Amino acid dipepetide frequency for Azospirillum lipoferum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.241AlaAla: 21.241 ± 0.184	1.134AlaCys: 1.134 ± 0.025	7.864AlaAsp: 7.864 ± 0.081	8.134AlaGlu: 8.134 ± 0.073	4.18AlaPhe: 4.18 ± 0.046	13.075AlaGly: 13.075 ± 0.124	2.303AlaHis: 2.303 ± 0.035	5.459AlaIle: 5.459 ± 0.058	3.419AlaLys: 3.419 ± 0.054	15.904AlaLeu: 15.904 ± 0.139	3.514AlaMet: 3.514 ± 0.047	2.704AlaAsn: 2.704 ± 0.039	6.525AlaPro: 6.525 ± 0.075	3.755AlaGln: 3.755 ± 0.051	9.867AlaArg: 9.867 ± 0.085	6.112AlaSer: 6.112 ± 0.064	6.612AlaThr: 6.612 ± 0.082	10.763AlaVal: 10.763 ± 0.094	1.53AlaTrp: 1.53 ± 0.031	2.371AlaTyr: 2.371 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.001CysAla: 1.001 ± 0.026	0.102CysCys: 0.102 ± 0.007	0.512CysAsp: 0.512 ± 0.017	0.362CysGlu: 0.362 ± 0.013	0.261CysPhe: 0.261 ± 0.011	0.935CysGly: 0.935 ± 0.024	0.246CysHis: 0.246 ± 0.012	0.295CysIle: 0.295 ± 0.012	0.153CysLys: 0.153 ± 0.008	0.808CysLeu: 0.808 ± 0.022	0.143CysMet: 0.143 ± 0.008	0.178CysAsn: 0.178 ± 0.008	0.468CysPro: 0.468 ± 0.017	0.204CysGln: 0.204 ± 0.009	0.69CysArg: 0.69 ± 0.019	0.399CysSer: 0.399 ± 0.014	0.395CysThr: 0.395 ± 0.012	0.61CysVal: 0.61 ± 0.018	0.115CysTrp: 0.115 ± 0.008	0.173CysTyr: 0.173 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.422AspAla: 7.422 ± 0.066	0.447AspCys: 0.447 ± 0.017	3.049AspAsp: 3.049 ± 0.062	3.242AspGlu: 3.242 ± 0.042	1.861AspPhe: 1.861 ± 0.027	6.281AspGly: 6.281 ± 0.096	1.271AspHis: 1.271 ± 0.024	2.43AspIle: 2.43 ± 0.036	1.223AspLys: 1.223 ± 0.03	6.374AspLeu: 6.374 ± 0.074	1.067AspMet: 1.067 ± 0.019	1.11AspAsn: 1.11 ± 0.023	3.792AspPro: 3.792 ± 0.05	1.501AspGln: 1.501 ± 0.026	5.27AspArg: 5.27 ± 0.056	2.631AspSer: 2.631 ± 0.044	2.794AspThr: 2.794 ± 0.08	3.876AspVal: 3.876 ± 0.049	0.962AspTrp: 0.962 ± 0.022	1.261AspTyr: 1.261 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.917GluAla: 7.917 ± 0.084	0.321GluCys: 0.321 ± 0.012	2.568GluAsp: 2.568 ± 0.038	3.107GluGlu: 3.107 ± 0.051	1.438GluPhe: 1.438 ± 0.026	4.172GluGly: 4.172 ± 0.05	1.146GluHis: 1.146 ± 0.024	2.71GluIle: 2.71 ± 0.038	1.586GluLys: 1.586 ± 0.027	5.265GluLeu: 5.265 ± 0.063	1.259GluMet: 1.259 ± 0.022	1.18GluAsn: 1.18 ± 0.025	2.825GluPro: 2.825 ± 0.042	1.92GluGln: 1.92 ± 0.034	5.78GluArg: 5.78 ± 0.065	2.346GluSer: 2.346 ± 0.034	3.215GluThr: 3.215 ± 0.04	3.627GluVal: 3.627 ± 0.043	0.6GluTrp: 0.6 ± 0.018	0.786GluTyr: 0.786 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	4.272PheAla: 4.272 ± 0.051	0.339PheCys: 0.339 ± 0.012	2.385PheAsp: 2.385 ± 0.037	1.752PheGlu: 1.752 ± 0.031	1.146PhePhe: 1.146 ± 0.026	3.35PheGly: 3.35 ± 0.044	0.751PheHis: 0.751 ± 0.018	1.206PheIle: 1.206 ± 0.025	0.79PheLys: 0.79 ± 0.022	3.338PheLeu: 3.338 ± 0.048	0.615PheMet: 0.615 ± 0.016	0.873PheAsn: 0.873 ± 0.022	1.533PhePro: 1.533 ± 0.03	1.054PheGln: 1.054 ± 0.019	2.26PheArg: 2.26 ± 0.032	1.669PheSer: 1.669 ± 0.028	1.938PheThr: 1.938 ± 0.034	2.477PheVal: 2.477 ± 0.038	0.433PheTrp: 0.433 ± 0.014	0.723PheTyr: 0.723 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.71GlyAla: 10.71 ± 0.114	0.891GlyCys: 0.891 ± 0.022	4.911GlyAsp: 4.911 ± 0.116	4.737GlyGlu: 4.737 ± 0.049	3.525GlyPhe: 3.525 ± 0.044	9.018GlyGly: 9.018 ± 0.224	1.96GlyHis: 1.96 ± 0.028	4.178GlyIle: 4.178 ± 0.046	2.741GlyLys: 2.741 ± 0.047	10.078GlyLeu: 10.078 ± 0.076	2.332GlyMet: 2.332 ± 0.037	2.248GlyAsn: 2.248 ± 0.079	4.034GlyPro: 4.034 ± 0.05	2.829GlyGln: 2.829 ± 0.036	7.615GlyArg: 7.615 ± 0.068	4.692GlySer: 4.692 ± 0.079	5.351GlyThr: 5.351 ± 0.088	6.886GlyVal: 6.886 ± 0.059	1.541GlyTrp: 1.541 ± 0.027	2.196GlyTyr: 2.196 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.583HisAla: 2.583 ± 0.037	0.223HisCys: 0.223 ± 0.01	1.202HisAsp: 1.202 ± 0.022	0.946HisGlu: 0.946 ± 0.02	0.689HisPhe: 0.689 ± 0.018	2.105HisGly: 2.105 ± 0.031	0.616HisHis: 0.616 ± 0.019	0.819HisIle: 0.819 ± 0.017	0.425HisLys: 0.425 ± 0.015	2.088HisLeu: 2.088 ± 0.036	0.434HisMet: 0.434 ± 0.016	0.408HisAsn: 0.408 ± 0.013	1.487HisPro: 1.487 ± 0.029	0.561HisGln: 0.561 ± 0.015	1.77HisArg: 1.77 ± 0.031	0.899HisSer: 0.899 ± 0.022	0.882HisThr: 0.882 ± 0.022	1.378HisVal: 1.378 ± 0.027	0.325HisTrp: 0.325 ± 0.013	0.454HisTyr: 0.454 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.322IleAla: 6.322 ± 0.062	0.319IleCys: 0.319 ± 0.011	3.186IleAsp: 3.186 ± 0.041	2.714IleGlu: 2.714 ± 0.039	1.142IlePhe: 1.142 ± 0.026	4.544IleGly: 4.544 ± 0.044	0.912IleHis: 0.912 ± 0.021	1.418IleIle: 1.418 ± 0.027	1.01IleLys: 1.01 ± 0.025	4.286IleLeu: 4.286 ± 0.044	0.686IleMet: 0.686 ± 0.018	1.073IleAsn: 1.073 ± 0.027	2.12IlePro: 2.12 ± 0.032	1.135IleGln: 1.135 ± 0.026	3.097IleArg: 3.097 ± 0.04	1.762IleSer: 1.762 ± 0.036	2.2IleThr: 2.2 ± 0.048	3.549IleVal: 3.549 ± 0.04	0.359IleTrp: 0.359 ± 0.014	0.744IleTyr: 0.744 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.699LysAla: 3.699 ± 0.054	0.109LysCys: 0.109 ± 0.007	1.39LysAsp: 1.39 ± 0.031	1.294LysGlu: 1.294 ± 0.029	0.63LysPhe: 0.63 ± 0.016	2.326LysGly: 2.326 ± 0.039	0.445LysHis: 0.445 ± 0.013	1.139LysIle: 1.139 ± 0.023	0.793LysLys: 0.793 ± 0.025	2.616LysLeu: 2.616 ± 0.041	0.549LysMet: 0.549 ± 0.017	0.596LysAsn: 0.596 ± 0.019	1.924LysPro: 1.924 ± 0.035	0.718LysGln: 0.718 ± 0.019	2.037LysArg: 2.037 ± 0.035	1.325LysSer: 1.325 ± 0.029	1.558LysThr: 1.558 ± 0.03	1.865LysVal: 1.865 ± 0.036	0.224LysTrp: 0.224 ± 0.011	0.429LysTyr: 0.429 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.495LeuAla: 15.495 ± 0.119	0.973LeuCys: 0.973 ± 0.022	6.739LeuAsp: 6.739 ± 0.065	5.413LeuGlu: 5.413 ± 0.059	3.775LeuPhe: 3.775 ± 0.043	9.083LeuGly: 9.083 ± 0.073	2.16LeuHis: 2.16 ± 0.032	4.241LeuIle: 4.241 ± 0.055	2.896LeuLys: 2.896 ± 0.038	11.081LeuLeu: 11.081 ± 0.11	2.234LeuMet: 2.234 ± 0.033	2.461LeuAsn: 2.461 ± 0.032	6.425LeuPro: 6.425 ± 0.075	2.377LeuGln: 2.377 ± 0.033	8.331LeuArg: 8.331 ± 0.073	6.438LeuSer: 6.438 ± 0.06	6.42LeuThr: 6.42 ± 0.09	8.106LeuVal: 8.106 ± 0.071	1.28LeuTrp: 1.28 ± 0.027	1.972LeuTyr: 1.972 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.247MetAla: 3.247 ± 0.04	0.127MetCys: 0.127 ± 0.008	1.166MetAsp: 1.166 ± 0.023	1.091MetGlu: 1.091 ± 0.025	0.538MetPhe: 0.538 ± 0.019	1.759MetGly: 1.759 ± 0.032	0.395MetHis: 0.395 ± 0.013	1.023MetIle: 1.023 ± 0.023	0.689MetLys: 0.689 ± 0.021	2.236MetLeu: 2.236 ± 0.038	0.589MetMet: 0.589 ± 0.017	0.582MetAsn: 0.582 ± 0.016	1.46MetPro: 1.46 ± 0.03	0.61MetGln: 0.61 ± 0.016	1.61MetArg: 1.61 ± 0.031	1.347MetSer: 1.347 ± 0.025	1.867MetThr: 1.867 ± 0.026	1.706MetVal: 1.706 ± 0.027	0.161MetTrp: 0.161 ± 0.008	0.243MetTyr: 0.243 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.008AsnAla: 3.008 ± 0.041	0.186AsnCys: 0.186 ± 0.009	1.293AsnAsp: 1.293 ± 0.061	0.965AsnGlu: 0.965 ± 0.022	0.712AsnPhe: 0.712 ± 0.021	2.367AsnGly: 2.367 ± 0.046	0.476AsnHis: 0.476 ± 0.015	1.002AsnIle: 1.002 ± 0.024	0.526AsnLys: 0.526 ± 0.019	2.459AsnLeu: 2.459 ± 0.038	0.453AsnMet: 0.453 ± 0.015	0.582AsnAsn: 0.582 ± 0.02	1.729AsnPro: 1.729 ± 0.037	0.651AsnGln: 0.651 ± 0.02	1.88AsnArg: 1.88 ± 0.028	1.059AsnSer: 1.059 ± 0.032	1.079AsnThr: 1.079 ± 0.03	1.582AsnVal: 1.582 ± 0.031	0.304AsnTrp: 0.304 ± 0.013	0.498AsnTyr: 0.498 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.232ProAla: 8.232 ± 0.093	0.344ProCys: 0.344 ± 0.012	4.185ProAsp: 4.185 ± 0.055	3.497ProGlu: 3.497 ± 0.049	1.927ProPhe: 1.927 ± 0.032	5.187ProGly: 5.187 ± 0.05	1.076ProHis: 1.076 ± 0.025	1.95ProIle: 1.95 ± 0.031	1.427ProLys: 1.427 ± 0.031	5.653ProLeu: 5.653 ± 0.058	1.246ProMet: 1.246 ± 0.026	1.237ProAsn: 1.237 ± 0.026	3.841ProPro: 3.841 ± 0.077	1.485ProGln: 1.485 ± 0.03	3.425ProArg: 3.425 ± 0.048	2.869ProSer: 2.869 ± 0.041	2.683ProThr: 2.683 ± 0.041	4.769ProVal: 4.769 ± 0.051	0.765ProTrp: 0.765 ± 0.021	1.06ProTyr: 1.06 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	4.119GlnAla: 4.119 ± 0.052	0.171GlnCys: 0.171 ± 0.01	1.355GlnAsp: 1.355 ± 0.026	1.343GlnGlu: 1.343 ± 0.027	0.836GlnPhe: 0.836 ± 0.021	2.487GlnGly: 2.487 ± 0.038	0.557GlnHis: 0.557 ± 0.017	1.425GlnIle: 1.425 ± 0.025	0.776GlnLys: 0.776 ± 0.021	2.547GlnLeu: 2.547 ± 0.038	0.661GlnMet: 0.661 ± 0.017	0.649GlnAsn: 0.649 ± 0.016	1.83GlnPro: 1.83 ± 0.033	1.065GlnGln: 1.065 ± 0.026	2.422GlnArg: 2.422 ± 0.038	1.49GlnSer: 1.49 ± 0.028	1.684GlnThr: 1.684 ± 0.029	1.979GlnVal: 1.979 ± 0.033	0.351GlnTrp: 0.351 ± 0.014	0.484GlnTyr: 0.484 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	9.375ArgAla: 9.375 ± 0.109	0.635ArgCys: 0.635 ± 0.018	4.487ArgAsp: 4.487 ± 0.049	4.023ArgGlu: 4.023 ± 0.049	3.146ArgPhe: 3.146 ± 0.047	5.373ArgGly: 5.373 ± 0.056	1.958ArgHis: 1.958 ± 0.035	3.961ArgIle: 3.961 ± 0.044	1.979ArgLys: 1.979 ± 0.034	9.679ArgLeu: 9.679 ± 0.087	1.976ArgMet: 1.976 ± 0.029	1.819ArgAsn: 1.819 ± 0.027	4.539ArgPro: 4.539 ± 0.054	2.545ArgGln: 2.545 ± 0.039	7.233ArgArg: 7.233 ± 0.086	3.835ArgSer: 3.835 ± 0.045	3.904ArgThr: 3.904 ± 0.054	5.597ArgVal: 5.597 ± 0.055	1.16ArgTrp: 1.16 ± 0.025	1.587ArgTyr: 1.587 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.179SerAla: 6.179 ± 0.071	0.399SerCys: 0.399 ± 0.015	2.609SerAsp: 2.609 ± 0.044	2.159SerGlu: 2.159 ± 0.034	1.97SerPhe: 1.97 ± 0.031	5.629SerGly: 5.629 ± 0.084	0.988SerHis: 0.988 ± 0.024	2.131SerIle: 2.131 ± 0.035	1.18SerLys: 1.18 ± 0.025	5.427SerLeu: 5.427 ± 0.052	1.149SerMet: 1.149 ± 0.025	1.13SerAsn: 1.13 ± 0.029	2.858SerPro: 2.858 ± 0.035	1.361SerGln: 1.361 ± 0.024	3.438SerArg: 3.438 ± 0.042	2.538SerSer: 2.538 ± 0.045	2.432SerThr: 2.432 ± 0.041	4.158SerVal: 4.158 ± 0.048	0.746SerTrp: 0.746 ± 0.017	1.107SerTyr: 1.107 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.47ThrAla: 7.47 ± 0.098	0.345ThrCys: 0.345 ± 0.011	3.042ThrAsp: 3.042 ± 0.05	2.499ThrGlu: 2.499 ± 0.033	1.511ThrPhe: 1.511 ± 0.029	5.657ThrGly: 5.657 ± 0.08	0.982ThrHis: 0.982 ± 0.023	2.562ThrIle: 2.562 ± 0.048	1.123ThrLys: 1.123 ± 0.026	6.613ThrLeu: 6.613 ± 0.094	1.168ThrMet: 1.168 ± 0.023	1.147ThrAsn: 1.147 ± 0.028	3.579ThrPro: 3.579 ± 0.056	1.311ThrGln: 1.311 ± 0.025	3.544ThrArg: 3.544 ± 0.046	2.399ThrSer: 2.399 ± 0.044	2.829ThrThr: 2.829 ± 0.05	5.231ThrVal: 5.231 ± 0.071	0.52ThrTrp: 0.52 ± 0.017	0.964ThrTyr: 0.964 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.569ValAla: 10.569 ± 0.089	0.67ValCys: 0.67 ± 0.017	3.959ValAsp: 3.959 ± 0.038	4.891ValGlu: 4.891 ± 0.054	2.465ValPhe: 2.465 ± 0.038	6.223ValGly: 6.223 ± 0.059	1.377ValHis: 1.377 ± 0.027	3.329ValIle: 3.329 ± 0.041	2.074ValLys: 2.074 ± 0.035	7.839ValLeu: 7.839 ± 0.067	1.709ValMet: 1.709 ± 0.032	1.962ValAsn: 1.962 ± 0.033	4.259ValPro: 4.259 ± 0.047	2.127ValGln: 2.127 ± 0.03	5.632ValArg: 5.632 ± 0.052	4.036ValSer: 4.036 ± 0.05	4.883ValThr: 4.883 ± 0.078	6.384ValVal: 6.384 ± 0.072	0.951ValTrp: 0.951 ± 0.022	1.394ValTyr: 1.394 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.287TrpAla: 1.287 ± 0.027	0.123TrpCys: 0.123 ± 0.007	0.672TrpAsp: 0.672 ± 0.02	0.592TrpGlu: 0.592 ± 0.019	0.478TrpPhe: 0.478 ± 0.016	0.903TrpGly: 0.903 ± 0.022	0.291TrpHis: 0.291 ± 0.01	0.588TrpIle: 0.588 ± 0.017	0.37TrpLys: 0.37 ± 0.016	1.614TrpLeu: 1.614 ± 0.03	0.333TrpMet: 0.333 ± 0.011	0.383TrpAsn: 0.383 ± 0.014	0.669TrpPro: 0.669 ± 0.018	0.435TrpGln: 0.435 ± 0.017	1.207TrpArg: 1.207 ± 0.027	0.797TrpSer: 0.797 ± 0.02	0.825TrpThr: 0.825 ± 0.02	0.807TrpVal: 0.807 ± 0.018	0.214TrpTrp: 0.214 ± 0.012	0.284TrpTyr: 0.284 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.32TyrAla: 2.32 ± 0.038	0.193TyrCys: 0.193 ± 0.008	1.291TyrAsp: 1.291 ± 0.023	1.008TyrGlu: 1.008 ± 0.025	0.674TyrPhe: 0.674 ± 0.019	1.998TyrGly: 1.998 ± 0.036	0.384TyrHis: 0.384 ± 0.014	0.709TyrIle: 0.709 ± 0.019	0.483TyrLys: 0.483 ± 0.015	1.993TyrLeu: 1.993 ± 0.034	0.329TyrMet: 0.329 ± 0.011	0.489TyrAsn: 0.489 ± 0.017	0.962TyrPro: 0.962 ± 0.021	0.585TyrGln: 0.585 ± 0.017	1.703TyrArg: 1.703 ± 0.03	0.947TyrSer: 0.947 ± 0.022	0.95TyrThr: 0.95 ± 0.02	1.38TyrVal: 1.38 ± 0.027	0.332TyrTrp: 0.332 ± 0.013	0.461TyrTyr: 0.461 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6618 proteins (2258444 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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