Amino acid dipepetide frequency for Paenarthrobacter aurescens (strain TC1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.506AlaAla: 18.506 ± 0.176	0.815AlaCys: 0.815 ± 0.028	6.684AlaAsp: 6.684 ± 0.081	7.494AlaGlu: 7.494 ± 0.09	3.795AlaPhe: 3.795 ± 0.055	12.056AlaGly: 12.056 ± 0.106	2.166AlaHis: 2.166 ± 0.041	5.325AlaIle: 5.325 ± 0.069	3.83AlaLys: 3.83 ± 0.055	12.434AlaLeu: 12.434 ± 0.114	2.912AlaMet: 2.912 ± 0.046	2.911AlaAsn: 2.911 ± 0.043	5.96AlaPro: 5.96 ± 0.097	3.74AlaGln: 3.74 ± 0.06	7.006AlaArg: 7.006 ± 0.075	7.338AlaSer: 7.338 ± 0.085	6.924AlaThr: 6.924 ± 0.088	10.949AlaVal: 10.949 ± 0.105	1.646AlaTrp: 1.646 ± 0.033	2.281AlaTyr: 2.281 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.722CysAla: 0.722 ± 0.022	0.088CysCys: 0.088 ± 0.008	0.366CysAsp: 0.366 ± 0.016	0.318CysGlu: 0.318 ± 0.015	0.23CysPhe: 0.23 ± 0.014	0.744CysGly: 0.744 ± 0.021	0.155CysHis: 0.155 ± 0.01	0.296CysIle: 0.296 ± 0.015	0.132CysLys: 0.132 ± 0.01	0.643CysLeu: 0.643 ± 0.02	0.119CysMet: 0.119 ± 0.01	0.154CysAsn: 0.154 ± 0.011	0.393CysPro: 0.393 ± 0.016	0.195CysGln: 0.195 ± 0.012	0.425CysArg: 0.425 ± 0.019	0.467CysSer: 0.467 ± 0.018	0.422CysThr: 0.422 ± 0.016	0.469CysVal: 0.469 ± 0.016	0.106CysTrp: 0.106 ± 0.009	0.135CysTyr: 0.135 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.986AspAla: 6.986 ± 0.081	0.313AspCys: 0.313 ± 0.015	3.1AspAsp: 3.1 ± 0.047	3.362AspGlu: 3.362 ± 0.054	1.92AspPhe: 1.92 ± 0.039	5.588AspGly: 5.588 ± 0.072	1.323AspHis: 1.323 ± 0.029	2.498AspIle: 2.498 ± 0.042	1.425AspLys: 1.425 ± 0.03	5.407AspLeu: 5.407 ± 0.061	0.968AspMet: 0.968 ± 0.024	1.209AspAsn: 1.209 ± 0.027	3.64AspPro: 3.64 ± 0.059	1.697AspGln: 1.697 ± 0.036	3.283AspArg: 3.283 ± 0.053	3.075AspSer: 3.075 ± 0.053	2.657AspThr: 2.657 ± 0.037	4.912AspVal: 4.912 ± 0.065	0.881AspTrp: 0.881 ± 0.025	1.298AspTyr: 1.298 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.115GluAla: 7.115 ± 0.079	0.325GluCys: 0.325 ± 0.015	2.999GluAsp: 2.999 ± 0.046	3.404GluGlu: 3.404 ± 0.064	1.766GluPhe: 1.766 ± 0.036	3.949GluGly: 3.949 ± 0.054	1.484GluHis: 1.484 ± 0.03	2.551GluIle: 2.551 ± 0.047	1.804GluLys: 1.804 ± 0.04	6.746GluLeu: 6.746 ± 0.085	1.013GluMet: 1.013 ± 0.027	1.547GluAsn: 1.547 ± 0.031	2.925GluPro: 2.925 ± 0.046	2.285GluGln: 2.285 ± 0.038	3.966GluArg: 3.966 ± 0.055	3.201GluSer: 3.201 ± 0.05	3.16GluThr: 3.16 ± 0.041	4.032GluVal: 4.032 ± 0.059	0.88GluTrp: 0.88 ± 0.026	1.148GluTyr: 1.148 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.941PheAla: 3.941 ± 0.057	0.26PheCys: 0.26 ± 0.014	2.185PheAsp: 2.185 ± 0.037	1.718PheGlu: 1.718 ± 0.035	1.217PhePhe: 1.217 ± 0.034	3.432PheGly: 3.432 ± 0.055	0.674PheHis: 0.674 ± 0.023	1.435PheIle: 1.435 ± 0.033	0.882PheLys: 0.882 ± 0.026	3.104PheLeu: 3.104 ± 0.05	0.675PheMet: 0.675 ± 0.021	0.96PheAsn: 0.96 ± 0.025	1.502PhePro: 1.502 ± 0.035	0.922PheGln: 0.922 ± 0.022	1.792PheArg: 1.792 ± 0.035	2.1PheSer: 2.1 ± 0.042	2.24PheThr: 2.24 ± 0.041	2.562PheVal: 2.562 ± 0.045	0.51PheTrp: 0.51 ± 0.018	0.745PheTyr: 0.745 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.648GlyAla: 9.648 ± 0.087	0.665GlyCys: 0.665 ± 0.021	4.297GlyAsp: 4.297 ± 0.062	4.431GlyGlu: 4.431 ± 0.056	3.274GlyPhe: 3.274 ± 0.052	7.311GlyGly: 7.311 ± 0.08	2.064GlyHis: 2.064 ± 0.038	4.748GlyIle: 4.748 ± 0.058	3.254GlyLys: 3.254 ± 0.051	9.027GlyLeu: 9.027 ± 0.081	2.042GlyMet: 2.042 ± 0.038	2.485GlyAsn: 2.485 ± 0.046	4.106GlyPro: 4.106 ± 0.056	2.988GlyGln: 2.988 ± 0.047	5.638GlyArg: 5.638 ± 0.059	6.047GlySer: 6.047 ± 0.065	5.92GlyThr: 5.92 ± 0.075	7.274GlyVal: 7.274 ± 0.075	1.677GlyTrp: 1.677 ± 0.035	2.31GlyTyr: 2.31 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.254HisAla: 2.254 ± 0.045	0.184HisCys: 0.184 ± 0.011	1.227HisAsp: 1.227 ± 0.033	1.189HisGlu: 1.189 ± 0.028	0.713HisPhe: 0.713 ± 0.024	2.088HisGly: 2.088 ± 0.038	0.695HisHis: 0.695 ± 0.026	0.88HisIle: 0.88 ± 0.022	0.5HisLys: 0.5 ± 0.017	2.076HisLeu: 2.076 ± 0.038	0.414HisMet: 0.414 ± 0.016	0.516HisAsn: 0.516 ± 0.017	1.453HisPro: 1.453 ± 0.03	0.747HisGln: 0.747 ± 0.022	1.459HisArg: 1.459 ± 0.036	1.309HisSer: 1.309 ± 0.028	1.122HisThr: 1.122 ± 0.031	1.706HisVal: 1.706 ± 0.034	0.331HisTrp: 0.331 ± 0.016	0.469HisTyr: 0.469 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.973IleAla: 5.973 ± 0.064	0.341IleCys: 0.341 ± 0.015	2.699IleAsp: 2.699 ± 0.049	2.488IleGlu: 2.488 ± 0.041	1.478IlePhe: 1.478 ± 0.036	4.258IleGly: 4.258 ± 0.059	0.929IleHis: 0.929 ± 0.025	2.019IleIle: 2.019 ± 0.041	1.285IleLys: 1.285 ± 0.028	4.087IleLeu: 4.087 ± 0.061	0.815IleMet: 0.815 ± 0.025	1.405IleAsn: 1.405 ± 0.032	2.567IlePro: 2.567 ± 0.045	1.265IleGln: 1.265 ± 0.031	2.754IleArg: 2.754 ± 0.037	2.908IleSer: 2.908 ± 0.047	2.869IleThr: 2.869 ± 0.05	3.749IleVal: 3.749 ± 0.052	0.498IleTrp: 0.498 ± 0.017	0.884IleTyr: 0.884 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.807LysAla: 3.807 ± 0.067	0.121LysCys: 0.121 ± 0.01	1.885LysAsp: 1.885 ± 0.04	1.684LysGlu: 1.684 ± 0.034	0.818LysPhe: 0.818 ± 0.023	2.203LysGly: 2.203 ± 0.044	0.668LysHis: 0.668 ± 0.021	1.385LysIle: 1.385 ± 0.031	1.127LysLys: 1.127 ± 0.035	2.845LysLeu: 2.845 ± 0.045	0.632LysMet: 0.632 ± 0.02	0.859LysAsn: 0.859 ± 0.03	1.851LysPro: 1.851 ± 0.045	0.967LysGln: 0.967 ± 0.026	1.828LysArg: 1.828 ± 0.034	1.745LysSer: 1.745 ± 0.038	1.833LysThr: 1.833 ± 0.034	2.467LysVal: 2.467 ± 0.042	0.341LysTrp: 0.341 ± 0.015	0.694LysTyr: 0.694 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.504LeuAla: 13.504 ± 0.119	0.644LeuCys: 0.644 ± 0.022	5.841LeuAsp: 5.841 ± 0.07	5.642LeuGlu: 5.642 ± 0.068	3.051LeuPhe: 3.051 ± 0.059	9.133LeuGly: 9.133 ± 0.1	2.052LeuHis: 2.052 ± 0.037	4.502LeuIle: 4.502 ± 0.065	2.817LeuLys: 2.817 ± 0.048	10.24LeuLeu: 10.24 ± 0.127	2.027LeuMet: 2.027 ± 0.043	2.621LeuAsn: 2.621 ± 0.04	5.645LeuPro: 5.645 ± 0.06	2.964LeuGln: 2.964 ± 0.047	6.567LeuArg: 6.567 ± 0.08	6.269LeuSer: 6.269 ± 0.061	5.955LeuThr: 5.955 ± 0.055	8.336LeuVal: 8.336 ± 0.09	1.306LeuTrp: 1.306 ± 0.035	1.803LeuTyr: 1.803 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.648MetAla: 2.648 ± 0.041	0.147MetCys: 0.147 ± 0.011	1.102MetAsp: 1.102 ± 0.026	0.977MetGlu: 0.977 ± 0.028	0.633MetPhe: 0.633 ± 0.02	1.669MetGly: 1.669 ± 0.032	0.367MetHis: 0.367 ± 0.015	0.933MetIle: 0.933 ± 0.031	0.645MetLys: 0.645 ± 0.019	2.013MetLeu: 2.013 ± 0.038	0.424MetMet: 0.424 ± 0.019	0.627MetAsn: 0.627 ± 0.023	1.156MetPro: 1.156 ± 0.028	0.595MetGln: 0.595 ± 0.022	1.226MetArg: 1.226 ± 0.03	1.586MetSer: 1.586 ± 0.029	1.722MetThr: 1.722 ± 0.027	1.692MetVal: 1.692 ± 0.034	0.248MetTrp: 0.248 ± 0.013	0.343MetTyr: 0.343 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.912AsnAla: 2.912 ± 0.045	0.198AsnCys: 0.198 ± 0.013	1.417AsnAsp: 1.417 ± 0.03	1.256AsnGlu: 1.256 ± 0.033	0.861AsnPhe: 0.861 ± 0.026	2.637AsnGly: 2.637 ± 0.046	0.603AsnHis: 0.603 ± 0.02	1.182AsnIle: 1.182 ± 0.027	0.782AsnLys: 0.782 ± 0.025	2.383AsnLeu: 2.383 ± 0.042	0.523AsnMet: 0.523 ± 0.019	0.868AsnAsn: 0.868 ± 0.03	1.965AsnPro: 1.965 ± 0.033	0.838AsnGln: 0.838 ± 0.024	1.634AsnArg: 1.634 ± 0.035	1.554AsnSer: 1.554 ± 0.033	1.525AsnThr: 1.525 ± 0.033	2.114AsnVal: 2.114 ± 0.047	0.419AsnTrp: 0.419 ± 0.017	0.638AsnTyr: 0.638 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.357ProAla: 7.357 ± 0.094	0.286ProCys: 0.286 ± 0.014	3.609ProAsp: 3.609 ± 0.053	3.978ProGlu: 3.978 ± 0.061	1.721ProPhe: 1.721 ± 0.034	5.434ProGly: 5.434 ± 0.063	1.164ProHis: 1.164 ± 0.031	1.841ProIle: 1.841 ± 0.032	1.488ProLys: 1.488 ± 0.036	4.966ProLeu: 4.966 ± 0.061	1.063ProMet: 1.063 ± 0.025	1.312ProAsn: 1.312 ± 0.033	2.238ProPro: 2.238 ± 0.045	1.747ProGln: 1.747 ± 0.038	2.817ProArg: 2.817 ± 0.04	3.469ProSer: 3.469 ± 0.053	3.198ProThr: 3.198 ± 0.061	4.801ProVal: 4.801 ± 0.061	0.886ProTrp: 0.886 ± 0.024	1.044ProTyr: 1.044 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.923GlnAla: 3.923 ± 0.051	0.175GlnCys: 0.175 ± 0.01	1.647GlnAsp: 1.647 ± 0.042	1.69GlnGlu: 1.69 ± 0.034	0.984GlnPhe: 0.984 ± 0.025	2.469GlnGly: 2.469 ± 0.037	0.771GlnHis: 0.771 ± 0.024	1.42GlnIle: 1.42 ± 0.029	0.922GlnLys: 0.922 ± 0.024	3.716GlnLeu: 3.716 ± 0.058	0.605GlnMet: 0.605 ± 0.019	0.776GlnAsn: 0.776 ± 0.027	1.918GlnPro: 1.918 ± 0.036	1.466GlnGln: 1.466 ± 0.036	2.428GlnArg: 2.428 ± 0.04	1.75GlnSer: 1.75 ± 0.038	1.629GlnThr: 1.629 ± 0.028	2.327GlnVal: 2.327 ± 0.043	0.543GlnTrp: 0.543 ± 0.019	0.714GlnTyr: 0.714 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.407ArgAla: 6.407 ± 0.076	0.412ArgCys: 0.412 ± 0.019	3.325ArgAsp: 3.325 ± 0.056	3.744ArgGlu: 3.744 ± 0.052	2.147ArgPhe: 2.147 ± 0.04	4.541ArgGly: 4.541 ± 0.061	1.519ArgHis: 1.519 ± 0.03	3.313ArgIle: 3.313 ± 0.043	2.055ArgLys: 2.055 ± 0.037	6.432ArgLeu: 6.432 ± 0.069	1.44ArgMet: 1.44 ± 0.034	1.746ArgAsn: 1.746 ± 0.035	3.308ArgPro: 3.308 ± 0.048	2.239ArgGln: 2.239 ± 0.037	5.143ArgArg: 5.143 ± 0.085	3.988ArgSer: 3.988 ± 0.053	3.844ArgThr: 3.844 ± 0.054	4.45ArgVal: 4.45 ± 0.06	1.01ArgTrp: 1.01 ± 0.027	1.433ArgTyr: 1.433 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.337SerAla: 7.337 ± 0.076	0.395SerCys: 0.395 ± 0.016	3.102SerAsp: 3.102 ± 0.049	3.147SerGlu: 3.147 ± 0.048	2.054SerPhe: 2.054 ± 0.037	6.36SerGly: 6.36 ± 0.08	1.251SerHis: 1.251 ± 0.029	2.688SerIle: 2.688 ± 0.045	1.835SerLys: 1.835 ± 0.038	5.97SerLeu: 5.97 ± 0.061	1.497SerMet: 1.497 ± 0.032	1.64SerAsn: 1.64 ± 0.032	3.486SerPro: 3.486 ± 0.059	1.812SerGln: 1.812 ± 0.034	3.907SerArg: 3.907 ± 0.051	4.155SerSer: 4.155 ± 0.057	3.941SerThr: 3.941 ± 0.05	5.073SerVal: 5.073 ± 0.061	1.011SerTrp: 1.011 ± 0.027	1.481SerTyr: 1.481 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.899ThrAla: 7.899 ± 0.077	0.34ThrCys: 0.34 ± 0.016	3.158ThrAsp: 3.158 ± 0.049	3.212ThrGlu: 3.212 ± 0.047	1.996ThrPhe: 1.996 ± 0.043	5.731ThrGly: 5.731 ± 0.063	1.141ThrHis: 1.141 ± 0.025	2.696ThrIle: 2.696 ± 0.044	1.698ThrLys: 1.698 ± 0.03	5.823ThrLeu: 5.823 ± 0.067	1.187ThrMet: 1.187 ± 0.028	1.424ThrAsn: 1.424 ± 0.032	3.888ThrPro: 3.888 ± 0.058	1.683ThrGln: 1.683 ± 0.037	3.122ThrArg: 3.122 ± 0.047	3.76ThrSer: 3.76 ± 0.055	3.95ThrThr: 3.95 ± 0.05	5.623ThrVal: 5.623 ± 0.068	0.856ThrTrp: 0.856 ± 0.023	1.188ThrTyr: 1.188 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.073ValAla: 10.073 ± 0.099	0.582ValCys: 0.582 ± 0.023	4.914ValAsp: 4.914 ± 0.059	4.775ValGlu: 4.775 ± 0.065	2.782ValPhe: 2.782 ± 0.041	6.476ValGly: 6.476 ± 0.064	1.622ValHis: 1.622 ± 0.035	4.02ValIle: 4.02 ± 0.057	2.193ValLys: 2.193 ± 0.041	8.984ValLeu: 8.984 ± 0.093	1.678ValMet: 1.678 ± 0.036	2.18ValAsn: 2.18 ± 0.043	4.654ValPro: 4.654 ± 0.058	2.376ValGln: 2.376 ± 0.042	5.015ValArg: 5.015 ± 0.062	5.16ValSer: 5.16 ± 0.063	5.285ValThr: 5.285 ± 0.072	8.074ValVal: 8.074 ± 0.095	1.043ValTrp: 1.043 ± 0.025	1.473ValTyr: 1.473 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.483TrpAla: 1.483 ± 0.031	0.123TrpCys: 0.123 ± 0.008	0.8TrpAsp: 0.8 ± 0.023	0.689TrpGlu: 0.689 ± 0.023	0.58TrpPhe: 0.58 ± 0.019	1.076TrpGly: 1.076 ± 0.03	0.347TrpHis: 0.347 ± 0.016	0.735TrpIle: 0.735 ± 0.024	0.471TrpLys: 0.471 ± 0.015	1.802TrpLeu: 1.802 ± 0.044	0.362TrpMet: 0.362 ± 0.015	0.503TrpAsn: 0.503 ± 0.021	0.676TrpPro: 0.676 ± 0.022	0.618TrpGln: 0.618 ± 0.022	1.03TrpArg: 1.03 ± 0.027	0.923TrpSer: 0.923 ± 0.028	0.929TrpThr: 0.929 ± 0.026	1.106TrpVal: 1.106 ± 0.03	0.312TrpTrp: 0.312 ± 0.016	0.298TrpTyr: 0.298 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.275TyrAla: 2.275 ± 0.036	0.166TyrCys: 0.166 ± 0.01	1.187TyrAsp: 1.187 ± 0.029	1.101TyrGlu: 1.101 ± 0.031	0.835TyrPhe: 0.835 ± 0.023	2.05TyrGly: 2.05 ± 0.034	0.333TyrHis: 0.333 ± 0.015	0.801TyrIle: 0.801 ± 0.025	0.617TyrLys: 0.617 ± 0.022	2.222TyrLeu: 2.222 ± 0.039	0.356TyrMet: 0.356 ± 0.014	0.568TyrAsn: 0.568 ± 0.02	1.086TyrPro: 1.086 ± 0.03	0.729TyrGln: 0.729 ± 0.021	1.456TyrArg: 1.456 ± 0.031	1.337TyrSer: 1.337 ± 0.035	1.25TyrThr: 1.25 ± 0.032	1.646TyrVal: 1.646 ± 0.037	0.361TyrTrp: 0.361 ± 0.015	0.513TyrTyr: 0.513 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4565 proteins (1514983 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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