Amino acid dipepetide frequency for Winogradskyella sp. PG-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.641AlaAla: 3.641 ± 0.079	0.533AlaCys: 0.533 ± 0.025	3.283AlaAsp: 3.283 ± 0.06	3.743AlaGlu: 3.743 ± 0.078	3.239AlaPhe: 3.239 ± 0.063	3.839AlaGly: 3.839 ± 0.074	1.023AlaHis: 1.023 ± 0.027	5.498AlaIle: 5.498 ± 0.089	4.562AlaLys: 4.562 ± 0.077	6.049AlaLeu: 6.049 ± 0.085	1.42AlaMet: 1.42 ± 0.037	3.599AlaAsn: 3.599 ± 0.062	1.714AlaPro: 1.714 ± 0.043	2.136AlaGln: 2.136 ± 0.043	1.772AlaArg: 1.772 ± 0.046	4.059AlaSer: 4.059 ± 0.069	3.585AlaThr: 3.585 ± 0.081	3.687AlaVal: 3.687 ± 0.063	0.573AlaTrp: 0.573 ± 0.023	2.476AlaTyr: 2.476 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.442CysAla: 0.442 ± 0.017	0.102CysCys: 0.102 ± 0.011	0.517CysAsp: 0.517 ± 0.03	0.441CysGlu: 0.441 ± 0.019	0.425CysPhe: 0.425 ± 0.023	0.594CysGly: 0.594 ± 0.029	0.161CysHis: 0.161 ± 0.014	0.646CysIle: 0.646 ± 0.029	0.492CysLys: 0.492 ± 0.022	0.636CysLeu: 0.636 ± 0.024	0.129CysMet: 0.129 ± 0.011	0.436CysAsn: 0.436 ± 0.024	0.292CysPro: 0.292 ± 0.02	0.201CysGln: 0.201 ± 0.015	0.179CysArg: 0.179 ± 0.012	0.525CysSer: 0.525 ± 0.027	0.383CysThr: 0.383 ± 0.021	0.41CysVal: 0.41 ± 0.021	0.065CysTrp: 0.065 ± 0.011	0.306CysTyr: 0.306 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.926AspAla: 3.926 ± 0.079	0.474AspCys: 0.474 ± 0.024	3.744AspAsp: 3.744 ± 0.124	3.853AspGlu: 3.853 ± 0.066	3.773AspPhe: 3.773 ± 0.065	4.071AspGly: 4.071 ± 0.12	0.822AspHis: 0.822 ± 0.03	5.166AspIle: 5.166 ± 0.077	4.168AspLys: 4.168 ± 0.082	5.575AspLeu: 5.575 ± 0.083	1.168AspMet: 1.168 ± 0.033	3.875AspAsn: 3.875 ± 0.066	1.626AspPro: 1.626 ± 0.061	1.443AspGln: 1.443 ± 0.035	1.752AspArg: 1.752 ± 0.037	3.686AspSer: 3.686 ± 0.067	3.07AspThr: 3.07 ± 0.089	3.814AspVal: 3.814 ± 0.066	0.766AspTrp: 0.766 ± 0.03	3.205AspTyr: 3.205 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.317GluAla: 4.317 ± 0.073	0.358GluCys: 0.358 ± 0.028	4.145GluAsp: 4.145 ± 0.06	4.319GluGlu: 4.319 ± 0.074	3.095GluPhe: 3.095 ± 0.053	3.662GluGly: 3.662 ± 0.065	1.1GluHis: 1.1 ± 0.03	5.287GluIle: 5.287 ± 0.071	4.972GluLys: 4.972 ± 0.076	6.079GluLeu: 6.079 ± 0.094	1.394GluMet: 1.394 ± 0.039	4.613GluAsn: 4.613 ± 0.064	1.549GluPro: 1.549 ± 0.041	2.199GluGln: 2.199 ± 0.046	2.364GluArg: 2.364 ± 0.057	3.757GluSer: 3.757 ± 0.057	3.849GluThr: 3.849 ± 0.067	4.155GluVal: 4.155 ± 0.084	0.584GluTrp: 0.584 ± 0.023	2.268GluTyr: 2.268 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.843PheAla: 2.843 ± 0.06	0.382PheCys: 0.382 ± 0.02	3.396PheAsp: 3.396 ± 0.053	3.485PheGlu: 3.485 ± 0.055	2.678PhePhe: 2.678 ± 0.068	3.7PheGly: 3.7 ± 0.073	0.751PheHis: 0.751 ± 0.027	4.127PheIle: 4.127 ± 0.073	4.098PheLys: 4.098 ± 0.073	4.502PheLeu: 4.502 ± 0.078	1.062PheMet: 1.062 ± 0.033	3.86PheAsn: 3.86 ± 0.065	1.614PhePro: 1.614 ± 0.04	1.499PheGln: 1.499 ± 0.04	1.562PheArg: 1.562 ± 0.041	4.121PheSer: 4.121 ± 0.072	3.134PheThr: 3.134 ± 0.065	2.966PheVal: 2.966 ± 0.057	0.573PheTrp: 0.573 ± 0.024	2.239PheTyr: 2.239 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	3.76GlyAla: 3.76 ± 0.072	0.6GlyCys: 0.6 ± 0.033	3.698GlyAsp: 3.698 ± 0.08	3.598GlyGlu: 3.598 ± 0.063	3.826GlyPhe: 3.826 ± 0.064	4.483GlyGly: 4.483 ± 0.086	1.068GlyHis: 1.068 ± 0.034	5.237GlyIle: 5.237 ± 0.089	4.645GlyLys: 4.645 ± 0.064	5.822GlyLeu: 5.822 ± 0.088	1.414GlyMet: 1.414 ± 0.042	3.976GlyAsn: 3.976 ± 0.09	1.326GlyPro: 1.326 ± 0.042	1.816GlyGln: 1.816 ± 0.038	2.033GlyArg: 2.033 ± 0.048	4.089GlySer: 4.089 ± 0.072	3.917GlyThr: 3.917 ± 0.082	4.052GlyVal: 4.052 ± 0.071	0.731GlyTrp: 0.731 ± 0.028	2.765GlyTyr: 2.765 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.872HisAla: 0.872 ± 0.032	0.183HisCys: 0.183 ± 0.012	0.794HisAsp: 0.794 ± 0.026	0.774HisGlu: 0.774 ± 0.027	1.067HisPhe: 1.067 ± 0.034	0.978HisGly: 0.978 ± 0.035	0.429HisHis: 0.429 ± 0.021	1.465HisIle: 1.465 ± 0.035	1.266HisLys: 1.266 ± 0.035	1.668HisLeu: 1.668 ± 0.042	0.303HisMet: 0.303 ± 0.016	1.121HisAsn: 1.121 ± 0.031	0.779HisPro: 0.779 ± 0.03	0.634HisGln: 0.634 ± 0.026	0.602HisArg: 0.602 ± 0.027	1.027HisSer: 1.027 ± 0.027	0.857HisThr: 0.857 ± 0.025	0.861HisVal: 0.861 ± 0.032	0.215HisTrp: 0.215 ± 0.013	0.823HisTyr: 0.823 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.541IleAla: 5.541 ± 0.084	0.649IleCys: 0.649 ± 0.026	5.485IleAsp: 5.485 ± 0.075	6.054IleGlu: 6.054 ± 0.091	3.634IlePhe: 3.634 ± 0.061	5.242IleGly: 5.242 ± 0.084	1.272IleHis: 1.272 ± 0.037	6.79IleIle: 6.79 ± 0.103	6.12IleLys: 6.12 ± 0.091	7.277IleLeu: 7.277 ± 0.102	1.429IleMet: 1.429 ± 0.037	5.445IleAsn: 5.445 ± 0.083	3.119IlePro: 3.119 ± 0.049	2.346IleGln: 2.346 ± 0.057	2.485IleArg: 2.485 ± 0.046	6.091IleSer: 6.091 ± 0.078	5.156IleThr: 5.156 ± 0.087	4.971IleVal: 4.971 ± 0.07	0.738IleTrp: 0.738 ± 0.029	3.053IleTyr: 3.053 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	5.035LysAla: 5.035 ± 0.091	0.312LysCys: 0.312 ± 0.019	4.912LysAsp: 4.912 ± 0.087	5.452LysGlu: 5.452 ± 0.089	3.003LysPhe: 3.003 ± 0.059	4.404LysGly: 4.404 ± 0.064	1.554LysHis: 1.554 ± 0.041	5.898LysIle: 5.898 ± 0.094	6.275LysLys: 6.275 ± 0.108	6.723LysLeu: 6.723 ± 0.087	1.809LysMet: 1.809 ± 0.044	4.922LysAsn: 4.922 ± 0.076	2.399LysPro: 2.399 ± 0.052	2.709LysGln: 2.709 ± 0.051	3.042LysArg: 3.042 ± 0.065	5.104LysSer: 5.104 ± 0.085	4.975LysThr: 4.975 ± 0.077	4.669LysVal: 4.669 ± 0.075	0.747LysTrp: 0.747 ± 0.032	3.011LysTyr: 3.011 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	5.292LeuAla: 5.292 ± 0.085	0.703LeuCys: 0.703 ± 0.026	5.434LeuAsp: 5.434 ± 0.079	5.942LeuGlu: 5.942 ± 0.069	4.916LeuPhe: 4.916 ± 0.099	5.604LeuGly: 5.604 ± 0.084	1.412LeuHis: 1.412 ± 0.035	7.237LeuIle: 7.237 ± 0.107	8.201LeuLys: 8.201 ± 0.122	8.229LeuLeu: 8.229 ± 0.117	2.017LeuMet: 2.017 ± 0.049	6.412LeuAsn: 6.412 ± 0.09	3.311LeuPro: 3.311 ± 0.058	2.857LeuGln: 2.857 ± 0.053	3.099LeuArg: 3.099 ± 0.054	6.756LeuSer: 6.756 ± 0.087	5.009LeuThr: 5.009 ± 0.077	5.424LeuVal: 5.424 ± 0.085	0.844LeuTrp: 0.844 ± 0.03	3.308LeuTyr: 3.308 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.449MetAla: 1.449 ± 0.041	0.129MetCys: 0.129 ± 0.011	1.094MetAsp: 1.094 ± 0.03	1.121MetGlu: 1.121 ± 0.029	0.859MetPhe: 0.859 ± 0.029	1.21MetGly: 1.21 ± 0.033	0.391MetHis: 0.391 ± 0.018	1.565MetIle: 1.565 ± 0.041	1.972MetLys: 1.972 ± 0.048	1.919MetLeu: 1.919 ± 0.047	0.542MetMet: 0.542 ± 0.024	1.328MetAsn: 1.328 ± 0.032	0.81MetPro: 0.81 ± 0.027	0.793MetGln: 0.793 ± 0.025	0.864MetArg: 0.864 ± 0.03	1.497MetSer: 1.497 ± 0.036	1.181MetThr: 1.181 ± 0.03	1.318MetVal: 1.318 ± 0.04	0.154MetTrp: 0.154 ± 0.012	0.745MetTyr: 0.745 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	4.019AsnAla: 4.019 ± 0.057	0.504AsnCys: 0.504 ± 0.028	3.971AsnAsp: 3.971 ± 0.081	3.973AsnGlu: 3.973 ± 0.064	3.267AsnPhe: 3.267 ± 0.054	4.363AsnGly: 4.363 ± 0.076	1.075AsnHis: 1.075 ± 0.031	5.393AsnIle: 5.393 ± 0.093	4.566AsnLys: 4.566 ± 0.084	5.745AsnLeu: 5.745 ± 0.071	1.4AsnMet: 1.4 ± 0.034	4.503AsnAsn: 4.503 ± 0.085	2.782AsnPro: 2.782 ± 0.063	2.331AsnGln: 2.331 ± 0.052	2.306AsnArg: 2.306 ± 0.05	4.581AsnSer: 4.581 ± 0.083	4.156AsnThr: 4.156 ± 0.096	3.779AsnVal: 3.779 ± 0.068	0.818AsnTrp: 0.818 ± 0.029	3.233AsnTyr: 3.233 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.555ProAla: 1.555 ± 0.041	0.203ProCys: 0.203 ± 0.015	1.885ProAsp: 1.885 ± 0.039	2.565ProGlu: 2.565 ± 0.051	1.842ProPhe: 1.842 ± 0.043	1.674ProGly: 1.674 ± 0.038	0.562ProHis: 0.562 ± 0.023	2.803ProIle: 2.803 ± 0.046	2.537ProLys: 2.537 ± 0.05	2.84ProLeu: 2.84 ± 0.049	0.688ProMet: 0.688 ± 0.028	2.405ProAsn: 2.405 ± 0.047	0.758ProPro: 0.758 ± 0.036	0.962ProGln: 0.962 ± 0.032	0.851ProArg: 0.851 ± 0.029	2.167ProSer: 2.167 ± 0.052	1.982ProThr: 1.982 ± 0.061	1.896ProVal: 1.896 ± 0.041	0.333ProTrp: 0.333 ± 0.019	1.379ProTyr: 1.379 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.722GlnAla: 1.722 ± 0.045	0.171GlnCys: 0.171 ± 0.012	1.669GlnAsp: 1.669 ± 0.041	1.959GlnGlu: 1.959 ± 0.042	1.707GlnPhe: 1.707 ± 0.047	1.663GlnGly: 1.663 ± 0.044	0.554GlnHis: 0.554 ± 0.024	2.507GlnIle: 2.507 ± 0.052	2.412GlnLys: 2.412 ± 0.056	3.556GlnLeu: 3.556 ± 0.064	0.759GlnMet: 0.759 ± 0.023	2.18GlnAsn: 2.18 ± 0.043	1.108GlnPro: 1.108 ± 0.028	1.24GlnGln: 1.24 ± 0.034	1.177GlnArg: 1.177 ± 0.033	1.992GlnSer: 1.992 ± 0.043	1.836GlnThr: 1.836 ± 0.044	1.76GlnVal: 1.76 ± 0.043	0.369GlnTrp: 0.369 ± 0.019	1.243GlnTyr: 1.243 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.085ArgAla: 2.085 ± 0.05	0.179ArgCys: 0.179 ± 0.012	1.797ArgAsp: 1.797 ± 0.038	1.835ArgGlu: 1.835 ± 0.043	1.9ArgPhe: 1.9 ± 0.051	1.908ArgGly: 1.908 ± 0.042	0.586ArgHis: 0.586 ± 0.024	2.897ArgIle: 2.897 ± 0.059	2.534ArgLys: 2.534 ± 0.051	3.295ArgLeu: 3.295 ± 0.058	0.822ArgMet: 0.822 ± 0.025	2.025ArgAsn: 2.025 ± 0.047	1.032ArgPro: 1.032 ± 0.029	1.178ArgGln: 1.178 ± 0.031	1.307ArgArg: 1.307 ± 0.035	1.955ArgSer: 1.955 ± 0.049	1.845ArgThr: 1.845 ± 0.042	2.014ArgVal: 2.014 ± 0.038	0.349ArgTrp: 0.349 ± 0.018	1.534ArgTyr: 1.534 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.777SerAla: 3.777 ± 0.061	0.592SerCys: 0.592 ± 0.024	3.99SerAsp: 3.99 ± 0.062	4.411SerGlu: 4.411 ± 0.066	3.778SerPhe: 3.778 ± 0.07	4.661SerGly: 4.661 ± 0.078	1.09SerHis: 1.09 ± 0.031	5.861SerIle: 5.861 ± 0.087	5.401SerLys: 5.401 ± 0.084	6.016SerLeu: 6.016 ± 0.09	1.268SerMet: 1.268 ± 0.038	4.603SerAsn: 4.603 ± 0.086	2.007SerPro: 2.007 ± 0.046	2.137SerGln: 2.137 ± 0.047	2.083SerArg: 2.083 ± 0.042	4.608SerSer: 4.608 ± 0.092	3.839SerThr: 3.839 ± 0.077	4.107SerVal: 4.107 ± 0.067	0.75SerTrp: 0.75 ± 0.028	2.957SerTyr: 2.957 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.489ThrAla: 3.489 ± 0.079	0.377ThrCys: 0.377 ± 0.025	3.434ThrAsp: 3.434 ± 0.071	3.623ThrGlu: 3.623 ± 0.063	3.192ThrPhe: 3.192 ± 0.062	3.859ThrGly: 3.859 ± 0.096	0.971ThrHis: 0.971 ± 0.029	5.502ThrIle: 5.502 ± 0.092	4.16ThrLys: 4.16 ± 0.068	5.459ThrLeu: 5.459 ± 0.088	1.018ThrMet: 1.018 ± 0.029	3.803ThrAsn: 3.803 ± 0.096	2.16ThrPro: 2.16 ± 0.052	1.752ThrGln: 1.752 ± 0.046	1.67ThrArg: 1.67 ± 0.047	4.042ThrSer: 4.042 ± 0.079	3.657ThrThr: 3.657 ± 0.101	3.722ThrVal: 3.722 ± 0.097	0.628ThrTrp: 0.628 ± 0.031	2.609ThrTyr: 2.609 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	3.757ValAla: 3.757 ± 0.08	0.495ValCys: 0.495 ± 0.021	3.613ValAsp: 3.613 ± 0.086	3.95ValGlu: 3.95 ± 0.064	3.287ValPhe: 3.287 ± 0.066	3.722ValGly: 3.722 ± 0.072	0.89ValHis: 0.89 ± 0.031	5.176ValIle: 5.176 ± 0.075	4.381ValLys: 4.381 ± 0.07	5.809ValLeu: 5.809 ± 0.077	1.241ValMet: 1.241 ± 0.031	3.872ValAsn: 3.872 ± 0.063	1.907ValPro: 1.907 ± 0.043	1.52ValGln: 1.52 ± 0.035	1.853ValArg: 1.853 ± 0.045	4.374ValSer: 4.374 ± 0.063	3.655ValThr: 3.655 ± 0.095	3.976ValVal: 3.976 ± 0.063	0.557ValTrp: 0.557 ± 0.027	2.384ValTyr: 2.384 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.547TrpAla: 0.547 ± 0.021	0.094TrpCys: 0.094 ± 0.008	0.622TrpAsp: 0.622 ± 0.026	0.651TrpGlu: 0.651 ± 0.028	0.601TrpPhe: 0.601 ± 0.027	0.58TrpGly: 0.58 ± 0.028	0.215TrpHis: 0.215 ± 0.014	0.78TrpIle: 0.78 ± 0.028	0.777TrpLys: 0.777 ± 0.028	0.995TrpLeu: 0.995 ± 0.037	0.285TrpMet: 0.285 ± 0.018	0.769TrpAsn: 0.769 ± 0.033	0.225TrpPro: 0.225 ± 0.016	0.398TrpGln: 0.398 ± 0.022	0.398TrpArg: 0.398 ± 0.018	0.703TrpSer: 0.703 ± 0.029	0.594TrpThr: 0.594 ± 0.024	0.577TrpVal: 0.577 ± 0.022	0.151TrpTrp: 0.151 ± 0.011	0.46TrpTyr: 0.46 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.359TyrAla: 2.359 ± 0.049	0.342TyrCys: 0.342 ± 0.017	2.491TyrAsp: 2.491 ± 0.052	2.319TyrGlu: 2.319 ± 0.046	2.502TyrPhe: 2.502 ± 0.056	2.641TyrGly: 2.641 ± 0.054	0.791TyrHis: 0.791 ± 0.025	3.064TyrIle: 3.064 ± 0.053	3.417TyrLys: 3.417 ± 0.063	3.812TyrLeu: 3.812 ± 0.077	0.772TyrMet: 0.772 ± 0.027	3.019TyrAsn: 3.019 ± 0.053	1.37TyrPro: 1.37 ± 0.038	1.434TyrGln: 1.434 ± 0.041	1.678TyrArg: 1.678 ± 0.036	2.802TyrSer: 2.802 ± 0.052	2.446TyrThr: 2.446 ± 0.073	2.261TyrVal: 2.261 ± 0.045	0.477TyrTrp: 0.477 ± 0.022	1.959TyrTyr: 1.959 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3520 proteins (1145739 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---