Amino acid dipepetide frequency for Pseudomonas kirkiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.571AlaAla: 12.571 ± 0.13	1.225AlaCys: 1.225 ± 0.034	5.835AlaAsp: 5.835 ± 0.08	7.007AlaGlu: 7.007 ± 0.091	3.755AlaPhe: 3.755 ± 0.064	9.666AlaGly: 9.666 ± 0.111	2.262AlaHis: 2.262 ± 0.046	5.356AlaIle: 5.356 ± 0.069	2.634AlaLys: 2.634 ± 0.058	14.573AlaLeu: 14.573 ± 0.131	2.539AlaMet: 2.539 ± 0.042	2.825AlaAsn: 2.825 ± 0.052	4.547AlaPro: 4.547 ± 0.077	4.986AlaGln: 4.986 ± 0.088	8.311AlaArg: 8.311 ± 0.094	6.969AlaSer: 6.969 ± 0.101	4.817AlaThr: 4.817 ± 0.083	7.012AlaVal: 7.012 ± 0.077	1.661AlaTrp: 1.661 ± 0.044	2.536AlaTyr: 2.536 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.015CysAla: 1.015 ± 0.032	0.134CysCys: 0.134 ± 0.011	0.512CysAsp: 0.512 ± 0.021	0.506CysGlu: 0.506 ± 0.02	0.289CysPhe: 0.289 ± 0.013	0.861CysGly: 0.861 ± 0.033	0.28CysHis: 0.28 ± 0.016	0.414CysIle: 0.414 ± 0.02	0.215CysLys: 0.215 ± 0.013	1.079CysLeu: 1.079 ± 0.032	0.185CysMet: 0.185 ± 0.011	0.251CysAsn: 0.251 ± 0.014	0.477CysPro: 0.477 ± 0.022	0.388CysGln: 0.388 ± 0.018	0.697CysArg: 0.697 ± 0.024	0.589CysSer: 0.589 ± 0.025	0.378CysThr: 0.378 ± 0.016	0.614CysVal: 0.614 ± 0.022	0.136CysTrp: 0.136 ± 0.01	0.226CysTyr: 0.226 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.752AspAla: 5.752 ± 0.071	0.5AspCys: 0.5 ± 0.024	3.087AspAsp: 3.087 ± 0.064	3.835AspGlu: 3.835 ± 0.058	2.182AspPhe: 2.182 ± 0.046	4.929AspGly: 4.929 ± 0.111	1.113AspHis: 1.113 ± 0.03	2.945AspIle: 2.945 ± 0.055	1.655AspLys: 1.655 ± 0.037	5.823AspLeu: 5.823 ± 0.059	1.117AspMet: 1.117 ± 0.032	1.688AspAsn: 1.688 ± 0.057	2.717AspPro: 2.717 ± 0.046	1.905AspGln: 1.905 ± 0.037	3.156AspArg: 3.156 ± 0.052	3.304AspSer: 3.304 ± 0.066	2.421AspThr: 2.421 ± 0.05	3.345AspVal: 3.345 ± 0.06	1.027AspTrp: 1.027 ± 0.028	1.819AspTyr: 1.819 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.849GluAla: 6.849 ± 0.1	0.428GluCys: 0.428 ± 0.02	2.679GluAsp: 2.679 ± 0.051	3.384GluGlu: 3.384 ± 0.065	1.687GluPhe: 1.687 ± 0.044	4.122GluGly: 4.122 ± 0.053	1.747GluHis: 1.747 ± 0.047	2.782GluIle: 2.782 ± 0.051	1.993GluLys: 1.993 ± 0.041	7.607GluLeu: 7.607 ± 0.102	1.154GluMet: 1.154 ± 0.033	1.652GluAsn: 1.652 ± 0.041	2.57GluPro: 2.57 ± 0.053	4.112GluGln: 4.112 ± 0.073	6.046GluArg: 6.046 ± 0.083	2.9GluSer: 2.9 ± 0.051	2.532GluThr: 2.532 ± 0.049	4.292GluVal: 4.292 ± 0.068	0.709GluTrp: 0.709 ± 0.022	1.317GluTyr: 1.317 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.872PheAla: 3.872 ± 0.07	0.399PheCys: 0.399 ± 0.02	2.523PheAsp: 2.523 ± 0.043	2.206PheGlu: 2.206 ± 0.041	1.361PhePhe: 1.361 ± 0.037	3.019PheGly: 3.019 ± 0.051	0.699PheHis: 0.699 ± 0.024	1.735PheIle: 1.735 ± 0.036	0.979PheLys: 0.979 ± 0.033	3.115PheLeu: 3.115 ± 0.056	0.762PheMet: 0.762 ± 0.021	1.217PheAsn: 1.217 ± 0.033	1.333PhePro: 1.333 ± 0.04	1.273PheGln: 1.273 ± 0.027	1.931PheArg: 1.931 ± 0.042	2.582PheSer: 2.582 ± 0.052	1.704PheThr: 1.704 ± 0.045	2.339PheVal: 2.339 ± 0.046	0.5PheTrp: 0.5 ± 0.022	0.949PheTyr: 0.949 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.615GlyAla: 7.615 ± 0.1	0.918GlyCys: 0.918 ± 0.028	4.257GlyAsp: 4.257 ± 0.092	5.288GlyGlu: 5.288 ± 0.077	3.288GlyPhe: 3.288 ± 0.054	6.493GlyGly: 6.493 ± 0.117	1.953GlyHis: 1.953 ± 0.039	4.309GlyIle: 4.309 ± 0.061	3.245GlyLys: 3.245 ± 0.052	10.049GlyLeu: 10.049 ± 0.129	1.985GlyMet: 1.985 ± 0.046	2.669GlyAsn: 2.669 ± 0.072	2.56GlyPro: 2.56 ± 0.044	3.877GlyGln: 3.877 ± 0.059	5.716GlyArg: 5.716 ± 0.077	5.21GlySer: 5.21 ± 0.14	3.884GlyThr: 3.884 ± 0.086	5.66GlyVal: 5.66 ± 0.075	1.42GlyTrp: 1.42 ± 0.037	2.52GlyTyr: 2.52 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.381HisAla: 2.381 ± 0.042	0.309HisCys: 0.309 ± 0.016	1.317HisAsp: 1.317 ± 0.036	1.338HisGlu: 1.338 ± 0.037	0.921HisPhe: 0.921 ± 0.027	2.073HisGly: 2.073 ± 0.042	0.589HisHis: 0.589 ± 0.026	1.082HisIle: 1.082 ± 0.027	0.596HisLys: 0.596 ± 0.023	2.582HisLeu: 2.582 ± 0.056	0.435HisMet: 0.435 ± 0.018	0.626HisAsn: 0.626 ± 0.021	1.39HisPro: 1.39 ± 0.039	0.941HisGln: 0.941 ± 0.031	1.412HisArg: 1.412 ± 0.042	1.245HisSer: 1.245 ± 0.03	0.95HisThr: 0.95 ± 0.026	1.338HisVal: 1.338 ± 0.035	0.484HisTrp: 0.484 ± 0.02	0.794HisTyr: 0.794 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.836IleAla: 5.836 ± 0.083	0.424IleCys: 0.424 ± 0.023	3.392IleAsp: 3.392 ± 0.059	3.628IleGlu: 3.628 ± 0.056	1.297IlePhe: 1.297 ± 0.035	4.539IleGly: 4.539 ± 0.071	0.976IleHis: 0.976 ± 0.032	1.897IleIle: 1.897 ± 0.044	1.335IleLys: 1.335 ± 0.04	4.295IleLeu: 4.295 ± 0.068	0.796IleMet: 0.796 ± 0.029	1.496IleAsn: 1.496 ± 0.041	2.201IlePro: 2.201 ± 0.042	1.615IleGln: 1.615 ± 0.042	3.183IleArg: 3.183 ± 0.055	2.928IleSer: 2.928 ± 0.058	2.391IleThr: 2.391 ± 0.065	3.11IleVal: 3.11 ± 0.062	0.496IleTrp: 0.496 ± 0.02	1.069IleTyr: 1.069 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.382LysAla: 3.382 ± 0.058	0.159LysCys: 0.159 ± 0.013	1.414LysAsp: 1.414 ± 0.038	1.447LysGlu: 1.447 ± 0.047	0.71LysPhe: 0.71 ± 0.025	2.342LysGly: 2.342 ± 0.048	0.609LysHis: 0.609 ± 0.023	1.26LysIle: 1.26 ± 0.036	1.047LysLys: 1.047 ± 0.039	3.176LysLeu: 3.176 ± 0.056	0.525LysMet: 0.525 ± 0.023	0.804LysAsn: 0.804 ± 0.027	1.631LysPro: 1.631 ± 0.039	1.206LysGln: 1.206 ± 0.039	2.11LysArg: 2.11 ± 0.046	1.628LysSer: 1.628 ± 0.035	1.477LysThr: 1.477 ± 0.042	2.222LysVal: 2.222 ± 0.044	0.305LysTrp: 0.305 ± 0.017	0.673LysTyr: 0.673 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	15.549LeuAla: 15.549 ± 0.149	1.198LeuCys: 1.198 ± 0.033	7.488LeuAsp: 7.488 ± 0.097	7.605LeuGlu: 7.605 ± 0.105	4.138LeuPhe: 4.138 ± 0.068	10.081LeuGly: 10.081 ± 0.133	2.556LeuHis: 2.556 ± 0.049	5.064LeuIle: 5.064 ± 0.067	3.674LeuLys: 3.674 ± 0.06	15.101LeuLeu: 15.101 ± 0.22	2.19LeuMet: 2.19 ± 0.048	3.306LeuAsn: 3.306 ± 0.058	6.631LeuPro: 6.631 ± 0.094	5.377LeuGln: 5.377 ± 0.095	8.571LeuArg: 8.571 ± 0.121	7.504LeuSer: 7.504 ± 0.092	5.086LeuThr: 5.086 ± 0.089	7.806LeuVal: 7.806 ± 0.089	1.41LeuTrp: 1.41 ± 0.043	2.681LeuTyr: 2.681 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.409MetAla: 2.409 ± 0.05	0.122MetCys: 0.122 ± 0.011	0.907MetAsp: 0.907 ± 0.026	0.906MetGlu: 0.906 ± 0.028	0.559MetPhe: 0.559 ± 0.026	1.407MetGly: 1.407 ± 0.037	0.49MetHis: 0.49 ± 0.024	0.899MetIle: 0.899 ± 0.03	0.714MetLys: 0.714 ± 0.022	2.488MetLeu: 2.488 ± 0.047	0.397MetMet: 0.397 ± 0.019	0.715MetAsn: 0.715 ± 0.026	1.263MetPro: 1.263 ± 0.035	0.937MetGln: 0.937 ± 0.031	1.508MetArg: 1.508 ± 0.035	1.54MetSer: 1.54 ± 0.036	1.164MetThr: 1.164 ± 0.033	1.278MetVal: 1.278 ± 0.04	0.143MetTrp: 0.143 ± 0.01	0.307MetTyr: 0.307 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.113AsnAla: 3.113 ± 0.063	0.235AsnCys: 0.235 ± 0.014	1.587AsnAsp: 1.587 ± 0.044	1.389AsnGlu: 1.389 ± 0.038	0.945AsnPhe: 0.945 ± 0.032	2.597AsnGly: 2.597 ± 0.065	0.589AsnHis: 0.589 ± 0.023	1.473AsnIle: 1.473 ± 0.042	0.674AsnLys: 0.674 ± 0.024	3.533AsnLeu: 3.533 ± 0.065	0.505AsnMet: 0.505 ± 0.021	0.891AsnAsn: 0.891 ± 0.035	1.78AsnPro: 1.78 ± 0.04	1.169AsnGln: 1.169 ± 0.04	1.965AsnArg: 1.965 ± 0.043	1.488AsnSer: 1.488 ± 0.045	1.426AsnThr: 1.426 ± 0.037	1.869AsnVal: 1.869 ± 0.051	0.442AsnTrp: 0.442 ± 0.02	0.811AsnTyr: 0.811 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.506ProAla: 5.506 ± 0.073	0.384ProCys: 0.384 ± 0.019	2.604ProAsp: 2.604 ± 0.054	3.388ProGlu: 3.388 ± 0.062	1.712ProPhe: 1.712 ± 0.04	4.225ProGly: 4.225 ± 0.064	1.083ProHis: 1.083 ± 0.032	1.832ProIle: 1.832 ± 0.037	1.104ProLys: 1.104 ± 0.034	6.044ProLeu: 6.044 ± 0.095	1.003ProMet: 1.003 ± 0.034	1.16ProAsn: 1.16 ± 0.035	1.963ProPro: 1.963 ± 0.05	2.277ProGln: 2.277 ± 0.044	3.035ProArg: 3.035 ± 0.056	2.629ProSer: 2.629 ± 0.043	1.953ProThr: 1.953 ± 0.039	3.514ProVal: 3.514 ± 0.069	0.785ProTrp: 0.785 ± 0.032	1.146ProTyr: 1.146 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	6.667GlnAla: 6.667 ± 0.084	0.325GlnCys: 0.325 ± 0.016	1.953GlnAsp: 1.953 ± 0.04	2.206GlnGlu: 2.206 ± 0.048	1.136GlnPhe: 1.136 ± 0.029	3.833GlnGly: 3.833 ± 0.073	1.086GlnHis: 1.086 ± 0.034	1.748GlnIle: 1.748 ± 0.039	1.07GlnLys: 1.07 ± 0.029	5.332GlnLeu: 5.332 ± 0.088	0.877GlnMet: 0.877 ± 0.032	1.024GlnAsn: 1.024 ± 0.028	2.608GlnPro: 2.608 ± 0.051	2.797GlnGln: 2.797 ± 0.068	4.355GlnArg: 4.355 ± 0.072	2.334GlnSer: 2.334 ± 0.047	1.808GlnThr: 1.808 ± 0.04	3.618GlnVal: 3.618 ± 0.066	0.673GlnTrp: 0.673 ± 0.025	1.011GlnTyr: 1.011 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.483ArgAla: 6.483 ± 0.078	0.613ArgCys: 0.613 ± 0.02	3.755ArgAsp: 3.755 ± 0.056	4.769ArgGlu: 4.769 ± 0.073	2.863ArgPhe: 2.863 ± 0.058	4.551ArgGly: 4.551 ± 0.076	2.111ArgHis: 2.111 ± 0.05	3.908ArgIle: 3.908 ± 0.063	2.024ArgLys: 2.024 ± 0.044	10.183ArgLeu: 10.183 ± 0.113	1.667ArgMet: 1.667 ± 0.035	2.129ArgAsn: 2.129 ± 0.046	3.183ArgPro: 3.183 ± 0.058	4.524ArgGln: 4.524 ± 0.074	5.294ArgArg: 5.294 ± 0.084	3.758ArgSer: 3.758 ± 0.062	2.905ArgThr: 2.905 ± 0.049	4.754ArgVal: 4.754 ± 0.061	1.078ArgTrp: 1.078 ± 0.034	2.252ArgTyr: 2.252 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.362SerAla: 6.362 ± 0.106	0.46SerCys: 0.46 ± 0.018	2.991SerAsp: 2.991 ± 0.059	3.248SerGlu: 3.248 ± 0.061	2.149SerPhe: 2.149 ± 0.046	6.044SerGly: 6.044 ± 0.13	1.397SerHis: 1.397 ± 0.039	3.034SerIle: 3.034 ± 0.063	1.422SerLys: 1.422 ± 0.038	7.604SerLeu: 7.604 ± 0.097	1.23SerMet: 1.23 ± 0.034	1.772SerAsn: 1.772 ± 0.055	2.617SerPro: 2.617 ± 0.043	2.393SerGln: 2.393 ± 0.043	4.122SerArg: 4.122 ± 0.056	3.77SerSer: 3.77 ± 0.09	2.825SerThr: 2.825 ± 0.059	4.019SerVal: 4.019 ± 0.076	0.743SerTrp: 0.743 ± 0.027	1.562SerTyr: 1.562 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.62ThrAla: 4.62 ± 0.073	0.409ThrCys: 0.409 ± 0.018	2.199ThrAsp: 2.199 ± 0.056	2.194ThrGlu: 2.194 ± 0.042	1.611ThrPhe: 1.611 ± 0.037	4.097ThrGly: 4.097 ± 0.083	0.984ThrHis: 0.984 ± 0.028	1.923ThrIle: 1.923 ± 0.056	0.786ThrLys: 0.786 ± 0.03	6.91ThrLeu: 6.91 ± 0.095	0.605ThrMet: 0.605 ± 0.023	1.076ThrAsn: 1.076 ± 0.037	2.911ThrPro: 2.911 ± 0.055	1.748ThrGln: 1.748 ± 0.044	3.214ThrArg: 3.214 ± 0.053	2.683ThrSer: 2.683 ± 0.072	2.234ThrThr: 2.234 ± 0.061	3.076ThrVal: 3.076 ± 0.071	0.662ThrTrp: 0.662 ± 0.021	1.151ThrTyr: 1.151 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.494ValAla: 7.494 ± 0.098	0.608ValCys: 0.608 ± 0.025	3.779ValAsp: 3.779 ± 0.068	4.363ValGlu: 4.363 ± 0.059	2.456ValPhe: 2.456 ± 0.049	5.007ValGly: 5.007 ± 0.072	1.333ValHis: 1.333 ± 0.034	3.659ValIle: 3.659 ± 0.055	1.925ValLys: 1.925 ± 0.046	8.055ValLeu: 8.055 ± 0.094	1.445ValMet: 1.445 ± 0.038	1.965ValAsn: 1.965 ± 0.051	3.017ValPro: 3.017 ± 0.053	2.565ValGln: 2.565 ± 0.047	4.703ValArg: 4.703 ± 0.07	4.161ValSer: 4.161 ± 0.069	3.397ValThr: 3.397 ± 0.09	4.866ValVal: 4.866 ± 0.073	0.778ValTrp: 0.778 ± 0.028	1.484ValTyr: 1.484 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.149TrpAla: 1.149 ± 0.033	0.143TrpCys: 0.143 ± 0.01	0.604TrpAsp: 0.604 ± 0.026	0.579TrpGlu: 0.579 ± 0.023	0.531TrpPhe: 0.531 ± 0.021	0.87TrpGly: 0.87 ± 0.03	0.391TrpHis: 0.391 ± 0.018	0.58TrpIle: 0.58 ± 0.021	0.382TrpLys: 0.382 ± 0.018	2.29TrpLeu: 2.29 ± 0.054	0.321TrpMet: 0.321 ± 0.015	0.468TrpAsn: 0.468 ± 0.02	0.678TrpPro: 0.678 ± 0.026	1.036TrpGln: 1.036 ± 0.028	1.233TrpArg: 1.233 ± 0.035	0.89TrpSer: 0.89 ± 0.028	0.536TrpThr: 0.536 ± 0.022	0.831TrpVal: 0.831 ± 0.028	0.19TrpTrp: 0.19 ± 0.013	0.321TrpTyr: 0.321 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.463TyrAla: 2.463 ± 0.042	0.253TyrCys: 0.253 ± 0.015	1.439TyrAsp: 1.439 ± 0.039	1.274TyrGlu: 1.274 ± 0.031	0.905TyrPhe: 0.905 ± 0.029	2.157TyrGly: 2.157 ± 0.049	0.557TyrHis: 0.557 ± 0.02	1.007TyrIle: 1.007 ± 0.028	0.654TyrLys: 0.654 ± 0.021	3.178TyrLeu: 3.178 ± 0.05	0.416TyrMet: 0.416 ± 0.02	0.745TyrAsn: 0.745 ± 0.03	1.268TyrPro: 1.268 ± 0.034	1.333TyrGln: 1.333 ± 0.033	2.246TyrArg: 2.246 ± 0.048	1.648TyrSer: 1.648 ± 0.043	1.209TyrThr: 1.209 ± 0.042	1.497TyrVal: 1.497 ± 0.044	0.38TyrTrp: 0.38 ± 0.019	0.705TyrTyr: 0.705 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3666 proteins (1248603 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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