Amino acid dipepetide frequency for Rhizophagus sp. MUCL 43196

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.591AlaAla: 2.591 ± 0.03	0.676AlaCys: 0.676 ± 0.01	2.296AlaAsp: 2.296 ± 0.02	2.874AlaGlu: 2.874 ± 0.024	2.14AlaPhe: 2.14 ± 0.024	1.958AlaGly: 1.958 ± 0.019	0.923AlaHis: 0.923 ± 0.012	3.847AlaIle: 3.847 ± 0.023	3.432AlaLys: 3.432 ± 0.022	4.179AlaLeu: 4.179 ± 0.029	0.934AlaMet: 0.934 ± 0.012	2.686AlaAsn: 2.686 ± 0.019	1.753AlaPro: 1.753 ± 0.022	1.582AlaGln: 1.582 ± 0.017	1.925AlaArg: 1.925 ± 0.019	3.385AlaSer: 3.385 ± 0.024	2.522AlaThr: 2.522 ± 0.02	2.31AlaVal: 2.31 ± 0.019	0.449AlaTrp: 0.449 ± 0.01	1.586AlaTyr: 1.586 ± 0.016	0.009AlaXaa: 0.009 ± 0.001
Cys	0.607CysAla: 0.607 ± 0.009	0.286CysCys: 0.286 ± 0.007	0.895CysAsp: 0.895 ± 0.011	0.947CysGlu: 0.947 ± 0.013	0.737CysPhe: 0.737 ± 0.009	0.967CysGly: 0.967 ± 0.013	0.372CysHis: 0.372 ± 0.008	1.153CysIle: 1.153 ± 0.012	1.27CysLys: 1.27 ± 0.016	1.477CysLeu: 1.477 ± 0.016	0.286CysMet: 0.286 ± 0.006	1.056CysAsn: 1.056 ± 0.014	0.616CysPro: 0.616 ± 0.011	0.625CysGln: 0.625 ± 0.01	0.662CysArg: 0.662 ± 0.012	1.09CysSer: 1.09 ± 0.013	0.694CysThr: 0.694 ± 0.01	0.691CysVal: 0.691 ± 0.01	0.354CysTrp: 0.354 ± 0.007	0.787CysTyr: 0.787 ± 0.014	0.005CysXaa: 0.005 ± 0.001
Asp	2.278AspAla: 2.278 ± 0.021	0.745AspCys: 0.745 ± 0.011	4.849AspAsp: 4.849 ± 0.038	4.712AspGlu: 4.712 ± 0.033	2.973AspPhe: 2.973 ± 0.018	2.636AspGly: 2.636 ± 0.022	1.104AspHis: 1.104 ± 0.014	5.206AspIle: 5.206 ± 0.031	4.253AspLys: 4.253 ± 0.028	5.288AspLeu: 5.288 ± 0.028	1.112AspMet: 1.112 ± 0.013	4.101AspAsn: 4.101 ± 0.024	2.222AspPro: 2.222 ± 0.021	1.786AspGln: 1.786 ± 0.017	2.007AspArg: 2.007 ± 0.022	3.958AspSer: 3.958 ± 0.024	2.626AspThr: 2.626 ± 0.018	2.944AspVal: 2.944 ± 0.023	0.678AspTrp: 0.678 ± 0.01	2.508AspTyr: 2.508 ± 0.019	0.016AspXaa: 0.016 ± 0.002
Glu	2.906GluAla: 2.906 ± 0.024	0.972GluCys: 0.972 ± 0.013	3.893GluAsp: 3.893 ± 0.025	6.163GluGlu: 6.163 ± 0.046	3.276GluPhe: 3.276 ± 0.021	2.551GluGly: 2.551 ± 0.021	1.224GluHis: 1.224 ± 0.011	6.687GluIle: 6.687 ± 0.033	6.266GluLys: 6.266 ± 0.042	6.634GluLeu: 6.634 ± 0.035	1.481GluMet: 1.481 ± 0.014	5.404GluAsn: 5.404 ± 0.034	1.93GluPro: 1.93 ± 0.016	2.41GluGln: 2.41 ± 0.02	3.053GluArg: 3.053 ± 0.026	4.506GluSer: 4.506 ± 0.025	3.292GluThr: 3.292 ± 0.023	3.621GluVal: 3.621 ± 0.023	0.953GluTrp: 0.953 ± 0.012	2.874GluTyr: 2.874 ± 0.023	0.016GluXaa: 0.016 ± 0.002
Phe	2.011PheAla: 2.011 ± 0.018	0.801PheCys: 0.801 ± 0.012	2.784PheAsp: 2.784 ± 0.019	3.1PheGlu: 3.1 ± 0.021	2.195PhePhe: 2.195 ± 0.02	2.734PheGly: 2.734 ± 0.021	1.206PheHis: 1.206 ± 0.015	4.024PheIle: 4.024 ± 0.03	3.339PheLys: 3.339 ± 0.02	4.173PheLeu: 4.173 ± 0.03	0.954PheMet: 0.954 ± 0.013	3.222PheAsn: 3.222 ± 0.024	1.686PhePro: 1.686 ± 0.018	1.66PheGln: 1.66 ± 0.015	1.807PheArg: 1.807 ± 0.016	3.778PheSer: 3.778 ± 0.024	2.523PheThr: 2.523 ± 0.02	2.376PheVal: 2.376 ± 0.019	0.542PheTrp: 0.542 ± 0.009	1.995PheTyr: 1.995 ± 0.017	0.011PheXaa: 0.011 ± 0.001
Gly	1.874GlyAla: 1.874 ± 0.02	0.708GlyCys: 0.708 ± 0.012	2.313GlyAsp: 2.313 ± 0.019	2.655GlyGlu: 2.655 ± 0.02	2.224GlyPhe: 2.224 ± 0.018	2.833GlyGly: 2.833 ± 0.032	1.014GlyHis: 1.014 ± 0.012	3.941GlyIle: 3.941 ± 0.029	3.614GlyLys: 3.614 ± 0.025	3.904GlyLeu: 3.904 ± 0.024	0.971GlyMet: 0.971 ± 0.012	3.027GlyAsn: 3.027 ± 0.025	1.406GlyPro: 1.406 ± 0.018	1.488GlyGln: 1.488 ± 0.017	2.019GlyArg: 2.019 ± 0.018	3.237GlySer: 3.237 ± 0.022	2.508GlyThr: 2.508 ± 0.022	2.524GlyVal: 2.524 ± 0.02	0.583GlyTrp: 0.583 ± 0.011	1.981GlyTyr: 1.981 ± 0.022	0.009GlyXaa: 0.009 ± 0.001
His	0.919HisAla: 0.919 ± 0.011	0.359HisCys: 0.359 ± 0.006	1.259HisAsp: 1.259 ± 0.014	1.342HisGlu: 1.342 ± 0.015	1.023HisPhe: 1.023 ± 0.013	0.965HisGly: 0.965 ± 0.013	0.711HisHis: 0.711 ± 0.013	1.674HisIle: 1.674 ± 0.014	1.43HisLys: 1.43 ± 0.012	2.058HisLeu: 2.058 ± 0.02	0.394HisMet: 0.394 ± 0.007	1.439HisAsn: 1.439 ± 0.015	1.032HisPro: 1.032 ± 0.011	0.929HisGln: 0.929 ± 0.013	0.982HisArg: 0.982 ± 0.011	1.73HisSer: 1.73 ± 0.017	0.977HisThr: 0.977 ± 0.012	1.103HisVal: 1.103 ± 0.013	0.248HisTrp: 0.248 ± 0.006	0.881HisTyr: 0.881 ± 0.012	0.006HisXaa: 0.006 ± 0.001
Ile	3.608IleAla: 3.608 ± 0.023	1.435IleCys: 1.435 ± 0.015	4.752IleAsp: 4.752 ± 0.028	5.504IleGlu: 5.504 ± 0.028	3.817IlePhe: 3.817 ± 0.027	3.502IleGly: 3.502 ± 0.024	1.868IleHis: 1.868 ± 0.017	7.246IleIle: 7.246 ± 0.039	6.56IleLys: 6.56 ± 0.033	7.741IleLeu: 7.741 ± 0.04	1.717IleMet: 1.717 ± 0.016	5.739IleAsn: 5.739 ± 0.035	3.773IlePro: 3.773 ± 0.026	2.985IleGln: 2.985 ± 0.021	3.367IleArg: 3.367 ± 0.023	6.668IleSer: 6.668 ± 0.033	4.445IleThr: 4.445 ± 0.026	4.055IleVal: 4.055 ± 0.027	0.902IleTrp: 0.902 ± 0.012	3.531IleTyr: 3.531 ± 0.026	0.021IleXaa: 0.021 ± 0.002
Lys	3.595LysAla: 3.595 ± 0.033	1.316LysCys: 1.316 ± 0.017	4.515LysAsp: 4.515 ± 0.025	6.32LysGlu: 6.32 ± 0.039	3.63LysPhe: 3.63 ± 0.028	3.075LysGly: 3.075 ± 0.025	1.493LysHis: 1.493 ± 0.015	6.58LysIle: 6.58 ± 0.031	7.38LysLys: 7.38 ± 0.047	7.343LysLeu: 7.343 ± 0.036	1.533LysMet: 1.533 ± 0.012	5.773LysAsn: 5.773 ± 0.03	2.622LysPro: 2.622 ± 0.021	2.752LysGln: 2.752 ± 0.022	4.03LysArg: 4.03 ± 0.025	5.742LysSer: 5.742 ± 0.035	3.56LysThr: 3.56 ± 0.025	3.9LysVal: 3.9 ± 0.024	0.993LysTrp: 0.993 ± 0.013	3.432LysTyr: 3.432 ± 0.026	0.014LysXaa: 0.014 ± 0.002
Leu	4.438LeuAla: 4.438 ± 0.03	1.48LeuCys: 1.48 ± 0.015	4.833LeuAsp: 4.833 ± 0.026	6.398LeuGlu: 6.398 ± 0.034	4.202LeuPhe: 4.202 ± 0.027	3.944LeuGly: 3.944 ± 0.029	2.145LeuHis: 2.145 ± 0.018	6.983LeuIle: 6.983 ± 0.036	7.635LeuLys: 7.635 ± 0.043	8.399LeuLeu: 8.399 ± 0.046	1.858LeuMet: 1.858 ± 0.016	6.099LeuAsn: 6.099 ± 0.036	3.96LeuPro: 3.96 ± 0.023	3.665LeuGln: 3.665 ± 0.026	4.366LeuArg: 4.366 ± 0.03	7.331LeuSer: 7.331 ± 0.035	4.567LeuThr: 4.567 ± 0.026	4.41LeuVal: 4.41 ± 0.027	1.085LeuTrp: 1.085 ± 0.012	3.5LeuTyr: 3.5 ± 0.024	0.023LeuXaa: 0.023 ± 0.002
Met	1.172MetAla: 1.172 ± 0.013	0.254MetCys: 0.254 ± 0.006	1.165MetAsp: 1.165 ± 0.015	1.486MetGlu: 1.486 ± 0.015	0.794MetPhe: 0.794 ± 0.013	0.839MetGly: 0.839 ± 0.011	0.346MetHis: 0.346 ± 0.007	1.633MetIle: 1.633 ± 0.016	1.684MetLys: 1.684 ± 0.016	1.57MetLeu: 1.57 ± 0.016	0.51MetMet: 0.51 ± 0.009	1.348MetAsn: 1.348 ± 0.014	0.715MetPro: 0.715 ± 0.011	0.71MetGln: 0.71 ± 0.01	0.832MetArg: 0.832 ± 0.01	1.736MetSer: 1.736 ± 0.015	1.1MetThr: 1.1 ± 0.012	1.079MetVal: 1.079 ± 0.013	0.26MetTrp: 0.26 ± 0.005	0.645MetTyr: 0.645 ± 0.011	0.005MetXaa: 0.005 ± 0.001
Asn	2.647AsnAla: 2.647 ± 0.02	1.048AsnCys: 1.048 ± 0.015	4.456AsnAsp: 4.456 ± 0.022	5.149AsnGlu: 5.149 ± 0.028	3.375AsnPhe: 3.375 ± 0.022	3.104AsnGly: 3.104 ± 0.025	1.403AsnHis: 1.403 ± 0.016	6.421AsnIle: 6.421 ± 0.037	5.185AsnLys: 5.185 ± 0.03	6.492AsnLeu: 6.492 ± 0.044	1.353AsnMet: 1.353 ± 0.014	6.828AsnAsn: 6.828 ± 0.055	2.633AsnPro: 2.633 ± 0.023	2.482AsnGln: 2.482 ± 0.018	2.519AsnArg: 2.519 ± 0.021	5.536AsnSer: 5.536 ± 0.033	3.566AsnThr: 3.566 ± 0.028	3.48AsnVal: 3.48 ± 0.021	0.872AsnTrp: 0.872 ± 0.013	3.065AsnTyr: 3.065 ± 0.022	0.014AsnXaa: 0.014 ± 0.001
Pro	1.673ProAla: 1.673 ± 0.017	0.433ProCys: 0.433 ± 0.01	2.172ProAsp: 2.172 ± 0.019	2.912ProGlu: 2.912 ± 0.021	1.992ProPhe: 1.992 ± 0.018	1.589ProGly: 1.589 ± 0.02	0.769ProHis: 0.769 ± 0.011	3.086ProIle: 3.086 ± 0.021	2.926ProLys: 2.926 ± 0.024	3.402ProLeu: 3.402 ± 0.023	0.631ProMet: 0.631 ± 0.011	2.775ProAsn: 2.775 ± 0.023	2.62ProPro: 2.62 ± 0.042	1.547ProGln: 1.547 ± 0.019	1.474ProArg: 1.474 ± 0.018	3.576ProSer: 3.576 ± 0.028	2.517ProThr: 2.517 ± 0.021	2.01ProVal: 2.01 ± 0.015	0.354ProTrp: 0.354 ± 0.008	1.712ProTyr: 1.712 ± 0.016	0.008ProXaa: 0.008 ± 0.001
Gln	1.592GlnAla: 1.592 ± 0.016	0.546GlnCys: 0.546 ± 0.008	1.903GlnAsp: 1.903 ± 0.019	2.657GlnGlu: 2.657 ± 0.021	1.555GlnPhe: 1.555 ± 0.017	1.31GlnGly: 1.31 ± 0.015	0.922GlnHis: 0.922 ± 0.012	2.97GlnIle: 2.97 ± 0.019	3.034GlnLys: 3.034 ± 0.021	3.426GlnLeu: 3.426 ± 0.024	0.758GlnMet: 0.758 ± 0.011	2.888GlnAsn: 2.888 ± 0.024	1.493GlnPro: 1.493 ± 0.02	2.35GlnGln: 2.35 ± 0.045	1.683GlnArg: 1.683 ± 0.017	2.616GlnSer: 2.616 ± 0.023	1.853GlnThr: 1.853 ± 0.017	1.8GlnVal: 1.8 ± 0.016	0.358GlnTrp: 0.358 ± 0.006	1.481GlnTyr: 1.481 ± 0.014	0.01GlnXaa: 0.01 ± 0.001
Arg	1.921ArgAla: 1.921 ± 0.022	0.652ArgCys: 0.652 ± 0.011	2.423ArgAsp: 2.423 ± 0.024	2.95ArgGlu: 2.95 ± 0.021	1.893ArgPhe: 1.893 ± 0.016	1.886ArgGly: 1.886 ± 0.021	0.93ArgHis: 0.93 ± 0.011	3.38ArgIle: 3.38 ± 0.024	3.819ArgLys: 3.819 ± 0.025	3.749ArgLeu: 3.749 ± 0.026	0.855ArgMet: 0.855 ± 0.009	2.898ArgAsn: 2.898 ± 0.02	1.943ArgPro: 1.943 ± 0.019	1.655ArgGln: 1.655 ± 0.014	2.449ArgArg: 2.449 ± 0.025	3.068ArgSer: 3.068 ± 0.024	2.049ArgThr: 2.049 ± 0.018	2.14ArgVal: 2.14 ± 0.018	0.513ArgTrp: 0.513 ± 0.008	1.609ArgTyr: 1.609 ± 0.017	0.009ArgXaa: 0.009 ± 0.001
Ser	3.225SerAla: 3.225 ± 0.025	1.116SerCys: 1.116 ± 0.013	4.613SerAsp: 4.613 ± 0.026	4.879SerGlu: 4.879 ± 0.03	3.825SerPhe: 3.825 ± 0.023	3.581SerGly: 3.581 ± 0.024	1.613SerHis: 1.613 ± 0.017	5.894SerIle: 5.894 ± 0.031	5.866SerLys: 5.866 ± 0.031	7.201SerLeu: 7.201 ± 0.034	1.384SerMet: 1.384 ± 0.013	5.684SerAsn: 5.684 ± 0.035	3.311SerPro: 3.311 ± 0.032	3.115SerGln: 3.115 ± 0.024	3.27SerArg: 3.27 ± 0.023	8.274SerSer: 8.274 ± 0.061	4.606SerThr: 4.606 ± 0.03	3.492SerVal: 3.492 ± 0.023	0.789SerTrp: 0.789 ± 0.01	2.756SerTyr: 2.756 ± 0.02	0.018SerXaa: 0.018 ± 0.002
Thr	2.377ThrAla: 2.377 ± 0.019	0.775ThrCys: 0.775 ± 0.011	2.564ThrAsp: 2.564 ± 0.019	3.139ThrGlu: 3.139 ± 0.022	2.519ThrPhe: 2.519 ± 0.02	2.445ThrGly: 2.445 ± 0.018	1.04ThrHis: 1.04 ± 0.012	4.257ThrIle: 4.257 ± 0.027	3.97ThrLys: 3.97 ± 0.025	4.849ThrLeu: 4.849 ± 0.027	0.951ThrMet: 0.951 ± 0.011	3.481ThrAsn: 3.481 ± 0.023	2.649ThrPro: 2.649 ± 0.022	1.769ThrGln: 1.769 ± 0.018	2.108ThrArg: 2.108 ± 0.019	4.905ThrSer: 4.905 ± 0.033	3.462ThrThr: 3.462 ± 0.03	2.516ThrVal: 2.516 ± 0.022	0.618ThrTrp: 0.618 ± 0.011	1.887ThrTyr: 1.887 ± 0.018	0.012ThrXaa: 0.012 ± 0.001
Val	2.534ValAla: 2.534 ± 0.02	0.751ValCys: 0.751 ± 0.01	3.021ValAsp: 3.021 ± 0.023	3.37ValGlu: 3.37 ± 0.022	2.182ValPhe: 2.182 ± 0.017	2.3ValGly: 2.3 ± 0.021	1.124ValHis: 1.124 ± 0.014	4.067ValIle: 4.067 ± 0.021	3.915ValLys: 3.915 ± 0.025	4.548ValLeu: 4.548 ± 0.025	1.09ValMet: 1.09 ± 0.012	3.264ValAsn: 3.264 ± 0.023	2.102ValPro: 2.102 ± 0.018	1.75ValGln: 1.75 ± 0.016	2.063ValArg: 2.063 ± 0.019	3.565ValSer: 3.565 ± 0.025	2.816ValThr: 2.816 ± 0.023	2.81ValVal: 2.81 ± 0.024	0.521ValTrp: 0.521 ± 0.009	1.935ValTyr: 1.935 ± 0.019	0.012ValXaa: 0.012 ± 0.001
Trp	0.481TrpAla: 0.481 ± 0.008	0.315TrpCys: 0.315 ± 0.007	0.829TrpAsp: 0.829 ± 0.01	0.853TrpGlu: 0.853 ± 0.01	0.491TrpPhe: 0.491 ± 0.009	0.476TrpGly: 0.476 ± 0.009	0.242TrpHis: 0.242 ± 0.006	1.055TrpIle: 1.055 ± 0.016	1.156TrpLys: 1.156 ± 0.013	0.894TrpLeu: 0.894 ± 0.011	0.269TrpMet: 0.269 ± 0.006	0.933TrpAsn: 0.933 ± 0.012	0.314TrpPro: 0.314 ± 0.007	0.356TrpGln: 0.356 ± 0.007	0.494TrpArg: 0.494 ± 0.008	0.745TrpSer: 0.745 ± 0.012	0.617TrpThr: 0.617 ± 0.009	0.575TrpVal: 0.575 ± 0.011	0.147TrpTrp: 0.147 ± 0.005	0.501TrpTyr: 0.501 ± 0.01	0.004TrpXaa: 0.004 ± 0.001
Tyr	1.595TyrAla: 1.595 ± 0.016	0.904TyrCys: 0.904 ± 0.01	2.451TyrAsp: 2.451 ± 0.017	2.688TyrGlu: 2.688 ± 0.021	2.069TyrPhe: 2.069 ± 0.019	2.126TyrGly: 2.126 ± 0.022	1.004TyrHis: 1.004 ± 0.012	3.119TyrIle: 3.119 ± 0.024	2.843TyrLys: 2.843 ± 0.023	3.976TyrLeu: 3.976 ± 0.028	0.837TyrMet: 0.837 ± 0.011	2.968TyrAsn: 2.968 ± 0.022	1.389TyrPro: 1.389 ± 0.013	1.579TyrGln: 1.579 ± 0.017	1.669TyrArg: 1.669 ± 0.015	3.052TyrSer: 3.052 ± 0.019	1.98TyrThr: 1.98 ± 0.018	1.893TyrVal: 1.893 ± 0.016	0.521TyrTrp: 0.521 ± 0.009	1.998TyrTyr: 1.998 ± 0.022	0.011TyrXaa: 0.011 ± 0.001
Xaa	0.012XaaAla: 0.012 ± 0.001	0.005XaaCys: 0.005 ± 0.001	0.016XaaAsp: 0.016 ± 0.002	0.016XaaGlu: 0.016 ± 0.002	0.009XaaPhe: 0.009 ± 0.001	0.012XaaGly: 0.012 ± 0.001	0.007XaaHis: 0.007 ± 0.001	0.017XaaIle: 0.017 ± 0.002	0.021XaaLys: 0.021 ± 0.002	0.019XaaLeu: 0.019 ± 0.002	0.005XaaMet: 0.005 ± 0.001	0.015XaaAsn: 0.015 ± 0.002	0.009XaaPro: 0.009 ± 0.001	0.01XaaGln: 0.01 ± 0.001	0.011XaaArg: 0.011 ± 0.001	0.015XaaSer: 0.015 ± 0.001	0.012XaaThr: 0.012 ± 0.001	0.009XaaVal: 0.009 ± 0.001	0.004XaaTrp: 0.004 ± 0.001	0.01XaaTyr: 0.01 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 22985 proteins (7538093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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