Amino acid dipepetide frequency for Olsenella profusa F0195

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.818AlaAla: 12.818 ± 0.174
2.059AlaCys: 2.059 ± 0.05
6.594AlaAsp: 6.594 ± 0.105
5.973AlaGlu: 5.973 ± 0.094
3.672AlaPhe: 3.672 ± 0.073
8.999AlaGly: 8.999 ± 0.121
2.667AlaHis: 2.667 ± 0.065
5.389AlaIle: 5.389 ± 0.102
3.341AlaLys: 3.341 ± 0.072
11.565AlaLeu: 11.565 ± 0.148
3.004AlaMet: 3.004 ± 0.062
2.765AlaAsn: 2.765 ± 0.056
4.283AlaPro: 4.283 ± 0.091
3.766AlaGln: 3.766 ± 0.07
8.364AlaArg: 8.364 ± 0.146
6.758AlaSer: 6.758 ± 0.107
6.044AlaThr: 6.044 ± 0.1
7.563AlaVal: 7.563 ± 0.093
1.293AlaTrp: 1.293 ± 0.04
3.002AlaTyr: 3.002 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
1.816CysAla: 1.816 ± 0.055
0.297CysCys: 0.297 ± 0.019
1.112CysAsp: 1.112 ± 0.039
0.982CysGlu: 0.982 ± 0.035
0.424CysPhe: 0.424 ± 0.025
1.782CysGly: 1.782 ± 0.054
0.425CysHis: 0.425 ± 0.023
0.742CysIle: 0.742 ± 0.029
0.358CysLys: 0.358 ± 0.023
1.349CysLeu: 1.349 ± 0.042
0.387CysMet: 0.387 ± 0.024
0.37CysAsn: 0.37 ± 0.022
0.821CysPro: 0.821 ± 0.04
0.381CysGln: 0.381 ± 0.025
1.046CysArg: 1.046 ± 0.041
0.845CysSer: 0.845 ± 0.032
0.872CysThr: 0.872 ± 0.033
1.227CysVal: 1.227 ± 0.04
0.17CysTrp: 0.17 ± 0.015
0.372CysTyr: 0.372 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
8.161AspAla: 8.161 ± 0.127
0.774AspCys: 0.774 ± 0.028
4.265AspAsp: 4.265 ± 0.086
5.121AspGlu: 5.121 ± 0.083
2.194AspPhe: 2.194 ± 0.055
6.279AspGly: 6.279 ± 0.116
1.251AspHis: 1.251 ± 0.044
2.931AspIle: 2.931 ± 0.065
1.735AspLys: 1.735 ± 0.044
5.839AspLeu: 5.839 ± 0.104
1.633AspMet: 1.633 ± 0.046
1.423AspAsn: 1.423 ± 0.048
2.992AspPro: 2.992 ± 0.062
1.601AspGln: 1.601 ± 0.05
3.84AspArg: 3.84 ± 0.07
2.826AspSer: 2.826 ± 0.072
2.984AspThr: 2.984 ± 0.064
5.933AspVal: 5.933 ± 0.094
0.811AspTrp: 0.811 ± 0.035
1.976AspTyr: 1.976 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
6.613GluAla: 6.613 ± 0.11
0.796GluCys: 0.796 ± 0.029
3.639GluAsp: 3.639 ± 0.073
4.01GluGlu: 4.01 ± 0.087
1.766GluPhe: 1.766 ± 0.043
5.795GluGly: 5.795 ± 0.079
1.606GluHis: 1.606 ± 0.046
2.324GluIle: 2.324 ± 0.073
1.688GluLys: 1.688 ± 0.054
6.363GluLeu: 6.363 ± 0.116
1.609GluMet: 1.609 ± 0.048
1.463GluAsn: 1.463 ± 0.048
2.337GluPro: 2.337 ± 0.061
2.068GluGln: 2.068 ± 0.052
6.1GluArg: 6.1 ± 0.116
2.891GluSer: 2.891 ± 0.069
2.783GluThr: 2.783 ± 0.055
4.656GluVal: 4.656 ± 0.088
0.698GluTrp: 0.698 ± 0.033
1.436GluTyr: 1.436 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.449PheAla: 3.449 ± 0.069
0.591PheCys: 0.591 ± 0.024
2.686PheAsp: 2.686 ± 0.06
2.069PheGlu: 2.069 ± 0.054
1.182PhePhe: 1.182 ± 0.045
3.248PheGly: 3.248 ± 0.064
0.634PheHis: 0.634 ± 0.032
1.203PheIle: 1.203 ± 0.041
0.92PheLys: 0.92 ± 0.037
2.905PheLeu: 2.905 ± 0.071
0.88PheMet: 0.88 ± 0.033
0.822PheAsn: 0.822 ± 0.037
1.287PhePro: 1.287 ± 0.039
0.822PheGln: 0.822 ± 0.036
1.682PheArg: 1.682 ± 0.053
2.395PheSer: 2.395 ± 0.053
1.687PheThr: 1.687 ± 0.043
3.085PheVal: 3.085 ± 0.069
0.417PheTrp: 0.417 ± 0.024
0.903PheTyr: 0.903 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
8.763GlyAla: 8.763 ± 0.128
1.515GlyCys: 1.515 ± 0.049
5.076GlyAsp: 5.076 ± 0.087
5.164GlyGlu: 5.164 ± 0.099
3.17GlyPhe: 3.17 ± 0.068
7.31GlyGly: 7.31 ± 0.132
1.977GlyHis: 1.977 ± 0.052
5.127GlyIle: 5.127 ± 0.096
3.067GlyLys: 3.067 ± 0.07
7.899GlyLeu: 7.899 ± 0.102
2.988GlyMet: 2.988 ± 0.067
2.271GlyAsn: 2.271 ± 0.08
2.753GlyPro: 2.753 ± 0.067
2.421GlyGln: 2.421 ± 0.058
6.631GlyArg: 6.631 ± 0.132
5.511GlySer: 5.511 ± 0.107
5.868GlyThr: 5.868 ± 0.104
6.91GlyVal: 6.91 ± 0.095
1.2GlyTrp: 1.2 ± 0.044
2.802GlyTyr: 2.802 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.519HisAla: 2.519 ± 0.065
0.312HisCys: 0.312 ± 0.019
1.663HisAsp: 1.663 ± 0.051
1.556HisGlu: 1.556 ± 0.049
0.71HisPhe: 0.71 ± 0.035
2.246HisGly: 2.246 ± 0.053
0.569HisHis: 0.569 ± 0.028
0.952HisIle: 0.952 ± 0.037
0.53HisLys: 0.53 ± 0.026
1.937HisLeu: 1.937 ± 0.045
0.616HisMet: 0.616 ± 0.027
0.532HisAsn: 0.532 ± 0.026
1.249HisPro: 1.249 ± 0.04
0.564HisGln: 0.564 ± 0.027
1.454HisArg: 1.454 ± 0.046
0.914HisSer: 0.914 ± 0.032
1.097HisThr: 1.097 ± 0.032
2.053HisVal: 2.053 ± 0.06
0.239HisTrp: 0.239 ± 0.016
0.675HisTyr: 0.675 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.512IleAla: 5.512 ± 0.092
0.877IleCys: 0.877 ± 0.036
3.605IleAsp: 3.605 ± 0.069
3.112IleGlu: 3.112 ± 0.067
1.262IlePhe: 1.262 ± 0.043
3.868IleGly: 3.868 ± 0.083
0.919IleHis: 0.919 ± 0.035
2.25IleIle: 2.25 ± 0.072
1.432IleLys: 1.432 ± 0.048
3.893IleLeu: 3.893 ± 0.079
1.138IleMet: 1.138 ± 0.047
1.341IleAsn: 1.341 ± 0.043
2.264IlePro: 2.264 ± 0.057
1.1IleGln: 1.1 ± 0.038
2.811IleArg: 2.811 ± 0.067
2.86IleSer: 2.86 ± 0.068
2.559IleThr: 2.559 ± 0.062
4.236IleVal: 4.236 ± 0.08
0.419IleTrp: 0.419 ± 0.023
1.172IleTyr: 1.172 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
3.3LysAla: 3.3 ± 0.073
0.264LysCys: 0.264 ± 0.019
1.835LysAsp: 1.835 ± 0.051
1.891LysGlu: 1.891 ± 0.061
0.662LysPhe: 0.662 ± 0.029
2.62LysGly: 2.62 ± 0.058
0.566LysHis: 0.566 ± 0.028
1.154LysIle: 1.154 ± 0.043
1.086LysLys: 1.086 ± 0.049
2.461LysLeu: 2.461 ± 0.062
0.763LysMet: 0.763 ± 0.034
0.869LysAsn: 0.869 ± 0.036
1.266LysPro: 1.266 ± 0.044
0.823LysGln: 0.823 ± 0.034
2.419LysArg: 2.419 ± 0.059
1.605LysSer: 1.605 ± 0.046
1.726LysThr: 1.726 ± 0.043
2.662LysVal: 2.662 ± 0.057
0.273LysTrp: 0.273 ± 0.02
0.733LysTyr: 0.733 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
11.611LeuAla: 11.611 ± 0.136
1.575LeuCys: 1.575 ± 0.047
6.406LeuAsp: 6.406 ± 0.091
5.3LeuGlu: 5.3 ± 0.094
3.149LeuPhe: 3.149 ± 0.072
8.516LeuGly: 8.516 ± 0.119
1.803LeuHis: 1.803 ± 0.044
3.72LeuIle: 3.72 ± 0.081
2.72LeuLys: 2.72 ± 0.084
8.983LeuLeu: 8.983 ± 0.142
2.72LeuMet: 2.72 ± 0.062
2.023LeuAsn: 2.023 ± 0.059
4.416LeuPro: 4.416 ± 0.08
2.155LeuGln: 2.155 ± 0.057
6.461LeuArg: 6.461 ± 0.096
6.651LeuSer: 6.651 ± 0.103
5.21LeuThr: 5.21 ± 0.095
8.56LeuVal: 8.56 ± 0.137
1.004LeuTrp: 1.004 ± 0.036
2.28LeuTyr: 2.28 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
3.361MetAla: 3.361 ± 0.081
0.386MetCys: 0.386 ± 0.026
1.754MetAsp: 1.754 ± 0.047
1.452MetGlu: 1.452 ± 0.047
0.689MetPhe: 0.689 ± 0.031
2.925MetGly: 2.925 ± 0.074
0.573MetHis: 0.573 ± 0.027
1.008MetIle: 1.008 ± 0.037
0.657MetLys: 0.657 ± 0.029
2.654MetLeu: 2.654 ± 0.062
0.713MetMet: 0.713 ± 0.03
0.737MetAsn: 0.737 ± 0.034
1.463MetPro: 1.463 ± 0.042
0.826MetGln: 0.826 ± 0.031
2.32MetArg: 2.32 ± 0.048
1.884MetSer: 1.884 ± 0.053
1.56MetThr: 1.56 ± 0.048
2.05MetVal: 2.05 ± 0.049
0.228MetTrp: 0.228 ± 0.017
0.497MetTyr: 0.497 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.694AsnAla: 2.694 ± 0.064
0.363AsnCys: 0.363 ± 0.023
1.585AsnAsp: 1.585 ± 0.047
1.449AsnGlu: 1.449 ± 0.048
0.781AsnPhe: 0.781 ± 0.03
2.32AsnGly: 2.32 ± 0.066
0.552AsnHis: 0.552 ± 0.028
1.243AsnIle: 1.243 ± 0.041
0.732AsnLys: 0.732 ± 0.033
2.339AsnLeu: 2.339 ± 0.06
0.675AsnMet: 0.675 ± 0.028
0.71AsnAsn: 0.71 ± 0.034
1.6AsnPro: 1.6 ± 0.045
0.732AsnGln: 0.732 ± 0.031
1.56AsnArg: 1.56 ± 0.051
1.153AsnSer: 1.153 ± 0.043
1.198AsnThr: 1.198 ± 0.044
2.417AsnVal: 2.417 ± 0.063
0.265AsnTrp: 0.265 ± 0.02
0.753AsnTyr: 0.753 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
4.489ProAla: 4.489 ± 0.082
0.662ProCys: 0.662 ± 0.029
3.072ProAsp: 3.072 ± 0.066
3.073ProGlu: 3.073 ± 0.065
1.552ProPhe: 1.552 ± 0.051
3.396ProGly: 3.396 ± 0.068
1.079ProHis: 1.079 ± 0.045
2.049ProIle: 2.049 ± 0.05
1.376ProLys: 1.376 ± 0.046
3.957ProLeu: 3.957 ± 0.069
1.018ProMet: 1.018 ± 0.039
1.161ProAsn: 1.161 ± 0.036
1.414ProPro: 1.414 ± 0.056
1.637ProGln: 1.637 ± 0.05
2.642ProArg: 2.642 ± 0.072
2.897ProSer: 2.897 ± 0.069
2.848ProThr: 2.848 ± 0.068
3.394ProVal: 3.394 ± 0.064
0.613ProTrp: 0.613 ± 0.026
1.317ProTyr: 1.317 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.453GlnAla: 3.453 ± 0.069
0.282GlnCys: 0.282 ± 0.019
1.683GlnAsp: 1.683 ± 0.048
1.85GlnGlu: 1.85 ± 0.05
0.806GlnPhe: 0.806 ± 0.031
2.654GlnGly: 2.654 ± 0.059
0.561GlnHis: 0.561 ± 0.023
1.403GlnIle: 1.403 ± 0.043
0.911GlnLys: 0.911 ± 0.04
2.845GlnLeu: 2.845 ± 0.074
0.914GlnMet: 0.914 ± 0.033
0.738GlnAsn: 0.738 ± 0.032
1.097GlnPro: 1.097 ± 0.047
1.087GlnGln: 1.087 ± 0.05
2.343GlnArg: 2.343 ± 0.06
1.547GlnSer: 1.547 ± 0.052
1.473GlnThr: 1.473 ± 0.048
2.557GlnVal: 2.557 ± 0.054
0.331GlnTrp: 0.331 ± 0.021
0.725GlnTyr: 0.725 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
7.272ArgAla: 7.272 ± 0.133
0.994ArgCys: 0.994 ± 0.036
4.411ArgAsp: 4.411 ± 0.09
4.921ArgGlu: 4.921 ± 0.089
2.278ArgPhe: 2.278 ± 0.058
5.532ArgGly: 5.532 ± 0.103
2.051ArgHis: 2.051 ± 0.058
3.462ArgIle: 3.462 ± 0.073
2.073ArgLys: 2.073 ± 0.047
7.088ArgLeu: 7.088 ± 0.114
2.368ArgMet: 2.368 ± 0.059
1.723ArgAsn: 1.723 ± 0.047
3.178ArgPro: 3.178 ± 0.076
2.5ArgGln: 2.5 ± 0.061
6.613ArgArg: 6.613 ± 0.144
3.948ArgSer: 3.948 ± 0.072
3.833ArgThr: 3.833 ± 0.072
5.16ArgVal: 5.16 ± 0.105
0.895ArgTrp: 0.895 ± 0.036
2.141ArgTyr: 2.141 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.826SerAla: 5.826 ± 0.094
0.977SerCys: 0.977 ± 0.037
3.687SerAsp: 3.687 ± 0.074
3.138SerGlu: 3.138 ± 0.065
2.364SerPhe: 2.364 ± 0.058
5.445SerGly: 5.445 ± 0.089
1.37SerHis: 1.37 ± 0.04
2.969SerIle: 2.969 ± 0.069
1.743SerLys: 1.743 ± 0.049
5.976SerLeu: 5.976 ± 0.092
1.701SerMet: 1.701 ± 0.05
1.49SerAsn: 1.49 ± 0.051
2.559SerPro: 2.559 ± 0.065
1.906SerGln: 1.906 ± 0.053
3.818SerArg: 3.818 ± 0.091
3.945SerSer: 3.945 ± 0.105
3.339SerThr: 3.339 ± 0.079
4.728SerVal: 4.728 ± 0.078
0.908SerTrp: 0.908 ± 0.033
2.0SerTyr: 2.0 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
5.121ThrAla: 5.121 ± 0.09
0.977ThrCys: 0.977 ± 0.031
3.222ThrAsp: 3.222 ± 0.068
2.573ThrGlu: 2.573 ± 0.058
2.093ThrPhe: 2.093 ± 0.051
5.022ThrGly: 5.022 ± 0.086
1.311ThrHis: 1.311 ± 0.045
3.148ThrIle: 3.148 ± 0.066
1.614ThrLys: 1.614 ± 0.047
5.428ThrLeu: 5.428 ± 0.084
1.429ThrMet: 1.429 ± 0.038
1.652ThrAsn: 1.652 ± 0.05
2.974ThrPro: 2.974 ± 0.064
1.532ThrGln: 1.532 ± 0.046
3.285ThrArg: 3.285 ± 0.063
3.551ThrSer: 3.551 ± 0.074
3.341ThrThr: 3.341 ± 0.082
4.471ThrVal: 4.471 ± 0.072
0.719ThrTrp: 0.719 ± 0.033
1.764ThrTyr: 1.764 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
9.135ValAla: 9.135 ± 0.124
1.496ValCys: 1.496 ± 0.048
5.295ValAsp: 5.295 ± 0.08
4.579ValGlu: 4.579 ± 0.086
2.664ValPhe: 2.664 ± 0.069
6.793ValGly: 6.793 ± 0.102
1.474ValHis: 1.474 ± 0.048
4.118ValIle: 4.118 ± 0.084
2.014ValLys: 2.014 ± 0.053
7.631ValLeu: 7.631 ± 0.104
2.266ValMet: 2.266 ± 0.059
1.946ValAsn: 1.946 ± 0.05
4.041ValPro: 4.041 ± 0.073
1.859ValGln: 1.859 ± 0.047
6.12ValArg: 6.12 ± 0.098
5.673ValSer: 5.673 ± 0.096
4.895ValThr: 4.895 ± 0.083
7.01ValVal: 7.01 ± 0.109
0.854ValTrp: 0.854 ± 0.038
1.907ValTyr: 1.907 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.091TrpAla: 1.091 ± 0.039
0.215TrpCys: 0.215 ± 0.019
0.806TrpAsp: 0.806 ± 0.037
0.69TrpGlu: 0.69 ± 0.03
0.422TrpPhe: 0.422 ± 0.024
1.089TrpGly: 1.089 ± 0.046
0.305TrpHis: 0.305 ± 0.02
0.437TrpIle: 0.437 ± 0.025
0.339TrpLys: 0.339 ± 0.022
1.212TrpLeu: 1.212 ± 0.042
0.342TrpMet: 0.342 ± 0.022
0.354TrpAsn: 0.354 ± 0.022
0.495TrpPro: 0.495 ± 0.026
0.5TrpGln: 0.5 ± 0.026
0.963TrpArg: 0.963 ± 0.039
0.699TrpSer: 0.699 ± 0.031
0.556TrpThr: 0.556 ± 0.031
0.778TrpVal: 0.778 ± 0.035
0.216TrpTrp: 0.216 ± 0.017
0.326TrpTyr: 0.326 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.918TyrAla: 2.918 ± 0.059
0.366TyrCys: 0.366 ± 0.02
2.172TyrAsp: 2.172 ± 0.079
1.737TyrGlu: 1.737 ± 0.052
1.027TyrPhe: 1.027 ± 0.036
2.583TyrGly: 2.583 ± 0.065
0.695TyrHis: 0.695 ± 0.029
1.001TyrIle: 1.001 ± 0.041
0.639TyrLys: 0.639 ± 0.032
2.939TyrLeu: 2.939 ± 0.07
0.571TyrMet: 0.571 ± 0.031
0.732TyrAsn: 0.732 ± 0.033
1.16TyrPro: 1.16 ± 0.04
0.979TyrGln: 0.979 ± 0.032
1.97TyrArg: 1.97 ± 0.053
1.335TyrSer: 1.335 ± 0.045
1.353TyrThr: 1.353 ± 0.048
2.319TyrVal: 2.319 ± 0.047
0.284TyrTrp: 0.284 ± 0.019
0.841TyrTyr: 0.841 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2650 proteins (795533 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski