Amino acid dipepetide frequency for Paenibacillus cellulosilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.344AlaAla: 10.344 ± 0.102	0.772AlaCys: 0.772 ± 0.021	5.062AlaAsp: 5.062 ± 0.058	5.601AlaGlu: 5.601 ± 0.06	3.382AlaPhe: 3.382 ± 0.047	6.859AlaGly: 6.859 ± 0.073	1.532AlaHis: 1.532 ± 0.03	5.756AlaIle: 5.756 ± 0.064	3.923AlaLys: 3.923 ± 0.047	8.274AlaLeu: 8.274 ± 0.077	2.317AlaMet: 2.317 ± 0.039	2.962AlaAsn: 2.962 ± 0.041	2.897AlaPro: 2.897 ± 0.046	2.993AlaGln: 2.993 ± 0.044	3.822AlaArg: 3.822 ± 0.047	6.041AlaSer: 6.041 ± 0.061	4.205AlaThr: 4.205 ± 0.085	6.853AlaVal: 6.853 ± 0.064	1.022AlaTrp: 1.022 ± 0.026	2.826AlaTyr: 2.826 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.573CysAla: 0.573 ± 0.019	0.122CysCys: 0.122 ± 0.008	0.394CysAsp: 0.394 ± 0.017	0.438CysGlu: 0.438 ± 0.014	0.32CysPhe: 0.32 ± 0.013	0.765CysGly: 0.765 ± 0.021	0.175CysHis: 0.175 ± 0.009	0.481CysIle: 0.481 ± 0.02	0.297CysLys: 0.297 ± 0.015	0.721CysLeu: 0.721 ± 0.019	0.232CysMet: 0.232 ± 0.011	0.262CysAsn: 0.262 ± 0.011	0.307CysPro: 0.307 ± 0.012	0.209CysGln: 0.209 ± 0.011	0.469CysArg: 0.469 ± 0.025	0.585CysSer: 0.585 ± 0.02	0.411CysThr: 0.411 ± 0.014	0.478CysVal: 0.478 ± 0.016	0.104CysTrp: 0.104 ± 0.008	0.259CysTyr: 0.259 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.576AspAla: 4.576 ± 0.061	0.395AspCys: 0.395 ± 0.016	2.834AspAsp: 2.834 ± 0.045	3.953AspGlu: 3.953 ± 0.046	2.007AspPhe: 2.007 ± 0.036	4.479AspGly: 4.479 ± 0.065	1.105AspHis: 1.105 ± 0.027	3.425AspIle: 3.425 ± 0.04	2.703AspLys: 2.703 ± 0.051	4.739AspLeu: 4.739 ± 0.049	1.344AspMet: 1.344 ± 0.024	2.168AspAsn: 2.168 ± 0.035	2.342AspPro: 2.342 ± 0.037	2.049AspGln: 2.049 ± 0.034	3.123AspArg: 3.123 ± 0.041	3.235AspSer: 3.235 ± 0.041	2.884AspThr: 2.884 ± 0.046	3.695AspVal: 3.695 ± 0.049	0.933AspTrp: 0.933 ± 0.023	2.214AspTyr: 2.214 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.114GluAla: 6.114 ± 0.065	0.362GluCys: 0.362 ± 0.015	2.971GluAsp: 2.971 ± 0.045	4.73GluGlu: 4.73 ± 0.058	1.855GluPhe: 1.855 ± 0.034	4.226GluGly: 4.226 ± 0.044	1.484GluHis: 1.484 ± 0.029	3.616GluIle: 3.616 ± 0.049	3.137GluLys: 3.137 ± 0.046	7.014GluLeu: 7.014 ± 0.078	1.839GluMet: 1.839 ± 0.033	1.967GluAsn: 1.967 ± 0.032	2.361GluPro: 2.361 ± 0.04	3.89GluGln: 3.89 ± 0.057	4.227GluArg: 4.227 ± 0.065	3.551GluSer: 3.551 ± 0.048	3.357GluThr: 3.357 ± 0.044	4.068GluVal: 4.068 ± 0.049	0.977GluTrp: 0.977 ± 0.022	1.845GluTyr: 1.845 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.256PheAla: 3.256 ± 0.041	0.312PheCys: 0.312 ± 0.012	2.409PheAsp: 2.409 ± 0.035	2.43PheGlu: 2.43 ± 0.038	1.494PhePhe: 1.494 ± 0.032	3.13PheGly: 3.13 ± 0.04	0.862PheHis: 0.862 ± 0.022	2.708PheIle: 2.708 ± 0.041	1.742PheLys: 1.742 ± 0.035	3.258PheLeu: 3.258 ± 0.055	1.082PheMet: 1.082 ± 0.022	1.671PheAsn: 1.671 ± 0.033	1.491PhePro: 1.491 ± 0.033	1.288PheGln: 1.288 ± 0.027	2.018PheArg: 2.018 ± 0.034	2.546PheSer: 2.546 ± 0.038	2.396PheThr: 2.396 ± 0.034	3.013PheVal: 3.013 ± 0.044	0.487PheTrp: 0.487 ± 0.016	1.422PheTyr: 1.422 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.982GlyAla: 5.982 ± 0.1	0.724GlyCys: 0.724 ± 0.02	3.689GlyAsp: 3.689 ± 0.05	4.375GlyGlu: 4.375 ± 0.05	3.062GlyPhe: 3.062 ± 0.034	5.694GlyGly: 5.694 ± 0.087	1.473GlyHis: 1.473 ± 0.028	5.4GlyIle: 5.4 ± 0.064	3.924GlyLys: 3.924 ± 0.055	6.857GlyLeu: 6.857 ± 0.071	2.337GlyMet: 2.337 ± 0.036	2.773GlyAsn: 2.773 ± 0.049	1.925GlyPro: 1.925 ± 0.037	2.81GlyGln: 2.81 ± 0.046	3.631GlyArg: 3.631 ± 0.056	5.16GlySer: 5.16 ± 0.066	4.963GlyThr: 4.963 ± 0.087	5.229GlyVal: 5.229 ± 0.055	1.147GlyTrp: 1.147 ± 0.026	2.938GlyTyr: 2.938 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.702HisAla: 1.702 ± 0.036	0.186HisCys: 0.186 ± 0.01	1.048HisAsp: 1.048 ± 0.021	1.273HisGlu: 1.273 ± 0.028	0.939HisPhe: 0.939 ± 0.024	1.495HisGly: 1.495 ± 0.033	0.611HisHis: 0.611 ± 0.02	1.321HisIle: 1.321 ± 0.027	0.794HisLys: 0.794 ± 0.024	1.943HisLeu: 1.943 ± 0.04	0.533HisMet: 0.533 ± 0.017	0.772HisAsn: 0.772 ± 0.02	1.158HisPro: 1.158 ± 0.029	0.778HisGln: 0.778 ± 0.021	1.149HisArg: 1.149 ± 0.026	1.213HisSer: 1.213 ± 0.026	1.114HisThr: 1.114 ± 0.024	1.377HisVal: 1.377 ± 0.027	0.347HisTrp: 0.347 ± 0.014	0.97HisTyr: 0.97 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.373IleAla: 6.373 ± 0.07	0.545IleCys: 0.545 ± 0.019	3.999IleAsp: 3.999 ± 0.042	4.349IleGlu: 4.349 ± 0.052	2.017IlePhe: 2.017 ± 0.035	5.427IleGly: 5.427 ± 0.055	1.377IleHis: 1.377 ± 0.027	4.118IleIle: 4.118 ± 0.054	2.613IleLys: 2.613 ± 0.039	4.902IleLeu: 4.902 ± 0.065	1.636IleMet: 1.636 ± 0.03	2.396IleAsn: 2.396 ± 0.044	2.894IlePro: 2.894 ± 0.041	2.349IleGln: 2.349 ± 0.032	3.818IleArg: 3.818 ± 0.051	4.061IleSer: 4.061 ± 0.05	3.961IleThr: 3.961 ± 0.066	5.556IleVal: 5.556 ± 0.056	0.68IleTrp: 0.68 ± 0.02	2.03IleTyr: 2.03 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.871LysAla: 3.871 ± 0.049	0.244LysCys: 0.244 ± 0.012	2.588LysAsp: 2.588 ± 0.043	3.37LysGlu: 3.37 ± 0.048	1.443LysPhe: 1.443 ± 0.028	3.105LysGly: 3.105 ± 0.043	1.068LysHis: 1.068 ± 0.024	2.35LysIle: 2.35 ± 0.042	2.583LysLys: 2.583 ± 0.042	5.491LysLeu: 5.491 ± 0.068	1.311LysMet: 1.311 ± 0.026	1.591LysAsn: 1.591 ± 0.032	2.212LysPro: 2.212 ± 0.035	2.471LysGln: 2.471 ± 0.038	2.774LysArg: 2.774 ± 0.038	2.864LysSer: 2.864 ± 0.039	2.536LysThr: 2.536 ± 0.043	3.19LysVal: 3.19 ± 0.049	0.651LysTrp: 0.651 ± 0.02	1.608LysTyr: 1.608 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	8.314LeuAla: 8.314 ± 0.077	0.795LeuCys: 0.795 ± 0.021	5.261LeuAsp: 5.261 ± 0.054	5.628LeuGlu: 5.628 ± 0.062	4.336LeuPhe: 4.336 ± 0.059	6.443LeuGly: 6.443 ± 0.073	2.191LeuHis: 2.191 ± 0.04	6.249LeuIle: 6.249 ± 0.067	4.585LeuLys: 4.585 ± 0.055	10.677LeuLeu: 10.677 ± 0.105	2.602LeuMet: 2.602 ± 0.04	3.756LeuAsn: 3.756 ± 0.044	4.356LeuPro: 4.356 ± 0.048	3.918LeuGln: 3.918 ± 0.046	5.142LeuArg: 5.142 ± 0.058	7.059LeuSer: 7.059 ± 0.068	6.01LeuThr: 6.01 ± 0.064	6.343LeuVal: 6.343 ± 0.068	1.021LeuTrp: 1.021 ± 0.025	3.17LeuTyr: 3.17 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.146MetAla: 2.146 ± 0.033	0.166MetCys: 0.166 ± 0.009	1.379MetAsp: 1.379 ± 0.023	1.639MetGlu: 1.639 ± 0.029	1.029MetPhe: 1.029 ± 0.023	1.561MetGly: 1.561 ± 0.031	0.526MetHis: 0.526 ± 0.019	1.776MetIle: 1.776 ± 0.034	1.807MetLys: 1.807 ± 0.028	3.047MetLeu: 3.047 ± 0.043	0.889MetMet: 0.889 ± 0.027	1.47MetAsn: 1.47 ± 0.025	1.247MetPro: 1.247 ± 0.029	1.058MetGln: 1.058 ± 0.024	1.5MetArg: 1.5 ± 0.025	1.915MetSer: 1.915 ± 0.033	1.837MetThr: 1.837 ± 0.029	1.592MetVal: 1.592 ± 0.027	0.243MetTrp: 0.243 ± 0.01	0.798MetTyr: 0.798 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.249AsnAla: 3.249 ± 0.043	0.27AsnCys: 0.27 ± 0.014	2.116AsnAsp: 2.116 ± 0.036	2.575AsnGlu: 2.575 ± 0.041	1.226AsnPhe: 1.226 ± 0.03	3.663AsnGly: 3.663 ± 0.061	0.822AsnHis: 0.822 ± 0.023	2.232AsnIle: 2.232 ± 0.037	1.971AsnLys: 1.971 ± 0.034	3.127AsnLeu: 3.127 ± 0.043	0.986AsnMet: 0.986 ± 0.02	1.811AsnAsn: 1.811 ± 0.044	1.928AsnPro: 1.928 ± 0.034	1.452AsnGln: 1.452 ± 0.03	2.211AsnArg: 2.211 ± 0.035	2.246AsnSer: 2.246 ± 0.042	2.123AsnThr: 2.123 ± 0.042	2.806AsnVal: 2.806 ± 0.04	0.561AsnTrp: 0.561 ± 0.017	1.383AsnTyr: 1.383 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.405ProAla: 3.405 ± 0.055	0.232ProCys: 0.232 ± 0.012	2.576ProAsp: 2.576 ± 0.036	2.914ProGlu: 2.914 ± 0.047	1.833ProPhe: 1.833 ± 0.035	2.736ProGly: 2.736 ± 0.047	0.834ProHis: 0.834 ± 0.021	2.785ProIle: 2.785 ± 0.039	1.61ProLys: 1.61 ± 0.026	3.892ProLeu: 3.892 ± 0.052	1.001ProMet: 1.001 ± 0.023	1.643ProAsn: 1.643 ± 0.031	1.261ProPro: 1.261 ± 0.036	1.334ProGln: 1.334 ± 0.026	1.468ProArg: 1.468 ± 0.028	2.8ProSer: 2.8 ± 0.042	2.236ProThr: 2.236 ± 0.04	3.016ProVal: 3.016 ± 0.041	0.509ProTrp: 0.509 ± 0.016	1.543ProTyr: 1.543 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.688GlnAla: 3.688 ± 0.05	0.225GlnCys: 0.225 ± 0.01	1.644GlnAsp: 1.644 ± 0.028	2.325GlnGlu: 2.325 ± 0.035	1.588GlnPhe: 1.588 ± 0.024	2.538GlnGly: 2.538 ± 0.043	0.872GlnHis: 0.872 ± 0.022	2.365GlnIle: 2.365 ± 0.036	1.538GlnLys: 1.538 ± 0.031	4.717GlnLeu: 4.717 ± 0.055	1.16GlnMet: 1.16 ± 0.024	1.205GlnAsn: 1.205 ± 0.023	1.637GlnPro: 1.637 ± 0.034	2.28GlnGln: 2.28 ± 0.043	2.033GlnArg: 2.033 ± 0.036	2.625GlnSer: 2.625 ± 0.037	2.206GlnThr: 2.206 ± 0.04	2.493GlnVal: 2.493 ± 0.04	0.65GlnTrp: 0.65 ± 0.019	1.508GlnTyr: 1.508 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.767ArgAla: 3.767 ± 0.047	0.415ArgCys: 0.415 ± 0.021	2.605ArgAsp: 2.605 ± 0.039	3.611ArgGlu: 3.611 ± 0.054	2.244ArgPhe: 2.244 ± 0.035	3.159ArgGly: 3.159 ± 0.051	1.116ArgHis: 1.116 ± 0.028	3.846ArgIle: 3.846 ± 0.046	2.823ArgLys: 2.823 ± 0.049	5.552ArgLeu: 5.552 ± 0.059	1.802ArgMet: 1.802 ± 0.034	2.127ArgAsn: 2.127 ± 0.033	1.797ArgPro: 1.797 ± 0.038	2.095ArgGln: 2.095 ± 0.035	3.034ArgArg: 3.034 ± 0.041	3.48ArgSer: 3.48 ± 0.047	3.041ArgThr: 3.041 ± 0.032	3.303ArgVal: 3.303 ± 0.042	0.746ArgTrp: 0.746 ± 0.02	2.043ArgTyr: 2.043 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.367SerAla: 5.367 ± 0.058	0.446SerCys: 0.446 ± 0.016	3.738SerAsp: 3.738 ± 0.053	3.857SerGlu: 3.857 ± 0.048	2.999SerPhe: 2.999 ± 0.04	5.633SerGly: 5.633 ± 0.069	1.173SerHis: 1.173 ± 0.025	4.567SerIle: 4.567 ± 0.052	3.058SerLys: 3.058 ± 0.039	6.361SerLeu: 6.361 ± 0.07	1.822SerMet: 1.822 ± 0.03	2.727SerAsn: 2.727 ± 0.05	2.391SerPro: 2.391 ± 0.043	2.109SerGln: 2.109 ± 0.036	3.201SerArg: 3.201 ± 0.043	5.088SerSer: 5.088 ± 0.076	3.938SerThr: 3.938 ± 0.072	4.792SerVal: 4.792 ± 0.06	0.877SerTrp: 0.877 ± 0.021	2.457SerTyr: 2.457 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.559ThrAla: 5.559 ± 0.089	0.339ThrCys: 0.339 ± 0.015	3.286ThrAsp: 3.286 ± 0.043	3.256ThrGlu: 3.256 ± 0.044	2.496ThrPhe: 2.496 ± 0.045	4.802ThrGly: 4.802 ± 0.08	1.009ThrHis: 1.009 ± 0.02	4.309ThrIle: 4.309 ± 0.061	2.512ThrLys: 2.512 ± 0.042	5.587ThrLeu: 5.587 ± 0.071	1.419ThrMet: 1.419 ± 0.027	2.355ThrAsn: 2.355 ± 0.04	2.548ThrPro: 2.548 ± 0.043	1.674ThrGln: 1.674 ± 0.032	2.366ThrArg: 2.366 ± 0.035	3.89ThrSer: 3.89 ± 0.068	3.643ThrThr: 3.643 ± 0.077	4.886ThrVal: 4.886 ± 0.097	0.658ThrTrp: 0.658 ± 0.024	2.055ThrTyr: 2.055 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	5.336ValAla: 5.336 ± 0.059	0.626ValCys: 0.626 ± 0.019	3.82ValAsp: 3.82 ± 0.051	4.225ValGlu: 4.225 ± 0.054	2.745ValPhe: 2.745 ± 0.048	4.819ValGly: 4.819 ± 0.049	1.468ValHis: 1.468 ± 0.028	4.88ValIle: 4.88 ± 0.055	3.498ValLys: 3.498 ± 0.045	6.978ValLeu: 6.978 ± 0.067	1.94ValMet: 1.94 ± 0.036	2.882ValAsn: 2.882 ± 0.045	3.005ValPro: 3.005 ± 0.042	2.787ValGln: 2.787 ± 0.043	3.74ValArg: 3.74 ± 0.05	5.019ValSer: 5.019 ± 0.068	4.938ValThr: 4.938 ± 0.096	5.329ValVal: 5.329 ± 0.065	0.869ValTrp: 0.869 ± 0.023	2.375ValTyr: 2.375 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.923TrpAla: 0.923 ± 0.022	0.114TrpCys: 0.114 ± 0.009	0.734TrpAsp: 0.734 ± 0.022	0.727TrpGlu: 0.727 ± 0.021	0.575TrpPhe: 0.575 ± 0.019	0.864TrpGly: 0.864 ± 0.021	0.308TrpHis: 0.308 ± 0.01	0.862TrpIle: 0.862 ± 0.023	0.653TrpLys: 0.653 ± 0.02	1.515TrpLeu: 1.515 ± 0.03	0.43TrpMet: 0.43 ± 0.015	0.691TrpAsn: 0.691 ± 0.02	0.408TrpPro: 0.408 ± 0.016	0.517TrpGln: 0.517 ± 0.018	0.714TrpArg: 0.714 ± 0.02	0.937TrpSer: 0.937 ± 0.026	0.797TrpThr: 0.797 ± 0.024	0.788TrpVal: 0.788 ± 0.023	0.195TrpTrp: 0.195 ± 0.01	0.461TrpTyr: 0.461 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.898TyrAla: 2.898 ± 0.041	0.313TyrCys: 0.313 ± 0.012	2.052TyrAsp: 2.052 ± 0.037	2.316TyrGlu: 2.316 ± 0.033	1.431TyrPhe: 1.431 ± 0.028	2.693TyrGly: 2.693 ± 0.042	0.717TyrHis: 0.717 ± 0.019	2.054TyrIle: 2.054 ± 0.036	1.551TyrLys: 1.551 ± 0.029	3.207TyrLeu: 3.207 ± 0.04	0.941TyrMet: 0.941 ± 0.023	1.527TyrAsn: 1.527 ± 0.031	1.461TyrPro: 1.461 ± 0.031	1.238TyrGln: 1.238 ± 0.024	2.167TyrArg: 2.167 ± 0.035	2.287TyrSer: 2.287 ± 0.038	2.051TyrThr: 2.051 ± 0.042	2.469TyrVal: 2.469 ± 0.036	0.534TyrTrp: 0.534 ± 0.016	1.484TyrTyr: 1.484 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6112 proteins (2016309 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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