Amino acid dipepetide frequency for Arthromitus sp. (strain SFB-mouse-Japan)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.831AlaAla: 1.831 ± 0.091	0.517AlaCys: 0.517 ± 0.036	1.824AlaAsp: 1.824 ± 0.076	2.128AlaGlu: 2.128 ± 0.079	1.909AlaPhe: 1.909 ± 0.064	2.295AlaGly: 2.295 ± 0.087	0.667AlaHis: 0.667 ± 0.039	4.525AlaIle: 4.525 ± 0.113	3.091AlaLys: 3.091 ± 0.096	4.022AlaLeu: 4.022 ± 0.109	1.085AlaMet: 1.085 ± 0.054	2.141AlaAsn: 2.141 ± 0.071	0.897AlaPro: 0.897 ± 0.043	1.035AlaGln: 1.035 ± 0.051	1.552AlaArg: 1.552 ± 0.063	2.84AlaSer: 2.84 ± 0.095	1.972AlaThr: 1.972 ± 0.072	2.407AlaVal: 2.407 ± 0.083	0.19AlaTrp: 0.19 ± 0.018	1.655AlaTyr: 1.655 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.486CysAla: 0.486 ± 0.028	0.177CysCys: 0.177 ± 0.025	0.912CysAsp: 0.912 ± 0.044	0.807CysGlu: 0.807 ± 0.045	0.627CysPhe: 0.627 ± 0.038	0.948CysGly: 0.948 ± 0.05	0.169CysHis: 0.169 ± 0.016	1.379CysIle: 1.379 ± 0.058	1.096CysLys: 1.096 ± 0.053	0.91CysLeu: 0.91 ± 0.047	0.304CysMet: 0.304 ± 0.026	0.853CysAsn: 0.853 ± 0.041	0.283CysPro: 0.283 ± 0.025	0.209CysGln: 0.209 ± 0.019	0.399CysArg: 0.399 ± 0.028	0.864CysSer: 0.864 ± 0.047	0.437CysThr: 0.437 ± 0.03	0.815CysVal: 0.815 ± 0.046	0.038CysTrp: 0.038 ± 0.008	0.494CysTyr: 0.494 ± 0.031	0.0CysXaa: 0.0 ± 0.0
Asp	2.308AspAla: 2.308 ± 0.073	0.65AspCys: 0.65 ± 0.042	3.767AspAsp: 3.767 ± 0.091	4.723AspGlu: 4.723 ± 0.103	3.568AspPhe: 3.568 ± 0.091	3.733AspGly: 3.733 ± 0.107	0.716AspHis: 0.716 ± 0.042	7.783AspIle: 7.783 ± 0.117	6.052AspLys: 6.052 ± 0.111	5.699AspLeu: 5.699 ± 0.114	1.402AspMet: 1.402 ± 0.047	4.278AspAsn: 4.278 ± 0.119	1.372AspPro: 1.372 ± 0.056	1.113AspGln: 1.113 ± 0.059	2.173AspArg: 2.173 ± 0.073	4.13AspSer: 4.13 ± 0.109	2.511AspThr: 2.511 ± 0.079	3.849AspVal: 3.849 ± 0.089	0.249AspTrp: 0.249 ± 0.022	2.99AspTyr: 2.99 ± 0.074	0.0AspXaa: 0.0 ± 0.0
Glu	2.521GluAla: 2.521 ± 0.082	0.819GluCys: 0.819 ± 0.041	4.189GluAsp: 4.189 ± 0.087	4.852GluGlu: 4.852 ± 0.119	3.995GluPhe: 3.995 ± 0.103	3.338GluGly: 3.338 ± 0.09	0.838GluHis: 0.838 ± 0.048	7.747GluIle: 7.747 ± 0.141	5.648GluLys: 5.648 ± 0.12	6.375GluLeu: 6.375 ± 0.128	1.649GluMet: 1.649 ± 0.064	5.625GluAsn: 5.625 ± 0.115	1.1GluPro: 1.1 ± 0.05	1.364GluGln: 1.364 ± 0.063	2.378GluArg: 2.378 ± 0.082	3.915GluSer: 3.915 ± 0.093	2.325GluThr: 2.325 ± 0.07	4.2GluVal: 4.2 ± 0.102	0.332GluTrp: 0.332 ± 0.028	3.317GluTyr: 3.317 ± 0.083	0.0GluXaa: 0.0 ± 0.0
Phe	1.594PheAla: 1.594 ± 0.058	0.64PheCys: 0.64 ± 0.038	3.37PheAsp: 3.37 ± 0.093	3.429PheGlu: 3.429 ± 0.086	2.185PhePhe: 2.185 ± 0.081	3.091PheGly: 3.091 ± 0.092	0.503PheHis: 0.503 ± 0.035	6.06PheIle: 6.06 ± 0.146	5.038PheLys: 5.038 ± 0.129	4.812PheLeu: 4.812 ± 0.114	1.32PheMet: 1.32 ± 0.049	4.215PheAsn: 4.215 ± 0.108	1.149PhePro: 1.149 ± 0.05	0.847PheGln: 0.847 ± 0.044	1.708PheArg: 1.708 ± 0.064	4.029PheSer: 4.029 ± 0.103	2.388PheThr: 2.388 ± 0.085	3.11PheVal: 3.11 ± 0.083	0.308PheTrp: 0.308 ± 0.026	2.234PheTyr: 2.234 ± 0.086	0.0PheXaa: 0.0 ± 0.0
Gly	2.777GlyAla: 2.777 ± 0.094	0.741GlyCys: 0.741 ± 0.045	3.501GlyAsp: 3.501 ± 0.102	3.691GlyGlu: 3.691 ± 0.083	3.153GlyPhe: 3.153 ± 0.088	3.499GlyGly: 3.499 ± 0.101	0.866GlyHis: 0.866 ± 0.048	6.85GlyIle: 6.85 ± 0.15	4.812GlyLys: 4.812 ± 0.113	4.538GlyLeu: 4.538 ± 0.124	1.37GlyMet: 1.37 ± 0.058	3.592GlyAsn: 3.592 ± 0.092	0.838GlyPro: 0.838 ± 0.049	1.14GlyGln: 1.14 ± 0.049	2.139GlyArg: 2.139 ± 0.061	3.974GlySer: 3.974 ± 0.109	2.821GlyThr: 2.821 ± 0.096	4.139GlyVal: 4.139 ± 0.112	0.291GlyTrp: 0.291 ± 0.024	2.737GlyTyr: 2.737 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	0.545HisAla: 0.545 ± 0.035	0.16HisCys: 0.16 ± 0.02	0.752HisAsp: 0.752 ± 0.037	0.819HisGlu: 0.819 ± 0.04	0.557HisPhe: 0.557 ± 0.036	0.906HisGly: 0.906 ± 0.044	0.228HisHis: 0.228 ± 0.022	1.383HisIle: 1.383 ± 0.055	1.128HisLys: 1.128 ± 0.043	1.182HisLeu: 1.182 ± 0.055	0.294HisMet: 0.294 ± 0.025	0.963HisAsn: 0.963 ± 0.045	0.462HisPro: 0.462 ± 0.038	0.251HisGln: 0.251 ± 0.025	0.545HisArg: 0.545 ± 0.033	0.79HisSer: 0.79 ± 0.038	0.585HisThr: 0.585 ± 0.035	0.741HisVal: 0.741 ± 0.04	0.065HisTrp: 0.065 ± 0.012	0.557HisTyr: 0.557 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	4.39IleAla: 4.39 ± 0.107	1.603IleCys: 1.603 ± 0.064	7.547IleAsp: 7.547 ± 0.138	7.348IleGlu: 7.348 ± 0.132	5.758IlePhe: 5.758 ± 0.141	6.02IleGly: 6.02 ± 0.146	1.396IleHis: 1.396 ± 0.052	11.13IleIle: 11.13 ± 0.186	9.776IleLys: 9.776 ± 0.17	11.052IleLeu: 11.052 ± 0.201	2.095IleMet: 2.095 ± 0.073	8.811IleAsn: 8.811 ± 0.185	3.184IlePro: 3.184 ± 0.083	2.31IleGln: 2.31 ± 0.076	3.68IleArg: 3.68 ± 0.093	8.761IleSer: 8.761 ± 0.162	4.664IleThr: 4.664 ± 0.116	6.51IleVal: 6.51 ± 0.13	0.441IleTrp: 0.441 ± 0.032	4.643IleTyr: 4.643 ± 0.114	0.0IleXaa: 0.0 ± 0.0
Lys	2.878LysAla: 2.878 ± 0.086	0.921LysCys: 0.921 ± 0.046	6.06LysAsp: 6.06 ± 0.131	6.647LysGlu: 6.647 ± 0.132	4.772LysPhe: 4.772 ± 0.107	3.915LysGly: 3.915 ± 0.1	1.054LysHis: 1.054 ± 0.042	10.106LysIle: 10.106 ± 0.171	7.221LysLys: 7.221 ± 0.152	7.57LysLeu: 7.57 ± 0.134	2.097LysMet: 2.097 ± 0.058	8.142LysAsn: 8.142 ± 0.169	1.845LysPro: 1.845 ± 0.1	2.004LysGln: 2.004 ± 0.074	2.775LysArg: 2.775 ± 0.076	5.771LysSer: 5.771 ± 0.104	3.619LysThr: 3.619 ± 0.108	5.283LysVal: 5.283 ± 0.128	0.414LysTrp: 0.414 ± 0.035	4.622LysTyr: 4.622 ± 0.101	0.0LysXaa: 0.0 ± 0.0
Leu	3.526LeuAla: 3.526 ± 0.108	1.223LeuCys: 1.223 ± 0.052	6.145LeuAsp: 6.145 ± 0.108	5.712LeuGlu: 5.712 ± 0.116	4.512LeuPhe: 4.512 ± 0.112	5.275LeuGly: 5.275 ± 0.121	1.081LeuHis: 1.081 ± 0.051	9.27LeuIle: 9.27 ± 0.18	8.626LeuLys: 8.626 ± 0.153	7.354LeuLeu: 7.354 ± 0.176	1.993LeuMet: 1.993 ± 0.066	8.29LeuAsn: 8.29 ± 0.164	2.238LeuPro: 2.238 ± 0.07	1.651LeuGln: 1.651 ± 0.075	3.558LeuArg: 3.558 ± 0.091	7.652LeuSer: 7.652 ± 0.145	4.122LeuThr: 4.122 ± 0.091	4.723LeuVal: 4.723 ± 0.107	0.416LeuTrp: 0.416 ± 0.032	3.6LeuTyr: 3.6 ± 0.095	0.0LeuXaa: 0.0 ± 0.0
Met	1.073MetAla: 1.073 ± 0.059	0.306MetCys: 0.306 ± 0.025	1.544MetAsp: 1.544 ± 0.059	1.514MetGlu: 1.514 ± 0.053	1.168MetPhe: 1.168 ± 0.05	1.381MetGly: 1.381 ± 0.057	0.281MetHis: 0.281 ± 0.024	2.331MetIle: 2.331 ± 0.078	2.122MetLys: 2.122 ± 0.064	1.864MetLeu: 1.864 ± 0.073	0.507MetMet: 0.507 ± 0.031	1.662MetAsn: 1.662 ± 0.063	0.633MetPro: 0.633 ± 0.044	0.503MetGln: 0.503 ± 0.032	0.935MetArg: 0.935 ± 0.054	1.719MetSer: 1.719 ± 0.061	0.921MetThr: 0.921 ± 0.041	1.362MetVal: 1.362 ± 0.06	0.11MetTrp: 0.11 ± 0.017	0.919MetTyr: 0.919 ± 0.045	0.0MetXaa: 0.0 ± 0.0
Asn	2.496AsnAla: 2.496 ± 0.075	0.811AsnCys: 0.811 ± 0.042	4.476AsnAsp: 4.476 ± 0.108	4.958AsnGlu: 4.958 ± 0.101	4.063AsnPhe: 4.063 ± 0.122	4.291AsnGly: 4.291 ± 0.112	0.893AsnHis: 0.893 ± 0.052	9.561AsnIle: 9.561 ± 0.186	7.325AsnLys: 7.325 ± 0.134	7.369AsnLeu: 7.369 ± 0.144	1.757AsnMet: 1.757 ± 0.064	6.225AsnAsn: 6.225 ± 0.165	1.943AsnPro: 1.943 ± 0.07	1.62AsnGln: 1.62 ± 0.056	2.489AsnArg: 2.489 ± 0.085	5.412AsnSer: 5.412 ± 0.131	3.321AsnThr: 3.321 ± 0.105	4.172AsnVal: 4.172 ± 0.103	0.374AsnTrp: 0.374 ± 0.028	3.598AsnTyr: 3.598 ± 0.085	0.0AsnXaa: 0.0 ± 0.0
Pro	0.883ProAla: 0.883 ± 0.043	0.264ProCys: 0.264 ± 0.025	1.307ProAsp: 1.307 ± 0.059	1.645ProGlu: 1.645 ± 0.073	1.191ProPhe: 1.191 ± 0.043	1.195ProGly: 1.195 ± 0.053	0.458ProHis: 0.458 ± 0.035	2.639ProIle: 2.639 ± 0.087	1.972ProLys: 1.972 ± 0.071	2.01ProLeu: 2.01 ± 0.077	0.509ProMet: 0.509 ± 0.033	1.78ProAsn: 1.78 ± 0.066	0.574ProPro: 0.574 ± 0.044	0.665ProGln: 0.665 ± 0.039	0.69ProArg: 0.69 ± 0.041	1.89ProSer: 1.89 ± 0.075	1.237ProThr: 1.237 ± 0.064	1.47ProVal: 1.47 ± 0.054	0.171ProTrp: 0.171 ± 0.022	1.157ProTyr: 1.157 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	1.068GlnAla: 1.068 ± 0.064	0.158GlnCys: 0.158 ± 0.021	1.282GlnAsp: 1.282 ± 0.061	1.408GlnGlu: 1.408 ± 0.064	0.906GlnPhe: 0.906 ± 0.048	1.305GlnGly: 1.305 ± 0.061	0.236GlnHis: 0.236 ± 0.022	2.302GlnIle: 2.302 ± 0.071	1.818GlnLys: 1.818 ± 0.062	1.744GlnLeu: 1.744 ± 0.061	0.568GlnMet: 0.568 ± 0.034	1.803GlnAsn: 1.803 ± 0.062	0.475GlnPro: 0.475 ± 0.031	0.511GlnGln: 0.511 ± 0.039	0.838GlnArg: 0.838 ± 0.047	1.311GlnSer: 1.311 ± 0.047	0.997GlnThr: 0.997 ± 0.054	1.324GlnVal: 1.324 ± 0.058	0.101GlnTrp: 0.101 ± 0.015	0.838GlnTyr: 0.838 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	1.495ArgAla: 1.495 ± 0.062	0.437ArgCys: 0.437 ± 0.031	2.534ArgAsp: 2.534 ± 0.084	3.045ArgGlu: 3.045 ± 0.09	1.86ArgPhe: 1.86 ± 0.067	2.071ArgGly: 2.071 ± 0.071	0.46ArgHis: 0.46 ± 0.032	3.718ArgIle: 3.718 ± 0.098	2.804ArgLys: 2.804 ± 0.084	2.675ArgLeu: 2.675 ± 0.075	0.87ArgMet: 0.87 ± 0.049	2.502ArgAsn: 2.502 ± 0.076	0.731ArgPro: 0.731 ± 0.042	0.731ArgGln: 0.731 ± 0.039	1.459ArgArg: 1.459 ± 0.066	2.033ArgSer: 2.033 ± 0.072	1.484ArgThr: 1.484 ± 0.057	2.5ArgVal: 2.5 ± 0.077	0.236ArgTrp: 0.236 ± 0.022	1.622ArgTyr: 1.622 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	2.639SerAla: 2.639 ± 0.094	0.819SerCys: 0.819 ± 0.042	3.993SerAsp: 3.993 ± 0.101	4.308SerGlu: 4.308 ± 0.102	3.674SerPhe: 3.674 ± 0.093	4.546SerGly: 4.546 ± 0.121	0.908SerHis: 0.908 ± 0.037	8.408SerIle: 8.408 ± 0.144	6.491SerLys: 6.491 ± 0.134	6.991SerLeu: 6.991 ± 0.125	1.641SerMet: 1.641 ± 0.059	5.543SerAsn: 5.543 ± 0.141	1.617SerPro: 1.617 ± 0.074	1.685SerGln: 1.685 ± 0.059	2.487SerArg: 2.487 ± 0.074	5.718SerSer: 5.718 ± 0.209	3.663SerThr: 3.663 ± 0.132	4.206SerVal: 4.206 ± 0.109	0.397SerTrp: 0.397 ± 0.031	3.136SerTyr: 3.136 ± 0.092	0.0SerXaa: 0.0 ± 0.0
Thr	1.919ThrAla: 1.919 ± 0.07	0.479ThrCys: 0.479 ± 0.031	2.342ThrAsp: 2.342 ± 0.073	2.289ThrGlu: 2.289 ± 0.081	2.28ThrPhe: 2.28 ± 0.077	3.131ThrGly: 3.131 ± 0.113	0.705ThrHis: 0.705 ± 0.041	4.514ThrIle: 4.514 ± 0.109	3.328ThrLys: 3.328 ± 0.093	4.538ThrLeu: 4.538 ± 0.103	0.828ThrMet: 0.828 ± 0.041	2.99ThrAsn: 2.99 ± 0.095	1.535ThrPro: 1.535 ± 0.064	1.246ThrGln: 1.246 ± 0.057	1.525ThrArg: 1.525 ± 0.064	3.727ThrSer: 3.727 ± 0.154	2.519ThrThr: 2.519 ± 0.112	2.595ThrVal: 2.595 ± 0.085	0.211ThrTrp: 0.211 ± 0.024	1.97ThrTyr: 1.97 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	2.407ValAla: 2.407 ± 0.075	0.965ValCys: 0.965 ± 0.046	3.906ValAsp: 3.906 ± 0.088	3.716ValGlu: 3.716 ± 0.097	3.074ValPhe: 3.074 ± 0.087	3.583ValGly: 3.583 ± 0.098	0.84ValHis: 0.84 ± 0.042	6.083ValIle: 6.083 ± 0.119	5.034ValLys: 5.034 ± 0.111	5.693ValLeu: 5.693 ± 0.124	1.349ValMet: 1.349 ± 0.057	4.136ValAsn: 4.136 ± 0.102	1.582ValPro: 1.582 ± 0.063	1.172ValGln: 1.172 ± 0.053	2.09ValArg: 2.09 ± 0.069	4.789ValSer: 4.789 ± 0.111	2.88ValThr: 2.88 ± 0.088	3.837ValVal: 3.837 ± 0.1	0.291ValTrp: 0.291 ± 0.025	2.633ValTyr: 2.633 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.213TrpAla: 0.213 ± 0.02	0.074TrpCys: 0.074 ± 0.015	0.355TrpAsp: 0.355 ± 0.028	0.308TrpGlu: 0.308 ± 0.024	0.291TrpPhe: 0.291 ± 0.028	0.346TrpGly: 0.346 ± 0.027	0.089TrpHis: 0.089 ± 0.012	0.543TrpIle: 0.543 ± 0.037	0.361TrpLys: 0.361 ± 0.03	0.336TrpLeu: 0.336 ± 0.029	0.156TrpMet: 0.156 ± 0.019	0.342TrpAsn: 0.342 ± 0.029	0.108TrpPro: 0.108 ± 0.014	0.148TrpGln: 0.148 ± 0.018	0.175TrpArg: 0.175 ± 0.018	0.302TrpSer: 0.302 ± 0.028	0.239TrpThr: 0.239 ± 0.026	0.294TrpVal: 0.294 ± 0.024	0.044TrpTrp: 0.044 ± 0.01	0.205TrpTyr: 0.205 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.537TyrAla: 1.537 ± 0.064	0.441TyrCys: 0.441 ± 0.036	3.262TyrAsp: 3.262 ± 0.099	3.182TyrGlu: 3.182 ± 0.08	2.485TyrPhe: 2.485 ± 0.088	2.597TyrGly: 2.597 ± 0.075	0.526TyrHis: 0.526 ± 0.032	4.787TyrIle: 4.787 ± 0.114	3.972TyrLys: 3.972 ± 0.094	4.231TyrLeu: 4.231 ± 0.101	1.058TyrMet: 1.058 ± 0.048	3.26TyrAsn: 3.26 ± 0.091	1.14TyrPro: 1.14 ± 0.061	0.792TyrGln: 0.792 ± 0.043	1.672TyrArg: 1.672 ± 0.059	3.245TyrSer: 3.245 ± 0.088	1.966TyrThr: 1.966 ± 0.072	2.525TyrVal: 2.525 ± 0.076	0.247TyrTrp: 0.247 ± 0.027	1.964TyrTyr: 1.964 ± 0.08	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1487 proteins (473593 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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