Amino acid dipepetide frequency for Paenibacillus beijingensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.248AlaAla: 11.248 ± 0.15	0.798AlaCys: 0.798 ± 0.026	4.961AlaAsp: 4.961 ± 0.063	6.131AlaGlu: 6.131 ± 0.097	3.643AlaPhe: 3.643 ± 0.054	8.184AlaGly: 8.184 ± 0.077	1.494AlaHis: 1.494 ± 0.036	5.208AlaIle: 5.208 ± 0.072	4.402AlaLys: 4.402 ± 0.058	9.142AlaLeu: 9.142 ± 0.089	2.382AlaMet: 2.382 ± 0.043	2.528AlaAsn: 2.528 ± 0.043	2.971AlaPro: 2.971 ± 0.06	2.739AlaGln: 2.739 ± 0.047	4.176AlaArg: 4.176 ± 0.063	5.485AlaSer: 5.485 ± 0.074	3.3AlaThr: 3.3 ± 0.055	7.634AlaVal: 7.634 ± 0.084	0.947AlaTrp: 0.947 ± 0.025	2.614AlaTyr: 2.614 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.636CysAla: 0.636 ± 0.022	0.121CysCys: 0.121 ± 0.009	0.396CysAsp: 0.396 ± 0.019	0.454CysGlu: 0.454 ± 0.02	0.324CysPhe: 0.324 ± 0.013	0.874CysGly: 0.874 ± 0.026	0.163CysHis: 0.163 ± 0.011	0.498CysIle: 0.498 ± 0.017	0.319CysLys: 0.319 ± 0.015	0.729CysLeu: 0.729 ± 0.023	0.211CysMet: 0.211 ± 0.012	0.286CysAsn: 0.286 ± 0.015	0.423CysPro: 0.423 ± 0.018	0.182CysGln: 0.182 ± 0.008	0.542CysArg: 0.542 ± 0.022	0.553CysSer: 0.553 ± 0.022	0.437CysThr: 0.437 ± 0.019	0.492CysVal: 0.492 ± 0.018	0.103CysTrp: 0.103 ± 0.008	0.252CysTyr: 0.252 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.065AspAla: 4.065 ± 0.06	0.397AspCys: 0.397 ± 0.016	2.403AspAsp: 2.403 ± 0.051	3.744AspGlu: 3.744 ± 0.054	1.997AspPhe: 1.997 ± 0.04	4.107AspGly: 4.107 ± 0.062	1.081AspHis: 1.081 ± 0.029	3.426AspIle: 3.426 ± 0.054	2.661AspLys: 2.661 ± 0.05	4.954AspLeu: 4.954 ± 0.057	1.346AspMet: 1.346 ± 0.031	1.745AspAsn: 1.745 ± 0.037	2.525AspPro: 2.525 ± 0.046	1.604AspGln: 1.604 ± 0.034	2.964AspArg: 2.964 ± 0.043	2.745AspSer: 2.745 ± 0.04	2.358AspThr: 2.358 ± 0.047	3.552AspVal: 3.552 ± 0.049	0.801AspTrp: 0.801 ± 0.022	1.909AspTyr: 1.909 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.536GluAla: 6.536 ± 0.079	0.378GluCys: 0.378 ± 0.017	2.923GluAsp: 2.923 ± 0.049	5.078GluGlu: 5.078 ± 0.086	2.105GluPhe: 2.105 ± 0.041	4.535GluGly: 4.535 ± 0.058	1.461GluHis: 1.461 ± 0.04	4.101GluIle: 4.101 ± 0.059	3.645GluLys: 3.645 ± 0.058	7.124GluLeu: 7.124 ± 0.081	2.002GluMet: 2.002 ± 0.04	2.206GluAsn: 2.206 ± 0.046	2.452GluPro: 2.452 ± 0.045	3.445GluGln: 3.445 ± 0.054	4.556GluArg: 4.556 ± 0.086	3.534GluSer: 3.534 ± 0.057	3.589GluThr: 3.589 ± 0.056	4.091GluVal: 4.091 ± 0.054	0.893GluTrp: 0.893 ± 0.024	1.762GluTyr: 1.762 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.638PheAla: 3.638 ± 0.057	0.385PheCys: 0.385 ± 0.016	2.305PheAsp: 2.305 ± 0.048	2.318PheGlu: 2.318 ± 0.041	1.876PhePhe: 1.876 ± 0.043	3.508PheGly: 3.508 ± 0.052	0.926PheHis: 0.926 ± 0.023	2.831PheIle: 2.831 ± 0.05	1.813PheLys: 1.813 ± 0.035	3.85PheLeu: 3.85 ± 0.064	1.112PheMet: 1.112 ± 0.027	1.519PheAsn: 1.519 ± 0.041	1.762PhePro: 1.762 ± 0.032	1.407PheGln: 1.407 ± 0.033	2.181PheArg: 2.181 ± 0.041	2.685PheSer: 2.685 ± 0.039	2.295PheThr: 2.295 ± 0.044	3.094PheVal: 3.094 ± 0.051	0.573PheTrp: 0.573 ± 0.02	1.359PheTyr: 1.359 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.662GlyAla: 6.662 ± 0.089	0.828GlyCys: 0.828 ± 0.027	3.515GlyAsp: 3.515 ± 0.047	4.695GlyGlu: 4.695 ± 0.066	3.447GlyPhe: 3.447 ± 0.052	6.387GlyGly: 6.387 ± 0.086	1.514GlyHis: 1.514 ± 0.032	5.935GlyIle: 5.935 ± 0.074	4.659GlyLys: 4.659 ± 0.068	7.591GlyLeu: 7.591 ± 0.078	2.501GlyMet: 2.501 ± 0.04	2.633GlyAsn: 2.633 ± 0.048	2.276GlyPro: 2.276 ± 0.04	2.569GlyGln: 2.569 ± 0.039	4.138GlyArg: 4.138 ± 0.068	5.272GlySer: 5.272 ± 0.078	4.515GlyThr: 4.515 ± 0.061	5.474GlyVal: 5.474 ± 0.074	1.118GlyTrp: 1.118 ± 0.03	2.862GlyTyr: 2.862 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.579HisAla: 1.579 ± 0.034	0.188HisCys: 0.188 ± 0.011	1.036HisAsp: 1.036 ± 0.029	1.223HisGlu: 1.223 ± 0.033	0.968HisPhe: 0.968 ± 0.029	1.539HisGly: 1.539 ± 0.031	0.6HisHis: 0.6 ± 0.023	1.314HisIle: 1.314 ± 0.03	0.81HisLys: 0.81 ± 0.025	2.16HisLeu: 2.16 ± 0.067	0.539HisMet: 0.539 ± 0.019	0.662HisAsn: 0.662 ± 0.023	1.303HisPro: 1.303 ± 0.03	0.674HisGln: 0.674 ± 0.02	1.175HisArg: 1.175 ± 0.033	1.211HisSer: 1.211 ± 0.032	0.954HisThr: 0.954 ± 0.025	1.354HisVal: 1.354 ± 0.033	0.268HisTrp: 0.268 ± 0.013	0.838HisTyr: 0.838 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.361IleAla: 6.361 ± 0.067	0.619IleCys: 0.619 ± 0.021	3.565IleAsp: 3.565 ± 0.057	4.131IleGlu: 4.131 ± 0.061	2.321IlePhe: 2.321 ± 0.045	5.794IleGly: 5.794 ± 0.076	1.325IleHis: 1.325 ± 0.031	3.976IleIle: 3.976 ± 0.058	2.783IleLys: 2.783 ± 0.051	5.396IleLeu: 5.396 ± 0.078	1.577IleMet: 1.577 ± 0.037	2.21IleAsn: 2.21 ± 0.039	3.091IlePro: 3.091 ± 0.046	2.15IleGln: 2.15 ± 0.036	4.099IleArg: 4.099 ± 0.058	4.099IleSer: 4.099 ± 0.061	3.415IleThr: 3.415 ± 0.049	5.431IleVal: 5.431 ± 0.064	0.672IleTrp: 0.672 ± 0.025	1.878IleTyr: 1.878 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.426LysAla: 4.426 ± 0.059	0.257LysCys: 0.257 ± 0.012	2.606LysAsp: 2.606 ± 0.047	4.089LysGlu: 4.089 ± 0.062	1.521LysPhe: 1.521 ± 0.035	3.591LysGly: 3.591 ± 0.059	1.017LysHis: 1.017 ± 0.024	2.903LysIle: 2.903 ± 0.053	2.956LysLys: 2.956 ± 0.054	5.419LysLeu: 5.419 ± 0.081	1.558LysMet: 1.558 ± 0.034	1.833LysAsn: 1.833 ± 0.045	2.321LysPro: 2.321 ± 0.04	2.354LysGln: 2.354 ± 0.045	3.095LysArg: 3.095 ± 0.052	2.807LysSer: 2.807 ± 0.049	2.769LysThr: 2.769 ± 0.049	3.449LysVal: 3.449 ± 0.058	0.685LysTrp: 0.685 ± 0.024	1.559LysTyr: 1.559 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	9.122LeuAla: 9.122 ± 0.112	0.814LeuCys: 0.814 ± 0.022	5.013LeuAsp: 5.013 ± 0.059	6.369LeuGlu: 6.369 ± 0.075	4.72LeuPhe: 4.72 ± 0.069	7.098LeuGly: 7.098 ± 0.089	2.196LeuHis: 2.196 ± 0.041	6.444LeuIle: 6.444 ± 0.078	5.227LeuLys: 5.227 ± 0.055	11.489LeuLeu: 11.489 ± 0.121	2.641LeuMet: 2.641 ± 0.046	3.656LeuAsn: 3.656 ± 0.06	4.648LeuPro: 4.648 ± 0.059	4.133LeuGln: 4.133 ± 0.065	5.314LeuArg: 5.314 ± 0.073	7.01LeuSer: 7.01 ± 0.079	5.72LeuThr: 5.72 ± 0.068	6.356LeuVal: 6.356 ± 0.072	1.068LeuTrp: 1.068 ± 0.026	3.122LeuTyr: 3.122 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.307MetAla: 2.307 ± 0.039	0.159MetCys: 0.159 ± 0.01	1.449MetAsp: 1.449 ± 0.034	1.899MetGlu: 1.899 ± 0.035	1.016MetPhe: 1.016 ± 0.028	1.742MetGly: 1.742 ± 0.036	0.446MetHis: 0.446 ± 0.018	1.98MetIle: 1.98 ± 0.038	1.964MetLys: 1.964 ± 0.032	2.976MetLeu: 2.976 ± 0.055	0.925MetMet: 0.925 ± 0.029	1.497MetAsn: 1.497 ± 0.038	1.164MetPro: 1.164 ± 0.028	0.959MetGln: 0.959 ± 0.025	1.436MetArg: 1.436 ± 0.034	1.687MetSer: 1.687 ± 0.033	1.794MetThr: 1.794 ± 0.036	1.715MetVal: 1.715 ± 0.035	0.216MetTrp: 0.216 ± 0.011	0.718MetTyr: 0.718 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.89AsnAla: 2.89 ± 0.053	0.236AsnCys: 0.236 ± 0.014	1.768AsnAsp: 1.768 ± 0.036	2.461AsnGlu: 2.461 ± 0.043	1.163AsnPhe: 1.163 ± 0.029	3.107AsnGly: 3.107 ± 0.061	0.674AsnHis: 0.674 ± 0.024	2.211AsnIle: 2.211 ± 0.043	1.863AsnLys: 1.863 ± 0.037	3.121AsnLeu: 3.121 ± 0.046	0.97AsnMet: 0.97 ± 0.023	1.337AsnAsn: 1.337 ± 0.035	2.008AsnPro: 2.008 ± 0.035	1.174AsnGln: 1.174 ± 0.033	2.171AsnArg: 2.171 ± 0.04	1.848AsnSer: 1.848 ± 0.04	1.719AsnThr: 1.719 ± 0.036	2.652AsnVal: 2.652 ± 0.043	0.467AsnTrp: 0.467 ± 0.018	1.202AsnTyr: 1.202 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.875ProAla: 3.875 ± 0.063	0.277ProCys: 0.277 ± 0.016	2.831ProAsp: 2.831 ± 0.047	3.432ProGlu: 3.432 ± 0.062	2.004ProPhe: 2.004 ± 0.036	3.365ProGly: 3.365 ± 0.055	0.958ProHis: 0.958 ± 0.028	2.327ProIle: 2.327 ± 0.034	1.766ProLys: 1.766 ± 0.031	4.352ProLeu: 4.352 ± 0.053	0.96ProMet: 0.96 ± 0.028	1.411ProAsn: 1.411 ± 0.031	1.374ProPro: 1.374 ± 0.03	1.494ProGln: 1.494 ± 0.038	1.585ProArg: 1.585 ± 0.036	2.591ProSer: 2.591 ± 0.044	1.731ProThr: 1.731 ± 0.033	3.531ProVal: 3.531 ± 0.057	0.559ProTrp: 0.559 ± 0.022	1.529ProTyr: 1.529 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.278GlnAla: 3.278 ± 0.053	0.204GlnCys: 0.204 ± 0.011	1.443GlnAsp: 1.443 ± 0.033	2.296GlnGlu: 2.296 ± 0.048	1.551GlnPhe: 1.551 ± 0.032	2.356GlnGly: 2.356 ± 0.042	0.736GlnHis: 0.736 ± 0.023	2.346GlnIle: 2.346 ± 0.038	1.787GlnLys: 1.787 ± 0.037	4.201GlnLeu: 4.201 ± 0.06	1.097GlnMet: 1.097 ± 0.025	1.16GlnAsn: 1.16 ± 0.03	1.527GlnPro: 1.527 ± 0.038	1.768GlnGln: 1.768 ± 0.036	2.026GlnArg: 2.026 ± 0.041	2.303GlnSer: 2.303 ± 0.046	2.029GlnThr: 2.029 ± 0.043	2.291GlnVal: 2.291 ± 0.039	0.506GlnTrp: 0.506 ± 0.021	1.2GlnTyr: 1.2 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.857ArgAla: 3.857 ± 0.059	0.412ArgCys: 0.412 ± 0.019	2.571ArgAsp: 2.571 ± 0.044	4.025ArgGlu: 4.025 ± 0.07	2.522ArgPhe: 2.522 ± 0.045	3.356ArgGly: 3.356 ± 0.058	1.194ArgHis: 1.194 ± 0.032	4.073ArgIle: 4.073 ± 0.061	3.283ArgLys: 3.283 ± 0.052	6.014ArgLeu: 6.014 ± 0.088	1.832ArgMet: 1.832 ± 0.036	2.079ArgAsn: 2.079 ± 0.037	1.971ArgPro: 1.971 ± 0.041	2.223ArgGln: 2.223 ± 0.042	3.262ArgArg: 3.262 ± 0.056	3.565ArgSer: 3.565 ± 0.054	2.994ArgThr: 2.994 ± 0.045	3.174ArgVal: 3.174 ± 0.05	0.727ArgTrp: 0.727 ± 0.023	2.003ArgTyr: 2.003 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.476SerAla: 5.476 ± 0.07	0.464SerCys: 0.464 ± 0.016	3.057SerAsp: 3.057 ± 0.042	3.72SerGlu: 3.72 ± 0.056	2.966SerPhe: 2.966 ± 0.048	6.16SerGly: 6.16 ± 0.084	1.154SerHis: 1.154 ± 0.029	4.01SerIle: 4.01 ± 0.064	2.949SerLys: 2.949 ± 0.044	6.322SerLeu: 6.322 ± 0.075	1.739SerMet: 1.739 ± 0.029	1.945SerAsn: 1.945 ± 0.036	2.488SerPro: 2.488 ± 0.046	1.819SerGln: 1.819 ± 0.034	3.402SerArg: 3.402 ± 0.053	4.089SerSer: 4.089 ± 0.069	2.754SerThr: 2.754 ± 0.048	4.668SerVal: 4.668 ± 0.08	0.799SerTrp: 0.799 ± 0.023	2.023SerTyr: 2.023 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.976ThrAla: 4.976 ± 0.065	0.366ThrCys: 0.366 ± 0.017	2.758ThrAsp: 2.758 ± 0.043	3.168ThrGlu: 3.168 ± 0.044	2.292ThrPhe: 2.292 ± 0.04	4.712ThrGly: 4.712 ± 0.065	0.988ThrHis: 0.988 ± 0.024	3.544ThrIle: 3.544 ± 0.055	2.315ThrLys: 2.315 ± 0.04	5.256ThrLeu: 5.256 ± 0.066	1.296ThrMet: 1.296 ± 0.028	1.703ThrAsn: 1.703 ± 0.038	2.397ThrPro: 2.397 ± 0.044	1.342ThrGln: 1.342 ± 0.031	2.246ThrArg: 2.246 ± 0.04	3.02ThrSer: 3.02 ± 0.051	2.544ThrThr: 2.544 ± 0.046	4.594ThrVal: 4.594 ± 0.058	0.532ThrTrp: 0.532 ± 0.02	1.642ThrTyr: 1.642 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	5.583ValAla: 5.583 ± 0.066	0.704ValCys: 0.704 ± 0.02	3.422ValAsp: 3.422 ± 0.05	4.3ValGlu: 4.3 ± 0.065	2.938ValPhe: 2.938 ± 0.047	4.674ValGly: 4.674 ± 0.062	1.533ValHis: 1.533 ± 0.033	4.962ValIle: 4.962 ± 0.054	3.792ValLys: 3.792 ± 0.056	7.455ValLeu: 7.455 ± 0.089	2.097ValMet: 2.097 ± 0.036	2.756ValAsn: 2.756 ± 0.052	3.326ValPro: 3.326 ± 0.047	2.566ValGln: 2.566 ± 0.051	3.984ValArg: 3.984 ± 0.052	4.779ValSer: 4.779 ± 0.063	4.455ValThr: 4.455 ± 0.087	5.181ValVal: 5.181 ± 0.065	0.841ValTrp: 0.841 ± 0.026	2.4ValTyr: 2.4 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.837TrpAla: 0.837 ± 0.023	0.095TrpCys: 0.095 ± 0.009	0.638TrpAsp: 0.638 ± 0.021	0.75TrpGlu: 0.75 ± 0.023	0.552TrpPhe: 0.552 ± 0.02	0.769TrpGly: 0.769 ± 0.023	0.275TrpHis: 0.275 ± 0.013	0.881TrpIle: 0.881 ± 0.026	0.737TrpLys: 0.737 ± 0.025	1.436TrpLeu: 1.436 ± 0.034	0.433TrpMet: 0.433 ± 0.016	0.65TrpAsn: 0.65 ± 0.022	0.383TrpPro: 0.383 ± 0.015	0.437TrpGln: 0.437 ± 0.019	0.634TrpArg: 0.634 ± 0.022	0.827TrpSer: 0.827 ± 0.026	0.68TrpThr: 0.68 ± 0.02	0.81TrpVal: 0.81 ± 0.025	0.173TrpTrp: 0.173 ± 0.012	0.371TrpTyr: 0.371 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.637TyrAla: 2.637 ± 0.042	0.294TyrCys: 0.294 ± 0.012	1.726TyrAsp: 1.726 ± 0.038	2.135TyrGlu: 2.135 ± 0.039	1.511TyrPhe: 1.511 ± 0.039	2.734TyrGly: 2.734 ± 0.041	0.661TyrHis: 0.661 ± 0.023	1.924TyrIle: 1.924 ± 0.038	1.483TyrLys: 1.483 ± 0.033	3.17TyrLeu: 3.17 ± 0.048	0.83TyrMet: 0.83 ± 0.022	1.226TyrAsn: 1.226 ± 0.029	1.541TyrPro: 1.541 ± 0.029	1.065TyrGln: 1.065 ± 0.029	2.152TyrArg: 2.152 ± 0.041	1.893TyrSer: 1.893 ± 0.036	1.638TyrThr: 1.638 ± 0.034	2.204TyrVal: 2.204 ± 0.035	0.419TyrTrp: 0.419 ± 0.018	1.189TyrTyr: 1.189 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4723 proteins (1475279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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