Amino acid dipepetide frequency for Alkaliphilus peptidifermentans DSM 18978

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.752AlaAla: 4.752 ± 0.083	0.648AlaCys: 0.648 ± 0.025	2.761AlaAsp: 2.761 ± 0.047	3.923AlaGlu: 3.923 ± 0.063	2.783AlaPhe: 2.783 ± 0.052	4.458AlaGly: 4.458 ± 0.076	0.99AlaHis: 0.99 ± 0.032	6.292AlaIle: 6.292 ± 0.079	4.129AlaLys: 4.129 ± 0.061	6.321AlaLeu: 6.321 ± 0.074	1.845AlaMet: 1.845 ± 0.04	2.705AlaAsn: 2.705 ± 0.05	1.589AlaPro: 1.589 ± 0.041	1.618AlaGln: 1.618 ± 0.045	2.128AlaArg: 2.128 ± 0.041	3.542AlaSer: 3.542 ± 0.051	3.329AlaThr: 3.329 ± 0.095	4.414AlaVal: 4.414 ± 0.061	0.432AlaTrp: 0.432 ± 0.021	2.248AlaTyr: 2.248 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.428CysAla: 0.428 ± 0.018	0.154CysCys: 0.154 ± 0.012	0.518CysAsp: 0.518 ± 0.019	0.519CysGlu: 0.519 ± 0.02	0.394CysPhe: 0.394 ± 0.019	0.914CysGly: 0.914 ± 0.035	0.261CysHis: 0.261 ± 0.016	0.856CysIle: 0.856 ± 0.022	0.71CysLys: 0.71 ± 0.027	0.728CysLeu: 0.728 ± 0.025	0.225CysMet: 0.225 ± 0.013	0.568CysAsn: 0.568 ± 0.023	0.436CysPro: 0.436 ± 0.024	0.305CysGln: 0.305 ± 0.015	0.394CysArg: 0.394 ± 0.017	0.721CysSer: 0.721 ± 0.022	0.484CysThr: 0.484 ± 0.019	0.523CysVal: 0.523 ± 0.023	0.078CysTrp: 0.078 ± 0.008	0.367CysTyr: 0.367 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.777AspAla: 2.777 ± 0.05	0.508AspCys: 0.508 ± 0.02	2.605AspAsp: 2.605 ± 0.061	4.492AspGlu: 4.492 ± 0.065	2.54AspPhe: 2.54 ± 0.05	3.495AspGly: 3.495 ± 0.067	0.837AspHis: 0.837 ± 0.027	6.046AspIle: 6.046 ± 0.071	4.038AspLys: 4.038 ± 0.058	4.844AspLeu: 4.844 ± 0.07	1.44AspMet: 1.44 ± 0.032	2.799AspAsn: 2.799 ± 0.048	1.554AspPro: 1.554 ± 0.036	1.173AspGln: 1.173 ± 0.034	1.992AspArg: 1.992 ± 0.036	2.844AspSer: 2.844 ± 0.049	2.533AspThr: 2.533 ± 0.054	3.392AspVal: 3.392 ± 0.055	0.511AspTrp: 0.511 ± 0.022	2.423AspTyr: 2.423 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.307GluAla: 5.307 ± 0.073	0.535GluCys: 0.535 ± 0.022	4.301GluAsp: 4.301 ± 0.065	7.199GluGlu: 7.199 ± 0.102	2.662GluPhe: 2.662 ± 0.046	4.865GluGly: 4.865 ± 0.073	1.017GluHis: 1.017 ± 0.032	7.704GluIle: 7.704 ± 0.092	6.734GluLys: 6.734 ± 0.085	6.773GluLeu: 6.773 ± 0.069	2.291GluMet: 2.291 ± 0.048	4.266GluAsn: 4.266 ± 0.063	1.551GluPro: 1.551 ± 0.035	1.649GluGln: 1.649 ± 0.044	2.783GluArg: 2.783 ± 0.049	3.38GluSer: 3.38 ± 0.05	3.168GluThr: 3.168 ± 0.052	5.398GluVal: 5.398 ± 0.067	0.562GluTrp: 0.562 ± 0.021	2.829GluTyr: 2.829 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.395PheAla: 2.395 ± 0.05	0.441PheCys: 0.441 ± 0.018	2.392PheAsp: 2.392 ± 0.039	2.603PheGlu: 2.603 ± 0.049	2.035PhePhe: 2.035 ± 0.049	2.713PheGly: 2.713 ± 0.057	0.754PheHis: 0.754 ± 0.022	4.485PheIle: 4.485 ± 0.074	2.977PheLys: 2.977 ± 0.055	3.865PheLeu: 3.865 ± 0.06	1.177PheMet: 1.177 ± 0.034	2.642PheAsn: 2.642 ± 0.052	1.365PhePro: 1.365 ± 0.036	1.293PheGln: 1.293 ± 0.034	1.358PheArg: 1.358 ± 0.032	3.065PheSer: 3.065 ± 0.048	2.4PheThr: 2.4 ± 0.045	2.642PheVal: 2.642 ± 0.045	0.366PheTrp: 0.366 ± 0.016	1.691PheTyr: 1.691 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.45GlyAla: 4.45 ± 0.097	0.838GlyCys: 0.838 ± 0.029	3.27GlyAsp: 3.27 ± 0.053	4.435GlyGlu: 4.435 ± 0.069	3.305GlyPhe: 3.305 ± 0.058	4.778GlyGly: 4.778 ± 0.096	1.228GlyHis: 1.228 ± 0.032	7.087GlyIle: 7.087 ± 0.078	5.1GlyLys: 5.1 ± 0.062	6.35GlyLeu: 6.35 ± 0.082	1.932GlyMet: 1.932 ± 0.044	3.304GlyAsn: 3.304 ± 0.053	1.471GlyPro: 1.471 ± 0.05	1.776GlyGln: 1.776 ± 0.035	2.649GlyArg: 2.649 ± 0.049	3.729GlySer: 3.729 ± 0.051	3.608GlyThr: 3.608 ± 0.07	4.823GlyVal: 4.823 ± 0.062	0.583GlyTrp: 0.583 ± 0.024	2.984GlyTyr: 2.984 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.831HisAla: 0.831 ± 0.028	0.219HisCys: 0.219 ± 0.013	0.806HisAsp: 0.806 ± 0.029	1.119HisGlu: 1.119 ± 0.028	0.814HisPhe: 0.814 ± 0.026	1.178HisGly: 1.178 ± 0.032	0.482HisHis: 0.482 ± 0.024	1.609HisIle: 1.609 ± 0.04	1.076HisLys: 1.076 ± 0.028	1.656HisLeu: 1.656 ± 0.038	0.448HisMet: 0.448 ± 0.017	0.898HisAsn: 0.898 ± 0.028	0.811HisPro: 0.811 ± 0.027	0.655HisGln: 0.655 ± 0.023	0.719HisArg: 0.719 ± 0.024	1.076HisSer: 1.076 ± 0.03	0.843HisThr: 0.843 ± 0.024	0.92HisVal: 0.92 ± 0.025	0.189HisTrp: 0.189 ± 0.015	0.753HisTyr: 0.753 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.267IleAla: 6.267 ± 0.078	0.989IleCys: 0.989 ± 0.033	5.906IleAsp: 5.906 ± 0.074	7.589IleGlu: 7.589 ± 0.083	4.068IlePhe: 4.068 ± 0.065	6.604IleGly: 6.604 ± 0.098	1.659IleHis: 1.659 ± 0.04	9.673IleIle: 9.673 ± 0.111	7.522IleLys: 7.522 ± 0.084	8.966IleLeu: 8.966 ± 0.108	2.457IleMet: 2.457 ± 0.042	5.675IleAsn: 5.675 ± 0.072	3.764IlePro: 3.764 ± 0.054	2.642IleGln: 2.642 ± 0.041	3.433IleArg: 3.433 ± 0.053	6.477IleSer: 6.477 ± 0.07	5.408IleThr: 5.408 ± 0.082	6.291IleVal: 6.291 ± 0.068	0.624IleTrp: 0.624 ± 0.027	3.444IleTyr: 3.444 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.64LysAla: 4.64 ± 0.068	0.581LysCys: 0.581 ± 0.022	4.616LysAsp: 4.616 ± 0.059	7.389LysGlu: 7.389 ± 0.084	2.171LysPhe: 2.171 ± 0.045	5.025LysGly: 5.025 ± 0.056	1.242LysHis: 1.242 ± 0.03	6.971LysIle: 6.971 ± 0.081	6.353LysLys: 6.353 ± 0.079	6.799LysLeu: 6.799 ± 0.081	2.189LysMet: 2.189 ± 0.042	4.525LysAsn: 4.525 ± 0.071	2.128LysPro: 2.128 ± 0.04	2.233LysGln: 2.233 ± 0.045	2.998LysArg: 2.998 ± 0.047	4.094LysSer: 4.094 ± 0.059	3.692LysThr: 3.692 ± 0.055	4.793LysVal: 4.793 ± 0.053	0.532LysTrp: 0.532 ± 0.023	3.134LysTyr: 3.134 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	5.671LeuAla: 5.671 ± 0.077	0.898LeuCys: 0.898 ± 0.025	4.891LeuAsp: 4.891 ± 0.069	6.852LeuGlu: 6.852 ± 0.082	4.003LeuPhe: 4.003 ± 0.075	6.131LeuGly: 6.131 ± 0.089	1.529LeuHis: 1.529 ± 0.036	8.567LeuIle: 8.567 ± 0.091	7.765LeuLys: 7.765 ± 0.092	9.314LeuLeu: 9.314 ± 0.103	2.748LeuMet: 2.748 ± 0.047	5.157LeuAsn: 5.157 ± 0.056	3.267LeuPro: 3.267 ± 0.05	2.978LeuGln: 2.978 ± 0.044	3.568LeuArg: 3.568 ± 0.054	6.36LeuSer: 6.36 ± 0.081	4.822LeuThr: 4.822 ± 0.066	5.781LeuVal: 5.781 ± 0.066	0.682LeuTrp: 0.682 ± 0.024	3.223LeuTyr: 3.223 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.004MetAla: 2.004 ± 0.042	0.192MetCys: 0.192 ± 0.012	1.558MetAsp: 1.558 ± 0.036	2.332MetGlu: 2.332 ± 0.04	0.962MetPhe: 0.962 ± 0.028	2.049MetGly: 2.049 ± 0.044	0.366MetHis: 0.366 ± 0.019	2.407MetIle: 2.407 ± 0.045	2.615MetLys: 2.615 ± 0.042	2.507MetLeu: 2.507 ± 0.051	0.872MetMet: 0.872 ± 0.033	1.509MetAsn: 1.509 ± 0.035	0.929MetPro: 0.929 ± 0.032	0.712MetGln: 0.712 ± 0.024	0.937MetArg: 0.937 ± 0.028	1.535MetSer: 1.535 ± 0.041	1.381MetThr: 1.381 ± 0.035	1.877MetVal: 1.877 ± 0.037	0.172MetTrp: 0.172 ± 0.012	0.796MetTyr: 0.796 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.685AsnAla: 2.685 ± 0.042	0.549AsnCys: 0.549 ± 0.024	2.55AsnAsp: 2.55 ± 0.048	3.833AsnGlu: 3.833 ± 0.062	2.009AsnPhe: 2.009 ± 0.039	3.284AsnGly: 3.284 ± 0.055	1.036AsnHis: 1.036 ± 0.025	5.955AsnIle: 5.955 ± 0.07	4.304AsnLys: 4.304 ± 0.058	4.944AsnLeu: 4.944 ± 0.063	1.393AsnMet: 1.393 ± 0.032	3.486AsnAsn: 3.486 ± 0.059	2.174AsnPro: 2.174 ± 0.046	2.023AsnGln: 2.023 ± 0.05	2.342AsnArg: 2.342 ± 0.045	3.309AsnSer: 3.309 ± 0.052	2.861AsnThr: 2.861 ± 0.055	3.108AsnVal: 3.108 ± 0.059	0.5AsnTrp: 0.5 ± 0.021	2.337AsnTyr: 2.337 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	1.807ProAla: 1.807 ± 0.043	0.285ProCys: 0.285 ± 0.016	1.645ProAsp: 1.645 ± 0.038	2.408ProGlu: 2.408 ± 0.04	1.522ProPhe: 1.522 ± 0.036	1.928ProGly: 1.928 ± 0.039	0.668ProHis: 0.668 ± 0.02	3.134ProIle: 3.134 ± 0.048	1.999ProLys: 1.999 ± 0.037	2.965ProLeu: 2.965 ± 0.048	0.815ProMet: 0.815 ± 0.023	1.55ProAsn: 1.55 ± 0.035	0.905ProPro: 0.905 ± 0.034	1.143ProGln: 1.143 ± 0.03	1.001ProArg: 1.001 ± 0.029	1.973ProSer: 1.973 ± 0.037	1.765ProThr: 1.765 ± 0.05	2.352ProVal: 2.352 ± 0.041	0.311ProTrp: 0.311 ± 0.015	1.41ProTyr: 1.41 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.689GlnAla: 1.689 ± 0.036	0.241GlnCys: 0.241 ± 0.012	1.338GlnAsp: 1.338 ± 0.031	2.273GlnGlu: 2.273 ± 0.042	1.14GlnPhe: 1.14 ± 0.03	1.753GlnGly: 1.753 ± 0.038	0.553GlnHis: 0.553 ± 0.023	2.498GlnIle: 2.498 ± 0.044	2.105GlnLys: 2.105 ± 0.038	3.253GlnLeu: 3.253 ± 0.055	0.922GlnMet: 0.922 ± 0.029	1.46GlnAsn: 1.46 ± 0.039	0.872GlnPro: 0.872 ± 0.029	1.394GlnGln: 1.394 ± 0.041	1.274GlnArg: 1.274 ± 0.031	1.591GlnSer: 1.591 ± 0.038	1.215GlnThr: 1.215 ± 0.031	1.867GlnVal: 1.867 ± 0.041	0.331GlnTrp: 0.331 ± 0.015	1.276GlnTyr: 1.276 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.114ArgAla: 2.114 ± 0.044	0.333ArgCys: 0.333 ± 0.015	1.993ArgAsp: 1.993 ± 0.04	2.973ArgGlu: 2.973 ± 0.049	1.637ArgPhe: 1.637 ± 0.036	2.417ArgGly: 2.417 ± 0.051	0.628ArgHis: 0.628 ± 0.02	3.705ArgIle: 3.705 ± 0.06	2.895ArgLys: 2.895 ± 0.05	3.647ArgLeu: 3.647 ± 0.054	1.088ArgMet: 1.088 ± 0.031	2.039ArgAsn: 2.039 ± 0.036	1.074ArgPro: 1.074 ± 0.032	1.215ArgGln: 1.215 ± 0.034	1.812ArgArg: 1.812 ± 0.039	1.948ArgSer: 1.948 ± 0.036	1.676ArgThr: 1.676 ± 0.038	2.652ArgVal: 2.652 ± 0.056	0.321ArgTrp: 0.321 ± 0.017	1.506ArgTyr: 1.506 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	2.994SerAla: 2.994 ± 0.052	0.584SerCys: 0.584 ± 0.024	2.774SerAsp: 2.774 ± 0.047	3.522SerGlu: 3.522 ± 0.047	3.172SerPhe: 3.172 ± 0.042	4.065SerGly: 4.065 ± 0.065	1.099SerHis: 1.099 ± 0.029	6.441SerIle: 6.441 ± 0.08	4.478SerLys: 4.478 ± 0.058	5.925SerLeu: 5.925 ± 0.073	1.676SerMet: 1.676 ± 0.035	3.357SerAsn: 3.357 ± 0.056	1.825SerPro: 1.825 ± 0.035	1.862SerGln: 1.862 ± 0.038	2.238SerArg: 2.238 ± 0.043	3.802SerSer: 3.802 ± 0.072	3.241SerThr: 3.241 ± 0.058	3.704SerVal: 3.704 ± 0.048	0.503SerTrp: 0.503 ± 0.022	2.465SerTyr: 2.465 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.433ThrAla: 3.433 ± 0.057	0.423ThrCys: 0.423 ± 0.019	2.546ThrAsp: 2.546 ± 0.051	3.222ThrGlu: 3.222 ± 0.047	2.161ThrPhe: 2.161 ± 0.046	4.154ThrGly: 4.154 ± 0.117	0.934ThrHis: 0.934 ± 0.024	5.262ThrIle: 5.262 ± 0.081	3.135ThrLys: 3.135 ± 0.043	4.87ThrLeu: 4.87 ± 0.061	1.272ThrMet: 1.272 ± 0.032	2.574ThrAsn: 2.574 ± 0.042	2.051ThrPro: 2.051 ± 0.039	1.316ThrGln: 1.316 ± 0.035	1.758ThrArg: 1.758 ± 0.034	3.132ThrSer: 3.132 ± 0.049	2.974ThrThr: 2.974 ± 0.055	3.669ThrVal: 3.669 ± 0.067	0.419ThrTrp: 0.419 ± 0.02	1.955ThrTyr: 1.955 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.32ValAla: 4.32 ± 0.068	0.635ValCys: 0.635 ± 0.021	3.782ValAsp: 3.782 ± 0.06	5.102ValGlu: 5.102 ± 0.075	2.983ValPhe: 2.983 ± 0.054	4.471ValGly: 4.471 ± 0.067	0.916ValHis: 0.916 ± 0.026	6.369ValIle: 6.369 ± 0.073	4.833ValLys: 4.833 ± 0.067	6.076ValLeu: 6.076 ± 0.071	1.728ValMet: 1.728 ± 0.039	3.374ValAsn: 3.374 ± 0.054	2.182ValPro: 2.182 ± 0.045	1.456ValGln: 1.456 ± 0.031	2.243ValArg: 2.243 ± 0.046	4.024ValSer: 4.024 ± 0.061	3.484ValThr: 3.484 ± 0.059	4.638ValVal: 4.638 ± 0.065	0.466ValTrp: 0.466 ± 0.021	2.342ValTyr: 2.342 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.448TrpAla: 0.448 ± 0.022	0.08TrpCys: 0.08 ± 0.008	0.448TrpAsp: 0.448 ± 0.024	0.545TrpGlu: 0.545 ± 0.023	0.375TrpPhe: 0.375 ± 0.02	0.63TrpGly: 0.63 ± 0.026	0.144TrpHis: 0.144 ± 0.011	0.722TrpIle: 0.722 ± 0.026	0.546TrpLys: 0.546 ± 0.021	0.723TrpLeu: 0.723 ± 0.023	0.23TrpMet: 0.23 ± 0.013	0.48TrpAsn: 0.48 ± 0.022	0.224TrpPro: 0.224 ± 0.015	0.299TrpGln: 0.299 ± 0.017	0.331TrpArg: 0.331 ± 0.018	0.459TrpSer: 0.459 ± 0.019	0.386TrpThr: 0.386 ± 0.02	0.51TrpVal: 0.51 ± 0.022	0.106TrpTrp: 0.106 ± 0.011	0.323TrpTyr: 0.323 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.895TyrAla: 1.895 ± 0.045	0.451TyrCys: 0.451 ± 0.02	2.141TyrAsp: 2.141 ± 0.045	2.646TyrGlu: 2.646 ± 0.048	1.922TyrPhe: 1.922 ± 0.044	2.788TyrGly: 2.788 ± 0.051	0.76TyrHis: 0.76 ± 0.026	3.674TyrIle: 3.674 ± 0.054	2.789TyrLys: 2.789 ± 0.053	3.677TyrLeu: 3.677 ± 0.063	0.963TyrMet: 0.963 ± 0.027	2.316TyrAsn: 2.316 ± 0.039	1.417TyrPro: 1.417 ± 0.036	1.3TyrGln: 1.3 ± 0.032	1.718TyrArg: 1.718 ± 0.037	2.667TyrSer: 2.667 ± 0.049	1.989TyrThr: 1.989 ± 0.039	2.07TyrVal: 2.07 ± 0.042	0.323TyrTrp: 0.323 ± 0.018	1.85TyrTyr: 1.85 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4235 proteins (1275674 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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