Amino acid dipepetide frequency for Desmospora activa DSM 45169

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.835AlaAla: 7.835 ± 0.105
0.718AlaCys: 0.718 ± 0.027
4.296AlaAsp: 4.296 ± 0.064
5.694AlaGlu: 5.694 ± 0.085
3.3AlaPhe: 3.3 ± 0.056
6.534AlaGly: 6.534 ± 0.098
1.686AlaHis: 1.686 ± 0.045
5.468AlaIle: 5.468 ± 0.077
3.83AlaLys: 3.83 ± 0.068
8.389AlaLeu: 8.389 ± 0.108
2.247AlaMet: 2.247 ± 0.044
2.368AlaAsn: 2.368 ± 0.048
2.701AlaPro: 2.701 ± 0.051
3.149AlaGln: 3.149 ± 0.06
4.163AlaArg: 4.163 ± 0.07
4.016AlaSer: 4.016 ± 0.064
3.968AlaThr: 3.968 ± 0.065
6.976AlaVal: 6.976 ± 0.091
1.139AlaTrp: 1.139 ± 0.035
2.328AlaTyr: 2.328 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.534CysAla: 0.534 ± 0.024
0.103CysCys: 0.103 ± 0.011
0.434CysAsp: 0.434 ± 0.02
0.43CysGlu: 0.43 ± 0.023
0.33CysPhe: 0.33 ± 0.02
0.811CysGly: 0.811 ± 0.032
0.231CysHis: 0.231 ± 0.017
0.432CysIle: 0.432 ± 0.021
0.256CysLys: 0.256 ± 0.013
0.793CysLeu: 0.793 ± 0.03
0.179CysMet: 0.179 ± 0.013
0.246CysAsn: 0.246 ± 0.015
0.424CysPro: 0.424 ± 0.022
0.263CysGln: 0.263 ± 0.015
0.555CysArg: 0.555 ± 0.025
0.492CysSer: 0.492 ± 0.022
0.396CysThr: 0.396 ± 0.019
0.437CysVal: 0.437 ± 0.021
0.134CysTrp: 0.134 ± 0.01
0.26CysTyr: 0.26 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.865AspAla: 3.865 ± 0.069
0.427AspCys: 0.427 ± 0.02
2.599AspAsp: 2.599 ± 0.066
4.032AspGlu: 4.032 ± 0.074
1.977AspPhe: 1.977 ± 0.047
4.282AspGly: 4.282 ± 0.066
1.418AspHis: 1.418 ± 0.036
2.96AspIle: 2.96 ± 0.049
2.054AspLys: 2.054 ± 0.05
4.979AspLeu: 4.979 ± 0.067
1.17AspMet: 1.17 ± 0.034
1.433AspAsn: 1.433 ± 0.04
2.878AspPro: 2.878 ± 0.057
2.336AspGln: 2.336 ± 0.05
3.521AspArg: 3.521 ± 0.062
2.467AspSer: 2.467 ± 0.05
2.512AspThr: 2.512 ± 0.06
3.781AspVal: 3.781 ± 0.055
0.986AspTrp: 0.986 ± 0.033
1.747AspTyr: 1.747 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
6.473GluAla: 6.473 ± 0.099
0.391GluCys: 0.391 ± 0.019
3.065GluAsp: 3.065 ± 0.061
7.143GluGlu: 7.143 ± 0.106
1.649GluPhe: 1.649 ± 0.044
5.078GluGly: 5.078 ± 0.074
1.419GluHis: 1.419 ± 0.037
4.102GluIle: 4.102 ± 0.073
4.938GluLys: 4.938 ± 0.079
6.251GluLeu: 6.251 ± 0.099
2.208GluMet: 2.208 ± 0.047
2.315GluAsn: 2.315 ± 0.055
2.498GluPro: 2.498 ± 0.052
3.821GluGln: 3.821 ± 0.067
5.397GluArg: 5.397 ± 0.086
3.515GluSer: 3.515 ± 0.064
3.689GluThr: 3.689 ± 0.06
5.325GluVal: 5.325 ± 0.09
1.307GluTrp: 1.307 ± 0.036
1.821GluTyr: 1.821 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.317PheAla: 3.317 ± 0.058
0.394PheCys: 0.394 ± 0.019
2.043PheAsp: 2.043 ± 0.044
1.995PheGlu: 1.995 ± 0.049
1.99PhePhe: 1.99 ± 0.058
3.178PheGly: 3.178 ± 0.062
1.078PheHis: 1.078 ± 0.031
2.504PheIle: 2.504 ± 0.064
1.229PheLys: 1.229 ± 0.033
4.192PheLeu: 4.192 ± 0.076
0.846PheMet: 0.846 ± 0.033
1.269PheAsn: 1.269 ± 0.037
1.836PhePro: 1.836 ± 0.038
1.804PheGln: 1.804 ± 0.039
2.157PheArg: 2.157 ± 0.045
2.666PheSer: 2.666 ± 0.048
2.305PheThr: 2.305 ± 0.045
2.695PheVal: 2.695 ± 0.053
0.556PheTrp: 0.556 ± 0.024
1.271PheTyr: 1.271 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.569GlyAla: 5.569 ± 0.078
0.81GlyCys: 0.81 ± 0.03
3.579GlyAsp: 3.579 ± 0.059
5.49GlyGlu: 5.49 ± 0.074
3.138GlyPhe: 3.138 ± 0.061
5.868GlyGly: 5.868 ± 0.09
1.559GlyHis: 1.559 ± 0.044
5.526GlyIle: 5.526 ± 0.086
4.517GlyLys: 4.517 ± 0.07
7.662GlyLeu: 7.662 ± 0.098
2.493GlyMet: 2.493 ± 0.053
2.55GlyAsn: 2.55 ± 0.055
2.228GlyPro: 2.228 ± 0.054
2.567GlyGln: 2.567 ± 0.054
4.017GlyArg: 4.017 ± 0.067
4.289GlySer: 4.289 ± 0.081
4.292GlyThr: 4.292 ± 0.073
6.195GlyVal: 6.195 ± 0.083
1.397GlyTrp: 1.397 ± 0.042
2.754GlyTyr: 2.754 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.674HisAla: 1.674 ± 0.043
0.239HisCys: 0.239 ± 0.014
1.108HisAsp: 1.108 ± 0.03
1.166HisGlu: 1.166 ± 0.034
1.099HisPhe: 1.099 ± 0.03
1.666HisGly: 1.666 ± 0.043
0.885HisHis: 0.885 ± 0.033
1.402HisIle: 1.402 ± 0.052
0.739HisLys: 0.739 ± 0.024
2.769HisLeu: 2.769 ± 0.081
0.509HisMet: 0.509 ± 0.021
0.661HisAsn: 0.661 ± 0.026
1.67HisPro: 1.67 ± 0.046
1.089HisGln: 1.089 ± 0.032
1.647HisArg: 1.647 ± 0.036
1.196HisSer: 1.196 ± 0.034
1.193HisThr: 1.193 ± 0.036
1.574HisVal: 1.574 ± 0.038
0.397HisTrp: 0.397 ± 0.019
0.85HisTyr: 0.85 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.671IleAla: 5.671 ± 0.092
0.552IleCys: 0.552 ± 0.024
3.443IleAsp: 3.443 ± 0.061
3.656IleGlu: 3.656 ± 0.062
2.179IlePhe: 2.179 ± 0.052
5.262IleGly: 5.262 ± 0.09
1.682IleHis: 1.682 ± 0.041
3.39IleIle: 3.39 ± 0.074
2.502IleLys: 2.502 ± 0.046
6.107IleLeu: 6.107 ± 0.091
1.227IleMet: 1.227 ± 0.036
2.052IleAsn: 2.052 ± 0.043
3.422IlePro: 3.422 ± 0.051
2.936IleGln: 2.936 ± 0.057
4.215IleArg: 4.215 ± 0.06
3.46IleSer: 3.46 ± 0.066
3.474IleThr: 3.474 ± 0.066
4.376IleVal: 4.376 ± 0.072
0.717IleTrp: 0.717 ± 0.032
1.71IleTyr: 1.71 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.717LysAla: 3.717 ± 0.062
0.224LysCys: 0.224 ± 0.012
2.32LysAsp: 2.32 ± 0.049
4.808LysGlu: 4.808 ± 0.087
0.989LysPhe: 0.989 ± 0.03
3.906LysGly: 3.906 ± 0.062
1.009LysHis: 1.009 ± 0.032
2.474LysIle: 2.474 ± 0.049
3.721LysLys: 3.721 ± 0.071
3.862LysLeu: 3.862 ± 0.066
1.454LysMet: 1.454 ± 0.036
1.788LysAsn: 1.788 ± 0.042
2.185LysPro: 2.185 ± 0.047
2.49LysGln: 2.49 ± 0.062
3.546LysArg: 3.546 ± 0.056
2.285LysSer: 2.285 ± 0.051
2.567LysThr: 2.567 ± 0.044
3.52LysVal: 3.52 ± 0.054
0.78LysTrp: 0.78 ± 0.024
1.203LysTyr: 1.203 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
8.8LeuAla: 8.8 ± 0.108
0.774LeuCys: 0.774 ± 0.029
5.202LeuAsp: 5.202 ± 0.078
6.819LeuGlu: 6.819 ± 0.084
4.785LeuPhe: 4.785 ± 0.08
6.962LeuGly: 6.962 ± 0.112
2.344LeuHis: 2.344 ± 0.056
6.211LeuIle: 6.211 ± 0.093
4.813LeuLys: 4.813 ± 0.073
11.228LeuLeu: 11.228 ± 0.145
2.554LeuMet: 2.554 ± 0.052
3.176LeuAsn: 3.176 ± 0.057
4.839LeuPro: 4.839 ± 0.069
4.396LeuGln: 4.396 ± 0.074
5.191LeuArg: 5.191 ± 0.085
6.505LeuSer: 6.505 ± 0.079
5.895LeuThr: 5.895 ± 0.083
7.034LeuVal: 7.034 ± 0.092
1.186LeuTrp: 1.186 ± 0.034
2.98LeuTyr: 2.98 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.396MetAla: 2.396 ± 0.05
0.13MetCys: 0.13 ± 0.011
1.534MetAsp: 1.534 ± 0.041
2.236MetGlu: 2.236 ± 0.041
0.83MetPhe: 0.83 ± 0.027
2.128MetGly: 2.128 ± 0.048
0.408MetHis: 0.408 ± 0.019
1.813MetIle: 1.813 ± 0.046
1.794MetLys: 1.794 ± 0.039
2.359MetLeu: 2.359 ± 0.046
0.882MetMet: 0.882 ± 0.03
1.03MetAsn: 1.03 ± 0.033
0.963MetPro: 0.963 ± 0.031
0.901MetGln: 0.901 ± 0.028
1.377MetArg: 1.377 ± 0.031
1.398MetSer: 1.398 ± 0.037
1.478MetThr: 1.478 ± 0.038
2.242MetVal: 2.242 ± 0.046
0.277MetTrp: 0.277 ± 0.016
0.584MetTyr: 0.584 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.226AsnAla: 2.226 ± 0.044
0.229AsnCys: 0.229 ± 0.014
1.577AsnAsp: 1.577 ± 0.048
2.086AsnGlu: 2.086 ± 0.044
0.95AsnPhe: 0.95 ± 0.032
2.712AsnGly: 2.712 ± 0.058
0.972AsnHis: 0.972 ± 0.033
1.92AsnIle: 1.92 ± 0.046
1.408AsnLys: 1.408 ± 0.038
3.039AsnLeu: 3.039 ± 0.058
0.77AsnMet: 0.77 ± 0.026
1.138AsnAsn: 1.138 ± 0.041
2.195AsnPro: 2.195 ± 0.048
1.76AsnGln: 1.76 ± 0.045
2.507AsnArg: 2.507 ± 0.045
1.425AsnSer: 1.425 ± 0.038
1.624AsnThr: 1.624 ± 0.044
2.126AsnVal: 2.126 ± 0.042
0.47AsnTrp: 0.47 ± 0.02
0.859AsnTyr: 0.859 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
3.369ProAla: 3.369 ± 0.055
0.278ProCys: 0.278 ± 0.015
2.924ProAsp: 2.924 ± 0.052
3.501ProGlu: 3.501 ± 0.061
2.098ProPhe: 2.098 ± 0.044
3.237ProGly: 3.237 ± 0.062
1.173ProHis: 1.173 ± 0.034
2.523ProIle: 2.523 ± 0.05
1.658ProLys: 1.658 ± 0.04
4.777ProLeu: 4.777 ± 0.07
1.029ProMet: 1.029 ± 0.029
1.335ProAsn: 1.335 ± 0.036
1.775ProPro: 1.775 ± 0.051
1.985ProGln: 1.985 ± 0.049
2.083ProArg: 2.083 ± 0.043
2.556ProSer: 2.556 ± 0.048
2.345ProThr: 2.345 ± 0.05
3.662ProVal: 3.662 ± 0.058
0.626ProTrp: 0.626 ± 0.024
1.504ProTyr: 1.504 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.971GlnAla: 3.971 ± 0.053
0.23GlnCys: 0.23 ± 0.015
1.799GlnAsp: 1.799 ± 0.037
3.497GlnGlu: 3.497 ± 0.063
1.501GlnPhe: 1.501 ± 0.036
2.931GlnGly: 2.931 ± 0.054
0.891GlnHis: 0.891 ± 0.031
2.256GlnIle: 2.256 ± 0.05
2.248GlnLys: 2.248 ± 0.048
4.501GlnLeu: 4.501 ± 0.072
1.19GlnMet: 1.19 ± 0.038
1.251GlnAsn: 1.251 ± 0.032
1.983GlnPro: 1.983 ± 0.047
2.476GlnGln: 2.476 ± 0.063
2.771GlnArg: 2.771 ± 0.049
2.407GlnSer: 2.407 ± 0.055
2.395GlnThr: 2.395 ± 0.051
3.313GlnVal: 3.313 ± 0.051
0.774GlnTrp: 0.774 ± 0.026
1.253GlnTyr: 1.253 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.64ArgAla: 3.64 ± 0.064
0.464ArgCys: 0.464 ± 0.027
2.952ArgAsp: 2.952 ± 0.053
4.972ArgGlu: 4.972 ± 0.083
2.753ArgPhe: 2.753 ± 0.059
3.699ArgGly: 3.699 ± 0.057
1.454ArgHis: 1.454 ± 0.055
3.996ArgIle: 3.996 ± 0.065
3.005ArgLys: 3.005 ± 0.052
6.814ArgLeu: 6.814 ± 0.097
1.877ArgMet: 1.877 ± 0.041
1.906ArgAsn: 1.906 ± 0.045
2.161ArgPro: 2.161 ± 0.043
2.805ArgGln: 2.805 ± 0.059
3.895ArgArg: 3.895 ± 0.075
3.232ArgSer: 3.232 ± 0.049
2.721ArgThr: 2.721 ± 0.049
4.246ArgVal: 4.246 ± 0.065
1.158ArgTrp: 1.158 ± 0.04
2.187ArgTyr: 2.187 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.905SerAla: 3.905 ± 0.065
0.396SerCys: 0.396 ± 0.021
2.821SerAsp: 2.821 ± 0.05
3.095SerGlu: 3.095 ± 0.053
2.746SerPhe: 2.746 ± 0.049
4.544SerGly: 4.544 ± 0.062
1.374SerHis: 1.374 ± 0.04
3.656SerIle: 3.656 ± 0.068
2.265SerLys: 2.265 ± 0.044
6.08SerLeu: 6.08 ± 0.088
1.574SerMet: 1.574 ± 0.033
1.735SerAsn: 1.735 ± 0.042
2.592SerPro: 2.592 ± 0.048
2.102SerGln: 2.102 ± 0.045
3.195SerArg: 3.195 ± 0.059
3.209SerSer: 3.209 ± 0.071
2.906SerThr: 2.906 ± 0.054
3.822SerVal: 3.822 ± 0.064
0.851SerTrp: 0.851 ± 0.033
1.741SerTyr: 1.741 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.802ThrAla: 4.802 ± 0.071
0.409ThrCys: 0.409 ± 0.019
2.878ThrAsp: 2.878 ± 0.061
3.258ThrGlu: 3.258 ± 0.063
2.215ThrPhe: 2.215 ± 0.046
4.614ThrGly: 4.614 ± 0.07
1.188ThrHis: 1.188 ± 0.035
3.602ThrIle: 3.602 ± 0.066
2.064ThrLys: 2.064 ± 0.053
5.546ThrLeu: 5.546 ± 0.08
1.343ThrMet: 1.343 ± 0.035
1.626ThrAsn: 1.626 ± 0.041
2.826ThrPro: 2.826 ± 0.06
1.754ThrGln: 1.754 ± 0.041
2.664ThrArg: 2.664 ± 0.053
2.797ThrSer: 2.797 ± 0.051
2.901ThrThr: 2.901 ± 0.075
4.69ThrVal: 4.69 ± 0.065
0.743ThrTrp: 0.743 ± 0.029
1.654ThrTyr: 1.654 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
6.076ValAla: 6.076 ± 0.084
0.614ValCys: 0.614 ± 0.022
4.361ValAsp: 4.361 ± 0.067
5.661ValGlu: 5.661 ± 0.074
2.826ValPhe: 2.826 ± 0.061
5.469ValGly: 5.469 ± 0.082
1.573ValHis: 1.573 ± 0.04
5.06ValIle: 5.06 ± 0.074
3.847ValLys: 3.847 ± 0.067
7.277ValLeu: 7.277 ± 0.088
2.02ValMet: 2.02 ± 0.044
2.436ValAsn: 2.436 ± 0.047
3.202ValPro: 3.202 ± 0.061
2.791ValGln: 2.791 ± 0.049
3.926ValArg: 3.926 ± 0.067
4.326ValSer: 4.326 ± 0.062
4.462ValThr: 4.462 ± 0.069
6.08ValVal: 6.08 ± 0.09
1.001ValTrp: 1.001 ± 0.032
2.124ValTyr: 2.124 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.932TrpAla: 0.932 ± 0.031
0.102TrpCys: 0.102 ± 0.009
0.761TrpAsp: 0.761 ± 0.027
1.031TrpGlu: 1.031 ± 0.033
0.659TrpPhe: 0.659 ± 0.026
1.124TrpGly: 1.124 ± 0.04
0.256TrpHis: 0.256 ± 0.015
1.067TrpIle: 1.067 ± 0.033
0.861TrpLys: 0.861 ± 0.033
1.79TrpLeu: 1.79 ± 0.049
0.543TrpMet: 0.543 ± 0.026
0.663TrpAsn: 0.663 ± 0.028
0.451TrpPro: 0.451 ± 0.021
0.592TrpGln: 0.592 ± 0.026
0.841TrpArg: 0.841 ± 0.036
0.837TrpSer: 0.837 ± 0.03
0.784TrpThr: 0.784 ± 0.032
1.203TrpVal: 1.203 ± 0.036
0.306TrpTrp: 0.306 ± 0.02
0.435TrpTyr: 0.435 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.034TyrAla: 2.034 ± 0.052
0.255TyrCys: 0.255 ± 0.015
1.728TyrAsp: 1.728 ± 0.053
1.836TyrGlu: 1.836 ± 0.043
1.31TyrPhe: 1.31 ± 0.038
2.494TyrGly: 2.494 ± 0.049
0.933TyrHis: 0.933 ± 0.034
1.673TyrIle: 1.673 ± 0.035
1.097TyrLys: 1.097 ± 0.032
3.278TyrLeu: 3.278 ± 0.056
0.647TyrMet: 0.647 ± 0.024
1.014TyrAsn: 1.014 ± 0.032
1.611TyrPro: 1.611 ± 0.042
1.621TyrGln: 1.621 ± 0.042
2.271TyrArg: 2.271 ± 0.05
1.529TyrSer: 1.529 ± 0.037
1.668TyrThr: 1.668 ± 0.042
1.835TyrVal: 1.835 ± 0.043
0.432TyrTrp: 0.432 ± 0.02
1.108TyrTyr: 1.108 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3643 proteins (1080795 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski