Amino acid dipepetide frequency for Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.387AlaAla: 17.387 ± 0.204	0.96AlaCys: 0.96 ± 0.032	7.228AlaAsp: 7.228 ± 0.098	6.158AlaGlu: 6.158 ± 0.105	4.591AlaPhe: 4.591 ± 0.075	10.799AlaGly: 10.799 ± 0.123	3.922AlaHis: 3.922 ± 0.083	3.553AlaIle: 3.553 ± 0.059	2.257AlaLys: 2.257 ± 0.061	18.143AlaLeu: 18.143 ± 0.232	2.338AlaMet: 2.338 ± 0.049	2.662AlaAsn: 2.662 ± 0.056	7.48AlaPro: 7.48 ± 0.11	5.767AlaGln: 5.767 ± 0.095	13.087AlaArg: 13.087 ± 0.149	5.746AlaSer: 5.746 ± 0.077	7.057AlaThr: 7.057 ± 0.096	9.15AlaVal: 9.15 ± 0.113	2.194AlaTrp: 2.194 ± 0.058	3.514AlaTyr: 3.514 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.744CysAla: 0.744 ± 0.031	0.049CysCys: 0.049 ± 0.008	0.307CysAsp: 0.307 ± 0.02	0.232CysGlu: 0.232 ± 0.019	0.135CysPhe: 0.135 ± 0.012	0.583CysGly: 0.583 ± 0.023	0.12CysHis: 0.12 ± 0.012	0.173CysIle: 0.173 ± 0.012	0.085CysLys: 0.085 ± 0.008	0.465CysLeu: 0.465 ± 0.022	0.079CysMet: 0.079 ± 0.009	0.134CysAsn: 0.134 ± 0.011	0.347CysPro: 0.347 ± 0.024	0.134CysGln: 0.134 ± 0.011	0.333CysArg: 0.333 ± 0.018	0.274CysSer: 0.274 ± 0.017	0.428CysThr: 0.428 ± 0.024	0.444CysVal: 0.444 ± 0.023	0.061CysTrp: 0.061 ± 0.008	0.116CysTyr: 0.116 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	9.574AspAla: 9.574 ± 0.096	0.2AspCys: 0.2 ± 0.016	3.001AspAsp: 3.001 ± 0.054	3.031AspGlu: 3.031 ± 0.059	1.722AspPhe: 1.722 ± 0.046	5.044AspGly: 5.044 ± 0.079	1.277AspHis: 1.277 ± 0.039	1.803AspIle: 1.803 ± 0.05	0.976AspLys: 0.976 ± 0.037	7.47AspLeu: 7.47 ± 0.098	0.852AspMet: 0.852 ± 0.029	0.934AspAsn: 0.934 ± 0.035	3.382AspPro: 3.382 ± 0.055	1.405AspGln: 1.405 ± 0.038	3.604AspArg: 3.604 ± 0.065	1.585AspSer: 1.585 ± 0.041	3.38AspThr: 3.38 ± 0.061	5.528AspVal: 5.528 ± 0.083	0.748AspTrp: 0.748 ± 0.029	1.068AspTyr: 1.068 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.779GluAla: 6.779 ± 0.11	0.201GluCys: 0.201 ± 0.015	2.695GluAsp: 2.695 ± 0.054	2.49GluGlu: 2.49 ± 0.062	1.435GluPhe: 1.435 ± 0.042	4.148GluGly: 4.148 ± 0.072	1.51GluHis: 1.51 ± 0.037	1.662GluIle: 1.662 ± 0.047	1.169GluLys: 1.169 ± 0.037	5.047GluLeu: 5.047 ± 0.079	0.841GluMet: 0.841 ± 0.03	1.143GluAsn: 1.143 ± 0.036	2.145GluPro: 2.145 ± 0.056	2.05GluGln: 2.05 ± 0.046	5.844GluArg: 5.844 ± 0.092	1.648GluSer: 1.648 ± 0.036	2.488GluThr: 2.488 ± 0.05	4.161GluVal: 4.161 ± 0.068	0.56GluTrp: 0.56 ± 0.025	1.109GluTyr: 1.109 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.733PheAla: 3.733 ± 0.068	0.171PheCys: 0.171 ± 0.013	1.916PheAsp: 1.916 ± 0.048	1.807PheGlu: 1.807 ± 0.042	0.91PhePhe: 0.91 ± 0.034	3.008PheGly: 3.008 ± 0.058	0.578PheHis: 0.578 ± 0.024	1.181PheIle: 1.181 ± 0.036	0.788PheLys: 0.788 ± 0.03	3.001PheLeu: 3.001 ± 0.062	0.642PheMet: 0.642 ± 0.023	0.831PheAsn: 0.831 ± 0.03	1.574PhePro: 1.574 ± 0.04	0.951PheGln: 0.951 ± 0.03	1.986PheArg: 1.986 ± 0.043	1.589PheSer: 1.589 ± 0.039	2.589PheThr: 2.589 ± 0.062	2.41PheVal: 2.41 ± 0.046	0.396PheTrp: 0.396 ± 0.022	0.732PheTyr: 0.732 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	11.391GlyAla: 11.391 ± 0.155	0.48GlyCys: 0.48 ± 0.022	4.415GlyAsp: 4.415 ± 0.083	4.597GlyGlu: 4.597 ± 0.068	2.866GlyPhe: 2.866 ± 0.05	7.873GlyGly: 7.873 ± 0.106	2.103GlyHis: 2.103 ± 0.048	2.953GlyIle: 2.953 ± 0.054	2.307GlyLys: 2.307 ± 0.056	9.205GlyLeu: 9.205 ± 0.125	1.607GlyMet: 1.607 ± 0.046	2.145GlyAsn: 2.145 ± 0.048	3.444GlyPro: 3.444 ± 0.062	3.278GlyGln: 3.278 ± 0.069	6.252GlyArg: 6.252 ± 0.103	3.906GlySer: 3.906 ± 0.08	6.173GlyThr: 6.173 ± 0.106	8.435GlyVal: 8.435 ± 0.103	1.271GlyTrp: 1.271 ± 0.034	2.206GlyTyr: 2.206 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	4.095HisAla: 4.095 ± 0.089	0.132HisCys: 0.132 ± 0.012	1.578HisAsp: 1.578 ± 0.04	1.248HisGlu: 1.248 ± 0.035	0.768HisPhe: 0.768 ± 0.026	2.228HisGly: 2.228 ± 0.056	0.798HisHis: 0.798 ± 0.032	0.727HisIle: 0.727 ± 0.031	0.344HisLys: 0.344 ± 0.021	3.441HisLeu: 3.441 ± 0.071	0.383HisMet: 0.383 ± 0.021	0.45HisAsn: 0.45 ± 0.023	1.981HisPro: 1.981 ± 0.051	0.611HisGln: 0.611 ± 0.026	1.463HisArg: 1.463 ± 0.044	0.799HisSer: 0.799 ± 0.029	1.513HisThr: 1.513 ± 0.042	2.12HisVal: 2.12 ± 0.049	0.303HisTrp: 0.303 ± 0.017	0.545HisTyr: 0.545 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.144IleAla: 4.144 ± 0.074	0.183IleCys: 0.183 ± 0.013	1.948IleAsp: 1.948 ± 0.046	2.049IleGlu: 2.049 ± 0.048	0.867IlePhe: 0.867 ± 0.032	3.25IleGly: 3.25 ± 0.066	0.752IleHis: 0.752 ± 0.026	1.494IleIle: 1.494 ± 0.039	0.835IleLys: 0.835 ± 0.035	3.228IleLeu: 3.228 ± 0.063	0.592IleMet: 0.592 ± 0.022	0.959IleAsn: 0.959 ± 0.031	1.825IlePro: 1.825 ± 0.044	1.068IleGln: 1.068 ± 0.039	2.227IleArg: 2.227 ± 0.053	1.704IleSer: 1.704 ± 0.036	2.525IleThr: 2.525 ± 0.056	2.848IleVal: 2.848 ± 0.058	0.284IleTrp: 0.284 ± 0.017	0.712IleTyr: 0.712 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.629LysAla: 2.629 ± 0.069	0.078LysCys: 0.078 ± 0.01	1.157LysAsp: 1.157 ± 0.041	0.813LysGlu: 0.813 ± 0.034	0.713LysPhe: 0.713 ± 0.029	1.648LysGly: 1.648 ± 0.04	0.479LysHis: 0.479 ± 0.02	0.853LysIle: 0.853 ± 0.036	0.779LysLys: 0.779 ± 0.031	2.473LysLeu: 2.473 ± 0.054	0.527LysMet: 0.527 ± 0.024	0.723LysAsn: 0.723 ± 0.028	1.318LysPro: 1.318 ± 0.037	0.673LysGln: 0.673 ± 0.031	1.639LysArg: 1.639 ± 0.044	0.963LysSer: 0.963 ± 0.033	1.434LysThr: 1.434 ± 0.043	1.848LysVal: 1.848 ± 0.049	0.231LysTrp: 0.231 ± 0.016	0.654LysTyr: 0.654 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.944LeuAla: 14.944 ± 0.161	0.561LeuCys: 0.561 ± 0.023	6.702LeuAsp: 6.702 ± 0.086	5.498LeuGlu: 5.498 ± 0.079	2.676LeuPhe: 2.676 ± 0.063	10.122LeuGly: 10.122 ± 0.123	3.249LeuHis: 3.249 ± 0.084	4.251LeuIle: 4.251 ± 0.077	2.741LeuLys: 2.741 ± 0.059	12.77LeuLeu: 12.77 ± 0.192	2.073LeuMet: 2.073 ± 0.05	3.527LeuAsn: 3.527 ± 0.066	7.016LeuPro: 7.016 ± 0.084	3.919LeuGln: 3.919 ± 0.071	9.162LeuArg: 9.162 ± 0.093	6.079LeuSer: 6.079 ± 0.086	8.769LeuThr: 8.769 ± 0.123	7.261LeuVal: 7.261 ± 0.095	1.168LeuTrp: 1.168 ± 0.035	2.368LeuTyr: 2.368 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.644MetAla: 1.644 ± 0.045	0.076MetCys: 0.076 ± 0.009	0.907MetAsp: 0.907 ± 0.033	0.643MetGlu: 0.643 ± 0.03	0.471MetPhe: 0.471 ± 0.022	1.335MetGly: 1.335 ± 0.041	0.475MetHis: 0.475 ± 0.022	0.729MetIle: 0.729 ± 0.028	0.61MetLys: 0.61 ± 0.025	1.936MetLeu: 1.936 ± 0.044	0.353MetMet: 0.353 ± 0.02	0.788MetAsn: 0.788 ± 0.028	1.111MetPro: 1.111 ± 0.031	0.669MetGln: 0.669 ± 0.027	1.413MetArg: 1.413 ± 0.039	1.086MetSer: 1.086 ± 0.034	1.882MetThr: 1.882 ± 0.043	1.132MetVal: 1.132 ± 0.032	0.148MetTrp: 0.148 ± 0.012	0.381MetTyr: 0.381 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.829AsnAla: 3.829 ± 0.077	0.139AsnCys: 0.139 ± 0.012	1.356AsnAsp: 1.356 ± 0.039	1.015AsnGlu: 1.015 ± 0.028	0.888AsnPhe: 0.888 ± 0.029	2.383AsnGly: 2.383 ± 0.07	0.483AsnHis: 0.483 ± 0.023	1.013AsnIle: 1.013 ± 0.037	0.582AsnLys: 0.582 ± 0.028	2.891AsnLeu: 2.891 ± 0.048	0.442AsnMet: 0.442 ± 0.022	0.654AsnAsn: 0.654 ± 0.036	1.82AsnPro: 1.82 ± 0.047	0.614AsnGln: 0.614 ± 0.027	1.432AsnArg: 1.432 ± 0.041	0.982AsnSer: 0.982 ± 0.038	1.624AsnThr: 1.624 ± 0.052	2.553AsnVal: 2.553 ± 0.058	0.305AsnTrp: 0.305 ± 0.019	0.587AsnTyr: 0.587 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.399ProAla: 7.399 ± 0.118	0.278ProCys: 0.278 ± 0.017	4.621ProAsp: 4.621 ± 0.069	3.737ProGlu: 3.737 ± 0.073	1.784ProPhe: 1.784 ± 0.039	5.212ProGly: 5.212 ± 0.082	1.701ProHis: 1.701 ± 0.04	1.651ProIle: 1.651 ± 0.042	1.164ProLys: 1.164 ± 0.036	5.915ProLeu: 5.915 ± 0.084	1.079ProMet: 1.079 ± 0.026	1.571ProAsn: 1.571 ± 0.043	2.837ProPro: 2.837 ± 0.064	1.863ProGln: 1.863 ± 0.05	3.518ProArg: 3.518 ± 0.07	2.498ProSer: 2.498 ± 0.054	3.882ProThr: 3.882 ± 0.072	4.285ProVal: 4.285 ± 0.071	0.734ProTrp: 0.734 ± 0.026	1.351ProTyr: 1.351 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.013GlnAla: 5.013 ± 0.076	0.105GlnCys: 0.105 ± 0.011	2.142GlnAsp: 2.142 ± 0.049	1.644GlnGlu: 1.644 ± 0.04	1.057GlnPhe: 1.057 ± 0.03	2.989GlnGly: 2.989 ± 0.077	1.016GlnHis: 1.016 ± 0.033	1.057GlnIle: 1.057 ± 0.033	0.823GlnLys: 0.823 ± 0.033	3.635GlnLeu: 3.635 ± 0.071	0.587GlnMet: 0.587 ± 0.02	0.965GlnAsn: 0.965 ± 0.032	2.051GlnPro: 2.051 ± 0.05	1.538GlnGln: 1.538 ± 0.046	2.571GlnArg: 2.571 ± 0.054	1.327GlnSer: 1.327 ± 0.043	1.914GlnThr: 1.914 ± 0.046	2.965GlnVal: 2.965 ± 0.052	0.414GlnTrp: 0.414 ± 0.021	0.918GlnTyr: 0.918 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	12.995ArgAla: 12.995 ± 0.153	0.306ArgCys: 0.306 ± 0.02	4.743ArgAsp: 4.743 ± 0.072	4.64ArgGlu: 4.64 ± 0.073	2.243ArgPhe: 2.243 ± 0.044	5.961ArgGly: 5.961 ± 0.102	1.78ArgHis: 1.78 ± 0.047	2.456ArgIle: 2.456 ± 0.053	1.5ArgLys: 1.5 ± 0.036	8.271ArgLeu: 8.271 ± 0.11	1.488ArgMet: 1.488 ± 0.042	1.672ArgAsn: 1.672 ± 0.042	3.802ArgPro: 3.802 ± 0.067	2.322ArgGln: 2.322 ± 0.053	5.356ArgArg: 5.356 ± 0.08	2.967ArgSer: 2.967 ± 0.057	5.296ArgThr: 5.296 ± 0.075	7.171ArgVal: 7.171 ± 0.099	0.924ArgTrp: 0.924 ± 0.028	1.912ArgTyr: 1.912 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.224SerAla: 6.224 ± 0.091	0.259SerCys: 0.259 ± 0.019	2.288SerAsp: 2.288 ± 0.053	1.929SerGlu: 1.929 ± 0.049	1.53SerPhe: 1.53 ± 0.04	5.309SerGly: 5.309 ± 0.091	0.788SerHis: 0.788 ± 0.03	1.609SerIle: 1.609 ± 0.043	1.035SerLys: 1.035 ± 0.036	4.269SerLeu: 4.269 ± 0.067	0.885SerMet: 0.885 ± 0.031	1.146SerAsn: 1.146 ± 0.038	2.266SerPro: 2.266 ± 0.046	1.019SerGln: 1.019 ± 0.035	2.634SerArg: 2.634 ± 0.049	2.508SerSer: 2.508 ± 0.06	2.954SerThr: 2.954 ± 0.066	4.104SerVal: 4.104 ± 0.067	0.538SerTrp: 0.538 ± 0.024	0.942SerTyr: 0.942 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.516ThrAla: 7.516 ± 0.107	0.402ThrCys: 0.402 ± 0.021	3.457ThrAsp: 3.457 ± 0.071	2.536ThrGlu: 2.536 ± 0.044	2.593ThrPhe: 2.593 ± 0.06	5.5ThrGly: 5.5 ± 0.085	1.7ThrHis: 1.7 ± 0.053	2.049ThrIle: 2.049 ± 0.05	1.064ThrLys: 1.064 ± 0.038	9.692ThrLeu: 9.692 ± 0.116	0.846ThrMet: 0.846 ± 0.032	1.516ThrAsn: 1.516 ± 0.057	5.934ThrPro: 5.934 ± 0.098	2.064ThrGln: 2.064 ± 0.047	4.905ThrArg: 4.905 ± 0.069	2.951ThrSer: 2.951 ± 0.063	4.134ThrThr: 4.134 ± 0.109	5.536ThrVal: 5.536 ± 0.094	0.925ThrTrp: 0.925 ± 0.033	1.886ThrTyr: 1.886 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	8.957ValAla: 8.957 ± 0.112	0.463ValCys: 0.463 ± 0.022	4.125ValAsp: 4.125 ± 0.068	3.684ValGlu: 3.684 ± 0.068	2.377ValPhe: 2.377 ± 0.05	6.181ValGly: 6.181 ± 0.078	1.911ValHis: 1.911 ± 0.051	3.302ValIle: 3.302 ± 0.056	1.885ValLys: 1.885 ± 0.05	8.929ValLeu: 8.929 ± 0.109	1.574ValMet: 1.574 ± 0.041	2.759ValAsn: 2.759 ± 0.063	4.799ValPro: 4.799 ± 0.078	3.505ValGln: 3.505 ± 0.061	7.124ValArg: 7.124 ± 0.102	3.928ValSer: 3.928 ± 0.056	6.436ValThr: 6.436 ± 0.105	6.124ValVal: 6.124 ± 0.094	0.987ValTrp: 0.987 ± 0.032	1.865ValTyr: 1.865 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.637TrpAla: 1.637 ± 0.047	0.067TrpCys: 0.067 ± 0.008	0.685TrpAsp: 0.685 ± 0.029	0.428TrpGlu: 0.428 ± 0.018	0.367TrpPhe: 0.367 ± 0.019	1.019TrpGly: 1.019 ± 0.034	0.339TrpHis: 0.339 ± 0.019	0.331TrpIle: 0.331 ± 0.017	0.231TrpLys: 0.231 ± 0.015	1.441TrpLeu: 1.441 ± 0.039	0.279TrpMet: 0.279 ± 0.017	0.419TrpAsn: 0.419 ± 0.021	0.636TrpPro: 0.636 ± 0.022	0.526TrpGln: 0.526 ± 0.026	1.219TrpArg: 1.219 ± 0.039	0.625TrpSer: 0.625 ± 0.027	1.007TrpThr: 1.007 ± 0.026	1.032TrpVal: 1.032 ± 0.03	0.24TrpTrp: 0.24 ± 0.016	0.247TrpTyr: 0.247 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.358TyrAla: 3.358 ± 0.061	0.136TyrCys: 0.136 ± 0.011	1.312TyrAsp: 1.312 ± 0.039	0.947TyrGlu: 0.947 ± 0.032	0.802TyrPhe: 0.802 ± 0.027	2.317TyrGly: 2.317 ± 0.05	0.546TyrHis: 0.546 ± 0.022	0.648TyrIle: 0.648 ± 0.027	0.458TyrLys: 0.458 ± 0.025	2.633TyrLeu: 2.633 ± 0.047	0.318TyrMet: 0.318 ± 0.022	0.595TyrAsn: 0.595 ± 0.029	1.311TyrPro: 1.311 ± 0.035	0.756TyrGln: 0.756 ± 0.029	2.034TyrArg: 2.034 ± 0.051	1.07TyrSer: 1.07 ± 0.038	1.723TyrThr: 1.723 ± 0.043	1.807TyrVal: 1.807 ± 0.046	0.343TyrTrp: 0.343 ± 0.019	0.605TyrTyr: 0.605 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3262 proteins (1032088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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