GluCys: 0.381 ± 0.016
2.624GluAsp: 2.624 ± 0.043
3.212GluGlu: 3.212 ± 0.061
1.951GluPhe: 1.951 ± 0.037
3.961GluGly: 3.961 ± 0.056
1.434GluHis: 1.434 ± 0.033
3.22GluIle: 3.22 ± 0.049
2.684GluLys: 2.684 ± 0.054
5.589GluLeu: 5.589 ± 0.066
1.346GluMet: 1.346 ± 0.031
2.038GluAsn: 2.038 ± 0.041
2.36GluPro: 2.36 ± 0.043
2.596GluGln: 2.596 ± 0.038
4.107GluArg: 4.107 ± 0.059
2.771GluSer: 2.771 ± 0.045
2.763GluThr: 2.763 ± 0.042
3.821GluVal: 3.821 ± 0.056
0.711GluTrp: 0.711 ± 0.02
1.48GluTyr: 1.48 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.588PheAla: 3.588 ± 0.051
0.389PheCys: 0.389 ± 0.017
2.633PheAsp: 2.633 ± 0.043
2.201PheGlu: 2.201 ± 0.039
1.615PhePhe: 1.615 ± 0.037
3.304PheGly: 3.304 ± 0.048
0.794PheHis: 0.794 ± 0.022
2.115PheIle: 2.115 ± 0.038
1.571PheLys: 1.571 ± 0.034
3.392PheLeu: 3.392 ± 0.05
0.938PheMet: 0.938 ± 0.024
1.521PheAsn: 1.521 ± 0.036
1.666PhePro: 1.666 ± 0.034
1.224PheGln: 1.224 ± 0.028
1.94PheArg: 1.94 ± 0.037
2.634PheSer: 2.634 ± 0.039
2.08PheThr: 2.08 ± 0.036
2.862PheVal: 2.862 ± 0.049
0.53PheTrp: 0.53 ± 0.019
1.188PheTyr: 1.188 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
7.637GlyAla: 7.637 ± 0.083
0.77GlyCys: 0.77 ± 0.025
3.882GlyAsp: 3.882 ± 0.056
3.933GlyGlu: 3.933 ± 0.048
3.239GlyPhe: 3.239 ± 0.048
6.21GlyGly: 6.21 ± 0.091
1.89GlyHis: 1.89 ± 0.041
4.773GlyIle: 4.773 ± 0.06
3.864GlyLys: 3.864 ± 0.064
8.196GlyLeu: 8.196 ± 0.089
2.354GlyMet: 2.354 ± 0.036
2.56GlyAsn: 2.56 ± 0.046
2.837GlyPro: 2.837 ± 0.048
3.04GlyGln: 3.04 ± 0.047
4.832GlyArg: 4.832 ± 0.066
4.667GlySer: 4.667 ± 0.059
4.543GlyThr: 4.543 ± 0.058
5.988GlyVal: 5.988 ± 0.07
1.202GlyTrp: 1.202 ± 0.029
2.764GlyTyr: 2.764 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.478HisAla: 2.478 ± 0.046
0.267HisCys: 0.267 ± 0.014
1.289HisAsp: 1.289 ± 0.03
1.214HisGlu: 1.214 ± 0.031
0.909HisPhe: 0.909 ± 0.029
1.927HisGly: 1.927 ± 0.039
0.645HisHis: 0.645 ± 0.024
1.414HisIle: 1.414 ± 0.03
0.741HisLys: 0.741 ± 0.022
2.053HisLeu: 2.053 ± 0.034
0.487HisMet: 0.487 ± 0.018
0.719HisAsn: 0.719 ± 0.023
1.38HisPro: 1.38 ± 0.03
0.777HisGln: 0.777 ± 0.022
1.38HisArg: 1.38 ± 0.031
1.147HisSer: 1.147 ± 0.03
1.14HisThr: 1.14 ± 0.03
1.638HisVal: 1.638 ± 0.032
0.375HisTrp: 0.375 ± 0.015
0.733HisTyr: 0.733 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.177IleAla: 6.177 ± 0.072
0.482IleCys: 0.482 ± 0.021
3.628IleAsp: 3.628 ± 0.049
3.61IleGlu: 3.61 ± 0.055
1.921IlePhe: 1.921 ± 0.036
4.711IleGly: 4.711 ± 0.061
1.171IleHis: 1.171 ± 0.027
2.839IleIle: 2.839 ± 0.049
2.419IleLys: 2.419 ± 0.048
4.828IleLeu: 4.828 ± 0.066
1.17IleMet: 1.17 ± 0.028
2.027IleAsn: 2.027 ± 0.039
2.696IlePro: 2.696 ± 0.042
1.922IleGln: 1.922 ± 0.034
3.184IleArg: 3.184 ± 0.043
3.366IleSer: 3.366 ± 0.044
3.016IleThr: 3.016 ± 0.044
4.424IleVal: 4.424 ± 0.057
0.613IleTrp: 0.613 ± 0.02
1.423IleTyr: 1.423 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.227LysAla: 4.227 ± 0.059
0.199LysCys: 0.199 ± 0.011
2.34LysAsp: 2.34 ± 0.048
2.65LysGlu: 2.65 ± 0.05
1.293LysPhe: 1.293 ± 0.035
3.019LysGly: 3.019 ± 0.046
0.847LysHis: 0.847 ± 0.023
2.349LysIle: 2.349 ± 0.051
2.301LysLys: 2.301 ± 0.058
3.967LysLeu: 3.967 ± 0.049
0.994LysMet: 0.994 ± 0.024
1.676LysAsn: 1.676 ± 0.043
2.129LysPro: 2.129 ± 0.039
1.657LysGln: 1.657 ± 0.038
2.463LysArg: 2.463 ± 0.04
2.336LysSer: 2.336 ± 0.044
2.41LysThr: 2.41 ± 0.046
2.997LysVal: 2.997 ± 0.051
0.525LysTrp: 0.525 ± 0.018
1.215LysTyr: 1.215 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
11.748LeuAla: 11.748 ± 0.109
1.038LeuCys: 1.038 ± 0.026
5.88LeuAsp: 5.88 ± 0.061
5.315LeuGlu: 5.315 ± 0.064
3.856LeuPhe: 3.856 ± 0.055
7.802LeuGly: 7.802 ± 0.079
2.244LeuHis: 2.244 ± 0.044
5.27LeuIle: 5.27 ± 0.075
4.217LeuLys: 4.217 ± 0.058
10.184LeuLeu: 10.184 ± 0.124
2.425LeuMet: 2.425 ± 0.043
3.382LeuAsn: 3.382 ± 0.047
5.301LeuPro: 5.301 ± 0.064
3.669LeuGln: 3.669 ± 0.052
6.397LeuArg: 6.397 ± 0.076
6.679LeuSer: 6.679 ± 0.063
5.32LeuThr: 5.32 ± 0.057
6.977LeuVal: 6.977 ± 0.081
1.14LeuTrp: 1.14 ± 0.029
2.638LeuTyr: 2.638 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.834MetAla: 2.834 ± 0.043
0.18MetCys: 0.18 ± 0.011
1.27MetAsp: 1.27 ± 0.028
1.214MetGlu: 1.214 ± 0.027
0.765MetPhe: 0.765 ± 0.024
1.884MetGly: 1.884 ± 0.04
0.532MetHis: 0.532 ± 0.02
1.191MetIle: 1.191 ± 0.031
1.294MetLys: 1.294 ± 0.03
2.645MetLeu: 2.645 ± 0.042
0.697MetMet: 0.697 ± 0.022
0.964MetAsn: 0.964 ± 0.025
1.427MetPro: 1.427 ± 0.029
1.04MetGln: 1.04 ± 0.027
1.548MetArg: 1.548 ± 0.031
1.692MetSer: 1.692 ± 0.033
1.545MetThr: 1.545 ± 0.03
1.723MetVal: 1.723 ± 0.035
0.221MetTrp: 0.221 ± 0.013
0.515MetTyr: 0.515 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.315AsnAla: 3.315 ± 0.042
0.263AsnCys: 0.263 ± 0.012
1.733AsnAsp: 1.733 ± 0.04
1.816AsnGlu: 1.816 ± 0.039
1.335AsnPhe: 1.335 ± 0.027
2.765AsnGly: 2.765 ± 0.048
0.643AsnHis: 0.643 ± 0.018
2.139AsnIle: 2.139 ± 0.042
1.538AsnLys: 1.538 ± 0.036
3.158AsnLeu: 3.158 ± 0.05
0.822AsnMet: 0.822 ± 0.025
1.367AsnAsn: 1.367 ± 0.041
2.057AsnPro: 2.057 ± 0.035
1.181AsnGln: 1.181 ± 0.031
2.018AsnArg: 2.018 ± 0.033
1.749AsnSer: 1.749 ± 0.038
1.964AsnThr: 1.964 ± 0.042
2.428AsnVal: 2.428 ± 0.041
0.507AsnTrp: 0.507 ± 0.021
1.091AsnTyr: 1.091 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
5.381ProAla: 5.381 ± 0.07
0.342ProCys: 0.342 ± 0.015
3.532ProAsp: 3.532 ± 0.052
3.23ProGlu: 3.23 ± 0.052
1.787ProPhe: 1.787 ± 0.032
3.892ProGly: 3.892 ± 0.055
1.035ProHis: 1.035 ± 0.028
2.342ProIle: 2.342 ± 0.04
1.674ProLys: 1.674 ± 0.035
4.594ProLeu: 4.594 ± 0.054
1.116ProMet: 1.116 ± 0.023
1.538ProAsn: 1.538 ± 0.033
2.055ProPro: 2.055 ± 0.043
1.813ProGln: 1.813 ± 0.036
2.452ProArg: 2.452 ± 0.047
2.838ProSer: 2.838 ± 0.042
2.504ProThr: 2.504 ± 0.039
3.828ProVal: 3.828 ± 0.048
0.68ProTrp: 0.68 ± 0.022
1.468ProTyr: 1.468 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.62GlnAla: 4.62 ± 0.067
0.264GlnCys: 0.264 ± 0.014
1.881GlnAsp: 1.881 ± 0.037
2.014GlnGlu: 2.014 ± 0.036
1.353GlnPhe: 1.353 ± 0.033
2.943GlnGly: 2.943 ± 0.045
0.991GlnHis: 0.991 ± 0.025
2.049GlnIle: 2.049 ± 0.041
1.586GlnLys: 1.586 ± 0.036
3.617GlnLeu: 3.617 ± 0.055
0.94GlnMet: 0.94 ± 0.026
1.188GlnAsn: 1.188 ± 0.028
1.769GlnPro: 1.769 ± 0.037
1.801GlnGln: 1.801 ± 0.04
2.761GlnArg: 2.761 ± 0.046
2.019GlnSer: 2.019 ± 0.039
1.893GlnThr: 1.893 ± 0.036
2.724GlnVal: 2.724 ± 0.039
0.59GlnTrp: 0.59 ± 0.022
1.054GlnTyr: 1.054 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
5.742ArgAla: 5.742 ± 0.07
0.507ArgCys: 0.507 ± 0.016
3.335ArgAsp: 3.335 ± 0.053
3.512ArgGlu: 3.512 ± 0.052
2.434ArgPhe: 2.434 ± 0.046
4.011ArgGly: 4.011 ± 0.059
1.698ArgHis: 1.698 ± 0.034
3.818ArgIle: 3.818 ± 0.056
2.589ArgLys: 2.589 ± 0.045
6.786ArgLeu: 6.786 ± 0.077
1.691ArgMet: 1.691 ± 0.035
2.169ArgAsn: 2.169 ± 0.04
2.875ArgPro: 2.875 ± 0.054
2.653ArgGln: 2.653 ± 0.04
4.351ArgArg: 4.351 ± 0.07
3.572ArgSer: 3.572 ± 0.05
2.902ArgThr: 2.902 ± 0.039
4.247ArgVal: 4.247 ± 0.056
0.91ArgTrp: 0.91 ± 0.028
2.221ArgTyr: 2.221 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.816SerAla: 5.816 ± 0.078
0.49SerCys: 0.49 ± 0.017
3.068SerAsp: 3.068 ± 0.04
2.802SerGlu: 2.802 ± 0.046
2.458SerPhe: 2.458 ± 0.042
5.287SerGly: 5.287 ± 0.061
1.25SerHis: 1.25 ± 0.032
3.349SerIle: 3.349 ± 0.046
2.207SerLys: 2.207 ± 0.045
6.097SerLeu: 6.097 ± 0.075
1.48SerMet: 1.48 ± 0.033
1.955SerAsn: 1.955 ± 0.04
2.765SerPro: 2.765 ± 0.04
1.954SerGln: 1.954 ± 0.037
3.647SerArg: 3.647 ± 0.057
3.712SerSer: 3.712 ± 0.053
3.308SerThr: 3.308 ± 0.054
4.26SerVal: 4.26 ± 0.059
0.781SerTrp: 0.781 ± 0.023
1.746SerTyr: 1.746 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
5.203ThrAla: 5.203 ± 0.072
0.417ThrCys: 0.417 ± 0.017
2.865ThrAsp: 2.865 ± 0.046
2.67ThrGlu: 2.67 ± 0.045
1.996ThrPhe: 1.996 ± 0.036
4.783ThrGly: 4.783 ± 0.06
1.236ThrHis: 1.236 ± 0.027
2.909ThrIle: 2.909 ± 0.05
1.777ThrLys: 1.777 ± 0.037
6.102ThrLeu: 6.102 ± 0.073
1.158ThrMet: 1.158 ± 0.031
1.625ThrAsn: 1.625 ± 0.031
3.227ThrPro: 3.227 ± 0.045
1.861ThrGln: 1.861 ± 0.04
2.981ThrArg: 2.981 ± 0.047
3.072ThrSer: 3.072 ± 0.048
2.941ThrThr: 2.941 ± 0.058
4.378ThrVal: 4.378 ± 0.06
0.73ThrTrp: 0.73 ± 0.021
1.47ThrTyr: 1.47 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
7.828ValAla: 7.828 ± 0.08
0.697ValCys: 0.697 ± 0.025
4.232ValAsp: 4.232 ± 0.055
3.905ValGlu: 3.905 ± 0.047
2.982ValPhe: 2.982 ± 0.043
5.285ValGly: 5.285 ± 0.069
1.621ValHis: 1.621 ± 0.035
3.988ValIle: 3.988 ± 0.058
2.877ValLys: 2.877 ± 0.049
7.755ValLeu: 7.755 ± 0.076
1.817ValMet: 1.817 ± 0.037
2.579ValAsn: 2.579 ± 0.047
3.638ValPro: 3.638 ± 0.054
2.711ValGln: 2.711 ± 0.043
4.302ValArg: 4.302 ± 0.053
4.586ValSer: 4.586 ± 0.058
3.882ValThr: 3.882 ± 0.056
5.92ValVal: 5.92 ± 0.075
0.873ValTrp: 0.873 ± 0.026
2.026ValTyr: 2.026 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.133TrpAla: 1.133 ± 0.024
0.141TrpCys: 0.141 ± 0.009
0.674TrpAsp: 0.674 ± 0.021
0.604TrpGlu: 0.604 ± 0.023
0.552TrpPhe: 0.552 ± 0.02
0.872TrpGly: 0.872 ± 0.024
0.368TrpHis: 0.368 ± 0.016
0.721TrpIle: 0.721 ± 0.02
0.557TrpLys: 0.557 ± 0.017
1.775TrpLeu: 1.775 ± 0.041
0.398TrpMet: 0.398 ± 0.018
0.532TrpAsn: 0.532 ± 0.018
0.599TrpPro: 0.599 ± 0.019
0.599TrpGln: 0.599 ± 0.019
1.023TrpArg: 1.023 ± 0.028
0.788TrpSer: 0.788 ± 0.024
0.708TrpThr: 0.708 ± 0.021
0.892TrpVal: 0.892 ± 0.026
0.23TrpTrp: 0.23 ± 0.013
0.388TrpTyr: 0.388 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.824TyrAla: 2.824 ± 0.043
0.291TyrCys: 0.291 ± 0.012
1.748TyrAsp: 1.748 ± 0.032
1.569TyrGlu: 1.569 ± 0.034
1.318TyrPhe: 1.318 ± 0.031
2.481TyrGly: 2.481 ± 0.042
0.612TyrHis: 0.612 ± 0.02
1.46TyrIle: 1.46 ± 0.031
1.25TyrLys: 1.25 ± 0.033
2.831TyrLeu: 2.831 ± 0.045
0.624TyrMet: 0.624 ± 0.024
1.072TyrAsn: 1.072 ± 0.028
1.412TyrPro: 1.412 ± 0.034
1.087TyrGln: 1.087 ± 0.026
1.956TyrArg: 1.956 ± 0.036
1.703TyrSer: 1.703 ± 0.04
1.734TyrThr: 1.734 ± 0.039
1.988TyrVal: 1.988 ± 0.04
0.43TyrTrp: 0.43 ± 0.018
1.015TyrTyr: 1.015 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5275 proteins (1582118 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski