Amino acid dipepetide frequency for Paracoccus aminovorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.134AlaAla: 20.134 ± 0.23	1.106AlaCys: 1.106 ± 0.037	7.05AlaAsp: 7.05 ± 0.083	9.454AlaGlu: 9.454 ± 0.116	3.96AlaPhe: 3.96 ± 0.068	12.432AlaGly: 12.432 ± 0.135	2.438AlaHis: 2.438 ± 0.045	5.879AlaIle: 5.879 ± 0.075	3.182AlaLys: 3.182 ± 0.075	15.274AlaLeu: 15.274 ± 0.149	3.933AlaMet: 3.933 ± 0.062	2.543AlaAsn: 2.543 ± 0.053	7.004AlaPro: 7.004 ± 0.109	4.865AlaGln: 4.865 ± 0.085	11.03AlaArg: 11.03 ± 0.113	5.587AlaSer: 5.587 ± 0.077	5.911AlaThr: 5.911 ± 0.077	9.001AlaVal: 9.001 ± 0.1	1.671AlaTrp: 1.671 ± 0.04	2.312AlaTyr: 2.312 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.055CysAla: 1.055 ± 0.031	0.114CysCys: 0.114 ± 0.011	0.561CysAsp: 0.561 ± 0.023	0.418CysGlu: 0.418 ± 0.021	0.309CysPhe: 0.309 ± 0.015	0.92CysGly: 0.92 ± 0.032	0.239CysHis: 0.239 ± 0.015	0.381CysIle: 0.381 ± 0.017	0.175CysLys: 0.175 ± 0.012	0.795CysLeu: 0.795 ± 0.025	0.185CysMet: 0.185 ± 0.014	0.173CysAsn: 0.173 ± 0.013	0.501CysPro: 0.501 ± 0.023	0.217CysGln: 0.217 ± 0.014	0.66CysArg: 0.66 ± 0.025	0.424CysSer: 0.424 ± 0.019	0.375CysThr: 0.375 ± 0.019	0.529CysVal: 0.529 ± 0.025	0.134CysTrp: 0.134 ± 0.01	0.194CysTyr: 0.194 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.185AspAla: 7.185 ± 0.091	0.514AspCys: 0.514 ± 0.025	3.022AspAsp: 3.022 ± 0.067	3.383AspGlu: 3.383 ± 0.057	2.254AspPhe: 2.254 ± 0.048	5.338AspGly: 5.338 ± 0.078	1.355AspHis: 1.355 ± 0.044	2.574AspIle: 2.574 ± 0.047	1.493AspLys: 1.493 ± 0.041	6.443AspLeu: 6.443 ± 0.093	1.423AspMet: 1.423 ± 0.038	1.122AspAsn: 1.122 ± 0.034	4.206AspPro: 4.206 ± 0.069	1.888AspGln: 1.888 ± 0.047	4.906AspArg: 4.906 ± 0.083	2.395AspSer: 2.395 ± 0.049	2.348AspThr: 2.348 ± 0.059	3.281AspVal: 3.281 ± 0.058	1.267AspTrp: 1.267 ± 0.038	1.549AspTyr: 1.549 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.136GluAla: 8.136 ± 0.103	0.336GluCys: 0.336 ± 0.018	3.037GluAsp: 3.037 ± 0.063	2.846GluGlu: 2.846 ± 0.061	1.715GluPhe: 1.715 ± 0.04	4.702GluGly: 4.702 ± 0.068	1.119GluHis: 1.119 ± 0.033	3.357GluIle: 3.357 ± 0.054	1.884GluLys: 1.884 ± 0.049	5.267GluLeu: 5.267 ± 0.072	1.644GluMet: 1.644 ± 0.041	1.515GluAsn: 1.515 ± 0.038	2.797GluPro: 2.797 ± 0.066	1.908GluGln: 1.908 ± 0.039	4.369GluArg: 4.369 ± 0.078	2.426GluSer: 2.426 ± 0.05	3.446GluThr: 3.446 ± 0.063	3.995GluVal: 3.995 ± 0.067	0.773GluTrp: 0.773 ± 0.027	1.012GluTyr: 1.012 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.436PheAla: 4.436 ± 0.059	0.38PheCys: 0.38 ± 0.018	2.573PheAsp: 2.573 ± 0.046	1.75PheGlu: 1.75 ± 0.045	1.259PhePhe: 1.259 ± 0.035	3.568PheGly: 3.568 ± 0.059	0.801PheHis: 0.801 ± 0.029	1.398PheIle: 1.398 ± 0.037	0.71PheLys: 0.71 ± 0.026	3.37PheLeu: 3.37 ± 0.062	0.802PheMet: 0.802 ± 0.028	0.855PheAsn: 0.855 ± 0.027	1.603PhePro: 1.603 ± 0.036	1.056PheGln: 1.056 ± 0.028	2.413PheArg: 2.413 ± 0.05	1.972PheSer: 1.972 ± 0.045	1.782PheThr: 1.782 ± 0.041	2.397PheVal: 2.397 ± 0.048	0.591PheTrp: 0.591 ± 0.027	0.811PheTyr: 0.811 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.84GlyAla: 10.84 ± 0.129	0.823GlyCys: 0.823 ± 0.034	4.767GlyAsp: 4.767 ± 0.078	4.716GlyGlu: 4.716 ± 0.068	3.793GlyPhe: 3.793 ± 0.061	7.763GlyGly: 7.763 ± 0.11	2.024GlyHis: 2.024 ± 0.044	4.511GlyIle: 4.511 ± 0.066	3.009GlyLys: 3.009 ± 0.063	9.88GlyLeu: 9.88 ± 0.106	2.587GlyMet: 2.587 ± 0.046	2.214GlyAsn: 2.214 ± 0.071	4.167GlyPro: 4.167 ± 0.064	3.357GlyGln: 3.357 ± 0.056	7.155GlyArg: 7.155 ± 0.087	4.279GlySer: 4.279 ± 0.065	4.685GlyThr: 4.685 ± 0.096	6.05GlyVal: 6.05 ± 0.077	1.712GlyTrp: 1.712 ± 0.041	2.15GlyTyr: 2.15 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.417HisAla: 2.417 ± 0.048	0.23HisCys: 0.23 ± 0.016	1.321HisAsp: 1.321 ± 0.035	1.114HisGlu: 1.114 ± 0.033	0.798HisPhe: 0.798 ± 0.025	2.043HisGly: 2.043 ± 0.05	0.532HisHis: 0.532 ± 0.022	0.841HisIle: 0.841 ± 0.026	0.419HisLys: 0.419 ± 0.02	2.141HisLeu: 2.141 ± 0.043	0.526HisMet: 0.526 ± 0.023	0.39HisAsn: 0.39 ± 0.018	1.512HisPro: 1.512 ± 0.043	0.562HisGln: 0.562 ± 0.02	1.619HisArg: 1.619 ± 0.037	0.852HisSer: 0.852 ± 0.031	0.635HisThr: 0.635 ± 0.023	1.51HisVal: 1.51 ± 0.036	0.353HisTrp: 0.353 ± 0.017	0.513HisTyr: 0.513 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.128IleAla: 7.128 ± 0.09	0.527IleCys: 0.527 ± 0.021	3.203IleAsp: 3.203 ± 0.055	3.204IleGlu: 3.204 ± 0.055	1.546IlePhe: 1.546 ± 0.035	4.658IleGly: 4.658 ± 0.077	0.918IleHis: 0.918 ± 0.026	1.737IleIle: 1.737 ± 0.043	1.058IleLys: 1.058 ± 0.032	4.617IleLeu: 4.617 ± 0.067	0.978IleMet: 0.978 ± 0.03	1.055IleAsn: 1.055 ± 0.031	2.273IlePro: 2.273 ± 0.053	1.141IleGln: 1.141 ± 0.03	3.756IleArg: 3.756 ± 0.059	2.529IleSer: 2.529 ± 0.049	2.455IleThr: 2.455 ± 0.058	3.461IleVal: 3.461 ± 0.064	0.691IleTrp: 0.691 ± 0.027	0.946IleTyr: 0.946 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.494LysAla: 3.494 ± 0.074	0.156LysCys: 0.156 ± 0.012	1.418LysAsp: 1.418 ± 0.042	1.172LysGlu: 1.172 ± 0.039	0.75LysPhe: 0.75 ± 0.029	2.41LysGly: 2.41 ± 0.058	0.494LysHis: 0.494 ± 0.022	1.293LysIle: 1.293 ± 0.037	0.904LysLys: 0.904 ± 0.037	2.635LysLeu: 2.635 ± 0.047	0.661LysMet: 0.661 ± 0.028	0.616LysAsn: 0.616 ± 0.023	1.798LysPro: 1.798 ± 0.046	0.832LysGln: 0.832 ± 0.026	1.93LysArg: 1.93 ± 0.046	1.383LysSer: 1.383 ± 0.036	1.588LysThr: 1.588 ± 0.043	1.934LysVal: 1.934 ± 0.046	0.347LysTrp: 0.347 ± 0.018	0.542LysTyr: 0.542 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.64LeuAla: 15.64 ± 0.187	0.946LeuCys: 0.946 ± 0.026	6.359LeuAsp: 6.359 ± 0.081	4.791LeuGlu: 4.791 ± 0.069	3.33LeuPhe: 3.33 ± 0.059	8.956LeuGly: 8.956 ± 0.113	1.994LeuHis: 1.994 ± 0.042	5.075LeuIle: 5.075 ± 0.078	2.732LeuLys: 2.732 ± 0.054	9.504LeuLeu: 9.504 ± 0.144	2.556LeuMet: 2.556 ± 0.053	2.505LeuAsn: 2.505 ± 0.046	6.423LeuPro: 6.423 ± 0.088	2.701LeuGln: 2.701 ± 0.048	8.382LeuArg: 8.382 ± 0.09	6.077LeuSer: 6.077 ± 0.092	5.87LeuThr: 5.87 ± 0.064	7.274LeuVal: 7.274 ± 0.085	1.437LeuTrp: 1.437 ± 0.042	1.941LeuTyr: 1.941 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.672MetAla: 3.672 ± 0.057	0.137MetCys: 0.137 ± 0.01	1.244MetAsp: 1.244 ± 0.036	1.105MetGlu: 1.105 ± 0.031	0.72MetPhe: 0.72 ± 0.021	2.114MetGly: 2.114 ± 0.043	0.405MetHis: 0.405 ± 0.02	1.401MetIle: 1.401 ± 0.033	0.855MetLys: 0.855 ± 0.029	2.636MetLeu: 2.636 ± 0.051	0.639MetMet: 0.639 ± 0.025	0.785MetAsn: 0.785 ± 0.028	1.591MetPro: 1.591 ± 0.034	0.987MetGln: 0.987 ± 0.029	2.156MetArg: 2.156 ± 0.049	1.452MetSer: 1.452 ± 0.035	1.927MetThr: 1.927 ± 0.045	1.777MetVal: 1.777 ± 0.045	0.205MetTrp: 0.205 ± 0.013	0.271MetTyr: 0.271 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.925AsnAla: 2.925 ± 0.056	0.216AsnCys: 0.216 ± 0.015	1.316AsnAsp: 1.316 ± 0.055	1.022AsnGlu: 1.022 ± 0.033	0.821AsnPhe: 0.821 ± 0.027	2.101AsnGly: 2.101 ± 0.046	0.459AsnHis: 0.459 ± 0.019	1.14AsnIle: 1.14 ± 0.03	0.514AsnLys: 0.514 ± 0.024	2.41AsnLeu: 2.41 ± 0.043	0.573AsnMet: 0.573 ± 0.022	0.513AsnAsn: 0.513 ± 0.027	1.752AsnPro: 1.752 ± 0.039	0.637AsnGln: 0.637 ± 0.025	1.888AsnArg: 1.888 ± 0.042	1.024AsnSer: 1.024 ± 0.04	1.07AsnThr: 1.07 ± 0.034	1.572AsnVal: 1.572 ± 0.034	0.41AsnTrp: 0.41 ± 0.022	0.567AsnTyr: 0.567 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.04ProAla: 8.04 ± 0.117	0.391ProCys: 0.391 ± 0.018	3.953ProAsp: 3.953 ± 0.064	4.531ProGlu: 4.531 ± 0.075	1.935ProPhe: 1.935 ± 0.035	5.717ProGly: 5.717 ± 0.072	1.079ProHis: 1.079 ± 0.036	2.087ProIle: 2.087 ± 0.042	1.339ProLys: 1.339 ± 0.038	5.175ProLeu: 5.175 ± 0.07	1.359ProMet: 1.359 ± 0.029	1.137ProAsn: 1.137 ± 0.031	2.949ProPro: 2.949 ± 0.062	2.103ProGln: 2.103 ± 0.037	3.708ProArg: 3.708 ± 0.067	2.434ProSer: 2.434 ± 0.044	2.233ProThr: 2.233 ± 0.046	4.564ProVal: 4.564 ± 0.067	0.749ProTrp: 0.749 ± 0.027	1.021ProTyr: 1.021 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.703GlnAla: 4.703 ± 0.083	0.194GlnCys: 0.194 ± 0.013	1.801GlnAsp: 1.801 ± 0.041	1.465GlnGlu: 1.465 ± 0.037	0.955GlnPhe: 0.955 ± 0.03	3.168GlnGly: 3.168 ± 0.06	0.606GlnHis: 0.606 ± 0.02	1.85GlnIle: 1.85 ± 0.04	0.97GlnLys: 0.97 ± 0.031	2.975GlnLeu: 2.975 ± 0.057	0.966GlnMet: 0.966 ± 0.03	0.853GlnAsn: 0.853 ± 0.029	2.039GlnPro: 2.039 ± 0.048	1.146GlnGln: 1.146 ± 0.037	2.468GlnArg: 2.468 ± 0.045	1.582GlnSer: 1.582 ± 0.035	1.59GlnThr: 1.59 ± 0.04	2.483GlnVal: 2.483 ± 0.05	0.371GlnTrp: 0.371 ± 0.017	0.51GlnTyr: 0.51 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.71ArgAla: 9.71 ± 0.117	0.542ArgCys: 0.542 ± 0.022	4.828ArgAsp: 4.828 ± 0.074	4.22ArgGlu: 4.22 ± 0.064	2.906ArgPhe: 2.906 ± 0.059	5.698ArgGly: 5.698 ± 0.075	1.831ArgHis: 1.831 ± 0.045	4.624ArgIle: 4.624 ± 0.066	2.185ArgLys: 2.185 ± 0.051	9.118ArgLeu: 9.118 ± 0.101	2.254ArgMet: 2.254 ± 0.039	1.82ArgAsn: 1.82 ± 0.04	4.448ArgPro: 4.448 ± 0.077	2.878ArgGln: 2.878 ± 0.046	6.667ArgArg: 6.667 ± 0.103	3.394ArgSer: 3.394 ± 0.052	3.01ArgThr: 3.01 ± 0.048	5.025ArgVal: 5.025 ± 0.073	1.165ArgTrp: 1.165 ± 0.03	1.567ArgTyr: 1.567 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.898SerAla: 5.898 ± 0.086	0.414SerCys: 0.414 ± 0.021	2.861SerAsp: 2.861 ± 0.054	2.345SerGlu: 2.345 ± 0.056	1.961SerPhe: 1.961 ± 0.042	5.375SerGly: 5.375 ± 0.084	1.002SerHis: 1.002 ± 0.027	2.133SerIle: 2.133 ± 0.046	1.177SerLys: 1.177 ± 0.034	4.809SerLeu: 4.809 ± 0.067	1.186SerMet: 1.186 ± 0.032	1.024SerAsn: 1.024 ± 0.033	2.607SerPro: 2.607 ± 0.046	1.527SerGln: 1.527 ± 0.037	3.623SerArg: 3.623 ± 0.062	2.262SerSer: 2.262 ± 0.047	2.223SerThr: 2.223 ± 0.042	3.413SerVal: 3.413 ± 0.056	0.818SerTrp: 0.818 ± 0.024	1.155SerTyr: 1.155 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.126ThrAla: 6.126 ± 0.073	0.428ThrCys: 0.428 ± 0.021	2.757ThrAsp: 2.757 ± 0.05	2.676ThrGlu: 2.676 ± 0.047	1.621ThrPhe: 1.621 ± 0.036	5.299ThrGly: 5.299 ± 0.076	1.02ThrHis: 1.02 ± 0.029	2.352ThrIle: 2.352 ± 0.05	1.021ThrLys: 1.021 ± 0.037	5.58ThrLeu: 5.58 ± 0.078	1.103ThrMet: 1.103 ± 0.035	1.025ThrAsn: 1.025 ± 0.031	3.294ThrPro: 3.294 ± 0.059	1.387ThrGln: 1.387 ± 0.037	3.734ThrArg: 3.734 ± 0.054	2.146ThrSer: 2.146 ± 0.045	2.458ThrThr: 2.458 ± 0.053	3.987ThrVal: 3.987 ± 0.072	0.616ThrTrp: 0.616 ± 0.02	1.027ThrTyr: 1.027 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.345ValAla: 9.345 ± 0.102	0.565ValCys: 0.565 ± 0.022	3.598ValAsp: 3.598 ± 0.06	4.353ValGlu: 4.353 ± 0.061	2.551ValPhe: 2.551 ± 0.053	5.098ValGly: 5.098 ± 0.071	1.201ValHis: 1.201 ± 0.034	3.828ValIle: 3.828 ± 0.069	1.827ValLys: 1.827 ± 0.044	7.744ValLeu: 7.744 ± 0.104	1.913ValMet: 1.913 ± 0.046	1.834ValAsn: 1.834 ± 0.04	3.734ValPro: 3.734 ± 0.063	2.114ValGln: 2.114 ± 0.047	4.376ValArg: 4.376 ± 0.062	3.796ValSer: 3.796 ± 0.065	4.333ValThr: 4.333 ± 0.059	5.407ValVal: 5.407 ± 0.076	1.017ValTrp: 1.017 ± 0.029	1.291ValTyr: 1.291 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.432TrpAla: 1.432 ± 0.033	0.125TrpCys: 0.125 ± 0.01	0.76TrpAsp: 0.76 ± 0.027	0.599TrpGlu: 0.599 ± 0.024	0.574TrpPhe: 0.574 ± 0.022	1.128TrpGly: 1.128 ± 0.033	0.352TrpHis: 0.352 ± 0.019	0.73TrpIle: 0.73 ± 0.025	0.436TrpLys: 0.436 ± 0.022	1.955TrpLeu: 1.955 ± 0.045	0.385TrpMet: 0.385 ± 0.015	0.435TrpAsn: 0.435 ± 0.019	0.793TrpPro: 0.793 ± 0.026	0.753TrpGln: 0.753 ± 0.028	1.413TrpArg: 1.413 ± 0.036	0.819TrpSer: 0.819 ± 0.029	0.851TrpThr: 0.851 ± 0.029	0.854TrpVal: 0.854 ± 0.03	0.255TrpTrp: 0.255 ± 0.016	0.278TrpTyr: 0.278 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.446TyrAla: 2.446 ± 0.047	0.214TyrCys: 0.214 ± 0.015	1.52TyrAsp: 1.52 ± 0.043	1.119TyrGlu: 1.119 ± 0.035	0.767TyrPhe: 0.767 ± 0.024	1.994TyrGly: 1.994 ± 0.049	0.461TyrHis: 0.461 ± 0.02	0.691TyrIle: 0.691 ± 0.024	0.469TyrLys: 0.469 ± 0.022	2.165TyrLeu: 2.165 ± 0.045	0.404TyrMet: 0.404 ± 0.019	0.518TyrAsn: 0.518 ± 0.023	1.013TyrPro: 1.013 ± 0.031	0.633TyrGln: 0.633 ± 0.022	1.639TyrArg: 1.639 ± 0.035	0.982TyrSer: 0.982 ± 0.029	0.868TyrThr: 0.868 ± 0.031	1.411TyrVal: 1.411 ± 0.032	0.344TyrTrp: 0.344 ± 0.018	0.503TyrTyr: 0.503 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3736 proteins (1156815 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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