Amino acid dipepetide frequency for Cohnella sp. CC-MHH1044

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.07AlaAla: 12.07 ± 0.133
0.796AlaCys: 0.796 ± 0.019
5.696AlaAsp: 5.696 ± 0.061
6.891AlaGlu: 6.891 ± 0.073
3.452AlaPhe: 3.452 ± 0.041
8.349AlaGly: 8.349 ± 0.083
1.399AlaHis: 1.399 ± 0.026
5.589AlaIle: 5.589 ± 0.048
4.061AlaLys: 4.061 ± 0.045
9.355AlaLeu: 9.355 ± 0.079
2.375AlaMet: 2.375 ± 0.033
3.048AlaAsn: 3.048 ± 0.05
3.42AlaPro: 3.42 ± 0.048
2.705AlaGln: 2.705 ± 0.041
4.683AlaArg: 4.683 ± 0.066
6.914AlaSer: 6.914 ± 0.075
4.662AlaThr: 4.662 ± 0.105
7.104AlaVal: 7.104 ± 0.068
1.198AlaTrp: 1.198 ± 0.025
3.1AlaTyr: 3.1 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.583CysAla: 0.583 ± 0.015
0.129CysCys: 0.129 ± 0.007
0.366CysAsp: 0.366 ± 0.015
0.466CysGlu: 0.466 ± 0.016
0.27CysPhe: 0.27 ± 0.011
0.773CysGly: 0.773 ± 0.02
0.153CysHis: 0.153 ± 0.009
0.348CysIle: 0.348 ± 0.013
0.239CysLys: 0.239 ± 0.01
0.743CysLeu: 0.743 ± 0.018
0.172CysMet: 0.172 ± 0.008
0.192CysAsn: 0.192 ± 0.009
0.336CysPro: 0.336 ± 0.015
0.16CysGln: 0.16 ± 0.008
0.559CysArg: 0.559 ± 0.018
0.51CysSer: 0.51 ± 0.015
0.34CysThr: 0.34 ± 0.013
0.463CysVal: 0.463 ± 0.015
0.09CysTrp: 0.09 ± 0.006
0.224CysTyr: 0.224 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
4.745AspAla: 4.745 ± 0.062
0.389AspCys: 0.389 ± 0.014
2.78AspAsp: 2.78 ± 0.042
3.975AspGlu: 3.975 ± 0.046
1.986AspPhe: 1.986 ± 0.033
5.248AspGly: 5.248 ± 0.068
0.888AspHis: 0.888 ± 0.019
3.167AspIle: 3.167 ± 0.039
2.355AspLys: 2.355 ± 0.036
4.717AspLeu: 4.717 ± 0.047
1.198AspMet: 1.198 ± 0.023
2.016AspAsn: 2.016 ± 0.041
2.604AspPro: 2.604 ± 0.033
1.47AspGln: 1.47 ± 0.028
3.427AspArg: 3.427 ± 0.043
3.45AspSer: 3.45 ± 0.049
2.669AspThr: 2.669 ± 0.041
3.601AspVal: 3.601 ± 0.047
1.033AspTrp: 1.033 ± 0.023
2.286AspTyr: 2.286 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.41GluAla: 7.41 ± 0.077
0.393GluCys: 0.393 ± 0.016
3.11GluAsp: 3.11 ± 0.04
5.378GluGlu: 5.378 ± 0.07
2.136GluPhe: 2.136 ± 0.032
4.828GluGly: 4.828 ± 0.049
1.262GluHis: 1.262 ± 0.027
3.396GluIle: 3.396 ± 0.042
3.105GluLys: 3.105 ± 0.044
7.753GluLeu: 7.753 ± 0.088
1.716GluMet: 1.716 ± 0.022
1.995GluAsn: 1.995 ± 0.034
2.703GluPro: 2.703 ± 0.034
3.164GluGln: 3.164 ± 0.069
5.027GluArg: 5.027 ± 0.072
3.633GluSer: 3.633 ± 0.047
3.285GluThr: 3.285 ± 0.051
3.949GluVal: 3.949 ± 0.047
1.144GluTrp: 1.144 ± 0.025
1.977GluTyr: 1.977 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.715PheAla: 3.715 ± 0.038
0.321PheCys: 0.321 ± 0.013
2.383PheAsp: 2.383 ± 0.034
2.368PheGlu: 2.368 ± 0.034
1.574PhePhe: 1.574 ± 0.036
3.301PheGly: 3.301 ± 0.042
0.77PheHis: 0.77 ± 0.016
2.056PheIle: 2.056 ± 0.032
1.682PheLys: 1.682 ± 0.028
3.696PheLeu: 3.696 ± 0.043
0.918PheMet: 0.918 ± 0.019
1.418PheAsn: 1.418 ± 0.028
1.519PhePro: 1.519 ± 0.028
1.103PheGln: 1.103 ± 0.023
2.395PheArg: 2.395 ± 0.038
2.571PheSer: 2.571 ± 0.04
2.099PheThr: 2.099 ± 0.039
2.969PheVal: 2.969 ± 0.04
0.52PheTrp: 0.52 ± 0.015
1.407PheTyr: 1.407 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
7.232GlyAla: 7.232 ± 0.094
0.722GlyCys: 0.722 ± 0.019
4.159GlyAsp: 4.159 ± 0.052
5.433GlyGlu: 5.433 ± 0.1
3.259GlyPhe: 3.259 ± 0.046
6.686GlyGly: 6.686 ± 0.098
1.449GlyHis: 1.449 ± 0.029
5.19GlyIle: 5.19 ± 0.049
3.826GlyLys: 3.826 ± 0.045
7.536GlyLeu: 7.536 ± 0.065
2.307GlyMet: 2.307 ± 0.035
2.867GlyAsn: 2.867 ± 0.056
2.247GlyPro: 2.247 ± 0.082
2.719GlyGln: 2.719 ± 0.039
4.594GlyArg: 4.594 ± 0.055
5.589GlySer: 5.589 ± 0.063
5.239GlyThr: 5.239 ± 0.086
5.253GlyVal: 5.253 ± 0.062
1.377GlyTrp: 1.377 ± 0.03
3.058GlyTyr: 3.058 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
1.49HisAla: 1.49 ± 0.027
0.166HisCys: 0.166 ± 0.009
0.897HisAsp: 0.897 ± 0.019
1.063HisGlu: 1.063 ± 0.026
0.8HisPhe: 0.8 ± 0.02
1.43HisGly: 1.43 ± 0.028
0.463HisHis: 0.463 ± 0.015
0.994HisIle: 0.994 ± 0.023
0.567HisLys: 0.567 ± 0.015
1.855HisLeu: 1.855 ± 0.032
0.418HisMet: 0.418 ± 0.014
0.563HisAsn: 0.563 ± 0.013
1.148HisPro: 1.148 ± 0.024
0.537HisGln: 0.537 ± 0.016
1.179HisArg: 1.179 ± 0.028
1.144HisSer: 1.144 ± 0.024
0.866HisThr: 0.866 ± 0.021
1.184HisVal: 1.184 ± 0.025
0.336HisTrp: 0.336 ± 0.014
0.848HisTyr: 0.848 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.096IleAla: 6.096 ± 0.056
0.425IleCys: 0.425 ± 0.013
3.549IleAsp: 3.549 ± 0.04
3.795IleGlu: 3.795 ± 0.04
1.831IlePhe: 1.831 ± 0.036
5.104IleGly: 5.104 ± 0.055
1.05IleHis: 1.05 ± 0.021
2.669IleIle: 2.669 ± 0.043
2.2IleLys: 2.2 ± 0.038
4.665IleLeu: 4.665 ± 0.054
1.198IleMet: 1.198 ± 0.023
1.846IleAsn: 1.846 ± 0.031
2.801IlePro: 2.801 ± 0.038
1.861IleGln: 1.861 ± 0.031
4.078IleArg: 4.078 ± 0.052
3.387IleSer: 3.387 ± 0.047
2.824IleThr: 2.824 ± 0.049
5.158IleVal: 5.158 ± 0.051
0.649IleTrp: 0.649 ± 0.018
1.779IleTyr: 1.779 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.742LysAla: 3.742 ± 0.046
0.167LysCys: 0.167 ± 0.008
2.296LysAsp: 2.296 ± 0.031
3.255LysGlu: 3.255 ± 0.046
1.298LysPhe: 1.298 ± 0.028
2.829LysGly: 2.829 ± 0.036
0.834LysHis: 0.834 ± 0.02
2.218LysIle: 2.218 ± 0.037
2.125LysLys: 2.125 ± 0.042
5.199LysLeu: 5.199 ± 0.057
1.067LysMet: 1.067 ± 0.02
1.511LysAsn: 1.511 ± 0.029
2.044LysPro: 2.044 ± 0.031
1.826LysGln: 1.826 ± 0.033
2.646LysArg: 2.646 ± 0.038
2.524LysSer: 2.524 ± 0.036
2.315LysThr: 2.315 ± 0.034
2.758LysVal: 2.758 ± 0.046
0.614LysTrp: 0.614 ± 0.017
1.421LysTyr: 1.421 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
10.088LeuAla: 10.088 ± 0.094
0.738LeuCys: 0.738 ± 0.019
5.278LeuAsp: 5.278 ± 0.047
6.253LeuGlu: 6.253 ± 0.066
4.431LeuPhe: 4.431 ± 0.057
7.076LeuGly: 7.076 ± 0.062
1.948LeuHis: 1.948 ± 0.038
5.528LeuIle: 5.528 ± 0.062
4.396LeuLys: 4.396 ± 0.052
11.605LeuLeu: 11.605 ± 0.12
2.249LeuMet: 2.249 ± 0.036
3.571LeuAsn: 3.571 ± 0.04
4.961LeuPro: 4.961 ± 0.056
3.694LeuGln: 3.694 ± 0.041
6.143LeuArg: 6.143 ± 0.079
7.116LeuSer: 7.116 ± 0.064
5.745LeuThr: 5.745 ± 0.061
6.352LeuVal: 6.352 ± 0.057
1.129LeuTrp: 1.129 ± 0.022
3.346LeuTyr: 3.346 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.233MetAla: 2.233 ± 0.032
0.13MetCys: 0.13 ± 0.008
1.305MetAsp: 1.305 ± 0.025
1.581MetGlu: 1.581 ± 0.027
0.855MetPhe: 0.855 ± 0.024
1.573MetGly: 1.573 ± 0.027
0.383MetHis: 0.383 ± 0.013
1.479MetIle: 1.479 ± 0.028
1.395MetLys: 1.395 ± 0.023
2.622MetLeu: 2.622 ± 0.04
0.71MetMet: 0.71 ± 0.02
1.219MetAsn: 1.219 ± 0.024
1.11MetPro: 1.11 ± 0.026
0.795MetGln: 0.795 ± 0.02
1.447MetArg: 1.447 ± 0.029
1.639MetSer: 1.639 ± 0.025
1.671MetThr: 1.671 ± 0.028
1.4MetVal: 1.4 ± 0.025
0.224MetTrp: 0.224 ± 0.01
0.666MetTyr: 0.666 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.149AsnAla: 3.149 ± 0.046
0.21AsnCys: 0.21 ± 0.01
1.961AsnAsp: 1.961 ± 0.035
2.294AsnGlu: 2.294 ± 0.037
1.149AsnPhe: 1.149 ± 0.023
3.591AsnGly: 3.591 ± 0.066
0.61AsnHis: 0.61 ± 0.015
1.781AsnIle: 1.781 ± 0.035
1.523AsnLys: 1.523 ± 0.033
3.022AsnLeu: 3.022 ± 0.039
0.74AsnMet: 0.74 ± 0.017
1.453AsnAsn: 1.453 ± 0.035
1.892AsnPro: 1.892 ± 0.033
1.099AsnGln: 1.099 ± 0.025
2.213AsnArg: 2.213 ± 0.032
2.122AsnSer: 2.122 ± 0.038
1.843AsnThr: 1.843 ± 0.036
2.582AsnVal: 2.582 ± 0.04
0.57AsnTrp: 0.57 ± 0.017
1.334AsnTyr: 1.334 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
4.115ProAla: 4.115 ± 0.049
0.243ProCys: 0.243 ± 0.011
2.905ProAsp: 2.905 ± 0.038
3.482ProGlu: 3.482 ± 0.049
1.795ProPhe: 1.795 ± 0.031
3.471ProGly: 3.471 ± 0.044
0.873ProHis: 0.873 ± 0.026
2.459ProIle: 2.459 ± 0.031
1.495ProLys: 1.495 ± 0.025
4.223ProLeu: 4.223 ± 0.045
0.951ProMet: 0.951 ± 0.02
1.526ProAsn: 1.526 ± 0.029
1.499ProPro: 1.499 ± 0.03
1.312ProGln: 1.312 ± 0.028
1.706ProArg: 1.706 ± 0.028
3.072ProSer: 3.072 ± 0.035
2.253ProThr: 2.253 ± 0.081
3.208ProVal: 3.208 ± 0.038
0.573ProTrp: 0.573 ± 0.014
1.59ProTyr: 1.59 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.726GlnAla: 3.726 ± 0.045
0.159GlnCys: 0.159 ± 0.008
1.47GlnAsp: 1.47 ± 0.026
2.199GlnGlu: 2.199 ± 0.038
1.339GlnPhe: 1.339 ± 0.027
2.514GlnGly: 2.514 ± 0.071
0.532GlnHis: 0.532 ± 0.015
1.929GlnIle: 1.929 ± 0.029
1.273GlnLys: 1.273 ± 0.027
3.661GlnLeu: 3.661 ± 0.047
0.922GlnMet: 0.922 ± 0.02
1.039GlnAsn: 1.039 ± 0.024
1.454GlnPro: 1.454 ± 0.021
1.414GlnGln: 1.414 ± 0.03
1.787GlnArg: 1.787 ± 0.029
2.096GlnSer: 2.096 ± 0.037
1.914GlnThr: 1.914 ± 0.033
2.22GlnVal: 2.22 ± 0.034
0.564GlnTrp: 0.564 ± 0.02
1.197GlnTyr: 1.197 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
4.499ArgAla: 4.499 ± 0.053
0.475ArgCys: 0.475 ± 0.015
2.745ArgAsp: 2.745 ± 0.035
4.52ArgGlu: 4.52 ± 0.062
2.591ArgPhe: 2.591 ± 0.035
3.713ArgGly: 3.713 ± 0.051
1.219ArgHis: 1.219 ± 0.026
4.209ArgIle: 4.209 ± 0.046
2.787ArgLys: 2.787 ± 0.035
6.806ArgLeu: 6.806 ± 0.085
1.916ArgMet: 1.916 ± 0.034
2.052ArgAsn: 2.052 ± 0.032
2.186ArgPro: 2.186 ± 0.035
2.303ArgGln: 2.303 ± 0.038
4.065ArgArg: 4.065 ± 0.06
3.948ArgSer: 3.948 ± 0.048
3.333ArgThr: 3.333 ± 0.042
3.434ArgVal: 3.434 ± 0.043
0.916ArgTrp: 0.916 ± 0.022
2.189ArgTyr: 2.189 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.382SerAla: 6.382 ± 0.058
0.429SerCys: 0.429 ± 0.014
3.507SerAsp: 3.507 ± 0.051
3.996SerGlu: 3.996 ± 0.043
3.018SerPhe: 3.018 ± 0.041
6.596SerGly: 6.596 ± 0.08
1.104SerHis: 1.104 ± 0.02
3.773SerIle: 3.773 ± 0.055
2.45SerLys: 2.45 ± 0.036
6.682SerLeu: 6.682 ± 0.056
1.54SerMet: 1.54 ± 0.024
2.203SerAsn: 2.203 ± 0.042
2.914SerPro: 2.914 ± 0.039
1.863SerGln: 1.863 ± 0.031
3.719SerArg: 3.719 ± 0.042
4.983SerSer: 4.983 ± 0.075
3.098SerThr: 3.098 ± 0.052
4.739SerVal: 4.739 ± 0.057
0.98SerTrp: 0.98 ± 0.022
2.47SerTyr: 2.47 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.382ThrAla: 5.382 ± 0.073
0.285ThrCys: 0.285 ± 0.011
3.102ThrAsp: 3.102 ± 0.052
3.178ThrGlu: 3.178 ± 0.04
2.231ThrPhe: 2.231 ± 0.036
5.004ThrGly: 5.004 ± 0.223
0.798ThrHis: 0.798 ± 0.019
3.702ThrIle: 3.702 ± 0.053
2.029ThrLys: 2.029 ± 0.031
5.513ThrLeu: 5.513 ± 0.049
1.242ThrMet: 1.242 ± 0.023
1.926ThrAsn: 1.926 ± 0.04
2.475ThrPro: 2.475 ± 0.037
1.362ThrGln: 1.362 ± 0.027
2.441ThrArg: 2.441 ± 0.032
3.418ThrSer: 3.418 ± 0.062
3.081ThrThr: 3.081 ± 0.064
4.683ThrVal: 4.683 ± 0.085
0.685ThrTrp: 0.685 ± 0.023
1.997ThrTyr: 1.997 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.999ValAla: 5.999 ± 0.059
0.599ValCys: 0.599 ± 0.016
3.679ValAsp: 3.679 ± 0.051
4.032ValGlu: 4.032 ± 0.048
2.758ValPhe: 2.758 ± 0.037
4.815ValGly: 4.815 ± 0.041
1.305ValHis: 1.305 ± 0.024
3.844ValIle: 3.844 ± 0.046
3.134ValLys: 3.134 ± 0.042
6.995ValLeu: 6.995 ± 0.07
1.59ValMet: 1.59 ± 0.029
2.602ValAsn: 2.602 ± 0.04
3.326ValPro: 3.326 ± 0.039
2.392ValGln: 2.392 ± 0.036
4.381ValArg: 4.381 ± 0.051
4.956ValSer: 4.956 ± 0.057
4.382ValThr: 4.382 ± 0.09
5.198ValVal: 5.198 ± 0.053
1.003ValTrp: 1.003 ± 0.023
2.553ValTyr: 2.553 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.068TrpAla: 1.068 ± 0.026
0.099TrpCys: 0.099 ± 0.006
0.721TrpAsp: 0.721 ± 0.018
0.845TrpGlu: 0.845 ± 0.02
0.576TrpPhe: 0.576 ± 0.016
0.985TrpGly: 0.985 ± 0.024
0.29TrpHis: 0.29 ± 0.013
0.845TrpIle: 0.845 ± 0.022
0.653TrpLys: 0.653 ± 0.018
1.552TrpLeu: 1.552 ± 0.03
0.425TrpMet: 0.425 ± 0.013
0.78TrpAsn: 0.78 ± 0.018
0.507TrpPro: 0.507 ± 0.016
0.577TrpGln: 0.577 ± 0.017
0.848TrpArg: 0.848 ± 0.02
1.007TrpSer: 1.007 ± 0.022
1.005TrpThr: 1.005 ± 0.026
0.845TrpVal: 0.845 ± 0.02
0.188TrpTrp: 0.188 ± 0.009
0.501TrpTyr: 0.501 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.143TyrAla: 3.143 ± 0.042
0.238TyrCys: 0.238 ± 0.009
2.093TyrAsp: 2.093 ± 0.059
2.359TyrGlu: 2.359 ± 0.034
1.437TyrPhe: 1.437 ± 0.026
2.855TyrGly: 2.855 ± 0.036
0.618TyrHis: 0.618 ± 0.016
1.79TyrIle: 1.79 ± 0.032
1.393TyrLys: 1.393 ± 0.025
3.449TyrLeu: 3.449 ± 0.044
0.783TyrMet: 0.783 ± 0.017
1.31TyrAsn: 1.31 ± 0.027
1.606TyrPro: 1.606 ± 0.027
1.052TyrGln: 1.052 ± 0.021
2.568TyrArg: 2.568 ± 0.032
2.367TyrSer: 2.367 ± 0.039
1.914TyrThr: 1.914 ± 0.047
2.442TyrVal: 2.442 ± 0.036
0.525TyrTrp: 0.525 ± 0.016
1.444TyrTyr: 1.444 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6462 proteins (2442047 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski