Amino acid dipepetide frequency for Ancylostoma ceylanicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.756AlaAla: 6.756 ± 0.033	1.452AlaCys: 1.452 ± 0.012	3.542AlaAsp: 3.542 ± 0.013	4.522AlaGlu: 4.522 ± 0.019	2.793AlaPhe: 2.793 ± 0.015	3.93AlaGly: 3.93 ± 0.02	1.677AlaHis: 1.677 ± 0.01	3.793AlaIle: 3.793 ± 0.015	3.903AlaLys: 3.903 ± 0.017	6.503AlaLeu: 6.503 ± 0.022	1.874AlaMet: 1.874 ± 0.011	2.738AlaAsn: 2.738 ± 0.012	3.917AlaPro: 3.917 ± 0.026	2.645AlaGln: 2.645 ± 0.014	4.255AlaArg: 4.255 ± 0.016	5.507AlaSer: 5.507 ± 0.019	4.295AlaThr: 4.295 ± 0.021	5.344AlaVal: 5.344 ± 0.018	0.751AlaTrp: 0.751 ± 0.006	1.87AlaTyr: 1.87 ± 0.01	0.003AlaXaa: 0.003 ± 0.0
Cys	1.582CysAla: 1.582 ± 0.012	0.696CysCys: 0.696 ± 0.01	1.259CysAsp: 1.259 ± 0.012	1.372CysGlu: 1.372 ± 0.011	0.979CysPhe: 0.979 ± 0.007	1.646CysGly: 1.646 ± 0.011	0.588CysHis: 0.588 ± 0.006	1.19CysIle: 1.19 ± 0.011	1.061CysLys: 1.061 ± 0.015	2.013CysLeu: 2.013 ± 0.013	0.556CysMet: 0.556 ± 0.006	0.922CysAsn: 0.922 ± 0.009	1.31CysPro: 1.31 ± 0.016	0.841CysGln: 0.841 ± 0.011	1.488CysArg: 1.488 ± 0.01	2.086CysSer: 2.086 ± 0.014	1.309CysThr: 1.309 ± 0.009	1.557CysVal: 1.557 ± 0.011	0.289CysTrp: 0.289 ± 0.004	0.682CysTyr: 0.682 ± 0.007	0.001CysXaa: 0.001 ± 0.0
Asp	3.674AspAla: 3.674 ± 0.016	1.182AspCys: 1.182 ± 0.012	3.628AspAsp: 3.628 ± 0.021	4.174AspGlu: 4.174 ± 0.018	2.231AspPhe: 2.231 ± 0.011	3.426AspGly: 3.426 ± 0.02	1.238AspHis: 1.238 ± 0.008	2.697AspIle: 2.697 ± 0.012	2.515AspLys: 2.515 ± 0.014	4.375AspLeu: 4.375 ± 0.016	1.221AspMet: 1.221 ± 0.009	1.896AspAsn: 1.896 ± 0.013	2.434AspPro: 2.434 ± 0.013	1.727AspGln: 1.727 ± 0.012	3.11AspArg: 3.11 ± 0.016	3.825AspSer: 3.825 ± 0.016	2.479AspThr: 2.479 ± 0.016	3.835AspVal: 3.835 ± 0.017	0.66AspTrp: 0.66 ± 0.005	1.664AspTyr: 1.664 ± 0.011	0.002AspXaa: 0.002 ± 0.0
Glu	4.372GluAla: 4.372 ± 0.019	1.301GluCys: 1.301 ± 0.011	3.588GluAsp: 3.588 ± 0.018	5.709GluGlu: 5.709 ± 0.044	2.166GluPhe: 2.166 ± 0.011	3.075GluGly: 3.075 ± 0.019	1.511GluHis: 1.511 ± 0.009	3.239GluIle: 3.239 ± 0.016	4.738GluLys: 4.738 ± 0.024	5.366GluLeu: 5.366 ± 0.024	1.768GluMet: 1.768 ± 0.01	2.933GluAsn: 2.933 ± 0.014	2.486GluPro: 2.486 ± 0.018	2.711GluGln: 2.711 ± 0.014	4.428GluArg: 4.428 ± 0.021	4.147GluSer: 4.147 ± 0.022	3.3GluThr: 3.3 ± 0.018	3.921GluVal: 3.921 ± 0.018	0.792GluTrp: 0.792 ± 0.007	1.763GluTyr: 1.763 ± 0.01	0.003GluXaa: 0.003 ± 0.0
Phe	2.922PheAla: 2.922 ± 0.013	1.086PheCys: 1.086 ± 0.008	2.332PheAsp: 2.332 ± 0.013	2.295PheGlu: 2.295 ± 0.012	2.012PhePhe: 2.012 ± 0.013	2.575PheGly: 2.575 ± 0.013	1.089PheHis: 1.089 ± 0.008	2.255PheIle: 2.255 ± 0.011	1.731PheLys: 1.731 ± 0.011	3.969PheLeu: 3.969 ± 0.017	0.98PheMet: 0.98 ± 0.008	1.623PheAsn: 1.623 ± 0.009	1.886PhePro: 1.886 ± 0.012	1.325PheGln: 1.325 ± 0.008	2.352PheArg: 2.352 ± 0.01	3.296PheSer: 3.296 ± 0.015	2.323PheThr: 2.323 ± 0.011	2.94PheVal: 2.94 ± 0.016	0.541PheTrp: 0.541 ± 0.006	1.496PheTyr: 1.496 ± 0.01	0.002PheXaa: 0.002 ± 0.0
Gly	3.852GlyAla: 3.852 ± 0.018	1.409GlyCys: 1.409 ± 0.011	2.995GlyAsp: 2.995 ± 0.014	3.402GlyGlu: 3.402 ± 0.018	2.446GlyPhe: 2.446 ± 0.014	4.211GlyGly: 4.211 ± 0.032	1.367GlyHis: 1.367 ± 0.009	2.897GlyIle: 2.897 ± 0.013	3.263GlyLys: 3.263 ± 0.017	4.301GlyLeu: 4.301 ± 0.016	1.429GlyMet: 1.429 ± 0.009	2.422GlyAsn: 2.422 ± 0.014	2.571GlyPro: 2.571 ± 0.026	2.07GlyGln: 2.07 ± 0.016	3.683GlyArg: 3.683 ± 0.017	4.556GlySer: 4.556 ± 0.02	3.235GlyThr: 3.235 ± 0.017	3.826GlyVal: 3.826 ± 0.015	0.717GlyTrp: 0.717 ± 0.006	1.915GlyTyr: 1.915 ± 0.012	0.002GlyXaa: 0.002 ± 0.0
His	1.555HisAla: 1.555 ± 0.01	0.668HisCys: 0.668 ± 0.007	1.175HisAsp: 1.175 ± 0.009	1.367HisGlu: 1.367 ± 0.01	1.146HisPhe: 1.146 ± 0.008	1.489HisGly: 1.489 ± 0.01	0.843HisHis: 0.843 ± 0.01	1.343HisIle: 1.343 ± 0.009	1.093HisLys: 1.093 ± 0.008	2.398HisLeu: 2.398 ± 0.012	0.603HisMet: 0.603 ± 0.006	0.937HisAsn: 0.937 ± 0.007	1.369HisPro: 1.369 ± 0.01	0.904HisGln: 0.904 ± 0.007	1.742HisArg: 1.742 ± 0.012	1.952HisSer: 1.952 ± 0.012	1.256HisThr: 1.256 ± 0.009	1.671HisVal: 1.671 ± 0.01	0.314HisTrp: 0.314 ± 0.004	0.845HisTyr: 0.845 ± 0.011	0.001HisXaa: 0.001 ± 0.0
Ile	3.984IleAla: 3.984 ± 0.016	1.354IleCys: 1.354 ± 0.01	2.909IleAsp: 2.909 ± 0.014	3.13IleGlu: 3.13 ± 0.015	2.329IlePhe: 2.329 ± 0.013	2.987IleGly: 2.987 ± 0.013	1.343IleHis: 1.343 ± 0.008	2.725IleIle: 2.725 ± 0.014	2.422IleLys: 2.422 ± 0.012	4.718IleLeu: 4.718 ± 0.018	1.217IleMet: 1.217 ± 0.008	1.972IleAsn: 1.972 ± 0.011	2.776IlePro: 2.776 ± 0.014	1.825IleGln: 1.825 ± 0.01	3.375IleArg: 3.375 ± 0.016	4.275IleSer: 4.275 ± 0.016	3.077IleThr: 3.077 ± 0.013	3.713IleVal: 3.713 ± 0.016	0.596IleTrp: 0.596 ± 0.005	1.636IleTyr: 1.636 ± 0.01	0.001IleXaa: 0.001 ± 0.0
Lys	3.719LysAla: 3.719 ± 0.017	1.261LysCys: 1.261 ± 0.012	2.819LysAsp: 2.819 ± 0.015	4.154LysGlu: 4.154 ± 0.023	1.938LysPhe: 1.938 ± 0.011	2.715LysGly: 2.715 ± 0.016	1.289LysHis: 1.289 ± 0.009	2.968LysIle: 2.968 ± 0.013	4.591LysLys: 4.591 ± 0.034	4.626LysLeu: 4.626 ± 0.019	1.57LysMet: 1.57 ± 0.008	2.417LysAsn: 2.417 ± 0.011	2.673LysPro: 2.673 ± 0.026	2.168LysGln: 2.168 ± 0.012	3.895LysArg: 3.895 ± 0.017	3.83LysSer: 3.83 ± 0.017	3.214LysThr: 3.214 ± 0.014	3.295LysVal: 3.295 ± 0.015	0.77LysTrp: 0.77 ± 0.007	1.65LysTyr: 1.65 ± 0.01	0.002LysXaa: 0.002 ± 0.0
Leu	6.402LeuAla: 6.402 ± 0.021	2.17LeuCys: 2.17 ± 0.012	4.335LeuAsp: 4.335 ± 0.017	5.227LeuGlu: 5.227 ± 0.021	3.934LeuPhe: 3.934 ± 0.016	4.344LeuGly: 4.344 ± 0.017	2.416LeuHis: 2.416 ± 0.014	4.566LeuIle: 4.566 ± 0.017	4.722LeuLys: 4.722 ± 0.018	9.126LeuLeu: 9.126 ± 0.033	2.186LeuMet: 2.186 ± 0.011	3.638LeuAsn: 3.638 ± 0.014	4.938LeuPro: 4.938 ± 0.023	3.54LeuGln: 3.54 ± 0.016	6.087LeuArg: 6.087 ± 0.019	7.29LeuSer: 7.29 ± 0.025	4.882LeuThr: 4.882 ± 0.017	5.523LeuVal: 5.523 ± 0.02	1.016LeuTrp: 1.016 ± 0.007	2.614LeuTyr: 2.614 ± 0.012	0.004LeuXaa: 0.004 ± 0.0
Met	1.793MetAla: 1.793 ± 0.009	0.561MetCys: 0.561 ± 0.006	1.386MetAsp: 1.386 ± 0.01	1.706MetGlu: 1.706 ± 0.009	1.045MetPhe: 1.045 ± 0.008	1.299MetGly: 1.299 ± 0.009	0.602MetHis: 0.602 ± 0.006	1.252MetIle: 1.252 ± 0.009	1.591MetLys: 1.591 ± 0.009	2.313MetLeu: 2.313 ± 0.013	0.781MetMet: 0.781 ± 0.008	1.144MetAsn: 1.144 ± 0.008	1.217MetPro: 1.217 ± 0.009	0.968MetGln: 0.968 ± 0.008	1.734MetArg: 1.734 ± 0.011	1.958MetSer: 1.958 ± 0.012	1.48MetThr: 1.48 ± 0.009	1.584MetVal: 1.584 ± 0.01	0.313MetTrp: 0.313 ± 0.004	0.747MetTyr: 0.747 ± 0.007	0.001MetXaa: 0.001 ± 0.0
Asn	2.925AsnAla: 2.925 ± 0.013	0.962AsnCys: 0.962 ± 0.008	2.179AsnAsp: 2.179 ± 0.012	2.666AsnGlu: 2.666 ± 0.014	1.655AsnPhe: 1.655 ± 0.01	2.922AsnGly: 2.922 ± 0.018	0.899AsnHis: 0.899 ± 0.007	2.354AsnIle: 2.354 ± 0.013	2.016AsnLys: 2.016 ± 0.011	3.315AsnLeu: 3.315 ± 0.016	1.08AsnMet: 1.08 ± 0.008	1.77AsnAsn: 1.77 ± 0.013	2.114AsnPro: 2.114 ± 0.02	1.452AsnGln: 1.452 ± 0.009	2.426AsnArg: 2.426 ± 0.011	3.085AsnSer: 3.085 ± 0.015	2.275AsnThr: 2.275 ± 0.012	2.854AsnVal: 2.854 ± 0.014	0.473AsnTrp: 0.473 ± 0.006	1.374AsnTyr: 1.374 ± 0.009	0.001AsnXaa: 0.001 ± 0.0
Pro	3.872ProAla: 3.872 ± 0.024	0.973ProCys: 0.973 ± 0.009	2.425ProAsp: 2.425 ± 0.014	3.067ProGlu: 3.067 ± 0.017	2.012ProPhe: 2.012 ± 0.012	3.059ProGly: 3.059 ± 0.04	1.28ProHis: 1.28 ± 0.01	2.521ProIle: 2.521 ± 0.013	2.65ProLys: 2.65 ± 0.017	4.378ProLeu: 4.378 ± 0.019	1.134ProMet: 1.134 ± 0.01	1.988ProAsn: 1.988 ± 0.017	4.566ProPro: 4.566 ± 0.036	2.156ProGln: 2.156 ± 0.013	3.085ProArg: 3.085 ± 0.014	4.858ProSer: 4.858 ± 0.026	3.429ProThr: 3.429 ± 0.022	3.361ProVal: 3.361 ± 0.016	0.559ProTrp: 0.559 ± 0.006	1.471ProTyr: 1.471 ± 0.011	0.003ProXaa: 0.003 ± 0.0
Gln	2.504GlnAla: 2.504 ± 0.014	0.977GlnCys: 0.977 ± 0.014	1.477GlnAsp: 1.477 ± 0.009	2.168GlnGlu: 2.168 ± 0.012	1.501GlnPhe: 1.501 ± 0.009	1.818GlnGly: 1.818 ± 0.012	1.021GlnHis: 1.021 ± 0.008	1.927GlnIle: 1.927 ± 0.012	2.327GlnLys: 2.327 ± 0.012	3.853GlnLeu: 3.853 ± 0.019	1.128GlnMet: 1.128 ± 0.008	1.635GlnAsn: 1.635 ± 0.01	2.172GlnPro: 2.172 ± 0.018	2.325GlnGln: 2.325 ± 0.029	2.651GlnArg: 2.651 ± 0.012	2.669GlnSer: 2.669 ± 0.012	1.988GlnThr: 1.988 ± 0.011	2.182GlnVal: 2.182 ± 0.01	0.519GlnTrp: 0.519 ± 0.005	1.185GlnTyr: 1.185 ± 0.008	0.003GlnXaa: 0.003 ± 0.0
Arg	4.084ArgAla: 4.084 ± 0.014	1.488ArgCys: 1.488 ± 0.013	3.064ArgAsp: 3.064 ± 0.016	3.969ArgGlu: 3.969 ± 0.018	2.559ArgPhe: 2.559 ± 0.012	3.345ArgGly: 3.345 ± 0.017	1.649ArgHis: 1.649 ± 0.011	3.568ArgIle: 3.568 ± 0.016	4.214ArgLys: 4.214 ± 0.018	5.91ArgLeu: 5.91 ± 0.02	1.718ArgMet: 1.718 ± 0.009	2.859ArgAsn: 2.859 ± 0.012	3.235ArgPro: 3.235 ± 0.018	2.553ArgGln: 2.553 ± 0.011	5.774ArgArg: 5.774 ± 0.027	5.153ArgSer: 5.153 ± 0.02	3.621ArgThr: 3.621 ± 0.013	3.76ArgVal: 3.76 ± 0.015	0.934ArgTrp: 0.934 ± 0.008	1.854ArgTyr: 1.854 ± 0.01	0.003ArgXaa: 0.003 ± 0.0
Ser	5.826SerAla: 5.826 ± 0.022	1.807SerCys: 1.807 ± 0.012	4.102SerAsp: 4.102 ± 0.019	4.645SerGlu: 4.645 ± 0.018	3.257SerPhe: 3.257 ± 0.013	4.564SerGly: 4.564 ± 0.019	1.858SerHis: 1.858 ± 0.009	4.017SerIle: 4.017 ± 0.017	3.981SerLys: 3.981 ± 0.019	6.9SerLeu: 6.9 ± 0.026	1.933SerMet: 1.933 ± 0.01	3.109SerAsn: 3.109 ± 0.018	4.386SerPro: 4.386 ± 0.022	2.853SerGln: 2.853 ± 0.013	5.072SerArg: 5.072 ± 0.02	8.302SerSer: 8.302 ± 0.041	5.459SerThr: 5.459 ± 0.031	5.013SerVal: 5.013 ± 0.017	0.889SerTrp: 0.889 ± 0.007	2.183SerTyr: 2.183 ± 0.011	0.004SerXaa: 0.004 ± 0.0
Thr	4.522ThrAla: 4.522 ± 0.021	1.375ThrCys: 1.375 ± 0.011	2.714ThrAsp: 2.714 ± 0.018	3.165ThrGlu: 3.165 ± 0.017	2.265ThrPhe: 2.265 ± 0.012	3.125ThrGly: 3.125 ± 0.015	1.262ThrHis: 1.262 ± 0.008	3.211ThrIle: 3.211 ± 0.015	2.961ThrLys: 2.961 ± 0.015	4.995ThrLeu: 4.995 ± 0.023	1.454ThrMet: 1.454 ± 0.009	2.253ThrAsn: 2.253 ± 0.013	3.434ThrPro: 3.434 ± 0.025	1.973ThrGln: 1.973 ± 0.011	3.284ThrArg: 3.284 ± 0.014	5.178ThrSer: 5.178 ± 0.026	4.962ThrThr: 4.962 ± 0.059	4.26ThrVal: 4.26 ± 0.021	0.7ThrTrp: 0.7 ± 0.006	1.579ThrTyr: 1.579 ± 0.011	0.003ThrXaa: 0.003 ± 0.0
Val	4.972ValAla: 4.972 ± 0.023	1.609ValCys: 1.609 ± 0.011	3.703ValAsp: 3.703 ± 0.016	4.181ValGlu: 4.181 ± 0.019	2.931ValPhe: 2.931 ± 0.015	3.468ValGly: 3.468 ± 0.016	1.654ValHis: 1.654 ± 0.01	3.586ValIle: 3.586 ± 0.014	3.433ValLys: 3.433 ± 0.02	6.161ValLeu: 6.161 ± 0.022	1.688ValMet: 1.688 ± 0.01	2.687ValAsn: 2.687 ± 0.014	3.437ValPro: 3.437 ± 0.015	2.436ValGln: 2.436 ± 0.013	3.985ValArg: 3.985 ± 0.016	4.903ValSer: 4.903 ± 0.016	3.712ValThr: 3.712 ± 0.016	5.165ValVal: 5.165 ± 0.032	0.726ValTrp: 0.726 ± 0.006	1.975ValTyr: 1.975 ± 0.01	0.003ValXaa: 0.003 ± 0.0
Trp	0.741TrpAla: 0.741 ± 0.007	0.273TrpCys: 0.273 ± 0.003	0.589TrpAsp: 0.589 ± 0.006	0.629TrpGlu: 0.629 ± 0.005	0.489TrpPhe: 0.489 ± 0.006	0.536TrpGly: 0.536 ± 0.007	0.28TrpHis: 0.28 ± 0.004	0.732TrpIle: 0.732 ± 0.006	0.829TrpLys: 0.829 ± 0.007	1.121TrpLeu: 1.121 ± 0.008	0.411TrpMet: 0.411 ± 0.005	0.619TrpAsn: 0.619 ± 0.005	0.526TrpPro: 0.526 ± 0.005	0.48TrpGln: 0.48 ± 0.005	0.904TrpArg: 0.904 ± 0.006	0.975TrpSer: 0.975 ± 0.008	0.797TrpThr: 0.797 ± 0.008	0.629TrpVal: 0.629 ± 0.006	0.226TrpTrp: 0.226 ± 0.004	0.393TrpTyr: 0.393 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.012TyrAla: 2.012 ± 0.01	0.823TyrCys: 0.823 ± 0.007	1.771TyrAsp: 1.771 ± 0.011	1.764TyrGlu: 1.764 ± 0.008	1.339TyrPhe: 1.339 ± 0.01	2.034TyrGly: 2.034 ± 0.012	0.801TyrHis: 0.801 ± 0.007	1.522TyrIle: 1.522 ± 0.01	1.519TyrLys: 1.519 ± 0.01	2.614TyrLeu: 2.614 ± 0.011	0.742TyrMet: 0.742 ± 0.006	1.237TyrAsn: 1.237 ± 0.01	1.396TyrPro: 1.396 ± 0.01	1.074TyrGln: 1.074 ± 0.008	1.982TyrArg: 1.982 ± 0.01	2.313TyrSer: 2.313 ± 0.013	1.581TyrThr: 1.581 ± 0.013	1.978TyrVal: 1.978 ± 0.011	0.395TyrTrp: 0.395 ± 0.005	1.14TyrTyr: 1.14 ± 0.017	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.005XaaLeu: 0.005 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.002XaaGln: 0.002 ± 0.0	0.004XaaArg: 0.004 ± 0.0	0.004XaaSer: 0.004 ± 0.0	0.003XaaThr: 0.003 ± 0.0	0.003XaaVal: 0.003 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.066XaaXaa: 0.066 ± 0.014

Statistics based on 65375 proteins (20039791 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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