Amino acid dipepetide frequency for Mariprofundus ferrinatatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.543AlaAla: 11.543 ± 0.278
1.236AlaCys: 1.236 ± 0.037
5.656AlaAsp: 5.656 ± 0.095
7.137AlaGlu: 7.137 ± 0.152
3.444AlaPhe: 3.444 ± 0.072
8.415AlaGly: 8.415 ± 0.118
2.156AlaHis: 2.156 ± 0.062
6.127AlaIle: 6.127 ± 0.098
3.956AlaLys: 3.956 ± 0.076
10.293AlaLeu: 10.293 ± 0.134
3.326AlaMet: 3.326 ± 0.073
2.993AlaAsn: 2.993 ± 0.078
3.246AlaPro: 3.246 ± 0.074
2.741AlaGln: 2.741 ± 0.071
5.389AlaArg: 5.389 ± 0.089
6.008AlaSer: 6.008 ± 0.105
4.742AlaThr: 4.742 ± 0.093
7.428AlaVal: 7.428 ± 0.12
1.31AlaTrp: 1.31 ± 0.044
2.327AlaTyr: 2.327 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.824CysAla: 0.824 ± 0.041
0.178CysCys: 0.178 ± 0.016
0.712CysAsp: 0.712 ± 0.032
0.678CysGlu: 0.678 ± 0.03
0.434CysPhe: 0.434 ± 0.024
1.109CysGly: 1.109 ± 0.037
0.356CysHis: 0.356 ± 0.024
0.598CysIle: 0.598 ± 0.031
0.448CysLys: 0.448 ± 0.025
1.02CysLeu: 1.02 ± 0.044
0.298CysMet: 0.298 ± 0.02
0.39CysAsn: 0.39 ± 0.025
0.547CysPro: 0.547 ± 0.032
0.311CysGln: 0.311 ± 0.024
0.688CysArg: 0.688 ± 0.034
0.763CysSer: 0.763 ± 0.033
0.469CysThr: 0.469 ± 0.031
0.601CysVal: 0.601 ± 0.029
0.165CysTrp: 0.165 ± 0.015
0.277CysTyr: 0.277 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
6.097AspAla: 6.097 ± 0.099
0.572AspCys: 0.572 ± 0.029
2.967AspAsp: 2.967 ± 0.077
4.509AspGlu: 4.509 ± 0.087
2.193AspPhe: 2.193 ± 0.058
4.392AspGly: 4.392 ± 0.081
1.41AspHis: 1.41 ± 0.048
4.013AspIle: 4.013 ± 0.083
2.224AspLys: 2.224 ± 0.064
5.046AspLeu: 5.046 ± 0.087
1.631AspMet: 1.631 ± 0.049
1.573AspAsn: 1.573 ± 0.049
2.387AspPro: 2.387 ± 0.063
1.875AspGln: 1.875 ± 0.05
3.345AspArg: 3.345 ± 0.07
3.109AspSer: 3.109 ± 0.074
2.278AspThr: 2.278 ± 0.062
3.996AspVal: 3.996 ± 0.08
0.674AspTrp: 0.674 ± 0.03
1.679AspTyr: 1.679 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
7.125GluAla: 7.125 ± 0.108
0.538GluCys: 0.538 ± 0.029
2.943GluAsp: 2.943 ± 0.067
4.354GluGlu: 4.354 ± 0.081
2.166GluPhe: 2.166 ± 0.057
4.626GluGly: 4.626 ± 0.084
1.803GluHis: 1.803 ± 0.051
4.325GluIle: 4.325 ± 0.083
4.147GluLys: 4.147 ± 0.125
7.136GluLeu: 7.136 ± 0.103
2.302GluMet: 2.302 ± 0.065
2.192GluAsn: 2.192 ± 0.061
2.353GluPro: 2.353 ± 0.068
3.147GluGln: 3.147 ± 0.076
4.433GluArg: 4.433 ± 0.075
4.248GluSer: 4.248 ± 0.093
3.229GluThr: 3.229 ± 0.072
4.729GluVal: 4.729 ± 0.092
0.762GluTrp: 0.762 ± 0.031
1.482GluTyr: 1.482 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.446PheAla: 3.446 ± 0.084
0.441PheCys: 0.441 ± 0.026
2.577PheAsp: 2.577 ± 0.066
2.625PheGlu: 2.625 ± 0.059
1.499PhePhe: 1.499 ± 0.059
3.154PheGly: 3.154 ± 0.066
0.88PheHis: 0.88 ± 0.037
2.186PheIle: 2.186 ± 0.063
1.334PheLys: 1.334 ± 0.044
3.367PheLeu: 3.367 ± 0.091
0.961PheMet: 0.961 ± 0.034
1.405PheAsn: 1.405 ± 0.052
1.412PhePro: 1.412 ± 0.047
1.003PheGln: 1.003 ± 0.033
2.036PheArg: 2.036 ± 0.056
2.909PheSer: 2.909 ± 0.087
1.944PheThr: 1.944 ± 0.053
2.514PheVal: 2.514 ± 0.059
0.483PheTrp: 0.483 ± 0.026
1.048PheTyr: 1.048 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
6.27GlyAla: 6.27 ± 0.108
1.111GlyCys: 1.111 ± 0.045
4.346GlyAsp: 4.346 ± 0.072
5.21GlyGlu: 5.21 ± 0.093
3.305GlyPhe: 3.305 ± 0.078
5.964GlyGly: 5.964 ± 0.115
2.066GlyHis: 2.066 ± 0.053
5.122GlyIle: 5.122 ± 0.102
4.212GlyLys: 4.212 ± 0.08
7.558GlyLeu: 7.558 ± 0.12
2.729GlyMet: 2.729 ± 0.067
2.532GlyAsn: 2.532 ± 0.061
2.05GlyPro: 2.05 ± 0.059
2.283GlyGln: 2.283 ± 0.06
4.556GlyArg: 4.556 ± 0.084
4.789GlySer: 4.789 ± 0.092
3.448GlyThr: 3.448 ± 0.083
5.717GlyVal: 5.717 ± 0.103
1.183GlyTrp: 1.183 ± 0.045
2.36GlyTyr: 2.36 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
2.529HisAla: 2.529 ± 0.059
0.314HisCys: 0.314 ± 0.02
1.347HisAsp: 1.347 ± 0.047
1.532HisGlu: 1.532 ± 0.048
1.048HisPhe: 1.048 ± 0.041
2.172HisGly: 2.172 ± 0.056
0.828HisHis: 0.828 ± 0.038
1.53HisIle: 1.53 ± 0.052
0.89HisLys: 0.89 ± 0.036
2.642HisLeu: 2.642 ± 0.059
0.64HisMet: 0.64 ± 0.03
0.695HisAsn: 0.695 ± 0.034
1.468HisPro: 1.468 ± 0.044
0.909HisGln: 0.909 ± 0.035
1.461HisArg: 1.461 ± 0.045
1.29HisSer: 1.29 ± 0.046
1.003HisThr: 1.003 ± 0.04
1.643HisVal: 1.643 ± 0.049
0.339HisTrp: 0.339 ± 0.02
0.797HisTyr: 0.797 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.482IleAla: 6.482 ± 0.103
0.769IleCys: 0.769 ± 0.033
3.859IleAsp: 3.859 ± 0.074
4.779IleGlu: 4.779 ± 0.089
2.036IlePhe: 2.036 ± 0.057
5.074IleGly: 5.074 ± 0.103
1.59IleHis: 1.59 ± 0.051
3.401IleIle: 3.401 ± 0.08
2.536IleLys: 2.536 ± 0.068
5.283IleLeu: 5.283 ± 0.088
1.371IleMet: 1.371 ± 0.052
2.291IleAsn: 2.291 ± 0.062
2.887IlePro: 2.887 ± 0.06
1.779IleGln: 1.779 ± 0.051
3.93IleArg: 3.93 ± 0.067
4.331IleSer: 4.331 ± 0.078
3.213IleThr: 3.213 ± 0.076
4.171IleVal: 4.171 ± 0.088
0.653IleTrp: 0.653 ± 0.028
1.482IleTyr: 1.482 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.649LysAla: 4.649 ± 0.115
0.324LysCys: 0.324 ± 0.022
2.118LysAsp: 2.118 ± 0.057
3.109LysGlu: 3.109 ± 0.073
1.146LysPhe: 1.146 ± 0.04
3.172LysGly: 3.172 ± 0.064
1.129LysHis: 1.129 ± 0.046
2.418LysIle: 2.418 ± 0.06
2.495LysLys: 2.495 ± 0.069
4.777LysLeu: 4.777 ± 0.087
1.344LysMet: 1.344 ± 0.045
1.479LysAsn: 1.479 ± 0.047
2.3LysPro: 2.3 ± 0.06
2.049LysGln: 2.049 ± 0.054
3.099LysArg: 3.099 ± 0.071
2.812LysSer: 2.812 ± 0.069
2.17LysThr: 2.17 ± 0.056
3.188LysVal: 3.188 ± 0.076
0.469LysTrp: 0.469 ± 0.024
0.914LysTyr: 0.914 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
10.873LeuAla: 10.873 ± 0.138
1.068LeuCys: 1.068 ± 0.038
5.839LeuAsp: 5.839 ± 0.099
6.234LeuGlu: 6.234 ± 0.101
4.18LeuPhe: 4.18 ± 0.079
7.006LeuGly: 7.006 ± 0.107
2.6LeuHis: 2.6 ± 0.057
6.282LeuIle: 6.282 ± 0.098
5.191LeuLys: 5.191 ± 0.102
11.853LeuLeu: 11.853 ± 0.206
2.839LeuMet: 2.839 ± 0.07
3.716LeuAsn: 3.716 ± 0.076
4.917LeuPro: 4.917 ± 0.076
3.64LeuGln: 3.64 ± 0.08
5.514LeuArg: 5.514 ± 0.093
7.147LeuSer: 7.147 ± 0.116
5.032LeuThr: 5.032 ± 0.092
6.332LeuVal: 6.332 ± 0.113
1.119LeuTrp: 1.119 ± 0.042
2.351LeuTyr: 2.351 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
3.058MetAla: 3.058 ± 0.065
0.226MetCys: 0.226 ± 0.016
1.496MetAsp: 1.496 ± 0.048
1.632MetGlu: 1.632 ± 0.053
0.911MetPhe: 0.911 ± 0.036
2.149MetGly: 2.149 ± 0.061
0.725MetHis: 0.725 ± 0.029
1.713MetIle: 1.713 ± 0.045
1.556MetLys: 1.556 ± 0.047
3.29MetLeu: 3.29 ± 0.068
0.913MetMet: 0.913 ± 0.039
1.121MetAsn: 1.121 ± 0.04
1.58MetPro: 1.58 ± 0.049
1.522MetGln: 1.522 ± 0.052
1.908MetArg: 1.908 ± 0.052
1.803MetSer: 1.803 ± 0.054
1.388MetThr: 1.388 ± 0.043
2.087MetVal: 2.087 ± 0.053
0.242MetTrp: 0.242 ± 0.017
0.466MetTyr: 0.466 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.963AsnAla: 2.963 ± 0.065
0.366AsnCys: 0.366 ± 0.022
1.655AsnAsp: 1.655 ± 0.047
1.878AsnGlu: 1.878 ± 0.06
1.078AsnPhe: 1.078 ± 0.04
2.6AsnGly: 2.6 ± 0.06
0.807AsnHis: 0.807 ± 0.034
2.329AsnIle: 2.329 ± 0.063
1.266AsnLys: 1.266 ± 0.041
3.349AsnLeu: 3.349 ± 0.067
0.94AsnMet: 0.94 ± 0.036
1.218AsnAsn: 1.218 ± 0.041
1.908AsnPro: 1.908 ± 0.053
1.015AsnGln: 1.015 ± 0.04
2.382AsnArg: 2.382 ± 0.064
2.038AsnSer: 2.038 ± 0.053
1.468AsnThr: 1.468 ± 0.04
2.117AsnVal: 2.117 ± 0.053
0.465AsnTrp: 0.465 ± 0.024
0.838AsnTyr: 0.838 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
4.304ProAla: 4.304 ± 0.09
0.406ProCys: 0.406 ± 0.023
3.112ProAsp: 3.112 ± 0.064
3.93ProGlu: 3.93 ± 0.08
1.793ProPhe: 1.793 ± 0.043
3.123ProGly: 3.123 ± 0.075
0.893ProHis: 0.893 ± 0.037
2.093ProIle: 2.093 ± 0.057
1.677ProLys: 1.677 ± 0.048
4.191ProLeu: 4.191 ± 0.088
1.078ProMet: 1.078 ± 0.038
1.205ProAsn: 1.205 ± 0.047
1.438ProPro: 1.438 ± 0.049
1.306ProGln: 1.306 ± 0.046
1.775ProArg: 1.775 ± 0.055
2.248ProSer: 2.248 ± 0.055
1.662ProThr: 1.662 ± 0.048
3.859ProVal: 3.859 ± 0.083
0.552ProTrp: 0.552 ± 0.025
1.116ProTyr: 1.116 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.691GlnAla: 3.691 ± 0.078
0.317GlnCys: 0.317 ± 0.021
1.4GlnAsp: 1.4 ± 0.046
2.137GlnGlu: 2.137 ± 0.058
1.267GlnPhe: 1.267 ± 0.044
2.483GlnGly: 2.483 ± 0.058
0.958GlnHis: 0.958 ± 0.039
1.997GlnIle: 1.997 ± 0.053
1.738GlnLys: 1.738 ± 0.048
4.074GlnLeu: 4.074 ± 0.077
1.187GlnMet: 1.187 ± 0.047
1.015GlnAsn: 1.015 ± 0.037
1.41GlnPro: 1.41 ± 0.044
2.084GlnGln: 2.084 ± 0.068
2.275GlnArg: 2.275 ± 0.059
1.985GlnSer: 1.985 ± 0.06
1.433GlnThr: 1.433 ± 0.053
2.539GlnVal: 2.539 ± 0.063
0.536GlnTrp: 0.536 ± 0.028
0.729GlnTyr: 0.729 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
4.835ArgAla: 4.835 ± 0.083
0.588ArgCys: 0.588 ± 0.029
3.342ArgAsp: 3.342 ± 0.064
4.2ArgGlu: 4.2 ± 0.085
2.576ArgPhe: 2.576 ± 0.062
3.64ArgGly: 3.64 ± 0.079
1.602ArgHis: 1.602 ± 0.044
4.18ArgIle: 4.18 ± 0.083
2.938ArgLys: 2.938 ± 0.069
6.743ArgLeu: 6.743 ± 0.106
2.009ArgMet: 2.009 ± 0.053
2.08ArgAsn: 2.08 ± 0.058
2.261ArgPro: 2.261 ± 0.054
2.43ArgGln: 2.43 ± 0.061
3.705ArgArg: 3.705 ± 0.081
3.439ArgSer: 3.439 ± 0.079
2.425ArgThr: 2.425 ± 0.059
3.918ArgVal: 3.918 ± 0.079
0.829ArgTrp: 0.829 ± 0.037
1.836ArgTyr: 1.836 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.505SerAla: 5.505 ± 0.099
0.691SerCys: 0.691 ± 0.033
3.899SerAsp: 3.899 ± 0.085
4.495SerGlu: 4.495 ± 0.096
2.406SerPhe: 2.406 ± 0.058
5.912SerGly: 5.912 ± 0.103
1.56SerHis: 1.56 ± 0.045
3.769SerIle: 3.769 ± 0.083
2.527SerLys: 2.527 ± 0.066
6.345SerLeu: 6.345 ± 0.102
1.888SerMet: 1.888 ± 0.053
1.977SerAsn: 1.977 ± 0.054
2.524SerPro: 2.524 ± 0.063
1.96SerGln: 1.96 ± 0.062
3.757SerArg: 3.757 ± 0.082
4.082SerSer: 4.082 ± 0.09
2.707SerThr: 2.707 ± 0.062
4.235SerVal: 4.235 ± 0.07
0.837SerTrp: 0.837 ± 0.038
1.608SerTyr: 1.608 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.746ThrAla: 4.746 ± 0.091
0.438ThrCys: 0.438 ± 0.024
2.422ThrAsp: 2.422 ± 0.06
2.7ThrGlu: 2.7 ± 0.05
1.715ThrPhe: 1.715 ± 0.051
4.231ThrGly: 4.231 ± 0.072
1.113ThrHis: 1.113 ± 0.04
3.007ThrIle: 3.007 ± 0.075
1.584ThrLys: 1.584 ± 0.047
5.269ThrLeu: 5.269 ± 0.09
1.263ThrMet: 1.263 ± 0.038
1.284ThrAsn: 1.284 ± 0.045
2.457ThrPro: 2.457 ± 0.063
1.341ThrGln: 1.341 ± 0.043
2.426ThrArg: 2.426 ± 0.064
2.71ThrSer: 2.71 ± 0.064
2.467ThrThr: 2.467 ± 0.064
3.461ThrVal: 3.461 ± 0.069
0.495ThrTrp: 0.495 ± 0.028
1.074ThrTyr: 1.074 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
7.52ValAla: 7.52 ± 0.112
0.793ValCys: 0.793 ± 0.034
4.3ValAsp: 4.3 ± 0.077
4.91ValGlu: 4.91 ± 0.09
2.37ValPhe: 2.37 ± 0.057
4.722ValGly: 4.722 ± 0.105
1.592ValHis: 1.592 ± 0.045
4.694ValIle: 4.694 ± 0.083
2.898ValLys: 2.898 ± 0.066
6.798ValLeu: 6.798 ± 0.113
2.028ValMet: 2.028 ± 0.059
2.32ValAsn: 2.32 ± 0.057
2.871ValPro: 2.871 ± 0.064
2.145ValGln: 2.145 ± 0.059
4.178ValArg: 4.178 ± 0.08
4.575ValSer: 4.575 ± 0.082
3.681ValThr: 3.681 ± 0.074
5.355ValVal: 5.355 ± 0.117
0.821ValTrp: 0.821 ± 0.033
1.645ValTyr: 1.645 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.74TrpAla: 0.74 ± 0.033
0.165TrpCys: 0.165 ± 0.016
0.569TrpAsp: 0.569 ± 0.03
0.585TrpGlu: 0.585 ± 0.03
0.578TrpPhe: 0.578 ± 0.031
0.745TrpGly: 0.745 ± 0.033
0.369TrpHis: 0.369 ± 0.02
0.736TrpIle: 0.736 ± 0.038
0.593TrpLys: 0.593 ± 0.028
1.84TrpLeu: 1.84 ± 0.059
0.394TrpMet: 0.394 ± 0.023
0.386TrpAsn: 0.386 ± 0.024
0.545TrpPro: 0.545 ± 0.026
0.803TrpGln: 0.803 ± 0.039
0.838TrpArg: 0.838 ± 0.038
0.814TrpSer: 0.814 ± 0.031
0.384TrpThr: 0.384 ± 0.027
0.848TrpVal: 0.848 ± 0.033
0.206TrpTrp: 0.206 ± 0.019
0.336TrpTyr: 0.336 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.274TyrAla: 2.274 ± 0.05
0.326TyrCys: 0.326 ± 0.023
1.409TyrAsp: 1.409 ± 0.043
1.406TyrGlu: 1.406 ± 0.047
1.081TyrPhe: 1.081 ± 0.038
2.122TyrGly: 2.122 ± 0.057
0.64TyrHis: 0.64 ± 0.031
1.397TyrIle: 1.397 ± 0.044
0.95TyrLys: 0.95 ± 0.041
2.86TyrLeu: 2.86 ± 0.064
0.643TyrMet: 0.643 ± 0.032
0.807TyrAsn: 0.807 ± 0.037
1.2TyrPro: 1.2 ± 0.044
0.911TyrGln: 0.911 ± 0.039
1.882TyrArg: 1.882 ± 0.056
1.581TyrSer: 1.581 ± 0.048
1.061TyrThr: 1.061 ± 0.036
1.479TyrVal: 1.479 ± 0.05
0.336TyrTrp: 0.336 ± 0.022
0.723TyrTyr: 0.723 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2236 proteins (707698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski