Amino acid dipepetide frequency for Enterospora canceri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.291AlaAla: 3.291 ± 0.088	0.889AlaCys: 0.889 ± 0.039	2.607AlaAsp: 2.607 ± 0.077	4.246AlaGlu: 4.246 ± 0.089	2.514AlaPhe: 2.514 ± 0.07	2.212AlaGly: 2.212 ± 0.069	0.904AlaHis: 0.904 ± 0.042	3.83AlaIle: 3.83 ± 0.077	3.7AlaLys: 3.7 ± 0.096	4.858AlaLeu: 4.858 ± 0.098	1.496AlaMet: 1.496 ± 0.053	2.47AlaAsn: 2.47 ± 0.066	1.42AlaPro: 1.42 ± 0.058	1.584AlaGln: 1.584 ± 0.061	2.15AlaArg: 2.15 ± 0.076	3.031AlaSer: 3.031 ± 0.089	2.912AlaThr: 2.912 ± 0.085	3.797AlaVal: 3.797 ± 0.098	0.295AlaTrp: 0.295 ± 0.024	2.048AlaTyr: 2.048 ± 0.053	0.005AlaXaa: 0.005 ± 0.003
Cys	0.879CysAla: 0.879 ± 0.041	0.525CysCys: 0.525 ± 0.034	1.16CysAsp: 1.16 ± 0.05	1.089CysGlu: 1.089 ± 0.047	0.925CysPhe: 0.925 ± 0.04	1.149CysGly: 1.149 ± 0.046	0.351CysHis: 0.351 ± 0.024	1.386CysIle: 1.386 ± 0.048	1.415CysLys: 1.415 ± 0.055	1.698CysLeu: 1.698 ± 0.058	0.535CysMet: 0.535 ± 0.037	1.134CysAsn: 1.134 ± 0.054	0.493CysPro: 0.493 ± 0.037	0.387CysGln: 0.387 ± 0.025	0.92CysArg: 0.92 ± 0.048	1.389CysSer: 1.389 ± 0.05	1.038CysThr: 1.038 ± 0.039	1.222CysVal: 1.222 ± 0.044	0.136CysTrp: 0.136 ± 0.013	0.836CysTyr: 0.836 ± 0.034	0.005CysXaa: 0.005 ± 0.003
Asp	2.849AspAla: 2.849 ± 0.081	1.038AspCys: 1.038 ± 0.043	3.137AspAsp: 3.137 ± 0.083	5.297AspGlu: 5.297 ± 0.106	2.615AspPhe: 2.615 ± 0.065	3.115AspGly: 3.115 ± 0.085	0.924AspHis: 0.924 ± 0.039	3.415AspIle: 3.415 ± 0.074	4.016AspLys: 4.016 ± 0.109	5.314AspLeu: 5.314 ± 0.102	1.253AspMet: 1.253 ± 0.051	2.367AspAsn: 2.367 ± 0.079	1.442AspPro: 1.442 ± 0.046	1.948AspGln: 1.948 ± 0.057	2.327AspArg: 2.327 ± 0.068	3.436AspSer: 3.436 ± 0.072	2.579AspThr: 2.579 ± 0.062	3.645AspVal: 3.645 ± 0.081	0.425AspTrp: 0.425 ± 0.03	2.168AspTyr: 2.168 ± 0.06	0.008AspXaa: 0.008 ± 0.003
Glu	3.85GluAla: 3.85 ± 0.091	1.354GluCys: 1.354 ± 0.058	3.552GluAsp: 3.552 ± 0.091	7.591GluGlu: 7.591 ± 0.172	3.811GluPhe: 3.811 ± 0.091	2.687GluGly: 2.687 ± 0.078	1.495GluHis: 1.495 ± 0.051	6.792GluIle: 6.792 ± 0.121	7.398GluLys: 7.398 ± 0.159	6.855GluLeu: 6.855 ± 0.123	3.228GluMet: 3.228 ± 0.082	4.946GluAsn: 4.946 ± 0.093	1.679GluPro: 1.679 ± 0.054	2.753GluGln: 2.753 ± 0.088	3.753GluArg: 3.753 ± 0.1	5.183GluSer: 5.183 ± 0.112	4.931GluThr: 4.931 ± 0.08	3.976GluVal: 3.976 ± 0.098	0.492GluTrp: 0.492 ± 0.032	3.822GluTyr: 3.822 ± 0.09	0.008GluXaa: 0.008 ± 0.004
Phe	1.996PheAla: 1.996 ± 0.062	0.993PheCys: 0.993 ± 0.043	3.104PheAsp: 3.104 ± 0.076	2.96PheGlu: 2.96 ± 0.069	1.909PhePhe: 1.909 ± 0.071	2.678PheGly: 2.678 ± 0.076	0.849PheHis: 0.849 ± 0.04	3.746PheIle: 3.746 ± 0.082	3.734PheLys: 3.734 ± 0.077	4.355PheLeu: 4.355 ± 0.103	1.414PheMet: 1.414 ± 0.052	2.809PheAsn: 2.809 ± 0.07	0.99PhePro: 0.99 ± 0.041	0.955PheGln: 0.955 ± 0.045	2.48PheArg: 2.48 ± 0.08	3.182PheSer: 3.182 ± 0.082	2.794PheThr: 2.794 ± 0.063	3.734PheVal: 3.734 ± 0.093	0.318PheTrp: 0.318 ± 0.023	2.586PheTyr: 2.586 ± 0.074	0.008PheXaa: 0.008 ± 0.004
Gly	2.518GlyAla: 2.518 ± 0.082	1.089GlyCys: 1.089 ± 0.046	2.834GlyAsp: 2.834 ± 0.077	3.446GlyGlu: 3.446 ± 0.088	2.581GlyPhe: 2.581 ± 0.076	2.824GlyGly: 2.824 ± 0.111	0.983GlyHis: 0.983 ± 0.047	4.226GlyIle: 4.226 ± 0.09	3.711GlyLys: 3.711 ± 0.084	4.355GlyLeu: 4.355 ± 0.099	1.688GlyMet: 1.688 ± 0.088	2.693GlyAsn: 2.693 ± 0.088	1.003GlyPro: 1.003 ± 0.044	1.21GlyGln: 1.21 ± 0.049	2.887GlyArg: 2.887 ± 0.083	3.478GlySer: 3.478 ± 0.087	2.71GlyThr: 2.71 ± 0.061	3.478GlyVal: 3.478 ± 0.072	0.333GlyTrp: 0.333 ± 0.025	1.809GlyTyr: 1.809 ± 0.069	0.012GlyXaa: 0.012 ± 0.004
His	0.872HisAla: 0.872 ± 0.041	0.417HisCys: 0.417 ± 0.026	0.814HisAsp: 0.814 ± 0.033	1.202HisGlu: 1.202 ± 0.049	1.238HisPhe: 1.238 ± 0.05	1.043HisGly: 1.043 ± 0.049	0.43HisHis: 0.43 ± 0.026	1.316HisIle: 1.316 ± 0.05	1.626HisLys: 1.626 ± 0.059	2.02HisLeu: 2.02 ± 0.061	0.467HisMet: 0.467 ± 0.026	1.018HisAsn: 1.018 ± 0.036	0.776HisPro: 0.776 ± 0.052	0.654HisGln: 0.654 ± 0.038	1.225HisArg: 1.225 ± 0.041	1.453HisSer: 1.453 ± 0.047	0.915HisThr: 0.915 ± 0.047	1.222HisVal: 1.222 ± 0.046	0.141HisTrp: 0.141 ± 0.015	0.79HisTyr: 0.79 ± 0.037	0.002HisXaa: 0.002 ± 0.002
Ile	3.4IleAla: 3.4 ± 0.083	1.516IleCys: 1.516 ± 0.059	4.395IleAsp: 4.395 ± 0.101	5.989IleGlu: 5.989 ± 0.108	3.357IlePhe: 3.357 ± 0.087	3.946IleGly: 3.946 ± 0.087	1.645IleHis: 1.645 ± 0.048	4.133IleIle: 4.133 ± 0.097	6.742IleLys: 6.742 ± 0.119	6.972IleLeu: 6.972 ± 0.127	1.463IleMet: 1.463 ± 0.051	4.147IleAsn: 4.147 ± 0.095	2.023IlePro: 2.023 ± 0.057	2.66IleGln: 2.66 ± 0.065	4.433IleArg: 4.433 ± 0.093	5.041IleSer: 5.041 ± 0.105	3.753IleThr: 3.753 ± 0.092	4.385IleVal: 4.385 ± 0.093	0.507IleTrp: 0.507 ± 0.03	2.829IleTyr: 2.829 ± 0.08	0.008IleXaa: 0.008 ± 0.004
Lys	4.218LysAla: 4.218 ± 0.082	1.533LysCys: 1.533 ± 0.062	3.777LysAsp: 3.777 ± 0.094	8.384LysGlu: 8.384 ± 0.184	3.014LysPhe: 3.014 ± 0.074	3.104LysGly: 3.104 ± 0.098	1.912LysHis: 1.912 ± 0.061	6.375LysIle: 6.375 ± 0.111	9.43LysLys: 9.43 ± 0.208	6.798LysLeu: 6.798 ± 0.126	3.504LysMet: 3.504 ± 0.068	5.347LysAsn: 5.347 ± 0.104	2.271LysPro: 2.271 ± 0.077	3.336LysGln: 3.336 ± 0.079	4.315LysArg: 4.315 ± 0.089	5.219LysSer: 5.219 ± 0.115	5.405LysThr: 5.405 ± 0.097	4.337LysVal: 4.337 ± 0.089	0.541LysTrp: 0.541 ± 0.032	3.877LysTyr: 3.877 ± 0.099	0.008LysXaa: 0.008 ± 0.003
Leu	4.219LeuAla: 4.219 ± 0.093	1.809LeuCys: 1.809 ± 0.061	4.804LeuAsp: 4.804 ± 0.086	6.325LeuGlu: 6.325 ± 0.116	5.158LeuPhe: 5.158 ± 0.114	4.45LeuGly: 4.45 ± 0.095	1.801LeuHis: 1.801 ± 0.056	6.681LeuIle: 6.681 ± 0.141	7.411LeuLys: 7.411 ± 0.127	9.151LeuLeu: 9.151 ± 0.147	2.24LeuMet: 2.24 ± 0.053	5.633LeuAsn: 5.633 ± 0.092	2.432LeuPro: 2.432 ± 0.065	2.718LeuGln: 2.718 ± 0.076	4.565LeuArg: 4.565 ± 0.089	5.847LeuSer: 5.847 ± 0.105	4.2LeuThr: 4.2 ± 0.088	6.237LeuVal: 6.237 ± 0.11	0.498LeuTrp: 0.498 ± 0.034	3.577LeuTyr: 3.577 ± 0.075	0.013LeuXaa: 0.013 ± 0.005
Met	1.723MetAla: 1.723 ± 0.053	0.502MetCys: 0.502 ± 0.027	1.66MetAsp: 1.66 ± 0.047	1.995MetGlu: 1.995 ± 0.061	1.268MetPhe: 1.268 ± 0.05	1.473MetGly: 1.473 ± 0.08	0.763MetHis: 0.763 ± 0.039	2.029MetIle: 2.029 ± 0.079	2.538MetLys: 2.538 ± 0.063	2.725MetLeu: 2.725 ± 0.075	0.761MetMet: 0.761 ± 0.042	1.895MetAsn: 1.895 ± 0.062	0.864MetPro: 0.864 ± 0.039	0.907MetGln: 0.907 ± 0.039	1.488MetArg: 1.488 ± 0.059	1.68MetSer: 1.68 ± 0.056	1.414MetThr: 1.414 ± 0.053	1.902MetVal: 1.902 ± 0.055	0.169MetTrp: 0.169 ± 0.017	0.834MetTyr: 0.834 ± 0.041	0.002MetXaa: 0.002 ± 0.002
Asn	2.526AsnAla: 2.526 ± 0.065	1.049AsnCys: 1.049 ± 0.05	2.831AsnAsp: 2.831 ± 0.067	5.016AsnGlu: 5.016 ± 0.116	2.145AsnPhe: 2.145 ± 0.064	3.17AsnGly: 3.17 ± 0.078	0.94AsnHis: 0.94 ± 0.046	4.142AsnIle: 4.142 ± 0.102	5.921AsnLys: 5.921 ± 0.13	4.834AsnLeu: 4.834 ± 0.097	1.771AsnMet: 1.771 ± 0.052	3.585AsnAsn: 3.585 ± 0.106	1.659AsnPro: 1.659 ± 0.058	2.038AsnGln: 2.038 ± 0.07	3.488AsnArg: 3.488 ± 0.09	4.33AsnSer: 4.33 ± 0.094	3.547AsnThr: 3.547 ± 0.098	3.195AsnVal: 3.195 ± 0.059	0.371AsnTrp: 0.371 ± 0.025	2.218AsnTyr: 2.218 ± 0.064	0.002AsnXaa: 0.002 ± 0.001
Pro	1.298ProAla: 1.298 ± 0.05	0.454ProCys: 0.454 ± 0.033	1.435ProAsp: 1.435 ± 0.052	2.387ProGlu: 2.387 ± 0.064	1.47ProPhe: 1.47 ± 0.054	1.584ProGly: 1.584 ± 0.062	0.434ProHis: 0.434 ± 0.027	2.033ProIle: 2.033 ± 0.061	2.066ProLys: 2.066 ± 0.08	2.188ProLeu: 2.188 ± 0.056	0.68ProMet: 0.68 ± 0.035	1.511ProAsn: 1.511 ± 0.053	0.955ProPro: 0.955 ± 0.053	0.73ProGln: 0.73 ± 0.04	1.233ProArg: 1.233 ± 0.049	1.841ProSer: 1.841 ± 0.07	1.506ProThr: 1.506 ± 0.055	2.006ProVal: 2.006 ± 0.069	0.126ProTrp: 0.126 ± 0.013	0.927ProTyr: 0.927 ± 0.042	0.005ProXaa: 0.005 ± 0.003
Gln	1.584GlnAla: 1.584 ± 0.052	0.49GlnCys: 0.49 ± 0.03	1.218GlnAsp: 1.218 ± 0.052	2.263GlnGlu: 2.263 ± 0.062	1.756GlnPhe: 1.756 ± 0.052	1.381GlnGly: 1.381 ± 0.054	0.642GlnHis: 0.642 ± 0.035	2.766GlnIle: 2.766 ± 0.071	2.867GlnLys: 2.867 ± 0.074	2.791GlnLeu: 2.791 ± 0.076	1.001GlnMet: 1.001 ± 0.04	2.399GlnAsn: 2.399 ± 0.067	0.925GlnPro: 0.925 ± 0.047	1.104GlnGln: 1.104 ± 0.051	1.462GlnArg: 1.462 ± 0.054	2.001GlnSer: 2.001 ± 0.063	1.722GlnThr: 1.722 ± 0.065	1.834GlnVal: 1.834 ± 0.052	0.18GlnTrp: 0.18 ± 0.022	1.083GlnTyr: 1.083 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.518ArgAla: 2.518 ± 0.077	0.801ArgCys: 0.801 ± 0.038	2.448ArgAsp: 2.448 ± 0.069	3.862ArgGlu: 3.862 ± 0.092	2.016ArgPhe: 2.016 ± 0.068	2.375ArgGly: 2.375 ± 0.08	1.073ArgHis: 1.073 ± 0.039	4.936ArgIle: 4.936 ± 0.093	4.441ArgLys: 4.441 ± 0.098	4.738ArgLeu: 4.738 ± 0.103	1.867ArgMet: 1.867 ± 0.063	3.428ArgAsn: 3.428 ± 0.081	1.453ArgPro: 1.453 ± 0.068	1.564ArgGln: 1.564 ± 0.057	3.622ArgArg: 3.622 ± 0.099	3.099ArgSer: 3.099 ± 0.08	2.394ArgThr: 2.394 ± 0.065	3.531ArgVal: 3.531 ± 0.097	0.338ArgTrp: 0.338 ± 0.024	1.642ArgTyr: 1.642 ± 0.056	0.005ArgXaa: 0.005 ± 0.003
Ser	2.966SerAla: 2.966 ± 0.078	1.179SerCys: 1.179 ± 0.043	3.753SerAsp: 3.753 ± 0.088	4.723SerGlu: 4.723 ± 0.103	3.087SerPhe: 3.087 ± 0.083	3.993SerGly: 3.993 ± 0.088	1.372SerHis: 1.372 ± 0.05	4.628SerIle: 4.628 ± 0.081	5.78SerLys: 5.78 ± 0.122	5.587SerLeu: 5.587 ± 0.115	1.578SerMet: 1.578 ± 0.049	4.185SerAsn: 4.185 ± 0.102	1.851SerPro: 1.851 ± 0.079	2.082SerGln: 2.082 ± 0.064	3.61SerArg: 3.61 ± 0.094	5.163SerSer: 5.163 ± 0.16	3.984SerThr: 3.984 ± 0.088	4.075SerVal: 4.075 ± 0.074	0.377SerTrp: 0.377 ± 0.026	2.188SerTyr: 2.188 ± 0.062	0.018SerXaa: 0.018 ± 0.005
Thr	2.897ThrAla: 2.897 ± 0.07	0.896ThrCys: 0.896 ± 0.043	2.855ThrAsp: 2.855 ± 0.068	4.224ThrGlu: 4.224 ± 0.095	2.587ThrPhe: 2.587 ± 0.078	3.168ThrGly: 3.168 ± 0.079	1.076ThrHis: 1.076 ± 0.053	3.883ThrIle: 3.883 ± 0.088	5.168ThrLys: 5.168 ± 0.102	4.365ThrLeu: 4.365 ± 0.108	1.16ThrMet: 1.16 ± 0.045	3.408ThrAsn: 3.408 ± 0.079	1.784ThrPro: 1.784 ± 0.06	1.614ThrGln: 1.614 ± 0.054	2.95ThrArg: 2.95 ± 0.073	3.413ThrSer: 3.413 ± 0.081	3.542ThrThr: 3.542 ± 0.108	4.354ThrVal: 4.354 ± 0.092	0.336ThrTrp: 0.336 ± 0.024	1.722ThrTyr: 1.722 ± 0.061	0.005ThrXaa: 0.005 ± 0.003
Val	4.019ValAla: 4.019 ± 0.097	1.228ValCys: 1.228 ± 0.044	4.112ValAsp: 4.112 ± 0.089	5.855ValGlu: 5.855 ± 0.124	3.559ValPhe: 3.559 ± 0.094	3.316ValGly: 3.316 ± 0.086	1.218ValHis: 1.218 ± 0.049	4.208ValIle: 4.208 ± 0.08	4.863ValLys: 4.863 ± 0.093	6.052ValLeu: 6.052 ± 0.114	1.425ValMet: 1.425 ± 0.055	3.024ValAsn: 3.024 ± 0.076	1.809ValPro: 1.809 ± 0.066	1.935ValGln: 1.935 ± 0.063	2.844ValArg: 2.844 ± 0.086	4.008ValSer: 4.008 ± 0.086	3.435ValThr: 3.435 ± 0.09	5.466ValVal: 5.466 ± 0.108	0.422ValTrp: 0.422 ± 0.027	2.478ValTyr: 2.478 ± 0.064	0.003ValXaa: 0.003 ± 0.002
Trp	0.382TrpAla: 0.382 ± 0.025	0.175TrpCys: 0.175 ± 0.018	0.298TrpAsp: 0.298 ± 0.025	0.338TrpGlu: 0.338 ± 0.024	0.387TrpPhe: 0.387 ± 0.026	0.285TrpGly: 0.285 ± 0.025	0.122TrpHis: 0.122 ± 0.014	0.584TrpIle: 0.584 ± 0.033	0.422TrpLys: 0.422 ± 0.025	0.639TrpLeu: 0.639 ± 0.034	0.207TrpMet: 0.207 ± 0.018	0.523TrpAsn: 0.523 ± 0.034	0.189TrpPro: 0.189 ± 0.018	0.137TrpGln: 0.137 ± 0.014	0.253TrpArg: 0.253 ± 0.023	0.463TrpSer: 0.463 ± 0.034	0.288TrpThr: 0.288 ± 0.02	0.308TrpVal: 0.308 ± 0.023	0.078TrpTrp: 0.078 ± 0.018	0.296TrpTyr: 0.296 ± 0.022	0.002TrpXaa: 0.002 ± 0.002
Tyr	2.253TyrAla: 2.253 ± 0.061	0.733TyrCys: 0.733 ± 0.038	2.519TyrAsp: 2.519 ± 0.06	2.953TyrGlu: 2.953 ± 0.07	2.192TyrPhe: 2.192 ± 0.067	1.907TyrGly: 1.907 ± 0.066	0.699TyrHis: 0.699 ± 0.035	2.22TyrIle: 2.22 ± 0.068	3.45TyrLys: 3.45 ± 0.086	3.468TyrLeu: 3.468 ± 0.086	0.848TyrMet: 0.848 ± 0.037	2.251TyrAsn: 2.251 ± 0.061	0.846TyrPro: 0.846 ± 0.04	1.15TyrGln: 1.15 ± 0.044	2.139TyrArg: 2.139 ± 0.059	2.91TyrSer: 2.91 ± 0.068	2.334TyrThr: 2.334 ± 0.06	2.567TyrVal: 2.567 ± 0.065	0.291TyrTrp: 0.291 ± 0.025	1.702TyrTyr: 1.702 ± 0.057	0.005TyrXaa: 0.005 ± 0.003
Xaa	0.0XaaAla: 0.0 ± 0.0	0.002XaaCys: 0.002 ± 0.002	0.005XaaAsp: 0.005 ± 0.003	0.01XaaGlu: 0.01 ± 0.004	0.003XaaPhe: 0.003 ± 0.003	0.01XaaGly: 0.01 ± 0.004	0.007XaaHis: 0.007 ± 0.003	0.015XaaIle: 0.015 ± 0.005	0.007XaaLys: 0.007 ± 0.003	0.008XaaLeu: 0.008 ± 0.003	0.003XaaMet: 0.003 ± 0.002	0.003XaaAsn: 0.003 ± 0.003	0.005XaaPro: 0.005 ± 0.003	0.002XaaGln: 0.002 ± 0.002	0.007XaaArg: 0.007 ± 0.003	0.013XaaSer: 0.013 ± 0.004	0.007XaaThr: 0.007 ± 0.003	0.008XaaVal: 0.008 ± 0.004	0.005XaaTrp: 0.005 ± 0.003	0.005XaaTyr: 0.005 ± 0.003	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2147 proteins (604107 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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