Amino acid dipepetide frequency for Limosilactobacillus ingluviei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.675AlaAla: 12.675 ± 0.248	0.528AlaCys: 0.528 ± 0.031	5.903AlaAsp: 5.903 ± 0.106	5.184AlaGlu: 5.184 ± 0.113	3.575AlaPhe: 3.575 ± 0.081	7.721AlaGly: 7.721 ± 0.13	2.284AlaHis: 2.284 ± 0.07	5.315AlaIle: 5.315 ± 0.104	6.358AlaLys: 6.358 ± 0.139	10.723AlaLeu: 10.723 ± 0.176	2.725AlaMet: 2.725 ± 0.067	4.277AlaAsn: 4.277 ± 0.104	3.924AlaPro: 3.924 ± 0.099	6.38AlaGln: 6.38 ± 0.184	4.028AlaArg: 4.028 ± 0.1	5.039AlaSer: 5.039 ± 0.328	6.979AlaThr: 6.979 ± 0.134	7.372AlaVal: 7.372 ± 0.116	1.104AlaTrp: 1.104 ± 0.045	3.133AlaTyr: 3.133 ± 0.083	0.005AlaXaa: 0.005 ± 0.003
Cys	0.408CysAla: 0.408 ± 0.029	0.051CysCys: 0.051 ± 0.011	0.262CysAsp: 0.262 ± 0.024	0.25CysGlu: 0.25 ± 0.019	0.255CysPhe: 0.255 ± 0.023	0.533CysGly: 0.533 ± 0.034	0.168CysHis: 0.168 ± 0.018	0.214CysIle: 0.214 ± 0.019	0.146CysLys: 0.146 ± 0.015	0.696CysLeu: 0.696 ± 0.033	0.107CysMet: 0.107 ± 0.014	0.168CysAsn: 0.168 ± 0.018	0.267CysPro: 0.267 ± 0.024	0.325CysGln: 0.325 ± 0.027	0.23CysArg: 0.23 ± 0.019	0.288CysSer: 0.288 ± 0.022	0.264CysThr: 0.264 ± 0.02	0.296CysVal: 0.296 ± 0.023	0.09CysTrp: 0.09 ± 0.014	0.214CysTyr: 0.214 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.222AspAla: 4.222 ± 0.104	0.269AspCys: 0.269 ± 0.024	2.954AspAsp: 2.954 ± 0.094	3.661AspGlu: 3.661 ± 0.1	2.435AspPhe: 2.435 ± 0.062	3.672AspGly: 3.672 ± 0.104	1.7AspHis: 1.7 ± 0.055	2.348AspIle: 2.348 ± 0.064	2.294AspLys: 2.294 ± 0.085	5.978AspLeu: 5.978 ± 0.093	1.123AspMet: 1.123 ± 0.042	1.88AspAsn: 1.88 ± 0.062	2.641AspPro: 2.641 ± 0.07	3.962AspGln: 3.962 ± 0.09	2.563AspArg: 2.563 ± 0.05	2.238AspSer: 2.238 ± 0.069	2.296AspThr: 2.296 ± 0.067	3.557AspVal: 3.557 ± 0.103	0.805AspTrp: 0.805 ± 0.039	2.391AspTyr: 2.391 ± 0.077	0.002AspXaa: 0.002 ± 0.002
Glu	5.15GluAla: 5.15 ± 0.104	0.22GluCys: 0.22 ± 0.019	2.221GluAsp: 2.221 ± 0.071	3.084GluGlu: 3.084 ± 0.091	2.039GluPhe: 2.039 ± 0.065	2.529GluGly: 2.529 ± 0.067	1.224GluHis: 1.224 ± 0.051	3.293GluIle: 3.293 ± 0.077	3.196GluLys: 3.196 ± 0.085	5.961GluLeu: 5.961 ± 0.13	1.603GluMet: 1.603 ± 0.053	2.11GluAsn: 2.11 ± 0.067	1.722GluPro: 1.722 ± 0.063	2.959GluGln: 2.959 ± 0.076	2.808GluArg: 2.808 ± 0.074	2.122GluSer: 2.122 ± 0.123	2.621GluThr: 2.621 ± 0.073	3.809GluVal: 3.809 ± 0.089	0.524GluTrp: 0.524 ± 0.03	1.692GluTyr: 1.692 ± 0.058	0.002GluXaa: 0.002 ± 0.002
Phe	4.072PheAla: 4.072 ± 0.097	0.271PheCys: 0.271 ± 0.021	2.563PheAsp: 2.563 ± 0.068	1.891PheGlu: 1.891 ± 0.059	1.811PhePhe: 1.811 ± 0.062	3.315PheGly: 3.315 ± 0.094	0.771PheHis: 0.771 ± 0.032	2.217PheIle: 2.217 ± 0.081	2.117PheLys: 2.117 ± 0.065	3.581PheLeu: 3.581 ± 0.087	1.001PheMet: 1.001 ± 0.049	1.836PheAsn: 1.836 ± 0.061	1.38PhePro: 1.38 ± 0.049	1.346PheGln: 1.346 ± 0.048	1.312PheArg: 1.312 ± 0.05	2.187PheSer: 2.187 ± 0.065	2.514PheThr: 2.514 ± 0.073	2.713PheVal: 2.713 ± 0.068	0.541PheTrp: 0.541 ± 0.031	1.401PheTyr: 1.401 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.851GlyAla: 5.851 ± 0.122	0.425GlyCys: 0.425 ± 0.027	3.484GlyAsp: 3.484 ± 0.106	3.591GlyGlu: 3.591 ± 0.078	2.815GlyPhe: 2.815 ± 0.077	4.52GlyGly: 4.52 ± 0.121	1.858GlyHis: 1.858 ± 0.063	4.677GlyIle: 4.677 ± 0.113	3.991GlyLys: 3.991 ± 0.092	7.398GlyLeu: 7.398 ± 0.127	2.012GlyMet: 2.012 ± 0.06	2.65GlyAsn: 2.65 ± 0.083	1.957GlyPro: 1.957 ± 0.061	4.14GlyGln: 4.14 ± 0.092	3.055GlyArg: 3.055 ± 0.089	3.502GlySer: 3.502 ± 0.088	4.297GlyThr: 4.297 ± 0.088	4.979GlyVal: 4.979 ± 0.093	1.023GlyTrp: 1.023 ± 0.05	2.675GlyTyr: 2.675 ± 0.065	0.003GlyXaa: 0.003 ± 0.002
His	1.867HisAla: 1.867 ± 0.06	0.15HisCys: 0.15 ± 0.018	1.292HisAsp: 1.292 ± 0.049	1.14HisGlu: 1.14 ± 0.045	1.247HisPhe: 1.247 ± 0.047	1.809HisGly: 1.809 ± 0.066	0.956HisHis: 0.956 ± 0.046	0.876HisIle: 0.876 ± 0.038	0.813HisLys: 0.813 ± 0.036	2.759HisLeu: 2.759 ± 0.07	0.458HisMet: 0.458 ± 0.031	0.817HisAsn: 0.817 ± 0.04	1.397HisPro: 1.397 ± 0.058	1.721HisGln: 1.721 ± 0.058	1.321HisArg: 1.321 ± 0.046	1.033HisSer: 1.033 ± 0.044	1.084HisThr: 1.084 ± 0.043	1.537HisVal: 1.537 ± 0.057	0.381HisTrp: 0.381 ± 0.028	1.04HisTyr: 1.04 ± 0.043	0.002HisXaa: 0.002 ± 0.002
Ile	5.441IleAla: 5.441 ± 0.126	0.425IleCys: 0.425 ± 0.031	3.547IleAsp: 3.547 ± 0.082	3.237IleGlu: 3.237 ± 0.078	2.279IlePhe: 2.279 ± 0.075	4.19IleGly: 4.19 ± 0.101	1.12IleHis: 1.12 ± 0.042	3.523IleIle: 3.523 ± 0.098	3.388IleLys: 3.388 ± 0.08	5.18IleLeu: 5.18 ± 0.096	1.353IleMet: 1.353 ± 0.049	2.728IleAsn: 2.728 ± 0.073	2.24IlePro: 2.24 ± 0.061	2.188IleGln: 2.188 ± 0.066	2.061IleArg: 2.061 ± 0.059	3.022IleSer: 3.022 ± 0.078	3.433IleThr: 3.433 ± 0.077	4.084IleVal: 4.084 ± 0.1	0.499IleTrp: 0.499 ± 0.031	1.766IleTyr: 1.766 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	5.122LysAla: 5.122 ± 0.122	0.155LysCys: 0.155 ± 0.016	2.852LysAsp: 2.852 ± 0.096	3.325LysGlu: 3.325 ± 0.088	1.555LysPhe: 1.555 ± 0.056	2.93LysGly: 2.93 ± 0.076	1.241LysHis: 1.241 ± 0.052	2.842LysIle: 2.842 ± 0.078	3.315LysLys: 3.315 ± 0.097	5.218LysLeu: 5.218 ± 0.095	1.789LysMet: 1.789 ± 0.061	2.088LysAsn: 2.088 ± 0.061	1.937LysPro: 1.937 ± 0.048	3.659LysGln: 3.659 ± 0.092	2.837LysArg: 2.837 ± 0.074	2.246LysSer: 2.246 ± 0.078	3.16LysThr: 3.16 ± 0.084	3.987LysVal: 3.987 ± 0.094	0.585LysTrp: 0.585 ± 0.035	1.909LysTyr: 1.909 ± 0.06	0.002LysXaa: 0.002 ± 0.002
Leu	12.957LeuAla: 12.957 ± 0.193	0.58LeuCys: 0.58 ± 0.034	5.116LeuAsp: 5.116 ± 0.091	4.096LeuGlu: 4.096 ± 0.084	3.742LeuPhe: 3.742 ± 0.085	7.355LeuGly: 7.355 ± 0.142	2.144LeuHis: 2.144 ± 0.054	5.96LeuIle: 5.96 ± 0.12	5.755LeuLys: 5.755 ± 0.1	10.422LeuLeu: 10.422 ± 0.194	2.588LeuMet: 2.588 ± 0.074	4.266LeuAsn: 4.266 ± 0.083	4.983LeuPro: 4.983 ± 0.106	4.779LeuGln: 4.779 ± 0.121	4.403LeuArg: 4.403 ± 0.097	5.725LeuSer: 5.725 ± 0.097	8.196LeuThr: 8.196 ± 0.144	8.089LeuVal: 8.089 ± 0.151	0.916LeuTrp: 0.916 ± 0.046	2.767LeuTyr: 2.767 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.854MetAla: 2.854 ± 0.065	0.129MetCys: 0.129 ± 0.014	1.22MetAsp: 1.22 ± 0.049	1.256MetGlu: 1.256 ± 0.044	0.739MetPhe: 0.739 ± 0.038	1.688MetGly: 1.688 ± 0.062	0.434MetHis: 0.434 ± 0.027	1.739MetIle: 1.739 ± 0.055	1.646MetLys: 1.646 ± 0.052	2.318MetLeu: 2.318 ± 0.071	0.796MetMet: 0.796 ± 0.04	1.053MetAsn: 1.053 ± 0.051	1.074MetPro: 1.074 ± 0.041	1.264MetGln: 1.264 ± 0.043	1.062MetArg: 1.062 ± 0.044	1.247MetSer: 1.247 ± 0.047	1.812MetThr: 1.812 ± 0.052	1.943MetVal: 1.943 ± 0.052	0.192MetTrp: 0.192 ± 0.02	0.628MetTyr: 0.628 ± 0.031	0.002MetXaa: 0.002 ± 0.002
Asn	3.409AsnAla: 3.409 ± 0.082	0.196AsnCys: 0.196 ± 0.017	2.357AsnAsp: 2.357 ± 0.072	2.258AsnGlu: 2.258 ± 0.06	1.63AsnPhe: 1.63 ± 0.054	3.278AsnGly: 3.278 ± 0.095	1.188AsnHis: 1.188 ± 0.048	1.746AsnIle: 1.746 ± 0.052	1.732AsnLys: 1.732 ± 0.08	4.091AsnLeu: 4.091 ± 0.079	1.007AsnMet: 1.007 ± 0.047	1.756AsnAsn: 1.756 ± 0.074	2.023AsnPro: 2.023 ± 0.061	2.605AsnGln: 2.605 ± 0.074	1.976AsnArg: 1.976 ± 0.061	1.923AsnSer: 1.923 ± 0.069	1.882AsnThr: 1.882 ± 0.063	2.68AsnVal: 2.68 ± 0.071	0.568AsnTrp: 0.568 ± 0.036	1.709AsnTyr: 1.709 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	5.582ProAla: 5.582 ± 0.141	0.191ProCys: 0.191 ± 0.021	2.171ProAsp: 2.171 ± 0.066	2.476ProGlu: 2.476 ± 0.071	1.589ProPhe: 1.589 ± 0.049	2.736ProGly: 2.736 ± 0.082	0.89ProHis: 0.89 ± 0.041	2.098ProIle: 2.098 ± 0.057	1.833ProLys: 1.833 ± 0.064	4.125ProLeu: 4.125 ± 0.09	0.745ProMet: 0.745 ± 0.039	1.62ProAsn: 1.62 ± 0.058	0.853ProPro: 0.853 ± 0.044	2.206ProGln: 2.206 ± 0.067	1.504ProArg: 1.504 ± 0.047	2.068ProSer: 2.068 ± 0.076	3.337ProThr: 3.337 ± 0.081	3.727ProVal: 3.727 ± 0.089	0.408ProTrp: 0.408 ± 0.027	1.264ProTyr: 1.264 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	7.866GlnAla: 7.866 ± 0.21	0.177GlnCys: 0.177 ± 0.019	2.044GlnAsp: 2.044 ± 0.063	2.347GlnGlu: 2.347 ± 0.071	1.845GlnPhe: 1.845 ± 0.053	3.033GlnGly: 3.033 ± 0.067	1.205GlnHis: 1.205 ± 0.05	3.177GlnIle: 3.177 ± 0.069	2.658GlnLys: 2.658 ± 0.076	6.634GlnLeu: 6.634 ± 0.15	1.338GlnMet: 1.338 ± 0.045	1.843GlnAsn: 1.843 ± 0.06	2.544GlnPro: 2.544 ± 0.07	3.026GlnGln: 3.026 ± 0.096	3.073GlnArg: 3.073 ± 0.087	2.325GlnSer: 2.325 ± 0.092	3.982GlnThr: 3.982 ± 0.11	4.569GlnVal: 4.569 ± 0.105	0.602GlnTrp: 0.602 ± 0.034	1.629GlnTyr: 1.629 ± 0.058	0.0GlnXaa: 0.0 ± 0.0
Arg	3.792ArgAla: 3.792 ± 0.088	0.208ArgCys: 0.208 ± 0.018	2.168ArgAsp: 2.168 ± 0.071	2.313ArgGlu: 2.313 ± 0.071	2.01ArgPhe: 2.01 ± 0.059	2.685ArgGly: 2.685 ± 0.078	1.339ArgHis: 1.339 ± 0.049	2.389ArgIle: 2.389 ± 0.06	2.107ArgLys: 2.107 ± 0.06	5.439ArgLeu: 5.439 ± 0.118	1.002ArgMet: 1.002 ± 0.041	1.535ArgAsn: 1.535 ± 0.053	2.02ArgPro: 2.02 ± 0.061	3.278ArgGln: 3.278 ± 0.094	2.694ArgArg: 2.694 ± 0.082	1.811ArgSer: 1.811 ± 0.05	2.219ArgThr: 2.219 ± 0.075	3.249ArgVal: 3.249 ± 0.078	0.553ArgTrp: 0.553 ± 0.033	1.863ArgTyr: 1.863 ± 0.062	0.002ArgXaa: 0.002 ± 0.002
Ser	4.933SerAla: 4.933 ± 0.352	0.248SerCys: 0.248 ± 0.021	2.548SerAsp: 2.548 ± 0.073	2.428SerGlu: 2.428 ± 0.117	2.294SerPhe: 2.294 ± 0.068	3.81SerGly: 3.81 ± 0.078	1.162SerHis: 1.162 ± 0.05	2.648SerIle: 2.648 ± 0.084	2.171SerLys: 2.171 ± 0.073	5.31SerLeu: 5.31 ± 0.119	1.154SerMet: 1.154 ± 0.05	1.932SerAsn: 1.932 ± 0.075	1.932SerPro: 1.932 ± 0.061	2.752SerGln: 2.752 ± 0.099	2.064SerArg: 2.064 ± 0.05	2.719SerSer: 2.719 ± 0.108	2.993SerThr: 2.993 ± 0.184	3.194SerVal: 3.194 ± 0.087	0.625SerTrp: 0.625 ± 0.034	1.831SerTyr: 1.831 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	6.526ThrAla: 6.526 ± 0.116	0.254ThrCys: 0.254 ± 0.022	3.402ThrAsp: 3.402 ± 0.081	2.605ThrGlu: 2.605 ± 0.069	2.381ThrPhe: 2.381 ± 0.063	4.879ThrGly: 4.879 ± 0.106	1.263ThrHis: 1.263 ± 0.046	3.906ThrIle: 3.906 ± 0.09	3.388ThrLys: 3.388 ± 0.091	6.39ThrLeu: 6.39 ± 0.111	1.533ThrMet: 1.533 ± 0.058	2.551ThrAsn: 2.551 ± 0.077	3.553ThrPro: 3.553 ± 0.088	2.542ThrGln: 2.542 ± 0.072	2.265ThrArg: 2.265 ± 0.06	3.465ThrSer: 3.465 ± 0.185	4.787ThrThr: 4.787 ± 0.114	5.138ThrVal: 5.138 ± 0.113	0.757ThrTrp: 0.757 ± 0.039	2.076ThrTyr: 2.076 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	8.805ValAla: 8.805 ± 0.148	0.453ValCys: 0.453 ± 0.028	4.268ValAsp: 4.268 ± 0.089	3.599ValGlu: 3.599 ± 0.081	2.406ValPhe: 2.406 ± 0.066	5.066ValGly: 5.066 ± 0.12	1.426ValHis: 1.426 ± 0.054	4.813ValIle: 4.813 ± 0.107	4.437ValLys: 4.437 ± 0.093	6.661ValLeu: 6.661 ± 0.116	1.887ValMet: 1.887 ± 0.059	3.233ValAsn: 3.233 ± 0.073	3.102ValPro: 3.102 ± 0.067	2.982ValGln: 2.982 ± 0.08	2.743ValArg: 2.743 ± 0.071	3.695ValSer: 3.695 ± 0.09	5.42ValThr: 5.42 ± 0.135	6.057ValVal: 6.057 ± 0.121	0.691ValTrp: 0.691 ± 0.037	2.272ValTyr: 2.272 ± 0.069	0.0ValXaa: 0.0 ± 0.0
Trp	0.958TrpAla: 0.958 ± 0.042	0.083TrpCys: 0.083 ± 0.011	0.522TrpAsp: 0.522 ± 0.037	0.432TrpGlu: 0.432 ± 0.03	0.499TrpPhe: 0.499 ± 0.032	0.793TrpGly: 0.793 ± 0.038	0.33TrpHis: 0.33 ± 0.025	0.485TrpIle: 0.485 ± 0.031	0.334TrpLys: 0.334 ± 0.024	1.794TrpLeu: 1.794 ± 0.073	0.286TrpMet: 0.286 ± 0.022	0.393TrpAsn: 0.393 ± 0.028	0.414TrpPro: 0.414 ± 0.029	0.985TrpGln: 0.985 ± 0.038	0.647TrpArg: 0.647 ± 0.035	0.541TrpSer: 0.541 ± 0.03	0.589TrpThr: 0.589 ± 0.033	0.699TrpVal: 0.699 ± 0.035	0.259TrpTrp: 0.259 ± 0.022	0.539TrpTyr: 0.539 ± 0.04	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.742TyrAla: 2.742 ± 0.077	0.223TyrCys: 0.223 ± 0.022	2.098TyrAsp: 2.098 ± 0.057	1.712TyrGlu: 1.712 ± 0.059	1.69TyrPhe: 1.69 ± 0.068	2.359TyrGly: 2.359 ± 0.072	0.996TyrHis: 0.996 ± 0.044	1.436TyrIle: 1.436 ± 0.052	1.077TyrLys: 1.077 ± 0.043	4.157TyrLeu: 4.157 ± 0.087	0.587TyrMet: 0.587 ± 0.033	1.278TyrAsn: 1.278 ± 0.048	1.458TyrPro: 1.458 ± 0.052	2.816TyrGln: 2.816 ± 0.077	2.03TyrArg: 2.03 ± 0.061	1.55TyrSer: 1.55 ± 0.057	1.797TyrThr: 1.797 ± 0.058	2.335TyrVal: 2.335 ± 0.058	0.458TyrTrp: 0.458 ± 0.029	1.578TyrTyr: 1.578 ± 0.081	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.002	0.002XaaPhe: 0.002 ± 0.002	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.005XaaLeu: 0.005 ± 0.003	0.002XaaMet: 0.002 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	1.384XaaXaa: 1.384 ± 0.432

Statistics based on 1922 proteins (587619 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---