Amino acid dipepetide frequency for Midichloria mitochondrii (strain IricVA)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.641AlaAla: 6.641 ± 0.18
0.795AlaCys: 0.795 ± 0.06
3.524AlaAsp: 3.524 ± 0.128
4.379AlaGlu: 4.379 ± 0.134
2.996AlaPhe: 2.996 ± 0.123
4.532AlaGly: 4.532 ± 0.144
1.34AlaHis: 1.34 ± 0.069
6.777AlaIle: 6.777 ± 0.139
5.426AlaLys: 5.426 ± 0.145
7.525AlaLeu: 7.525 ± 0.174
1.742AlaMet: 1.742 ± 0.086
3.552AlaAsn: 3.552 ± 0.141
2.255AlaPro: 2.255 ± 0.111
2.394AlaGln: 2.394 ± 0.093
3.043AlaArg: 3.043 ± 0.1
4.707AlaSer: 4.707 ± 0.131
3.456AlaThr: 3.456 ± 0.122
5.458AlaVal: 5.458 ± 0.148
0.538AlaTrp: 0.538 ± 0.045
2.195AlaTyr: 2.195 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.681CysAla: 0.681 ± 0.05
0.328CysCys: 0.328 ± 0.033
0.542CysAsp: 0.542 ± 0.047
0.481CysGlu: 0.481 ± 0.046
0.566CysPhe: 0.566 ± 0.045
0.841CysGly: 0.841 ± 0.058
0.278CysHis: 0.278 ± 0.031
0.887CysIle: 0.887 ± 0.063
0.709CysLys: 0.709 ± 0.052
1.108CysLeu: 1.108 ± 0.076
0.289CysMet: 0.289 ± 0.031
0.659CysAsn: 0.659 ± 0.044
0.374CysPro: 0.374 ± 0.045
0.36CysGln: 0.36 ± 0.033
0.431CysArg: 0.431 ± 0.04
0.941CysSer: 0.941 ± 0.068
0.602CysThr: 0.602 ± 0.043
0.645CysVal: 0.645 ± 0.047
0.125CysTrp: 0.125 ± 0.022
0.445CysTyr: 0.445 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
2.832AspAla: 2.832 ± 0.107
0.527AspCys: 0.527 ± 0.046
2.095AspAsp: 2.095 ± 0.088
3.036AspGlu: 3.036 ± 0.097
2.79AspPhe: 2.79 ± 0.113
2.622AspGly: 2.622 ± 0.104
0.844AspHis: 0.844 ± 0.052
4.924AspIle: 4.924 ± 0.119
3.73AspLys: 3.73 ± 0.122
5.237AspLeu: 5.237 ± 0.118
1.122AspMet: 1.122 ± 0.052
2.451AspAsn: 2.451 ± 0.093
1.65AspPro: 1.65 ± 0.092
1.707AspGln: 1.707 ± 0.072
2.042AspArg: 2.042 ± 0.089
3.036AspSer: 3.036 ± 0.098
1.97AspThr: 1.97 ± 0.101
2.701AspVal: 2.701 ± 0.096
0.477AspTrp: 0.477 ± 0.045
1.892AspTyr: 1.892 ± 0.085
0.0AspXaa: 0.0 ± 0.0
Glu
4.746GluAla: 4.746 ± 0.131
0.428GluCys: 0.428 ± 0.035
2.775GluAsp: 2.775 ± 0.104
4.86GluGlu: 4.86 ± 0.156
2.594GluPhe: 2.594 ± 0.095
3.192GluGly: 3.192 ± 0.125
1.119GluHis: 1.119 ± 0.067
6.239GluIle: 6.239 ± 0.168
5.818GluLys: 5.818 ± 0.159
6.249GluLeu: 6.249 ± 0.136
1.486GluMet: 1.486 ± 0.084
3.353GluAsn: 3.353 ± 0.123
1.621GluPro: 1.621 ± 0.076
2.394GluGln: 2.394 ± 0.099
2.758GluArg: 2.758 ± 0.114
3.428GluSer: 3.428 ± 0.096
2.519GluThr: 2.519 ± 0.08
4.536GluVal: 4.536 ± 0.132
0.41GluTrp: 0.41 ± 0.034
1.906GluTyr: 1.906 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
3.449PheAla: 3.449 ± 0.124
0.773PheCys: 0.773 ± 0.058
2.54PheAsp: 2.54 ± 0.093
2.441PheGlu: 2.441 ± 0.107
2.922PhePhe: 2.922 ± 0.124
3.135PheGly: 3.135 ± 0.101
0.852PheHis: 0.852 ± 0.058
4.29PheIle: 4.29 ± 0.154
3.028PheLys: 3.028 ± 0.097
5.138PheLeu: 5.138 ± 0.156
1.069PheMet: 1.069 ± 0.067
2.633PheAsn: 2.633 ± 0.106
1.236PhePro: 1.236 ± 0.066
1.144PheGln: 1.144 ± 0.068
1.414PheArg: 1.414 ± 0.076
3.773PheSer: 3.773 ± 0.11
2.323PheThr: 2.323 ± 0.093
2.697PheVal: 2.697 ± 0.126
0.442PheTrp: 0.442 ± 0.045
1.735PheTyr: 1.735 ± 0.077
0.0PheXaa: 0.0 ± 0.0
Gly
4.632GlyAla: 4.632 ± 0.134
0.809GlyCys: 0.809 ± 0.058
2.736GlyAsp: 2.736 ± 0.12
3.545GlyGlu: 3.545 ± 0.127
3.118GlyPhe: 3.118 ± 0.102
4.194GlyGly: 4.194 ± 0.151
1.162GlyHis: 1.162 ± 0.067
5.476GlyIle: 5.476 ± 0.138
4.732GlyLys: 4.732 ± 0.13
6.043GlyLeu: 6.043 ± 0.162
1.482GlyMet: 1.482 ± 0.077
2.587GlyAsn: 2.587 ± 0.09
1.45GlyPro: 1.45 ± 0.073
1.778GlyGln: 1.778 ± 0.075
2.829GlyArg: 2.829 ± 0.113
4.158GlySer: 4.158 ± 0.129
3.164GlyThr: 3.164 ± 0.109
4.336GlyVal: 4.336 ± 0.14
0.62GlyTrp: 0.62 ± 0.055
2.237GlyTyr: 2.237 ± 0.092
0.0GlyXaa: 0.0 ± 0.0
His
1.097HisAla: 1.097 ± 0.063
0.253HisCys: 0.253 ± 0.03
0.855HisAsp: 0.855 ± 0.056
0.884HisGlu: 0.884 ± 0.055
0.919HisPhe: 0.919 ± 0.066
1.251HisGly: 1.251 ± 0.056
0.492HisHis: 0.492 ± 0.044
1.632HisIle: 1.632 ± 0.096
1.194HisLys: 1.194 ± 0.062
2.017HisLeu: 2.017 ± 0.078
0.417HisMet: 0.417 ± 0.038
1.179HisAsn: 1.179 ± 0.058
0.816HisPro: 0.816 ± 0.056
0.616HisGln: 0.616 ± 0.047
0.709HisArg: 0.709 ± 0.054
1.397HisSer: 1.397 ± 0.066
0.983HisThr: 0.983 ± 0.051
0.93HisVal: 0.93 ± 0.056
0.157HisTrp: 0.157 ± 0.025
0.969HisTyr: 0.969 ± 0.059
0.0HisXaa: 0.0 ± 0.0
Ile
7.364IleAla: 7.364 ± 0.171
1.047IleCys: 1.047 ± 0.058
4.585IleAsp: 4.585 ± 0.136
6.417IleGlu: 6.417 ± 0.152
3.983IlePhe: 3.983 ± 0.146
5.865IleGly: 5.865 ± 0.169
1.407IleHis: 1.407 ± 0.063
7.935IleIle: 7.935 ± 0.193
7.008IleLys: 7.008 ± 0.168
8.455IleLeu: 8.455 ± 0.227
2.173IleMet: 2.173 ± 0.084
5.43IleAsn: 5.43 ± 0.163
3.164IlePro: 3.164 ± 0.106
2.316IleGln: 2.316 ± 0.103
3.556IleArg: 3.556 ± 0.109
6.983IleSer: 6.983 ± 0.149
4.764IleThr: 4.764 ± 0.132
5.369IleVal: 5.369 ± 0.14
0.677IleTrp: 0.677 ± 0.053
2.751IleTyr: 2.751 ± 0.102
0.0IleXaa: 0.0 ± 0.0
Lys
5.156LysAla: 5.156 ± 0.118
0.588LysCys: 0.588 ± 0.051
3.837LysAsp: 3.837 ± 0.131
5.408LysGlu: 5.408 ± 0.143
3.068LysPhe: 3.068 ± 0.095
3.919LysGly: 3.919 ± 0.118
1.329LysHis: 1.329 ± 0.073
7.546LysIle: 7.546 ± 0.188
6.648LysLys: 6.648 ± 0.194
7.115LysLeu: 7.115 ± 0.17
2.049LysMet: 2.049 ± 0.094
4.927LysAsn: 4.927 ± 0.14
2.323LysPro: 2.323 ± 0.123
2.736LysGln: 2.736 ± 0.105
3.153LysArg: 3.153 ± 0.104
5.291LysSer: 5.291 ± 0.139
3.463LysThr: 3.463 ± 0.116
4.756LysVal: 4.756 ± 0.146
0.52LysTrp: 0.52 ± 0.043
2.398LysTyr: 2.398 ± 0.083
0.0LysXaa: 0.0 ± 0.0
Leu
7.414LeuAla: 7.414 ± 0.157
1.126LeuCys: 1.126 ± 0.07
4.927LeuAsp: 4.927 ± 0.141
6.62LeuGlu: 6.62 ± 0.166
4.817LeuPhe: 4.817 ± 0.155
5.711LeuGly: 5.711 ± 0.158
1.974LeuHis: 1.974 ± 0.08
8.654LeuIle: 8.654 ± 0.208
8.031LeuLys: 8.031 ± 0.182
10.051LeuLeu: 10.051 ± 0.247
2.352LeuMet: 2.352 ± 0.103
5.508LeuAsn: 5.508 ± 0.143
4.226LeuPro: 4.226 ± 0.137
3.274LeuGln: 3.274 ± 0.1
4.215LeuArg: 4.215 ± 0.129
7.735LeuSer: 7.735 ± 0.17
5.038LeuThr: 5.038 ± 0.137
5.982LeuVal: 5.982 ± 0.151
0.709LeuTrp: 0.709 ± 0.053
3.271LeuTyr: 3.271 ± 0.116
0.0LeuXaa: 0.0 ± 0.0
Met
1.935MetAla: 1.935 ± 0.082
0.228MetCys: 0.228 ± 0.031
1.072MetAsp: 1.072 ± 0.059
1.226MetGlu: 1.226 ± 0.07
0.919MetPhe: 0.919 ± 0.059
1.486MetGly: 1.486 ± 0.073
0.581MetHis: 0.581 ± 0.046
1.838MetIle: 1.838 ± 0.086
1.689MetLys: 1.689 ± 0.08
2.754MetLeu: 2.754 ± 0.116
0.631MetMet: 0.631 ± 0.051
1.165MetAsn: 1.165 ± 0.067
1.097MetPro: 1.097 ± 0.059
1.115MetGln: 1.115 ± 0.053
1.14MetArg: 1.14 ± 0.064
1.86MetSer: 1.86 ± 0.086
1.033MetThr: 1.033 ± 0.061
1.528MetVal: 1.528 ± 0.077
0.146MetTrp: 0.146 ± 0.023
0.542MetTyr: 0.542 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.456AsnAla: 3.456 ± 0.126
0.723AsnCys: 0.723 ± 0.052
2.437AsnAsp: 2.437 ± 0.091
2.9AsnGlu: 2.9 ± 0.116
2.907AsnPhe: 2.907 ± 0.117
2.747AsnGly: 2.747 ± 0.11
1.094AsnHis: 1.094 ± 0.06
5.159AsnIle: 5.159 ± 0.139
4.429AsnLys: 4.429 ± 0.112
5.751AsnLeu: 5.751 ± 0.147
1.268AsnMet: 1.268 ± 0.072
3.435AsnAsn: 3.435 ± 0.146
2.131AsnPro: 2.131 ± 0.088
1.931AsnGln: 1.931 ± 0.082
2.134AsnArg: 2.134 ± 0.085
3.901AsnSer: 3.901 ± 0.113
2.537AsnThr: 2.537 ± 0.102
2.743AsnVal: 2.743 ± 0.096
0.474AsnTrp: 0.474 ± 0.037
2.116AsnTyr: 2.116 ± 0.085
0.0AsnXaa: 0.0 ± 0.0
Pro
2.209ProAla: 2.209 ± 0.094
0.374ProCys: 0.374 ± 0.036
1.742ProAsp: 1.742 ± 0.107
2.352ProGlu: 2.352 ± 0.097
1.774ProPhe: 1.774 ± 0.089
2.173ProGly: 2.173 ± 0.089
0.695ProHis: 0.695 ± 0.051
2.868ProIle: 2.868 ± 0.112
2.316ProLys: 2.316 ± 0.094
3.299ProLeu: 3.299 ± 0.103
0.738ProMet: 0.738 ± 0.047
1.675ProAsn: 1.675 ± 0.064
0.969ProPro: 0.969 ± 0.067
1.133ProGln: 1.133 ± 0.066
1.208ProArg: 1.208 ± 0.067
2.227ProSer: 2.227 ± 0.087
1.924ProThr: 1.924 ± 0.087
2.23ProVal: 2.23 ± 0.088
0.371ProTrp: 0.371 ± 0.034
1.158ProTyr: 1.158 ± 0.074
0.0ProXaa: 0.0 ± 0.0
Gln
2.366GlnAla: 2.366 ± 0.092
0.26GlnCys: 0.26 ± 0.034
1.628GlnAsp: 1.628 ± 0.076
2.523GlnGlu: 2.523 ± 0.087
1.236GlnPhe: 1.236 ± 0.064
1.774GlnGly: 1.774 ± 0.09
0.631GlnHis: 0.631 ± 0.044
2.932GlnIle: 2.932 ± 0.113
2.704GlnLys: 2.704 ± 0.103
3.207GlnLeu: 3.207 ± 0.126
0.791GlnMet: 0.791 ± 0.052
1.952GlnAsn: 1.952 ± 0.081
1.055GlnPro: 1.055 ± 0.07
1.429GlnGln: 1.429 ± 0.082
1.511GlnArg: 1.511 ± 0.064
2.034GlnSer: 2.034 ± 0.076
1.411GlnThr: 1.411 ± 0.079
2.038GlnVal: 2.038 ± 0.078
0.242GlnTrp: 0.242 ± 0.029
1.179GlnTyr: 1.179 ± 0.063
0.0GlnXaa: 0.0 ± 0.0
Arg
3.082ArgAla: 3.082 ± 0.113
0.47ArgCys: 0.47 ± 0.042
2.081ArgAsp: 2.081 ± 0.102
2.54ArgGlu: 2.54 ± 0.102
1.931ArgPhe: 1.931 ± 0.09
2.551ArgGly: 2.551 ± 0.102
0.819ArgHis: 0.819 ± 0.056
3.623ArgIle: 3.623 ± 0.119
2.907ArgLys: 2.907 ± 0.091
4.051ArgLeu: 4.051 ± 0.123
1.122ArgMet: 1.122 ± 0.06
2.066ArgAsn: 2.066 ± 0.072
1.365ArgPro: 1.365 ± 0.08
1.379ArgGln: 1.379 ± 0.068
1.981ArgArg: 1.981 ± 0.092
2.612ArgSer: 2.612 ± 0.105
1.717ArgThr: 1.717 ± 0.072
2.53ArgVal: 2.53 ± 0.101
0.452ArgTrp: 0.452 ± 0.042
1.717ArgTyr: 1.717 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
4.992SerAla: 4.992 ± 0.144
0.891SerCys: 0.891 ± 0.067
2.986SerAsp: 2.986 ± 0.111
3.723SerGlu: 3.723 ± 0.115
3.595SerPhe: 3.595 ± 0.123
4.817SerGly: 4.817 ± 0.149
1.19SerHis: 1.19 ± 0.064
6.68SerIle: 6.68 ± 0.173
5.031SerLys: 5.031 ± 0.135
7.632SerLeu: 7.632 ± 0.168
1.593SerMet: 1.593 ± 0.076
3.68SerAsn: 3.68 ± 0.133
2.159SerPro: 2.159 ± 0.086
2.116SerGln: 2.116 ± 0.082
2.811SerArg: 2.811 ± 0.103
5.53SerSer: 5.53 ± 0.138
3.588SerThr: 3.588 ± 0.124
4.268SerVal: 4.268 ± 0.116
0.723SerTrp: 0.723 ± 0.049
2.466SerTyr: 2.466 ± 0.088
0.0SerXaa: 0.0 ± 0.0
Thr
3.848ThrAla: 3.848 ± 0.124
0.353ThrCys: 0.353 ± 0.036
2.316ThrAsp: 2.316 ± 0.087
2.982ThrGlu: 2.982 ± 0.109
2.095ThrPhe: 2.095 ± 0.076
3.264ThrGly: 3.264 ± 0.138
0.912ThrHis: 0.912 ± 0.06
4.201ThrIle: 4.201 ± 0.138
3.556ThrLys: 3.556 ± 0.129
4.696ThrLeu: 4.696 ± 0.13
0.876ThrMet: 0.876 ± 0.051
2.537ThrAsn: 2.537 ± 0.112
2.038ThrPro: 2.038 ± 0.084
1.667ThrGln: 1.667 ± 0.079
1.785ThrArg: 1.785 ± 0.083
3.513ThrSer: 3.513 ± 0.109
2.736ThrThr: 2.736 ± 0.116
3.203ThrVal: 3.203 ± 0.122
0.271ThrTrp: 0.271 ± 0.032
1.482ThrTyr: 1.482 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
4.785ValAla: 4.785 ± 0.138
0.727ValCys: 0.727 ± 0.059
3.089ValAsp: 3.089 ± 0.115
3.784ValGlu: 3.784 ± 0.128
2.761ValPhe: 2.761 ± 0.102
4.254ValGly: 4.254 ± 0.135
0.969ValHis: 0.969 ± 0.06
6.121ValIle: 6.121 ± 0.148
4.311ValLys: 4.311 ± 0.125
6.712ValLeu: 6.712 ± 0.145
1.66ValMet: 1.66 ± 0.077
3.004ValAsn: 3.004 ± 0.102
2.148ValPro: 2.148 ± 0.082
1.692ValGln: 1.692 ± 0.069
2.376ValArg: 2.376 ± 0.095
4.283ValSer: 4.283 ± 0.108
3.271ValThr: 3.271 ± 0.113
4.553ValVal: 4.553 ± 0.176
0.435ValTrp: 0.435 ± 0.038
1.799ValTyr: 1.799 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.431TrpAla: 0.431 ± 0.037
0.15TrpCys: 0.15 ± 0.021
0.328TrpAsp: 0.328 ± 0.035
0.324TrpGlu: 0.324 ± 0.036
0.428TrpPhe: 0.428 ± 0.04
0.531TrpGly: 0.531 ± 0.044
0.267TrpHis: 0.267 ± 0.033
0.638TrpIle: 0.638 ± 0.048
0.492TrpLys: 0.492 ± 0.044
1.047TrpLeu: 1.047 ± 0.066
0.153TrpMet: 0.153 ± 0.023
0.431TrpAsn: 0.431 ± 0.036
0.296TrpPro: 0.296 ± 0.035
0.488TrpGln: 0.488 ± 0.043
0.442TrpArg: 0.442 ± 0.039
0.517TrpSer: 0.517 ± 0.043
0.281TrpThr: 0.281 ± 0.037
0.499TrpVal: 0.499 ± 0.039
0.139TrpTrp: 0.139 ± 0.022
0.385TrpTyr: 0.385 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.159TyrAla: 2.159 ± 0.089
0.442TyrCys: 0.442 ± 0.04
1.589TyrAsp: 1.589 ± 0.069
2.006TyrGlu: 2.006 ± 0.091
1.614TyrPhe: 1.614 ± 0.082
2.227TyrGly: 2.227 ± 0.093
0.812TyrHis: 0.812 ± 0.051
2.829TyrIle: 2.829 ± 0.121
2.473TyrLys: 2.473 ± 0.1
3.549TyrLeu: 3.549 ± 0.113
0.969TyrMet: 0.969 ± 0.067
2.049TyrAsn: 2.049 ± 0.093
1.062TyrPro: 1.062 ± 0.063
1.233TyrGln: 1.233 ± 0.071
1.461TyrArg: 1.461 ± 0.067
2.547TyrSer: 2.547 ± 0.099
1.553TyrThr: 1.553 ± 0.079
1.732TyrVal: 1.732 ± 0.08
0.338TyrTrp: 0.338 ± 0.038
1.279TyrTyr: 1.279 ± 0.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1181 proteins (280672 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski