Amino acid dipepetide frequency for Sulfurospirillum cavolei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.6AlaAla: 5.6 ± 0.123	1.17AlaCys: 1.17 ± 0.057	3.378AlaAsp: 3.378 ± 0.085	3.824AlaGlu: 3.824 ± 0.104	4.418AlaPhe: 4.418 ± 0.093	4.482AlaGly: 4.482 ± 0.121	2.108AlaHis: 2.108 ± 0.065	6.53AlaIle: 6.53 ± 0.119	6.571AlaLys: 6.571 ± 0.121	11.106AlaLeu: 11.106 ± 0.156	2.728AlaMet: 2.728 ± 0.066	3.139AlaAsn: 3.139 ± 0.077	2.364AlaPro: 2.364 ± 0.071	3.48AlaGln: 3.48 ± 0.089	3.157AlaArg: 3.157 ± 0.079	5.427AlaSer: 5.427 ± 0.115	4.158AlaThr: 4.158 ± 0.087	4.548AlaVal: 4.548 ± 0.11	0.741AlaTrp: 0.741 ± 0.041	3.605AlaTyr: 3.605 ± 0.092	0.013AlaXaa: 0.013 ± 0.006
Cys	1.04CysAla: 1.04 ± 0.045	0.152CysCys: 0.152 ± 0.017	0.774CysAsp: 0.774 ± 0.046	0.899CysGlu: 0.899 ± 0.044	0.52CysPhe: 0.52 ± 0.032	0.945CysGly: 0.945 ± 0.044	0.353CysHis: 0.353 ± 0.029	0.767CysIle: 0.767 ± 0.044	0.682CysLys: 0.682 ± 0.033	0.923CysLeu: 0.923 ± 0.046	0.292CysMet: 0.292 ± 0.026	0.42CysAsn: 0.42 ± 0.028	0.552CysPro: 0.552 ± 0.039	0.345CysGln: 0.345 ± 0.025	0.386CysArg: 0.386 ± 0.026	0.724CysSer: 0.724 ± 0.039	0.579CysThr: 0.579 ± 0.036	0.802CysVal: 0.802 ± 0.044	0.063CysTrp: 0.063 ± 0.01	0.358CysTyr: 0.358 ± 0.023	0.004CysXaa: 0.004 ± 0.003
Asp	5.05AspAla: 5.05 ± 0.096	0.433AspCys: 0.433 ± 0.033	2.665AspAsp: 2.665 ± 0.079	4.274AspGlu: 4.274 ± 0.099	2.89AspPhe: 2.89 ± 0.067	2.78AspGly: 2.78 ± 0.091	0.921AspHis: 0.921 ± 0.042	3.817AspIle: 3.817 ± 0.087	3.486AspLys: 3.486 ± 0.079	4.862AspLeu: 4.862 ± 0.1	1.306AspMet: 1.306 ± 0.052	1.772AspAsn: 1.772 ± 0.064	1.75AspPro: 1.75 ± 0.051	1.43AspGln: 1.43 ± 0.047	2.045AspArg: 2.045 ± 0.071	2.357AspSer: 2.357 ± 0.07	3.194AspThr: 3.194 ± 0.13	3.885AspVal: 3.885 ± 0.082	0.399AspTrp: 0.399 ± 0.027	1.837AspTyr: 1.837 ± 0.069	0.002AspXaa: 0.002 ± 0.002
Glu	6.499GluAla: 6.499 ± 0.124	0.667GluCys: 0.667 ± 0.037	2.901GluAsp: 2.901 ± 0.075	5.442GluGlu: 5.442 ± 0.149	2.543GluPhe: 2.543 ± 0.073	4.368GluGly: 4.368 ± 0.102	1.95GluHis: 1.95 ± 0.072	5.282GluIle: 5.282 ± 0.104	5.785GluLys: 5.785 ± 0.126	6.289GluLeu: 6.289 ± 0.105	1.813GluMet: 1.813 ± 0.059	3.386GluAsn: 3.386 ± 0.08	1.811GluPro: 1.811 ± 0.06	2.333GluGln: 2.333 ± 0.066	3.159GluArg: 3.159 ± 0.086	3.8GluSer: 3.8 ± 0.089	3.753GluThr: 3.753 ± 0.087	4.288GluVal: 4.288 ± 0.09	0.526GluTrp: 0.526 ± 0.032	2.138GluTyr: 2.138 ± 0.065	0.004GluXaa: 0.004 ± 0.002
Phe	4.049PheAla: 4.049 ± 0.089	0.709PheCys: 0.709 ± 0.039	2.979PheAsp: 2.979 ± 0.066	3.69PheGlu: 3.69 ± 0.103	3.042PhePhe: 3.042 ± 0.092	3.59PheGly: 3.59 ± 0.091	0.988PheHis: 0.988 ± 0.05	3.501PheIle: 3.501 ± 0.101	3.076PheLys: 3.076 ± 0.079	5.198PheLeu: 5.198 ± 0.12	1.216PheMet: 1.216 ± 0.049	1.959PheAsn: 1.959 ± 0.064	1.326PhePro: 1.326 ± 0.055	1.347PheGln: 1.347 ± 0.055	1.521PheArg: 1.521 ± 0.052	3.657PheSer: 3.657 ± 0.09	2.45PheThr: 2.45 ± 0.074	3.373PheVal: 3.373 ± 0.095	0.555PheTrp: 0.555 ± 0.039	1.954PheTyr: 1.954 ± 0.067	0.006PheXaa: 0.006 ± 0.003
Gly	4.89GlyAla: 4.89 ± 0.112	0.908GlyCys: 0.908 ± 0.046	3.219GlyAsp: 3.219 ± 0.101	4.019GlyGlu: 4.019 ± 0.093	3.57GlyPhe: 3.57 ± 0.088	4.19GlyGly: 4.19 ± 0.124	1.22GlyHis: 1.22 ± 0.042	5.403GlyIle: 5.403 ± 0.105	4.353GlyLys: 4.353 ± 0.091	5.813GlyLeu: 5.813 ± 0.125	1.991GlyMet: 1.991 ± 0.071	2.249GlyAsn: 2.249 ± 0.095	0.923GlyPro: 0.923 ± 0.045	1.412GlyGln: 1.412 ± 0.054	2.333GlyArg: 2.333 ± 0.069	3.793GlySer: 3.793 ± 0.115	3.282GlyThr: 3.282 ± 0.097	4.953GlyVal: 4.953 ± 0.11	0.628GlyTrp: 0.628 ± 0.038	2.866GlyTyr: 2.866 ± 0.066	0.011GlyXaa: 0.011 ± 0.004
His	1.867HisAla: 1.867 ± 0.063	0.256HisCys: 0.256 ± 0.021	1.228HisAsp: 1.228 ± 0.054	1.566HisGlu: 1.566 ± 0.066	1.319HisPhe: 1.319 ± 0.042	1.361HisGly: 1.361 ± 0.057	0.696HisHis: 0.696 ± 0.037	1.558HisIle: 1.558 ± 0.061	1.17HisLys: 1.17 ± 0.041	2.277HisLeu: 2.277 ± 0.069	0.583HisMet: 0.583 ± 0.038	0.873HisAsn: 0.873 ± 0.044	1.079HisPro: 1.079 ± 0.053	0.817HisGln: 0.817 ± 0.038	0.999HisArg: 0.999 ± 0.047	1.265HisSer: 1.265 ± 0.044	1.242HisThr: 1.242 ± 0.05	1.989HisVal: 1.989 ± 0.07	0.173HisTrp: 0.173 ± 0.017	0.942HisTyr: 0.942 ± 0.042	0.004HisXaa: 0.004 ± 0.003
Ile	7.44IleAla: 7.44 ± 0.117	0.752IleCys: 0.752 ± 0.042	4.89IleAsp: 4.89 ± 0.097	5.754IleGlu: 5.754 ± 0.101	3.363IlePhe: 3.363 ± 0.089	5.336IleGly: 5.336 ± 0.118	1.4IleHis: 1.4 ± 0.053	4.563IleIle: 4.563 ± 0.101	4.671IleLys: 4.671 ± 0.105	6.824IleLeu: 6.824 ± 0.134	1.374IleMet: 1.374 ± 0.055	2.975IleAsn: 2.975 ± 0.081	2.535IlePro: 2.535 ± 0.068	2.247IleGln: 2.247 ± 0.065	2.877IleArg: 2.877 ± 0.078	4.545IleSer: 4.545 ± 0.091	3.59IleThr: 3.59 ± 0.092	6.006IleVal: 6.006 ± 0.125	0.459IleTrp: 0.459 ± 0.027	2.186IleTyr: 2.186 ± 0.07	0.013IleXaa: 0.013 ± 0.005
Lys	6.203LysAla: 6.203 ± 0.127	0.565LysCys: 0.565 ± 0.036	3.451LysAsp: 3.451 ± 0.08	7.115LysGlu: 7.115 ± 0.128	2.019LysPhe: 2.019 ± 0.073	3.871LysGly: 3.871 ± 0.081	1.458LysHis: 1.458 ± 0.055	5.596LysIle: 5.596 ± 0.099	5.271LysLys: 5.271 ± 0.13	5.997LysLeu: 5.997 ± 0.108	1.88LysMet: 1.88 ± 0.067	3.62LysAsn: 3.62 ± 0.074	2.299LysPro: 2.299 ± 0.071	2.268LysGln: 2.268 ± 0.074	3.434LysArg: 3.434 ± 0.085	4.151LysSer: 4.151 ± 0.086	4.181LysThr: 4.181 ± 0.084	4.067LysVal: 4.067 ± 0.093	0.47LysTrp: 0.47 ± 0.033	1.978LysTyr: 1.978 ± 0.065	0.002LysXaa: 0.002 ± 0.002
Leu	8.008LeuAla: 8.008 ± 0.135	1.371LeuCys: 1.371 ± 0.051	5.163LeuAsp: 5.163 ± 0.109	7.05LeuGlu: 7.05 ± 0.141	6.036LeuPhe: 6.036 ± 0.132	6.749LeuGly: 6.749 ± 0.114	2.81LeuHis: 2.81 ± 0.083	6.818LeuIle: 6.818 ± 0.148	7.661LeuLys: 7.661 ± 0.117	10.817LeuLeu: 10.817 ± 0.196	2.598LeuMet: 2.598 ± 0.076	4.236LeuAsn: 4.236 ± 0.087	3.688LeuPro: 3.688 ± 0.095	3.298LeuGln: 3.298 ± 0.092	4.041LeuArg: 4.041 ± 0.089	8.653LeuSer: 8.653 ± 0.138	4.823LeuThr: 4.823 ± 0.086	5.912LeuVal: 5.912 ± 0.098	0.884LeuTrp: 0.884 ± 0.045	3.486LeuTyr: 3.486 ± 0.082	0.011LeuXaa: 0.011 ± 0.005
Met	1.816MetAla: 1.816 ± 0.056	0.236MetCys: 0.236 ± 0.022	1.213MetAsp: 1.213 ± 0.047	1.415MetGlu: 1.415 ± 0.051	1.036MetPhe: 1.036 ± 0.048	1.64MetGly: 1.64 ± 0.062	0.7MetHis: 0.7 ± 0.038	2.219MetIle: 2.219 ± 0.066	2.037MetLys: 2.037 ± 0.057	2.986MetLeu: 2.986 ± 0.088	0.914MetMet: 0.914 ± 0.046	1.282MetAsn: 1.282 ± 0.057	1.122MetPro: 1.122 ± 0.044	1.276MetGln: 1.276 ± 0.05	1.309MetArg: 1.309 ± 0.049	1.924MetSer: 1.924 ± 0.065	1.12MetThr: 1.12 ± 0.047	1.612MetVal: 1.612 ± 0.055	0.18MetTrp: 0.18 ± 0.019	0.752MetTyr: 0.752 ± 0.039	0.0MetXaa: 0.0 ± 0.0
Asn	4.262AsnAla: 4.262 ± 0.097	0.301AsnCys: 0.301 ± 0.026	2.583AsnAsp: 2.583 ± 0.09	2.894AsnGlu: 2.894 ± 0.076	1.755AsnPhe: 1.755 ± 0.057	2.557AsnGly: 2.557 ± 0.081	0.865AsnHis: 0.865 ± 0.034	2.983AsnIle: 2.983 ± 0.085	2.099AsnLys: 2.099 ± 0.065	3.871AsnLeu: 3.871 ± 0.081	0.83AsnMet: 0.83 ± 0.046	1.475AsnAsn: 1.475 ± 0.06	1.971AsnPro: 1.971 ± 0.062	1.397AsnGln: 1.397 ± 0.051	1.9AsnArg: 1.9 ± 0.055	2.023AsnSer: 2.023 ± 0.072	2.305AsnThr: 2.305 ± 0.065	3.228AsnVal: 3.228 ± 0.087	0.232AsnTrp: 0.232 ± 0.02	1.577AsnTyr: 1.577 ± 0.05	0.002AsnXaa: 0.002 ± 0.002
Pro	1.792ProAla: 1.792 ± 0.056	0.368ProCys: 0.368 ± 0.029	1.443ProAsp: 1.443 ± 0.056	2.16ProGlu: 2.16 ± 0.076	1.956ProPhe: 1.956 ± 0.07	1.215ProGly: 1.215 ± 0.048	0.938ProHis: 0.938 ± 0.044	2.515ProIle: 2.515 ± 0.076	2.507ProLys: 2.507 ± 0.075	3.889ProLeu: 3.889 ± 0.095	0.914ProMet: 0.914 ± 0.039	1.465ProAsn: 1.465 ± 0.053	0.919ProPro: 0.919 ± 0.052	1.235ProGln: 1.235 ± 0.05	1.053ProArg: 1.053 ± 0.053	2.569ProSer: 2.569 ± 0.083	1.874ProThr: 1.874 ± 0.065	2.058ProVal: 2.058 ± 0.064	0.301ProTrp: 0.301 ± 0.025	1.404ProTyr: 1.404 ± 0.061	0.009ProXaa: 0.009 ± 0.004
Gln	2.882GlnAla: 2.882 ± 0.084	0.325GlnCys: 0.325 ± 0.027	1.386GlnAsp: 1.386 ± 0.06	2.797GlnGlu: 2.797 ± 0.085	1.112GlnPhe: 1.112 ± 0.045	2.047GlnGly: 2.047 ± 0.06	0.607GlnHis: 0.607 ± 0.033	2.327GlnIle: 2.327 ± 0.073	3.395GlnLys: 3.395 ± 0.074	2.301GlnLeu: 2.301 ± 0.073	0.875GlnMet: 0.875 ± 0.035	2.03GlnAsn: 2.03 ± 0.065	0.914GlnPro: 0.914 ± 0.041	0.878GlnGln: 0.878 ± 0.042	1.436GlnArg: 1.436 ± 0.059	2.448GlnSer: 2.448 ± 0.068	2.613GlnThr: 2.613 ± 0.086	1.317GlnVal: 1.317 ± 0.045	0.277GlnTrp: 0.277 ± 0.025	0.914GlnTyr: 0.914 ± 0.042	0.004GlnXaa: 0.004 ± 0.003
Arg	3.009ArgAla: 3.009 ± 0.081	0.442ArgCys: 0.442 ± 0.029	1.924ArgAsp: 1.924 ± 0.065	2.626ArgGlu: 2.626 ± 0.075	2.645ArgPhe: 2.645 ± 0.066	2.045ArgGly: 2.045 ± 0.055	0.901ArgHis: 0.901 ± 0.04	3.389ArgIle: 3.389 ± 0.082	2.457ArgLys: 2.457 ± 0.072	4.478ArgLeu: 4.478 ± 0.091	1.124ArgMet: 1.124 ± 0.049	1.64ArgAsn: 1.64 ± 0.052	1.01ArgPro: 1.01 ± 0.045	1.298ArgGln: 1.298 ± 0.05	1.722ArgArg: 1.722 ± 0.06	2.448ArgSer: 2.448 ± 0.067	1.813ArgThr: 1.813 ± 0.064	2.669ArgVal: 2.669 ± 0.057	0.409ArgTrp: 0.409 ± 0.027	2.147ArgTyr: 2.147 ± 0.073	0.007ArgXaa: 0.007 ± 0.004
Ser	4.961SerAla: 4.961 ± 0.088	0.663SerCys: 0.663 ± 0.033	3.291SerAsp: 3.291 ± 0.092	3.545SerGlu: 3.545 ± 0.078	3.61SerPhe: 3.61 ± 0.094	4.4SerGly: 4.4 ± 0.124	1.553SerHis: 1.553 ± 0.049	4.948SerIle: 4.948 ± 0.109	4.127SerLys: 4.127 ± 0.096	7.381SerLeu: 7.381 ± 0.159	1.774SerMet: 1.774 ± 0.063	2.351SerAsn: 2.351 ± 0.091	1.963SerPro: 1.963 ± 0.062	2.011SerGln: 2.011 ± 0.068	2.32SerArg: 2.32 ± 0.073	4.632SerSer: 4.632 ± 0.106	3.278SerThr: 3.278 ± 0.091	4.496SerVal: 4.496 ± 0.098	0.568SerTrp: 0.568 ± 0.035	2.44SerTyr: 2.44 ± 0.078	0.011SerXaa: 0.011 ± 0.004
Thr	3.64ThrAla: 3.64 ± 0.106	0.867ThrCys: 0.867 ± 0.045	2.156ThrAsp: 2.156 ± 0.065	1.987ThrGlu: 1.987 ± 0.064	2.745ThrPhe: 2.745 ± 0.073	3.079ThrGly: 3.079 ± 0.084	1.454ThrHis: 1.454 ± 0.054	4.316ThrIle: 4.316 ± 0.092	3.438ThrLys: 3.438 ± 0.078	7.414ThrLeu: 7.414 ± 0.147	1.4ThrMet: 1.4 ± 0.05	1.965ThrAsn: 1.965 ± 0.055	2.598ThrPro: 2.598 ± 0.078	2.076ThrGln: 2.076 ± 0.073	1.828ThrArg: 1.828 ± 0.059	3.081ThrSer: 3.081 ± 0.079	3.011ThrThr: 3.011 ± 0.09	3.25ThrVal: 3.25 ± 0.085	0.457ThrTrp: 0.457 ± 0.028	2.069ThrTyr: 2.069 ± 0.07	0.007ThrXaa: 0.007 ± 0.004
Val	5.499ValAla: 5.499 ± 0.121	0.934ValCys: 0.934 ± 0.043	3.607ValAsp: 3.607 ± 0.09	4.409ValGlu: 4.409 ± 0.09	3.159ValPhe: 3.159 ± 0.078	4.322ValGly: 4.322 ± 0.098	1.387ValHis: 1.387 ± 0.041	4.569ValIle: 4.569 ± 0.084	4.301ValLys: 4.301 ± 0.097	7.163ValLeu: 7.163 ± 0.13	1.902ValMet: 1.902 ± 0.067	2.63ValAsn: 2.63 ± 0.067	2.229ValPro: 2.229 ± 0.065	2.028ValGln: 2.028 ± 0.065	2.582ValArg: 2.582 ± 0.074	4.496ValSer: 4.496 ± 0.099	3.235ValThr: 3.235 ± 0.09	5.128ValVal: 5.128 ± 0.109	0.6ValTrp: 0.6 ± 0.036	2.37ValTyr: 2.37 ± 0.066	0.009ValXaa: 0.009 ± 0.004
Trp	0.535TrpAla: 0.535 ± 0.032	0.089TrpCys: 0.089 ± 0.012	0.435TrpAsp: 0.435 ± 0.03	0.492TrpGlu: 0.492 ± 0.033	0.438TrpPhe: 0.438 ± 0.027	0.555TrpGly: 0.555 ± 0.033	0.199TrpHis: 0.199 ± 0.019	0.706TrpIle: 0.706 ± 0.038	0.503TrpLys: 0.503 ± 0.032	0.953TrpLeu: 0.953 ± 0.047	0.323TrpMet: 0.323 ± 0.025	0.37TrpAsn: 0.37 ± 0.027	0.162TrpPro: 0.162 ± 0.019	0.377TrpGln: 0.377 ± 0.03	0.323TrpArg: 0.323 ± 0.025	0.516TrpSer: 0.516 ± 0.037	0.342TrpThr: 0.342 ± 0.025	0.598TrpVal: 0.598 ± 0.032	0.104TrpTrp: 0.104 ± 0.014	0.358TrpTyr: 0.358 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.493TyrAla: 3.493 ± 0.084	0.373TyrCys: 0.373 ± 0.025	2.459TyrAsp: 2.459 ± 0.068	2.771TyrGlu: 2.771 ± 0.075	2.002TyrPhe: 2.002 ± 0.07	2.481TyrGly: 2.481 ± 0.07	0.752TyrHis: 0.752 ± 0.036	1.991TyrIle: 1.991 ± 0.064	2.299TyrLys: 2.299 ± 0.074	3.558TyrLeu: 3.558 ± 0.082	0.951TyrMet: 0.951 ± 0.042	1.267TyrAsn: 1.267 ± 0.054	1.365TyrPro: 1.365 ± 0.049	1.326TyrGln: 1.326 ± 0.049	1.77TyrArg: 1.77 ± 0.057	1.811TyrSer: 1.811 ± 0.072	1.989TyrThr: 1.989 ± 0.075	2.375TyrVal: 2.375 ± 0.075	0.353TyrTrp: 0.353 ± 0.027	1.486TyrTyr: 1.486 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.013XaaAla: 0.013 ± 0.005	0.0XaaCys: 0.0 ± 0.0	0.009XaaAsp: 0.009 ± 0.004	0.006XaaGlu: 0.006 ± 0.003	0.007XaaPhe: 0.007 ± 0.003	0.011XaaGly: 0.011 ± 0.004	0.002XaaHis: 0.002 ± 0.002	0.004XaaIle: 0.004 ± 0.003	0.004XaaLys: 0.004 ± 0.003	0.015XaaLeu: 0.015 ± 0.005	0.002XaaMet: 0.002 ± 0.002	0.006XaaAsn: 0.006 ± 0.003	0.006XaaPro: 0.006 ± 0.003	0.004XaaGln: 0.004 ± 0.002	0.007XaaArg: 0.007 ± 0.004	0.006XaaSer: 0.006 ± 0.003	0.007XaaThr: 0.007 ± 0.003	0.004XaaVal: 0.004 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.007XaaTyr: 0.007 ± 0.004	0.03XaaXaa: 0.03 ± 0.008

Statistics based on 1874 proteins (538432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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