Amino acid dipepetide frequency for Paenibacillus piri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.215AlaAla: 10.215 ± 0.121	0.802AlaCys: 0.802 ± 0.021	4.55AlaAsp: 4.55 ± 0.047	5.525AlaGlu: 5.525 ± 0.062	3.385AlaPhe: 3.385 ± 0.044	7.242AlaGly: 7.242 ± 0.075	1.434AlaHis: 1.434 ± 0.028	5.293AlaIle: 5.293 ± 0.059	4.408AlaLys: 4.408 ± 0.05	8.421AlaLeu: 8.421 ± 0.078	2.416AlaMet: 2.416 ± 0.032	2.839AlaAsn: 2.839 ± 0.037	2.972AlaPro: 2.972 ± 0.048	2.893AlaGln: 2.893 ± 0.041	3.655AlaArg: 3.655 ± 0.05	5.106AlaSer: 5.106 ± 0.056	3.502AlaThr: 3.502 ± 0.136	6.939AlaVal: 6.939 ± 0.062	0.97AlaTrp: 0.97 ± 0.021	2.777AlaTyr: 2.777 ± 0.039	0.001AlaXaa: 0.001 ± 0.001
Cys	0.598CysAla: 0.598 ± 0.016	0.124CysCys: 0.124 ± 0.008	0.424CysAsp: 0.424 ± 0.013	0.442CysGlu: 0.442 ± 0.016	0.336CysPhe: 0.336 ± 0.013	0.839CysGly: 0.839 ± 0.02	0.219CysHis: 0.219 ± 0.013	0.551CysIle: 0.551 ± 0.019	0.327CysLys: 0.327 ± 0.012	0.825CysLeu: 0.825 ± 0.02	0.222CysMet: 0.222 ± 0.01	0.271CysAsn: 0.271 ± 0.011	0.381CysPro: 0.381 ± 0.017	0.225CysGln: 0.225 ± 0.01	0.533CysArg: 0.533 ± 0.017	0.673CysSer: 0.673 ± 0.017	0.443CysThr: 0.443 ± 0.015	0.48CysVal: 0.48 ± 0.018	0.113CysTrp: 0.113 ± 0.007	0.295CysTyr: 0.295 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.155AspAla: 4.155 ± 0.052	0.418AspCys: 0.418 ± 0.015	2.467AspAsp: 2.467 ± 0.037	3.582AspGlu: 3.582 ± 0.049	2.074AspPhe: 2.074 ± 0.033	4.151AspGly: 4.151 ± 0.051	1.131AspHis: 1.131 ± 0.027	3.43AspIle: 3.43 ± 0.049	2.807AspLys: 2.807 ± 0.041	4.627AspLeu: 4.627 ± 0.051	1.427AspMet: 1.427 ± 0.025	1.76AspAsn: 1.76 ± 0.034	2.48AspPro: 2.48 ± 0.039	1.796AspGln: 1.796 ± 0.028	2.887AspArg: 2.887 ± 0.038	2.768AspSer: 2.768 ± 0.035	2.446AspThr: 2.446 ± 0.035	3.437AspVal: 3.437 ± 0.041	0.88AspTrp: 0.88 ± 0.021	2.08AspTyr: 2.08 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.081GluAla: 6.081 ± 0.062	0.398GluCys: 0.398 ± 0.015	2.627GluAsp: 2.627 ± 0.037	4.415GluGlu: 4.415 ± 0.058	2.102GluPhe: 2.102 ± 0.034	3.892GluGly: 3.892 ± 0.043	1.541GluHis: 1.541 ± 0.028	3.937GluIle: 3.937 ± 0.044	3.649GluLys: 3.649 ± 0.049	7.151GluLeu: 7.151 ± 0.075	1.82GluMet: 1.82 ± 0.031	2.168GluAsn: 2.168 ± 0.029	2.467GluPro: 2.467 ± 0.035	3.736GluGln: 3.736 ± 0.056	3.973GluArg: 3.973 ± 0.058	3.333GluSer: 3.333 ± 0.043	3.289GluThr: 3.289 ± 0.034	3.854GluVal: 3.854 ± 0.052	0.912GluTrp: 0.912 ± 0.023	1.84GluTyr: 1.84 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.401PheAla: 3.401 ± 0.038	0.374PheCys: 0.374 ± 0.014	2.358PheAsp: 2.358 ± 0.034	2.347PheGlu: 2.347 ± 0.036	1.939PhePhe: 1.939 ± 0.035	3.202PheGly: 3.202 ± 0.043	0.951PheHis: 0.951 ± 0.019	3.113PheIle: 3.113 ± 0.049	2.121PheLys: 2.121 ± 0.036	3.849PheLeu: 3.849 ± 0.062	1.188PheMet: 1.188 ± 0.026	1.654PheAsn: 1.654 ± 0.028	1.696PhePro: 1.696 ± 0.03	1.55PheGln: 1.55 ± 0.029	2.055PheArg: 2.055 ± 0.031	2.811PheSer: 2.811 ± 0.041	2.492PheThr: 2.492 ± 0.035	2.959PheVal: 2.959 ± 0.043	0.536PheTrp: 0.536 ± 0.018	1.532PheTyr: 1.532 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	5.859GlyAla: 5.859 ± 0.167	0.87GlyCys: 0.87 ± 0.02	3.461GlyAsp: 3.461 ± 0.049	4.201GlyGlu: 4.201 ± 0.044	3.249GlyPhe: 3.249 ± 0.043	5.802GlyGly: 5.802 ± 0.078	1.592GlyHis: 1.592 ± 0.029	5.7GlyIle: 5.7 ± 0.061	4.651GlyLys: 4.651 ± 0.056	7.334GlyLeu: 7.334 ± 0.06	2.364GlyMet: 2.364 ± 0.036	2.618GlyAsn: 2.618 ± 0.052	2.113GlyPro: 2.113 ± 0.032	2.804GlyGln: 2.804 ± 0.039	3.626GlyArg: 3.626 ± 0.05	5.005GlySer: 5.005 ± 0.057	4.384GlyThr: 4.384 ± 0.059	5.076GlyVal: 5.076 ± 0.052	1.184GlyTrp: 1.184 ± 0.024	2.916GlyTyr: 2.916 ± 0.036	0.0GlyXaa: 0.0 ± 0.001
His	1.68HisAla: 1.68 ± 0.034	0.218HisCys: 0.218 ± 0.01	1.075HisAsp: 1.075 ± 0.025	1.257HisGlu: 1.257 ± 0.024	1.086HisPhe: 1.086 ± 0.022	1.555HisGly: 1.555 ± 0.029	0.615HisHis: 0.615 ± 0.016	1.529HisIle: 1.529 ± 0.024	0.897HisLys: 0.897 ± 0.018	2.058HisLeu: 2.058 ± 0.035	0.616HisMet: 0.616 ± 0.016	0.695HisAsn: 0.695 ± 0.017	1.248HisPro: 1.248 ± 0.026	0.793HisGln: 0.793 ± 0.017	1.133HisArg: 1.133 ± 0.024	1.194HisSer: 1.194 ± 0.029	1.042HisThr: 1.042 ± 0.022	1.441HisVal: 1.441 ± 0.028	0.356HisTrp: 0.356 ± 0.012	0.908HisTyr: 0.908 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.004IleAla: 6.004 ± 0.055	0.649IleCys: 0.649 ± 0.016	3.738IleAsp: 3.738 ± 0.047	4.22IleGlu: 4.22 ± 0.047	2.462IlePhe: 2.462 ± 0.04	5.513IleGly: 5.513 ± 0.061	1.51IleHis: 1.51 ± 0.025	4.278IleIle: 4.278 ± 0.066	2.974IleLys: 2.974 ± 0.042	5.489IleLeu: 5.489 ± 0.066	1.722IleMet: 1.722 ± 0.03	2.457IleAsn: 2.457 ± 0.036	3.265IlePro: 3.265 ± 0.042	2.478IleGln: 2.478 ± 0.039	4.053IleArg: 4.053 ± 0.048	4.296IleSer: 4.296 ± 0.049	3.528IleThr: 3.528 ± 0.041	5.282IleVal: 5.282 ± 0.062	0.771IleTrp: 0.771 ± 0.02	2.108IleTyr: 2.108 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.352LysAla: 4.352 ± 0.055	0.233LysCys: 0.233 ± 0.01	2.915LysAsp: 2.915 ± 0.045	4.091LysGlu: 4.091 ± 0.049	1.647LysPhe: 1.647 ± 0.032	3.571LysGly: 3.571 ± 0.04	1.171LysHis: 1.171 ± 0.025	3.093LysIle: 3.093 ± 0.044	3.373LysLys: 3.373 ± 0.058	5.582LysLeu: 5.582 ± 0.062	1.653LysMet: 1.653 ± 0.03	2.123LysAsn: 2.123 ± 0.037	2.525LysPro: 2.525 ± 0.035	2.744LysGln: 2.744 ± 0.041	2.874LysArg: 2.874 ± 0.034	3.046LysSer: 3.046 ± 0.037	2.83LysThr: 2.83 ± 0.036	3.561LysVal: 3.561 ± 0.04	0.733LysTrp: 0.733 ± 0.02	1.819LysTyr: 1.819 ± 0.03	0.0LysXaa: 0.0 ± 0.001
Leu	8.232LeuAla: 8.232 ± 0.074	0.879LeuCys: 0.879 ± 0.023	5.054LeuAsp: 5.054 ± 0.053	6.045LeuGlu: 6.045 ± 0.057	4.66LeuPhe: 4.66 ± 0.067	6.539LeuGly: 6.539 ± 0.068	2.172LeuHis: 2.172 ± 0.032	6.551LeuIle: 6.551 ± 0.065	5.461LeuLys: 5.461 ± 0.06	11.154LeuLeu: 11.154 ± 0.112	2.6LeuMet: 2.6 ± 0.033	3.944LeuAsn: 3.944 ± 0.047	4.737LeuPro: 4.737 ± 0.049	4.455LeuGln: 4.455 ± 0.054	4.991LeuArg: 4.991 ± 0.055	6.879LeuSer: 6.879 ± 0.056	5.545LeuThr: 5.545 ± 0.051	6.166LeuVal: 6.166 ± 0.056	1.101LeuTrp: 1.101 ± 0.025	3.23LeuTyr: 3.23 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.325MetAla: 2.325 ± 0.033	0.162MetCys: 0.162 ± 0.009	1.559MetAsp: 1.559 ± 0.026	1.891MetGlu: 1.891 ± 0.031	1.124MetPhe: 1.124 ± 0.026	1.727MetGly: 1.727 ± 0.027	0.488MetHis: 0.488 ± 0.013	2.007MetIle: 2.007 ± 0.032	2.047MetLys: 2.047 ± 0.033	3.012MetLeu: 3.012 ± 0.038	0.946MetMet: 0.946 ± 0.023	1.473MetAsn: 1.473 ± 0.027	1.211MetPro: 1.211 ± 0.024	1.024MetGln: 1.024 ± 0.02	1.4MetArg: 1.4 ± 0.025	1.771MetSer: 1.771 ± 0.029	1.635MetThr: 1.635 ± 0.024	1.807MetVal: 1.807 ± 0.03	0.27MetTrp: 0.27 ± 0.012	0.833MetTyr: 0.833 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.869AsnAla: 2.869 ± 0.04	0.277AsnCys: 0.277 ± 0.012	1.949AsnAsp: 1.949 ± 0.034	2.492AsnGlu: 2.492 ± 0.034	1.376AsnPhe: 1.376 ± 0.025	3.43AsnGly: 3.43 ± 0.059	0.813AsnHis: 0.813 ± 0.02	2.374AsnIle: 2.374 ± 0.034	2.113AsnLys: 2.113 ± 0.034	3.192AsnLeu: 3.192 ± 0.036	1.053AsnMet: 1.053 ± 0.023	1.559AsnAsn: 1.559 ± 0.032	2.056AsnPro: 2.056 ± 0.03	1.474AsnGln: 1.474 ± 0.027	2.234AsnArg: 2.234 ± 0.03	2.088AsnSer: 2.088 ± 0.037	1.953AsnThr: 1.953 ± 0.035	2.624AsnVal: 2.624 ± 0.04	0.522AsnTrp: 0.522 ± 0.016	1.391AsnTyr: 1.391 ± 0.025	0.001AsnXaa: 0.001 ± 0.001
Pro	3.849ProAla: 3.849 ± 0.055	0.252ProCys: 0.252 ± 0.01	2.804ProAsp: 2.804 ± 0.041	3.238ProGlu: 3.238 ± 0.05	2.096ProPhe: 2.096 ± 0.03	3.296ProGly: 3.296 ± 0.046	0.995ProHis: 0.995 ± 0.022	2.538ProIle: 2.538 ± 0.041	1.927ProLys: 1.927 ± 0.03	4.21ProLeu: 4.21 ± 0.049	1.1ProMet: 1.1 ± 0.023	1.649ProAsn: 1.649 ± 0.033	1.425ProPro: 1.425 ± 0.03	1.577ProGln: 1.577 ± 0.027	1.491ProArg: 1.491 ± 0.029	2.498ProSer: 2.498 ± 0.04	1.875ProThr: 1.875 ± 0.031	3.529ProVal: 3.529 ± 0.042	0.555ProTrp: 0.555 ± 0.015	1.569ProTyr: 1.569 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.666GlnAla: 3.666 ± 0.05	0.264GlnCys: 0.264 ± 0.012	1.651GlnAsp: 1.651 ± 0.027	2.422GlnGlu: 2.422 ± 0.044	1.708GlnPhe: 1.708 ± 0.031	2.614GlnGly: 2.614 ± 0.036	0.823GlnHis: 0.823 ± 0.022	2.584GlnIle: 2.584 ± 0.033	2.037GlnLys: 2.037 ± 0.035	4.59GlnLeu: 4.59 ± 0.061	1.209GlnMet: 1.209 ± 0.028	1.358GlnAsn: 1.358 ± 0.023	1.797GlnPro: 1.797 ± 0.035	2.007GlnGln: 2.007 ± 0.039	1.946GlnArg: 1.946 ± 0.033	2.504GlnSer: 2.504 ± 0.035	2.111GlnThr: 2.111 ± 0.032	2.596GlnVal: 2.596 ± 0.037	0.586GlnTrp: 0.586 ± 0.017	1.337GlnTyr: 1.337 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.403ArgAla: 3.403 ± 0.043	0.433ArgCys: 0.433 ± 0.015	2.366ArgAsp: 2.366 ± 0.035	3.502ArgGlu: 3.502 ± 0.05	2.385ArgPhe: 2.385 ± 0.034	3.033ArgGly: 3.033 ± 0.042	1.198ArgHis: 1.198 ± 0.024	3.828ArgIle: 3.828 ± 0.043	3.047ArgLys: 3.047 ± 0.041	5.688ArgLeu: 5.688 ± 0.063	1.777ArgMet: 1.777 ± 0.032	2.078ArgAsn: 2.078 ± 0.029	1.852ArgPro: 1.852 ± 0.031	2.402ArgGln: 2.402 ± 0.039	2.808ArgArg: 2.808 ± 0.044	3.273ArgSer: 3.273 ± 0.04	2.708ArgThr: 2.708 ± 0.038	2.997ArgVal: 2.997 ± 0.037	0.766ArgTrp: 0.766 ± 0.021	1.886ArgTyr: 1.886 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.957SerAla: 4.957 ± 0.053	0.49SerCys: 0.49 ± 0.015	3.01SerAsp: 3.01 ± 0.041	3.461SerGlu: 3.461 ± 0.043	3.115SerPhe: 3.115 ± 0.041	5.639SerGly: 5.639 ± 0.064	1.202SerHis: 1.202 ± 0.022	4.263SerIle: 4.263 ± 0.053	3.147SerLys: 3.147 ± 0.044	6.298SerLeu: 6.298 ± 0.06	1.861SerMet: 1.861 ± 0.028	2.252SerAsn: 2.252 ± 0.037	2.5SerPro: 2.5 ± 0.036	1.981SerGln: 1.981 ± 0.026	3.213SerArg: 3.213 ± 0.041	4.035SerSer: 4.035 ± 0.053	2.941SerThr: 2.941 ± 0.039	4.607SerVal: 4.607 ± 0.051	0.838SerTrp: 0.838 ± 0.019	2.27SerTyr: 2.27 ± 0.037	0.001SerXaa: 0.001 ± 0.001
Thr	4.843ThrAla: 4.843 ± 0.053	0.365ThrCys: 0.365 ± 0.013	2.842ThrAsp: 2.842 ± 0.038	2.936ThrGlu: 2.936 ± 0.039	2.258ThrPhe: 2.258 ± 0.038	4.668ThrGly: 4.668 ± 0.157	0.953ThrHis: 0.953 ± 0.017	3.669ThrIle: 3.669 ± 0.05	2.419ThrLys: 2.419 ± 0.032	5.18ThrLeu: 5.18 ± 0.047	1.35ThrMet: 1.35 ± 0.025	1.906ThrAsn: 1.906 ± 0.033	2.466ThrPro: 2.466 ± 0.038	1.44ThrGln: 1.44 ± 0.025	2.231ThrArg: 2.231 ± 0.033	3.006ThrSer: 3.006 ± 0.041	2.6ThrThr: 2.6 ± 0.047	4.614ThrVal: 4.614 ± 0.066	0.637ThrTrp: 0.637 ± 0.02	1.851ThrTyr: 1.851 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	5.203ValAla: 5.203 ± 0.05	0.709ValCys: 0.709 ± 0.024	3.424ValAsp: 3.424 ± 0.046	4.153ValGlu: 4.153 ± 0.043	2.92ValPhe: 2.92 ± 0.045	4.551ValGly: 4.551 ± 0.048	1.515ValHis: 1.515 ± 0.025	4.91ValIle: 4.91 ± 0.06	3.979ValLys: 3.979 ± 0.053	6.959ValLeu: 6.959 ± 0.051	1.995ValMet: 1.995 ± 0.027	2.826ValAsn: 2.826 ± 0.037	3.243ValPro: 3.243 ± 0.045	2.757ValGln: 2.757 ± 0.038	3.572ValArg: 3.572 ± 0.037	4.768ValSer: 4.768 ± 0.048	4.321ValThr: 4.321 ± 0.066	4.88ValVal: 4.88 ± 0.056	0.892ValTrp: 0.892 ± 0.019	2.499ValTyr: 2.499 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.867TrpAla: 0.867 ± 0.02	0.097TrpCys: 0.097 ± 0.006	0.712TrpAsp: 0.712 ± 0.02	0.78TrpGlu: 0.78 ± 0.02	0.568TrpPhe: 0.568 ± 0.015	0.882TrpGly: 0.882 ± 0.021	0.324TrpHis: 0.324 ± 0.012	0.941TrpIle: 0.941 ± 0.021	0.831TrpLys: 0.831 ± 0.019	1.467TrpLeu: 1.467 ± 0.029	0.464TrpMet: 0.464 ± 0.015	0.742TrpAsn: 0.742 ± 0.02	0.4TrpPro: 0.4 ± 0.014	0.504TrpGln: 0.504 ± 0.016	0.636TrpArg: 0.636 ± 0.016	0.87TrpSer: 0.87 ± 0.02	0.705TrpThr: 0.705 ± 0.02	0.888TrpVal: 0.888 ± 0.019	0.189TrpTrp: 0.189 ± 0.011	0.43TrpTyr: 0.43 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.787TyrAla: 2.787 ± 0.037	0.31TyrCys: 0.31 ± 0.012	1.816TyrAsp: 1.816 ± 0.034	2.185TyrGlu: 2.185 ± 0.029	1.638TyrPhe: 1.638 ± 0.03	2.662TyrGly: 2.662 ± 0.037	0.749TyrHis: 0.749 ± 0.018	2.21TyrIle: 2.21 ± 0.034	1.722TyrLys: 1.722 ± 0.029	3.306TyrLeu: 3.306 ± 0.043	0.927TyrMet: 0.927 ± 0.023	1.468TyrAsn: 1.468 ± 0.026	1.639TyrPro: 1.639 ± 0.029	1.172TyrGln: 1.172 ± 0.024	2.118TyrArg: 2.118 ± 0.031	2.155TyrSer: 2.155 ± 0.031	1.884TyrThr: 1.884 ± 0.032	2.337TyrVal: 2.337 ± 0.035	0.486TyrTrp: 0.486 ± 0.015	1.348TyrTyr: 1.348 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6802 proteins (2221892 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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