Amino acid dipepetide frequency for Acetobacter nitrogenifigens DSM 23921 = LMG 23498

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.266AlaAla: 17.266 ± 0.192	1.284AlaCys: 1.284 ± 0.033	6.433AlaAsp: 6.433 ± 0.081	6.594AlaGlu: 6.594 ± 0.089	4.302AlaPhe: 4.302 ± 0.067	10.377AlaGly: 10.377 ± 0.109	2.531AlaHis: 2.531 ± 0.052	5.995AlaIle: 5.995 ± 0.079	3.069AlaLys: 3.069 ± 0.065	14.04AlaLeu: 14.04 ± 0.158	3.281AlaMet: 3.281 ± 0.058	2.825AlaAsn: 2.825 ± 0.056	6.904AlaPro: 6.904 ± 0.106	4.181AlaGln: 4.181 ± 0.058	9.463AlaArg: 9.463 ± 0.107	7.716AlaSer: 7.716 ± 0.095	6.958AlaThr: 6.958 ± 0.081	8.316AlaVal: 8.316 ± 0.088	1.634AlaTrp: 1.634 ± 0.036	2.444AlaTyr: 2.444 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.211CysAla: 1.211 ± 0.034	0.132CysCys: 0.132 ± 0.013	0.57CysAsp: 0.57 ± 0.02	0.447CysGlu: 0.447 ± 0.022	0.339CysPhe: 0.339 ± 0.017	1.05CysGly: 1.05 ± 0.031	0.234CysHis: 0.234 ± 0.014	0.364CysIle: 0.364 ± 0.019	0.161CysLys: 0.161 ± 0.011	0.853CysLeu: 0.853 ± 0.027	0.167CysMet: 0.167 ± 0.013	0.22CysAsn: 0.22 ± 0.013	0.471CysPro: 0.471 ± 0.019	0.247CysGln: 0.247 ± 0.015	0.613CysArg: 0.613 ± 0.023	0.534CysSer: 0.534 ± 0.023	0.423CysThr: 0.423 ± 0.019	0.832CysVal: 0.832 ± 0.027	0.125CysTrp: 0.125 ± 0.01	0.192CysTyr: 0.192 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.853AspAla: 7.853 ± 0.093	0.472AspCys: 0.472 ± 0.02	3.145AspAsp: 3.145 ± 0.067	3.183AspGlu: 3.183 ± 0.06	1.976AspPhe: 1.976 ± 0.043	5.247AspGly: 5.247 ± 0.072	1.281AspHis: 1.281 ± 0.033	2.871AspIle: 2.871 ± 0.058	1.296AspLys: 1.296 ± 0.033	5.625AspLeu: 5.625 ± 0.075	1.395AspMet: 1.395 ± 0.034	1.235AspAsn: 1.235 ± 0.034	3.344AspPro: 3.344 ± 0.059	1.596AspGln: 1.596 ± 0.041	4.178AspArg: 4.178 ± 0.073	2.451AspSer: 2.451 ± 0.042	2.625AspThr: 2.625 ± 0.047	4.453AspVal: 4.453 ± 0.062	0.977AspTrp: 0.977 ± 0.029	1.406AspTyr: 1.406 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.152GluAla: 7.152 ± 0.088	0.362GluCys: 0.362 ± 0.019	2.618GluAsp: 2.618 ± 0.053	2.735GluGlu: 2.735 ± 0.055	1.597GluPhe: 1.597 ± 0.037	3.925GluGly: 3.925 ± 0.06	1.226GluHis: 1.226 ± 0.034	3.112GluIle: 3.112 ± 0.065	1.903GluLys: 1.903 ± 0.048	4.529GluLeu: 4.529 ± 0.073	1.27GluMet: 1.27 ± 0.032	1.615GluAsn: 1.615 ± 0.042	2.326GluPro: 2.326 ± 0.05	2.042GluGln: 2.042 ± 0.04	4.868GluArg: 4.868 ± 0.081	2.628GluSer: 2.628 ± 0.049	3.517GluThr: 3.517 ± 0.061	3.152GluVal: 3.152 ± 0.059	0.686GluTrp: 0.686 ± 0.026	0.934GluTyr: 0.934 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.092PheAla: 4.092 ± 0.063	0.46PheCys: 0.46 ± 0.022	2.507PheAsp: 2.507 ± 0.054	1.772PheGlu: 1.772 ± 0.043	1.318PhePhe: 1.318 ± 0.038	3.493PheGly: 3.493 ± 0.059	0.796PheHis: 0.796 ± 0.025	1.516PheIle: 1.516 ± 0.037	0.762PheLys: 0.762 ± 0.028	3.346PheLeu: 3.346 ± 0.061	0.848PheMet: 0.848 ± 0.03	1.077PheAsn: 1.077 ± 0.033	1.651PhePro: 1.651 ± 0.037	0.93PheGln: 0.93 ± 0.026	2.353PheArg: 2.353 ± 0.05	2.567PheSer: 2.567 ± 0.049	1.95PheThr: 1.95 ± 0.048	2.701PheVal: 2.701 ± 0.05	0.526PheTrp: 0.526 ± 0.026	0.897PheTyr: 0.897 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.502GlyAla: 10.502 ± 0.121	0.926GlyCys: 0.926 ± 0.029	4.424GlyAsp: 4.424 ± 0.061	4.46GlyGlu: 4.46 ± 0.061	3.467GlyPhe: 3.467 ± 0.063	8.095GlyGly: 8.095 ± 0.118	1.964GlyHis: 1.964 ± 0.04	3.297GlyIle: 3.297 ± 0.059	2.833GlyLys: 2.833 ± 0.06	8.887GlyLeu: 8.887 ± 0.094	2.344GlyMet: 2.344 ± 0.046	1.983GlyAsn: 1.983 ± 0.052	3.469GlyPro: 3.469 ± 0.061	2.78GlyGln: 2.78 ± 0.054	6.519GlyArg: 6.519 ± 0.088	5.068GlySer: 5.068 ± 0.071	4.034GlyThr: 4.034 ± 0.066	7.815GlyVal: 7.815 ± 0.086	1.494GlyTrp: 1.494 ± 0.04	2.287GlyTyr: 2.287 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.597HisAla: 2.597 ± 0.045	0.224HisCys: 0.224 ± 0.015	1.442HisAsp: 1.442 ± 0.041	1.171HisGlu: 1.171 ± 0.034	0.823HisPhe: 0.823 ± 0.026	2.113HisGly: 2.113 ± 0.045	0.573HisHis: 0.573 ± 0.027	1.012HisIle: 1.012 ± 0.031	0.479HisLys: 0.479 ± 0.02	1.945HisLeu: 1.945 ± 0.04	0.523HisMet: 0.523 ± 0.021	0.564HisAsn: 0.564 ± 0.022	1.361HisPro: 1.361 ± 0.033	0.542HisGln: 0.542 ± 0.02	1.427HisArg: 1.427 ± 0.037	1.113HisSer: 1.113 ± 0.028	1.045HisThr: 1.045 ± 0.031	1.759HisVal: 1.759 ± 0.039	0.348HisTrp: 0.348 ± 0.017	0.624HisTyr: 0.624 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.527IleAla: 6.527 ± 0.089	0.513IleCys: 0.513 ± 0.021	3.16IleAsp: 3.16 ± 0.05	3.054IleGlu: 3.054 ± 0.06	1.484IlePhe: 1.484 ± 0.039	4.725IleGly: 4.725 ± 0.068	0.95IleHis: 0.95 ± 0.028	1.848IleIle: 1.848 ± 0.047	1.1IleLys: 1.1 ± 0.035	4.144IleLeu: 4.144 ± 0.063	0.947IleMet: 0.947 ± 0.03	1.276IleAsn: 1.276 ± 0.035	2.363IlePro: 2.363 ± 0.047	1.136IleGln: 1.136 ± 0.029	3.257IleArg: 3.257 ± 0.059	3.072IleSer: 3.072 ± 0.06	2.543IleThr: 2.543 ± 0.053	4.113IleVal: 4.113 ± 0.061	0.542IleTrp: 0.542 ± 0.022	1.014IleTyr: 1.014 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.307LysAla: 3.307 ± 0.068	0.125LysCys: 0.125 ± 0.011	1.398LysAsp: 1.398 ± 0.04	1.23LysGlu: 1.23 ± 0.037	0.793LysPhe: 0.793 ± 0.027	2.206LysGly: 2.206 ± 0.048	0.502LysHis: 0.502 ± 0.021	1.61LysIle: 1.61 ± 0.044	1.082LysLys: 1.082 ± 0.039	2.71LysLeu: 2.71 ± 0.044	0.631LysMet: 0.631 ± 0.022	0.854LysAsn: 0.854 ± 0.032	1.703LysPro: 1.703 ± 0.043	0.913LysGln: 0.913 ± 0.028	1.988LysArg: 1.988 ± 0.044	1.667LysSer: 1.667 ± 0.038	1.835LysThr: 1.835 ± 0.04	1.795LysVal: 1.795 ± 0.046	0.288LysTrp: 0.288 ± 0.017	0.526LysTyr: 0.526 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.977LeuAla: 12.977 ± 0.137	1.028LeuCys: 1.028 ± 0.029	5.959LeuAsp: 5.959 ± 0.085	4.592LeuGlu: 4.592 ± 0.072	3.439LeuPhe: 3.439 ± 0.061	8.296LeuGly: 8.296 ± 0.097	2.216LeuHis: 2.216 ± 0.046	4.568LeuIle: 4.568 ± 0.068	2.799LeuLys: 2.799 ± 0.052	9.843LeuLeu: 9.843 ± 0.115	2.185LeuMet: 2.185 ± 0.047	2.659LeuAsn: 2.659 ± 0.048	6.062LeuPro: 6.062 ± 0.079	2.814LeuGln: 2.814 ± 0.05	7.761LeuArg: 7.761 ± 0.083	7.216LeuSer: 7.216 ± 0.085	6.037LeuThr: 6.037 ± 0.065	6.756LeuVal: 6.756 ± 0.08	1.253LeuTrp: 1.253 ± 0.035	2.02LeuTyr: 2.02 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.845MetAla: 2.845 ± 0.051	0.149MetCys: 0.149 ± 0.013	1.059MetAsp: 1.059 ± 0.03	1.106MetGlu: 1.106 ± 0.032	0.74MetPhe: 0.74 ± 0.027	1.687MetGly: 1.687 ± 0.036	0.457MetHis: 0.457 ± 0.022	1.323MetIle: 1.323 ± 0.032	0.856MetLys: 0.856 ± 0.026	2.487MetLeu: 2.487 ± 0.037	0.543MetMet: 0.543 ± 0.024	0.772MetAsn: 0.772 ± 0.027	1.404MetPro: 1.404 ± 0.04	0.837MetGln: 0.837 ± 0.028	1.812MetArg: 1.812 ± 0.04	1.712MetSer: 1.712 ± 0.037	2.076MetThr: 2.076 ± 0.039	1.483MetVal: 1.483 ± 0.037	0.218MetTrp: 0.218 ± 0.016	0.29MetTyr: 0.29 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.39AsnAla: 3.39 ± 0.055	0.2AsnCys: 0.2 ± 0.014	1.476AsnAsp: 1.476 ± 0.039	1.186AsnGlu: 1.186 ± 0.03	1.025AsnPhe: 1.025 ± 0.032	2.562AsnGly: 2.562 ± 0.058	0.551AsnHis: 0.551 ± 0.023	1.379AsnIle: 1.379 ± 0.04	0.62AsnLys: 0.62 ± 0.025	2.371AsnLeu: 2.371 ± 0.058	0.594AsnMet: 0.594 ± 0.021	0.734AsnAsn: 0.734 ± 0.032	1.723AsnPro: 1.723 ± 0.04	0.773AsnGln: 0.773 ± 0.031	1.71AsnArg: 1.71 ± 0.038	1.327AsnSer: 1.327 ± 0.039	1.363AsnThr: 1.363 ± 0.043	2.1AsnVal: 2.1 ± 0.053	0.464AsnTrp: 0.464 ± 0.022	0.772AsnTyr: 0.772 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.287ProAla: 6.287 ± 0.095	0.36ProCys: 0.36 ± 0.019	4.024ProAsp: 4.024 ± 0.061	3.731ProGlu: 3.731 ± 0.062	2.018ProPhe: 2.018 ± 0.05	4.843ProGly: 4.843 ± 0.06	1.282ProHis: 1.282 ± 0.037	2.125ProIle: 2.125 ± 0.043	1.416ProLys: 1.416 ± 0.041	4.994ProLeu: 4.994 ± 0.069	1.132ProMet: 1.132 ± 0.031	1.379ProAsn: 1.379 ± 0.038	3.084ProPro: 3.084 ± 0.075	1.678ProGln: 1.678 ± 0.035	3.101ProArg: 3.101 ± 0.054	3.371ProSer: 3.371 ± 0.055	2.939ProThr: 2.939 ± 0.057	4.484ProVal: 4.484 ± 0.066	0.783ProTrp: 0.783 ± 0.028	1.197ProTyr: 1.197 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.093GlnAla: 4.093 ± 0.066	0.206GlnCys: 0.206 ± 0.013	1.614GlnAsp: 1.614 ± 0.037	1.471GlnGlu: 1.471 ± 0.037	1.096GlnPhe: 1.096 ± 0.029	2.258GlnGly: 2.258 ± 0.049	0.644GlnHis: 0.644 ± 0.024	1.96GlnIle: 1.96 ± 0.044	1.017GlnLys: 1.017 ± 0.029	2.543GlnLeu: 2.543 ± 0.048	0.782GlnMet: 0.782 ± 0.025	0.906GlnAsn: 0.906 ± 0.03	1.76GlnPro: 1.76 ± 0.035	1.114GlnGln: 1.114 ± 0.036	2.212GlnArg: 2.212 ± 0.048	1.926GlnSer: 1.926 ± 0.045	1.965GlnThr: 1.965 ± 0.038	2.073GlnVal: 2.073 ± 0.044	0.428GlnTrp: 0.428 ± 0.019	0.684GlnTyr: 0.684 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.461ArgAla: 8.461 ± 0.098	0.575ArgCys: 0.575 ± 0.023	4.252ArgAsp: 4.252 ± 0.07	4.095ArgGlu: 4.095 ± 0.071	2.929ArgPhe: 2.929 ± 0.058	5.021ArgGly: 5.021 ± 0.065	1.784ArgHis: 1.784 ± 0.039	3.819ArgIle: 3.819 ± 0.06	2.223ArgLys: 2.223 ± 0.046	8.33ArgLeu: 8.33 ± 0.11	1.849ArgMet: 1.849 ± 0.039	2.019ArgAsn: 2.019 ± 0.035	3.72ArgPro: 3.72 ± 0.062	2.53ArgGln: 2.53 ± 0.049	6.484ArgArg: 6.484 ± 0.085	4.144ArgSer: 4.144 ± 0.058	3.477ArgThr: 3.477 ± 0.048	5.108ArgVal: 5.108 ± 0.072	1.093ArgTrp: 1.093 ± 0.036	1.797ArgTyr: 1.797 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.272SerAla: 7.272 ± 0.092	0.563SerCys: 0.563 ± 0.021	3.378SerAsp: 3.378 ± 0.061	2.946SerGlu: 2.946 ± 0.053	2.347SerPhe: 2.347 ± 0.048	6.41SerGly: 6.41 ± 0.097	1.28SerHis: 1.28 ± 0.033	2.84SerIle: 2.84 ± 0.053	1.332SerLys: 1.332 ± 0.034	6.271SerLeu: 6.271 ± 0.077	1.378SerMet: 1.378 ± 0.034	1.524SerAsn: 1.524 ± 0.037	3.51SerPro: 3.51 ± 0.062	1.72SerGln: 1.72 ± 0.044	4.078SerArg: 4.078 ± 0.066	4.028SerSer: 4.028 ± 0.084	3.137SerThr: 3.137 ± 0.067	4.796SerVal: 4.796 ± 0.07	0.859SerTrp: 0.859 ± 0.025	1.522SerTyr: 1.522 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	6.39ThrAla: 6.39 ± 0.087	0.466ThrCys: 0.466 ± 0.021	2.855ThrAsp: 2.855 ± 0.053	2.514ThrGlu: 2.514 ± 0.048	1.915ThrPhe: 1.915 ± 0.04	5.274ThrGly: 5.274 ± 0.082	1.275ThrHis: 1.275 ± 0.033	2.757ThrIle: 2.757 ± 0.05	1.306ThrLys: 1.306 ± 0.035	6.427ThrLeu: 6.427 ± 0.084	1.29ThrMet: 1.29 ± 0.032	1.5ThrAsn: 1.5 ± 0.04	4.124ThrPro: 4.124 ± 0.061	1.726ThrGln: 1.726 ± 0.045	3.632ThrArg: 3.632 ± 0.054	3.29ThrSer: 3.29 ± 0.062	3.289ThrThr: 3.289 ± 0.062	4.242ThrVal: 4.242 ± 0.055	0.715ThrTrp: 0.715 ± 0.026	1.308ThrTyr: 1.308 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.645ValAla: 9.645 ± 0.099	0.74ValCys: 0.74 ± 0.025	4.144ValAsp: 4.144 ± 0.058	4.192ValGlu: 4.192 ± 0.071	2.577ValPhe: 2.577 ± 0.058	5.845ValGly: 5.845 ± 0.069	1.364ValHis: 1.364 ± 0.036	3.818ValIle: 3.818 ± 0.071	1.892ValLys: 1.892 ± 0.042	7.338ValLeu: 7.338 ± 0.086	1.897ValMet: 1.897 ± 0.043	2.012ValAsn: 2.012 ± 0.049	3.459ValPro: 3.459 ± 0.052	2.061ValGln: 2.061 ± 0.04	4.941ValArg: 4.941 ± 0.08	5.113ValSer: 5.113 ± 0.072	5.063ValThr: 5.063 ± 0.068	6.053ValVal: 6.053 ± 0.082	1.008ValTrp: 1.008 ± 0.031	1.357ValTyr: 1.357 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.256TrpAla: 1.256 ± 0.031	0.149TrpCys: 0.149 ± 0.01	0.637TrpAsp: 0.637 ± 0.026	0.567TrpGlu: 0.567 ± 0.024	0.52TrpPhe: 0.52 ± 0.021	1.009TrpGly: 1.009 ± 0.032	0.322TrpHis: 0.322 ± 0.015	0.677TrpIle: 0.677 ± 0.027	0.457TrpLys: 0.457 ± 0.022	1.714TrpLeu: 1.714 ± 0.044	0.367TrpMet: 0.367 ± 0.021	0.489TrpAsn: 0.489 ± 0.022	0.684TrpPro: 0.684 ± 0.029	0.417TrpGln: 0.417 ± 0.019	1.586TrpArg: 1.586 ± 0.037	0.957TrpSer: 0.957 ± 0.035	0.837TrpThr: 0.837 ± 0.028	0.79TrpVal: 0.79 ± 0.026	0.209TrpTrp: 0.209 ± 0.015	0.312TrpTyr: 0.312 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.492TyrAla: 2.492 ± 0.054	0.249TyrCys: 0.249 ± 0.014	1.513TyrAsp: 1.513 ± 0.042	1.149TyrGlu: 1.149 ± 0.034	0.857TyrPhe: 0.857 ± 0.027	2.211TyrGly: 2.211 ± 0.054	0.454TyrHis: 0.454 ± 0.022	0.88TyrIle: 0.88 ± 0.031	0.557TyrLys: 0.557 ± 0.024	2.086TyrLeu: 2.086 ± 0.044	0.433TyrMet: 0.433 ± 0.02	0.676TyrAsn: 0.676 ± 0.029	1.105TyrPro: 1.105 ± 0.031	0.715TyrGln: 0.715 ± 0.027	1.726TyrArg: 1.726 ± 0.04	1.29TyrSer: 1.29 ± 0.04	1.18TyrThr: 1.18 ± 0.038	1.699TyrVal: 1.699 ± 0.036	0.307TyrTrp: 0.307 ± 0.018	0.679TyrTyr: 0.679 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3660 proteins (1164225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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