Amino acid dipepetide frequency for Trypanosoma rangeli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.682AlaAla: 11.682 ± 0.093	1.681AlaCys: 1.681 ± 0.017	3.725AlaAsp: 3.725 ± 0.029	6.307AlaGlu: 6.307 ± 0.049	3.161AlaPhe: 3.161 ± 0.027	5.552AlaGly: 5.552 ± 0.04	2.013AlaHis: 2.013 ± 0.025	3.057AlaIle: 3.057 ± 0.029	3.683AlaLys: 3.683 ± 0.034	9.538AlaLeu: 9.538 ± 0.06	2.401AlaMet: 2.401 ± 0.023	2.456AlaAsn: 2.456 ± 0.025	4.436AlaPro: 4.436 ± 0.043	3.145AlaGln: 3.145 ± 0.027	5.435AlaArg: 5.435 ± 0.04	7.404AlaSer: 7.404 ± 0.041	5.735AlaThr: 5.735 ± 0.044	7.584AlaVal: 7.584 ± 0.049	1.03AlaTrp: 1.03 ± 0.015	1.954AlaTyr: 1.954 ± 0.022	0.006AlaXaa: 0.006 ± 0.001
Cys	1.834CysAla: 1.834 ± 0.021	0.699CysCys: 0.699 ± 0.014	1.01CysAsp: 1.01 ± 0.017	1.153CysGlu: 1.153 ± 0.015	0.952CysPhe: 0.952 ± 0.014	1.863CysGly: 1.863 ± 0.024	0.553CysHis: 0.553 ± 0.012	0.954CysIle: 0.954 ± 0.015	0.669CysLys: 0.669 ± 0.013	1.93CysLeu: 1.93 ± 0.019	0.494CysMet: 0.494 ± 0.011	0.647CysAsn: 0.647 ± 0.013	0.948CysPro: 0.948 ± 0.015	0.616CysGln: 0.616 ± 0.012	1.541CysArg: 1.541 ± 0.021	1.659CysSer: 1.659 ± 0.02	1.204CysThr: 1.204 ± 0.017	1.9CysVal: 1.9 ± 0.022	0.254CysTrp: 0.254 ± 0.008	0.501CysTyr: 0.501 ± 0.013	0.001CysXaa: 0.001 ± 0.0
Asp	5.676AspAla: 5.676 ± 0.045	0.822AspCys: 0.822 ± 0.013	3.314AspAsp: 3.314 ± 0.04	3.871AspGlu: 3.871 ± 0.042	1.619AspPhe: 1.619 ± 0.021	3.933AspGly: 3.933 ± 0.033	0.92AspHis: 0.92 ± 0.014	2.061AspIle: 2.061 ± 0.021	1.694AspLys: 1.694 ± 0.021	3.557AspLeu: 3.557 ± 0.03	1.183AspMet: 1.183 ± 0.016	1.635AspAsn: 1.635 ± 0.019	2.169AspPro: 2.169 ± 0.021	1.012AspGln: 1.012 ± 0.017	2.445AspArg: 2.445 ± 0.024	3.027AspSer: 3.027 ± 0.033	2.731AspThr: 2.731 ± 0.026	4.386AspVal: 4.386 ± 0.029	0.525AspTrp: 0.525 ± 0.01	1.129AspTyr: 1.129 ± 0.017	0.002AspXaa: 0.002 ± 0.001
Glu	6.789GluAla: 6.789 ± 0.048	1.075GluCys: 1.075 ± 0.016	3.678GluAsp: 3.678 ± 0.035	7.49GluGlu: 7.49 ± 0.065	1.915GluPhe: 1.915 ± 0.021	4.544GluGly: 4.544 ± 0.036	1.509GluHis: 1.509 ± 0.02	2.106GluIle: 2.106 ± 0.026	3.763GluLys: 3.763 ± 0.034	6.596GluLeu: 6.596 ± 0.046	1.818GluMet: 1.818 ± 0.022	2.256GluAsn: 2.256 ± 0.023	2.177GluPro: 2.177 ± 0.024	2.809GluGln: 2.809 ± 0.035	5.319GluArg: 5.319 ± 0.047	3.898GluSer: 3.898 ± 0.031	3.401GluThr: 3.401 ± 0.03	5.046GluVal: 5.046 ± 0.036	0.858GluTrp: 0.858 ± 0.015	1.534GluTyr: 1.534 ± 0.021	0.004GluXaa: 0.004 ± 0.001
Phe	3.084PheAla: 3.084 ± 0.027	0.957PheCys: 0.957 ± 0.016	1.832PheAsp: 1.832 ± 0.022	1.821PheGlu: 1.821 ± 0.02	2.037PhePhe: 2.037 ± 0.025	2.282PheGly: 2.282 ± 0.024	0.948PheHis: 0.948 ± 0.015	1.51PheIle: 1.51 ± 0.021	1.086PheLys: 1.086 ± 0.015	4.114PheLeu: 4.114 ± 0.036	0.884PheMet: 0.884 ± 0.014	1.159PheAsn: 1.159 ± 0.017	1.823PhePro: 1.823 ± 0.024	1.091PheGln: 1.091 ± 0.016	2.059PheArg: 2.059 ± 0.024	3.046PheSer: 3.046 ± 0.026	2.081PheThr: 2.081 ± 0.023	3.041PheVal: 3.041 ± 0.028	0.438PheTrp: 0.438 ± 0.011	1.066PheTyr: 1.066 ± 0.016	0.004PheXaa: 0.004 ± 0.001
Gly	5.866GlyAla: 5.866 ± 0.047	1.457GlyCys: 1.457 ± 0.019	3.704GlyAsp: 3.704 ± 0.034	4.496GlyGlu: 4.496 ± 0.03	2.205GlyPhe: 2.205 ± 0.025	6.547GlyGly: 6.547 ± 0.067	1.459GlyHis: 1.459 ± 0.021	2.524GlyIle: 2.524 ± 0.029	3.067GlyLys: 3.067 ± 0.029	4.858GlyLeu: 4.858 ± 0.035	1.583GlyMet: 1.583 ± 0.022	2.55GlyAsn: 2.55 ± 0.028	2.351GlyPro: 2.351 ± 0.028	1.786GlyGln: 1.786 ± 0.018	4.384GlyArg: 4.384 ± 0.034	5.1GlySer: 5.1 ± 0.04	3.842GlyThr: 3.842 ± 0.036	5.525GlyVal: 5.525 ± 0.04	0.707GlyTrp: 0.707 ± 0.014	1.467GlyTyr: 1.467 ± 0.021	0.007GlyXaa: 0.007 ± 0.001
His	2.412HisAla: 2.412 ± 0.024	0.647HisCys: 0.647 ± 0.011	1.272HisAsp: 1.272 ± 0.017	1.538HisGlu: 1.538 ± 0.019	1.012HisPhe: 1.012 ± 0.015	1.804HisGly: 1.804 ± 0.023	0.97HisHis: 0.97 ± 0.017	1.07HisIle: 1.07 ± 0.016	0.878HisLys: 0.878 ± 0.016	2.549HisLeu: 2.549 ± 0.025	0.605HisMet: 0.605 ± 0.011	0.865HisAsn: 0.865 ± 0.015	1.47HisPro: 1.47 ± 0.017	1.021HisGln: 1.021 ± 0.015	1.997HisArg: 1.997 ± 0.023	1.908HisSer: 1.908 ± 0.021	1.504HisThr: 1.504 ± 0.021	2.09HisVal: 2.09 ± 0.021	0.344HisTrp: 0.344 ± 0.009	0.76HisTyr: 0.76 ± 0.012	0.001HisXaa: 0.001 ± 0.0
Ile	3.274IleAla: 3.274 ± 0.026	0.801IleCys: 0.801 ± 0.013	1.865IleAsp: 1.865 ± 0.023	2.16IleGlu: 2.16 ± 0.028	1.491IlePhe: 1.491 ± 0.02	2.139IleGly: 2.139 ± 0.023	0.984IleHis: 0.984 ± 0.016	1.669IleIle: 1.669 ± 0.023	1.35IleLys: 1.35 ± 0.018	3.474IleLeu: 3.474 ± 0.029	0.862IleMet: 0.862 ± 0.017	1.22IleAsn: 1.22 ± 0.018	2.059IlePro: 2.059 ± 0.024	1.302IleGln: 1.302 ± 0.019	2.344IleArg: 2.344 ± 0.021	2.724IleSer: 2.724 ± 0.028	2.102IleThr: 2.102 ± 0.024	2.923IleVal: 2.923 ± 0.028	0.331IleTrp: 0.331 ± 0.008	0.926IleTyr: 0.926 ± 0.015	0.001IleXaa: 0.001 ± 0.0
Lys	3.395LysAla: 3.395 ± 0.033	0.699LysCys: 0.699 ± 0.014	2.104LysAsp: 2.104 ± 0.023	3.593LysGlu: 3.593 ± 0.037	1.069LysPhe: 1.069 ± 0.017	2.683LysGly: 2.683 ± 0.024	1.092LysHis: 1.092 ± 0.017	1.334LysIle: 1.334 ± 0.019	2.823LysLys: 2.823 ± 0.038	3.86LysLeu: 3.86 ± 0.037	1.099LysMet: 1.099 ± 0.017	1.566LysAsn: 1.566 ± 0.021	1.676LysPro: 1.676 ± 0.022	1.836LysGln: 1.836 ± 0.022	3.402LysArg: 3.402 ± 0.03	2.494LysSer: 2.494 ± 0.029	2.265LysThr: 2.265 ± 0.026	2.648LysVal: 2.648 ± 0.032	0.501LysTrp: 0.501 ± 0.01	1.09LysTyr: 1.09 ± 0.018	0.003LysXaa: 0.003 ± 0.001
Leu	7.734LeuAla: 7.734 ± 0.051	2.417LeuCys: 2.417 ± 0.024	4.164LeuAsp: 4.164 ± 0.036	6.174LeuGlu: 6.174 ± 0.049	3.945LeuPhe: 3.945 ± 0.029	5.12LeuGly: 5.12 ± 0.039	3.277LeuHis: 3.277 ± 0.031	3.016LeuIle: 3.016 ± 0.029	3.743LeuLys: 3.743 ± 0.036	12.369LeuLeu: 12.369 ± 0.086	2.324LeuMet: 2.324 ± 0.023	2.859LeuAsn: 2.859 ± 0.028	5.597LeuPro: 5.597 ± 0.036	5.484LeuGln: 5.484 ± 0.044	8.564LeuArg: 8.564 ± 0.052	7.63LeuSer: 7.63 ± 0.053	5.141LeuThr: 5.141 ± 0.04	6.428LeuVal: 6.428 ± 0.042	1.333LeuTrp: 1.333 ± 0.02	2.524LeuTyr: 2.524 ± 0.026	0.009LeuXaa: 0.009 ± 0.001
Met	1.935MetAla: 1.935 ± 0.021	0.488MetCys: 0.488 ± 0.01	1.226MetAsp: 1.226 ± 0.018	1.89MetGlu: 1.89 ± 0.02	0.768MetPhe: 0.768 ± 0.014	1.423MetGly: 1.423 ± 0.016	0.726MetHis: 0.726 ± 0.013	0.812MetIle: 0.812 ± 0.015	1.115MetLys: 1.115 ± 0.014	2.524MetLeu: 2.524 ± 0.023	0.725MetMet: 0.725 ± 0.014	0.865MetAsn: 0.865 ± 0.016	1.283MetPro: 1.283 ± 0.019	1.29MetGln: 1.29 ± 0.017	2.049MetArg: 2.049 ± 0.021	1.742MetSer: 1.742 ± 0.019	1.408MetThr: 1.408 ± 0.017	1.443MetVal: 1.443 ± 0.019	0.356MetTrp: 0.356 ± 0.009	0.635MetTyr: 0.635 ± 0.012	0.001MetXaa: 0.001 ± 0.001
Asn	3.258AsnAla: 3.258 ± 0.026	0.671AsnCys: 0.671 ± 0.012	1.859AsnAsp: 1.859 ± 0.023	2.227AsnGlu: 2.227 ± 0.026	1.135AsnPhe: 1.135 ± 0.017	2.421AsnGly: 2.421 ± 0.027	0.717AsnHis: 0.717 ± 0.012	1.417AsnIle: 1.417 ± 0.02	1.436AsnLys: 1.436 ± 0.02	2.412AsnLeu: 2.412 ± 0.025	0.816AsnMet: 0.816 ± 0.015	1.472AsnAsn: 1.472 ± 0.022	1.554AsnPro: 1.554 ± 0.024	0.825AsnGln: 0.825 ± 0.012	1.774AsnArg: 1.774 ± 0.021	2.404AsnSer: 2.404 ± 0.026	2.099AsnThr: 2.099 ± 0.023	2.528AsnVal: 2.528 ± 0.026	0.348AsnTrp: 0.348 ± 0.01	0.859AsnTyr: 0.859 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.136ProAla: 4.136 ± 0.039	0.964ProCys: 0.964 ± 0.02	1.84ProAsp: 1.84 ± 0.021	2.719ProGlu: 2.719 ± 0.027	1.995ProPhe: 1.995 ± 0.023	2.457ProGly: 2.457 ± 0.035	1.557ProHis: 1.557 ± 0.023	1.691ProIle: 1.691 ± 0.02	1.726ProLys: 1.726 ± 0.021	5.45ProLeu: 5.45 ± 0.041	1.062ProMet: 1.062 ± 0.017	1.501ProAsn: 1.501 ± 0.024	4.328ProPro: 4.328 ± 0.053	2.239ProGln: 2.239 ± 0.025	3.316ProArg: 3.316 ± 0.03	4.611ProSer: 4.611 ± 0.041	3.144ProThr: 3.144 ± 0.029	3.496ProVal: 3.496 ± 0.031	0.554ProTrp: 0.554 ± 0.012	1.16ProTyr: 1.16 ± 0.018	0.005ProXaa: 0.005 ± 0.001
Gln	2.851GlnAla: 2.851 ± 0.029	0.816GlnCys: 0.816 ± 0.015	1.389GlnAsp: 1.389 ± 0.018	2.896GlnGlu: 2.896 ± 0.029	1.15GlnPhe: 1.15 ± 0.016	2.088GlnGly: 2.088 ± 0.023	1.379GlnHis: 1.379 ± 0.02	1.147GlnIle: 1.147 ± 0.017	1.911GlnLys: 1.911 ± 0.024	4.763GlnLeu: 4.763 ± 0.041	0.972GlnMet: 0.972 ± 0.015	1.126GlnAsn: 1.126 ± 0.014	1.892GlnPro: 1.892 ± 0.026	3.414GlnGln: 3.414 ± 0.053	4.193GlnArg: 4.193 ± 0.036	2.404GlnSer: 2.404 ± 0.022	1.889GlnThr: 1.889 ± 0.021	2.142GlnVal: 2.142 ± 0.02	0.579GlnTrp: 0.579 ± 0.012	0.96GlnTyr: 0.96 ± 0.014	0.001GlnXaa: 0.001 ± 0.001
Arg	5.575ArgAla: 5.575 ± 0.038	1.87ArgCys: 1.87 ± 0.02	3.334ArgAsp: 3.334 ± 0.028	5.204ArgGlu: 5.204 ± 0.046	2.441ArgPhe: 2.441 ± 0.026	4.811ArgGly: 4.811 ± 0.042	2.37ArgHis: 2.37 ± 0.021	2.634ArgIle: 2.634 ± 0.024	3.052ArgLys: 3.052 ± 0.028	7.257ArgLeu: 7.257 ± 0.047	1.751ArgMet: 1.751 ± 0.021	2.243ArgAsn: 2.243 ± 0.023	2.968ArgPro: 2.968 ± 0.027	3.499ArgGln: 3.499 ± 0.032	7.5ArgArg: 7.5 ± 0.061	4.84ArgSer: 4.84 ± 0.033	3.353ArgThr: 3.353 ± 0.031	5.108ArgVal: 5.108 ± 0.031	1.071ArgTrp: 1.071 ± 0.018	1.873ArgTyr: 1.873 ± 0.02	0.005ArgXaa: 0.005 ± 0.001
Ser	6.589SerAla: 6.589 ± 0.044	1.68SerCys: 1.68 ± 0.022	3.293SerAsp: 3.293 ± 0.028	3.957SerGlu: 3.957 ± 0.034	3.006SerPhe: 3.006 ± 0.027	5.159SerGly: 5.159 ± 0.033	1.961SerHis: 1.961 ± 0.02	2.792SerIle: 2.792 ± 0.028	2.671SerLys: 2.671 ± 0.025	7.848SerLeu: 7.848 ± 0.051	1.786SerMet: 1.786 ± 0.02	2.399SerAsn: 2.399 ± 0.026	4.296SerPro: 4.296 ± 0.047	2.501SerGln: 2.501 ± 0.024	4.862SerArg: 4.862 ± 0.038	7.641SerSer: 7.641 ± 0.056	4.594SerThr: 4.594 ± 0.041	5.683SerVal: 5.683 ± 0.042	0.9SerTrp: 0.9 ± 0.014	1.639SerTyr: 1.639 ± 0.02	0.004SerXaa: 0.004 ± 0.001
Thr	5.843ThrAla: 5.843 ± 0.043	0.998ThrCys: 0.998 ± 0.015	2.442ThrAsp: 2.442 ± 0.026	3.483ThrGlu: 3.483 ± 0.029	1.969ThrPhe: 1.969 ± 0.023	3.439ThrGly: 3.439 ± 0.029	1.446ThrHis: 1.446 ± 0.016	2.161ThrIle: 2.161 ± 0.021	2.083ThrLys: 2.083 ± 0.022	5.743ThrLeu: 5.743 ± 0.034	1.358ThrMet: 1.358 ± 0.017	1.734ThrAsn: 1.734 ± 0.019	3.574ThrPro: 3.574 ± 0.037	2.059ThrGln: 2.059 ± 0.022	3.522ThrArg: 3.522 ± 0.025	4.591ThrSer: 4.591 ± 0.04	4.113ThrThr: 4.113 ± 0.04	4.508ThrVal: 4.508 ± 0.039	0.642ThrTrp: 0.642 ± 0.014	1.192ThrTyr: 1.192 ± 0.018	0.005ThrXaa: 0.005 ± 0.001
Val	7.112ValAla: 7.112 ± 0.04	1.687ValCys: 1.687 ± 0.018	3.72ValAsp: 3.72 ± 0.029	5.285ValGlu: 5.285 ± 0.038	2.991ValPhe: 2.991 ± 0.032	4.766ValGly: 4.766 ± 0.043	1.802ValHis: 1.802 ± 0.021	2.597ValIle: 2.597 ± 0.026	2.923ValLys: 2.923 ± 0.03	7.617ValLeu: 7.617 ± 0.054	1.946ValMet: 1.946 ± 0.021	2.292ValAsn: 2.292 ± 0.023	3.88ValPro: 3.88 ± 0.034	2.766ValGln: 2.766 ± 0.026	5.145ValArg: 5.145 ± 0.035	5.629ValSer: 5.629 ± 0.043	4.296ValThr: 4.296 ± 0.036	6.545ValVal: 6.545 ± 0.047	0.93ValTrp: 0.93 ± 0.015	1.835ValTyr: 1.835 ± 0.023	0.008ValXaa: 0.008 ± 0.001
Trp	0.822TrpAla: 0.822 ± 0.014	0.349TrpCys: 0.349 ± 0.008	0.599TrpAsp: 0.599 ± 0.012	0.832TrpGlu: 0.832 ± 0.015	0.384TrpPhe: 0.384 ± 0.009	0.851TrpGly: 0.851 ± 0.016	0.323TrpHis: 0.323 ± 0.009	0.416TrpIle: 0.416 ± 0.01	0.69TrpLys: 0.69 ± 0.012	1.115TrpLeu: 1.115 ± 0.016	0.388TrpMet: 0.388 ± 0.01	0.478TrpAsn: 0.478 ± 0.01	0.461TrpPro: 0.461 ± 0.009	0.476TrpGln: 0.476 ± 0.012	1.211TrpArg: 1.211 ± 0.018	0.906TrpSer: 0.906 ± 0.016	0.58TrpThr: 0.58 ± 0.011	0.815TrpVal: 0.815 ± 0.014	0.235TrpTrp: 0.235 ± 0.008	0.313TrpTyr: 0.313 ± 0.009	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.111TyrAla: 2.111 ± 0.024	0.601TyrCys: 0.601 ± 0.015	1.342TyrAsp: 1.342 ± 0.02	1.486TyrGlu: 1.486 ± 0.021	1.112TyrPhe: 1.112 ± 0.016	1.594TyrGly: 1.594 ± 0.023	0.707TyrHis: 0.707 ± 0.013	1.035TyrIle: 1.035 ± 0.019	0.865TyrLys: 0.865 ± 0.015	2.274TyrLeu: 2.274 ± 0.024	0.647TyrMet: 0.647 ± 0.013	0.908TyrAsn: 0.908 ± 0.015	1.004TyrPro: 1.004 ± 0.013	0.788TyrGln: 0.788 ± 0.015	1.689TyrArg: 1.689 ± 0.021	1.6TyrSer: 1.6 ± 0.019	1.421TyrThr: 1.421 ± 0.019	1.923TyrVal: 1.923 ± 0.022	0.309TyrTrp: 0.309 ± 0.008	0.847TyrTyr: 0.847 ± 0.015	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.008XaaAla: 0.008 ± 0.001	0.004XaaCys: 0.004 ± 0.001	0.001XaaAsp: 0.001 ± 0.0	0.003XaaGlu: 0.003 ± 0.001	0.004XaaPhe: 0.004 ± 0.001	0.006XaaGly: 0.006 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.008XaaLeu: 0.008 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.002XaaAsn: 0.002 ± 0.001	0.004XaaPro: 0.004 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.008XaaArg: 0.008 ± 0.001	0.005XaaSer: 0.005 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.006XaaVal: 0.006 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.544XaaXaa: 0.544 ± 0.031

Statistics based on 10070 proteins (4520539 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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