Amino acid dipepetide frequency for Eremomyces bilateralis CBS 781.70

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.6AlaAla: 8.6 ± 0.064	1.028AlaCys: 1.028 ± 0.019	4.238AlaAsp: 4.238 ± 0.033	5.213AlaGlu: 5.213 ± 0.045	3.112AlaPhe: 3.112 ± 0.032	5.942AlaGly: 5.942 ± 0.042	1.795AlaHis: 1.795 ± 0.024	4.282AlaIle: 4.282 ± 0.039	4.05AlaLys: 4.05 ± 0.035	7.616AlaLeu: 7.616 ± 0.052	1.938AlaMet: 1.938 ± 0.02	2.806AlaAsn: 2.806 ± 0.027	4.95AlaPro: 4.95 ± 0.052	3.227AlaGln: 3.227 ± 0.035	5.058AlaArg: 5.058 ± 0.034	7.086AlaSer: 7.086 ± 0.05	5.216AlaThr: 5.216 ± 0.042	5.372AlaVal: 5.372 ± 0.037	1.107AlaTrp: 1.107 ± 0.018	2.096AlaTyr: 2.096 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.926CysAla: 0.926 ± 0.016	0.265CysCys: 0.265 ± 0.009	0.626CysAsp: 0.626 ± 0.014	0.592CysGlu: 0.592 ± 0.012	0.515CysPhe: 0.515 ± 0.013	0.973CysGly: 0.973 ± 0.018	0.325CysHis: 0.325 ± 0.009	0.708CysIle: 0.708 ± 0.013	0.491CysLys: 0.491 ± 0.011	1.211CysLeu: 1.211 ± 0.021	0.266CysMet: 0.266 ± 0.008	0.419CysAsn: 0.419 ± 0.012	0.675CysPro: 0.675 ± 0.015	0.411CysGln: 0.411 ± 0.01	0.783CysArg: 0.783 ± 0.016	0.878CysSer: 0.878 ± 0.016	0.672CysThr: 0.672 ± 0.012	0.781CysVal: 0.781 ± 0.014	0.196CysTrp: 0.196 ± 0.007	0.331CysTyr: 0.331 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.877AspAla: 4.877 ± 0.033	0.601AspCys: 0.601 ± 0.013	4.109AspAsp: 4.109 ± 0.045	4.438AspGlu: 4.438 ± 0.045	2.114AspPhe: 2.114 ± 0.024	4.237AspGly: 4.237 ± 0.036	1.254AspHis: 1.254 ± 0.02	3.009AspIle: 3.009 ± 0.027	2.145AspLys: 2.145 ± 0.023	4.961AspLeu: 4.961 ± 0.033	1.256AspMet: 1.256 ± 0.018	1.652AspAsn: 1.652 ± 0.022	3.651AspPro: 3.651 ± 0.031	1.867AspGln: 1.867 ± 0.022	3.321AspArg: 3.321 ± 0.036	3.942AspSer: 3.942 ± 0.035	2.901AspThr: 2.901 ± 0.027	3.71AspVal: 3.71 ± 0.032	0.901AspTrp: 0.901 ± 0.014	1.469AspTyr: 1.469 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.18GluAla: 5.18 ± 0.043	0.617GluCys: 0.617 ± 0.014	4.132GluAsp: 4.132 ± 0.038	5.682GluGlu: 5.682 ± 0.067	1.999GluPhe: 1.999 ± 0.026	4.241GluGly: 4.241 ± 0.038	1.407GluHis: 1.407 ± 0.02	2.961GluIle: 2.961 ± 0.026	3.743GluLys: 3.743 ± 0.037	5.28GluLeu: 5.28 ± 0.037	1.515GluMet: 1.515 ± 0.02	2.171GluAsn: 2.171 ± 0.023	2.85GluPro: 2.85 ± 0.037	2.426GluGln: 2.426 ± 0.027	4.394GluArg: 4.394 ± 0.04	4.302GluSer: 4.302 ± 0.035	3.424GluThr: 3.424 ± 0.032	3.696GluVal: 3.696 ± 0.036	0.912GluTrp: 0.912 ± 0.015	1.64GluTyr: 1.64 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.036PheAla: 3.036 ± 0.03	0.545PheCys: 0.545 ± 0.011	2.232PheAsp: 2.232 ± 0.023	2.171PheGlu: 2.171 ± 0.025	1.525PhePhe: 1.525 ± 0.023	2.901PheGly: 2.901 ± 0.031	0.932PheHis: 0.932 ± 0.015	1.786PheIle: 1.786 ± 0.024	1.492PheLys: 1.492 ± 0.019	3.445PheLeu: 3.445 ± 0.033	0.772PheMet: 0.772 ± 0.014	1.367PheAsn: 1.367 ± 0.021	2.082PhePro: 2.082 ± 0.023	1.35PheGln: 1.35 ± 0.021	2.093PheArg: 2.093 ± 0.026	2.994PheSer: 2.994 ± 0.028	2.073PheThr: 2.073 ± 0.021	2.317PheVal: 2.317 ± 0.025	0.634PheTrp: 0.634 ± 0.014	1.043PheTyr: 1.043 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.62GlyAla: 5.62 ± 0.044	0.865GlyCys: 0.865 ± 0.014	3.754GlyAsp: 3.754 ± 0.036	4.045GlyGlu: 4.045 ± 0.034	2.79GlyPhe: 2.79 ± 0.033	6.352GlyGly: 6.352 ± 0.072	1.74GlyHis: 1.74 ± 0.021	3.59GlyIle: 3.59 ± 0.032	3.726GlyLys: 3.726 ± 0.036	6.084GlyLeu: 6.084 ± 0.045	1.831GlyMet: 1.831 ± 0.02	2.5GlyAsn: 2.5 ± 0.028	3.475GlyPro: 3.475 ± 0.033	2.565GlyGln: 2.565 ± 0.025	4.529GlyArg: 4.529 ± 0.04	5.876GlySer: 5.876 ± 0.056	4.194GlyThr: 4.194 ± 0.037	4.565GlyVal: 4.565 ± 0.033	1.216GlyTrp: 1.216 ± 0.019	2.121GlyTyr: 2.121 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.98HisAla: 1.98 ± 0.022	0.344HisCys: 0.344 ± 0.01	1.358HisAsp: 1.358 ± 0.019	1.316HisGlu: 1.316 ± 0.016	0.939HisPhe: 0.939 ± 0.015	1.816HisGly: 1.816 ± 0.021	0.946HisHis: 0.946 ± 0.019	1.229HisIle: 1.229 ± 0.018	0.854HisLys: 0.854 ± 0.013	2.321HisLeu: 2.321 ± 0.025	0.495HisMet: 0.495 ± 0.01	0.79HisAsn: 0.79 ± 0.013	1.927HisPro: 1.927 ± 0.022	0.998HisGln: 0.998 ± 0.015	1.662HisArg: 1.662 ± 0.023	1.913HisSer: 1.913 ± 0.024	1.28HisThr: 1.28 ± 0.019	1.413HisVal: 1.413 ± 0.018	0.353HisTrp: 0.353 ± 0.009	0.667HisTyr: 0.667 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.168IleAla: 4.168 ± 0.039	0.745IleCys: 0.745 ± 0.016	2.85IleAsp: 2.85 ± 0.028	2.848IleGlu: 2.848 ± 0.028	1.957IlePhe: 1.957 ± 0.025	3.249IleGly: 3.249 ± 0.028	1.254IleHis: 1.254 ± 0.017	2.426IleIle: 2.426 ± 0.031	2.044IleLys: 2.044 ± 0.022	4.507IleLeu: 4.507 ± 0.035	0.972IleMet: 0.972 ± 0.016	1.681IleAsn: 1.681 ± 0.02	3.273IlePro: 3.273 ± 0.025	1.887IleGln: 1.887 ± 0.024	2.974IleArg: 2.974 ± 0.028	3.873IleSer: 3.873 ± 0.03	2.727IleThr: 2.727 ± 0.029	3.169IleVal: 3.169 ± 0.029	0.722IleTrp: 0.722 ± 0.015	1.365IleTyr: 1.365 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.003LysAla: 4.003 ± 0.038	0.494LysCys: 0.494 ± 0.01	2.774LysAsp: 2.774 ± 0.028	3.49LysGlu: 3.49 ± 0.036	1.484LysPhe: 1.484 ± 0.018	3.174LysGly: 3.174 ± 0.031	1.139LysHis: 1.139 ± 0.018	2.162LysIle: 2.162 ± 0.024	3.182LysLys: 3.182 ± 0.049	3.967LysLeu: 3.967 ± 0.035	0.99LysMet: 0.99 ± 0.015	1.589LysAsn: 1.589 ± 0.02	2.775LysPro: 2.775 ± 0.035	1.772LysGln: 1.772 ± 0.02	3.618LysArg: 3.618 ± 0.036	3.604LysSer: 3.604 ± 0.033	2.62LysThr: 2.62 ± 0.027	2.814LysVal: 2.814 ± 0.029	0.694LysTrp: 0.694 ± 0.013	1.328LysTyr: 1.328 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.608LeuAla: 7.608 ± 0.044	1.161LeuCys: 1.161 ± 0.019	5.114LeuAsp: 5.114 ± 0.043	5.442LeuGlu: 5.442 ± 0.043	3.284LeuPhe: 3.284 ± 0.033	5.883LeuGly: 5.883 ± 0.045	2.318LeuHis: 2.318 ± 0.026	3.917LeuIle: 3.917 ± 0.036	4.192LeuLys: 4.192 ± 0.037	8.358LeuLeu: 8.358 ± 0.068	1.775LeuMet: 1.775 ± 0.022	3.085LeuAsn: 3.085 ± 0.026	5.591LeuPro: 5.591 ± 0.043	3.701LeuGln: 3.701 ± 0.034	5.99LeuArg: 5.99 ± 0.039	7.251LeuSer: 7.251 ± 0.053	4.746LeuThr: 4.746 ± 0.037	5.339LeuVal: 5.339 ± 0.043	1.174LeuTrp: 1.174 ± 0.021	2.301LeuTyr: 2.301 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.178MetAla: 2.178 ± 0.02	0.239MetCys: 0.239 ± 0.008	1.344MetAsp: 1.344 ± 0.017	1.381MetGlu: 1.381 ± 0.018	0.729MetPhe: 0.729 ± 0.013	1.534MetGly: 1.534 ± 0.02	0.493MetHis: 0.493 ± 0.011	0.971MetIle: 0.971 ± 0.017	1.083MetLys: 1.083 ± 0.016	1.798MetLeu: 1.798 ± 0.021	0.57MetMet: 0.57 ± 0.013	0.797MetAsn: 0.797 ± 0.014	1.272MetPro: 1.272 ± 0.016	0.847MetGln: 0.847 ± 0.016	1.334MetArg: 1.334 ± 0.015	1.842MetSer: 1.842 ± 0.021	1.226MetThr: 1.226 ± 0.016	1.391MetVal: 1.391 ± 0.017	0.262MetTrp: 0.262 ± 0.007	0.489MetTyr: 0.489 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.002AsnAla: 3.002 ± 0.027	0.448AsnCys: 0.448 ± 0.011	1.852AsnAsp: 1.852 ± 0.022	1.957AsnGlu: 1.957 ± 0.02	1.312AsnPhe: 1.312 ± 0.018	2.955AsnGly: 2.955 ± 0.036	0.869AsnHis: 0.869 ± 0.013	1.926AsnIle: 1.926 ± 0.022	1.378AsnLys: 1.378 ± 0.019	3.138AsnLeu: 3.138 ± 0.028	0.776AsnMet: 0.776 ± 0.016	1.226AsnAsn: 1.226 ± 0.016	2.621AsnPro: 2.621 ± 0.028	1.309AsnGln: 1.309 ± 0.022	2.036AsnArg: 2.036 ± 0.02	2.534AsnSer: 2.534 ± 0.024	1.975AsnThr: 1.975 ± 0.021	2.188AsnVal: 2.188 ± 0.022	0.526AsnTrp: 0.526 ± 0.013	0.935AsnTyr: 0.935 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.154ProAla: 5.154 ± 0.05	0.522ProCys: 0.522 ± 0.014	3.309ProAsp: 3.309 ± 0.029	3.781ProGlu: 3.781 ± 0.035	2.162ProPhe: 2.162 ± 0.025	4.206ProGly: 4.206 ± 0.041	1.555ProHis: 1.555 ± 0.02	2.72ProIle: 2.72 ± 0.028	2.738ProLys: 2.738 ± 0.029	4.906ProLeu: 4.906 ± 0.036	1.093ProMet: 1.093 ± 0.017	2.362ProAsn: 2.362 ± 0.025	5.866ProPro: 5.866 ± 0.082	2.478ProGln: 2.478 ± 0.037	3.669ProArg: 3.669 ± 0.043	6.689ProSer: 6.689 ± 0.062	4.366ProThr: 4.366 ± 0.042	3.476ProVal: 3.476 ± 0.031	0.725ProTrp: 0.725 ± 0.013	1.522ProTyr: 1.522 ± 0.019	0.001ProXaa: 0.001 ± 0.0
Gln	3.185GlnAla: 3.185 ± 0.027	0.433GlnCys: 0.433 ± 0.01	1.927GlnAsp: 1.927 ± 0.022	2.338GlnGlu: 2.338 ± 0.025	1.354GlnPhe: 1.354 ± 0.018	2.408GlnGly: 2.408 ± 0.027	1.023GlnHis: 1.023 ± 0.017	1.793GlnIle: 1.793 ± 0.019	1.88GlnLys: 1.88 ± 0.022	3.372GlnLeu: 3.372 ± 0.032	0.888GlnMet: 0.888 ± 0.016	1.472GlnAsn: 1.472 ± 0.018	2.545GlnPro: 2.545 ± 0.036	2.089GlnGln: 2.089 ± 0.052	2.726GlnArg: 2.726 ± 0.027	3.128GlnSer: 3.128 ± 0.031	2.231GlnThr: 2.231 ± 0.025	2.081GlnVal: 2.081 ± 0.024	0.557GlnTrp: 0.557 ± 0.013	1.116GlnTyr: 1.116 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.923ArgAla: 4.923 ± 0.039	0.778ArgCys: 0.778 ± 0.014	3.487ArgAsp: 3.487 ± 0.04	4.116ArgGlu: 4.116 ± 0.037	2.245ArgPhe: 2.245 ± 0.024	4.154ArgGly: 4.154 ± 0.037	1.661ArgHis: 1.661 ± 0.019	3.113ArgIle: 3.113 ± 0.027	3.674ArgLys: 3.674 ± 0.033	5.64ArgLeu: 5.64 ± 0.042	1.447ArgMet: 1.447 ± 0.019	2.386ArgAsn: 2.386 ± 0.027	3.808ArgPro: 3.808 ± 0.038	2.558ArgGln: 2.558 ± 0.023	5.57ArgArg: 5.57 ± 0.055	5.15ArgSer: 5.15 ± 0.048	3.642ArgThr: 3.642 ± 0.031	3.679ArgVal: 3.679 ± 0.031	1.018ArgTrp: 1.018 ± 0.019	1.7ArgTyr: 1.7 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.688SerAla: 6.688 ± 0.052	0.855SerCys: 0.855 ± 0.014	4.202SerAsp: 4.202 ± 0.039	4.163SerGlu: 4.163 ± 0.031	2.955SerPhe: 2.955 ± 0.029	5.897SerGly: 5.897 ± 0.052	2.032SerHis: 2.032 ± 0.023	4.126SerIle: 4.126 ± 0.033	3.717SerLys: 3.717 ± 0.037	7.021SerLeu: 7.021 ± 0.048	1.704SerMet: 1.704 ± 0.02	2.966SerAsn: 2.966 ± 0.028	5.797SerPro: 5.797 ± 0.052	3.125SerGln: 3.125 ± 0.033	5.288SerArg: 5.288 ± 0.049	8.548SerSer: 8.548 ± 0.082	5.648SerThr: 5.648 ± 0.045	4.583SerVal: 4.583 ± 0.038	1.084SerTrp: 1.084 ± 0.02	1.973SerTyr: 1.973 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.188ThrAla: 5.188 ± 0.035	0.719ThrCys: 0.719 ± 0.014	2.845ThrAsp: 2.845 ± 0.026	3.136ThrGlu: 3.136 ± 0.03	2.204ThrPhe: 2.204 ± 0.025	4.24ThrGly: 4.24 ± 0.036	1.327ThrHis: 1.327 ± 0.017	3.029ThrIle: 3.029 ± 0.029	2.594ThrLys: 2.594 ± 0.028	5.185ThrLeu: 5.185 ± 0.043	1.218ThrMet: 1.218 ± 0.018	2.026ThrAsn: 2.026 ± 0.022	4.414ThrPro: 4.414 ± 0.05	2.003ThrGln: 2.003 ± 0.024	3.306ThrArg: 3.306 ± 0.028	5.252ThrSer: 5.252 ± 0.041	4.168ThrThr: 4.168 ± 0.041	3.767ThrVal: 3.767 ± 0.033	0.805ThrTrp: 0.805 ± 0.013	1.528ThrTyr: 1.528 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.243ValAla: 5.243 ± 0.035	0.788ValCys: 0.788 ± 0.014	3.774ValAsp: 3.774 ± 0.028	4.107ValGlu: 4.107 ± 0.035	2.372ValPhe: 2.372 ± 0.027	4.278ValGly: 4.278 ± 0.041	1.449ValHis: 1.449 ± 0.02	2.832ValIle: 2.832 ± 0.031	2.866ValLys: 2.866 ± 0.031	5.528ValLeu: 5.528 ± 0.039	1.293ValMet: 1.293 ± 0.017	2.08ValAsn: 2.08 ± 0.02	3.637ValPro: 3.637 ± 0.034	2.343ValGln: 2.343 ± 0.025	3.789ValArg: 3.789 ± 0.031	4.52ValSer: 4.52 ± 0.033	3.403ValThr: 3.403 ± 0.03	4.349ValVal: 4.349 ± 0.036	0.868ValTrp: 0.868 ± 0.016	1.633ValTyr: 1.633 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.103TrpAla: 1.103 ± 0.019	0.189TrpCys: 0.189 ± 0.007	0.896TrpAsp: 0.896 ± 0.02	0.859TrpGlu: 0.859 ± 0.013	0.549TrpPhe: 0.549 ± 0.013	0.953TrpGly: 0.953 ± 0.019	0.346TrpHis: 0.346 ± 0.009	0.775TrpIle: 0.775 ± 0.015	0.789TrpLys: 0.789 ± 0.012	1.332TrpLeu: 1.332 ± 0.023	0.383TrpMet: 0.383 ± 0.008	0.585TrpAsn: 0.585 ± 0.012	0.577TrpPro: 0.577 ± 0.01	0.542TrpGln: 0.542 ± 0.013	1.003TrpArg: 1.003 ± 0.016	1.032TrpSer: 1.032 ± 0.016	0.92TrpThr: 0.92 ± 0.015	0.918TrpVal: 0.918 ± 0.015	0.277TrpTrp: 0.277 ± 0.008	0.408TrpTyr: 0.408 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.071TyrAla: 2.071 ± 0.021	0.41TyrCys: 0.41 ± 0.011	1.593TyrAsp: 1.593 ± 0.02	1.495TyrGlu: 1.495 ± 0.018	1.186TyrPhe: 1.186 ± 0.016	2.042TyrGly: 2.042 ± 0.025	0.738TyrHis: 0.738 ± 0.013	1.336TyrIle: 1.336 ± 0.016	1.038TyrLys: 1.038 ± 0.016	2.561TyrLeu: 2.561 ± 0.026	0.598TyrMet: 0.598 ± 0.011	1.003TyrAsn: 1.003 ± 0.015	1.513TyrPro: 1.513 ± 0.021	1.045TyrGln: 1.045 ± 0.018	1.608TyrArg: 1.608 ± 0.023	1.958TyrSer: 1.958 ± 0.021	1.522TyrThr: 1.522 ± 0.021	1.545TyrVal: 1.545 ± 0.02	0.404TyrTrp: 0.404 ± 0.01	0.868TyrTyr: 0.868 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.02XaaXaa: 0.02 ± 0.007

Statistics based on 9854 proteins (4362718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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