Amino acid dipepetide frequency for Microcystis aeruginosa Ma_AC_P_19900807_S299

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.272AlaAla: 6.272 ± 0.108
0.741AlaCys: 0.741 ± 0.034
3.716AlaAsp: 3.716 ± 0.067
4.715AlaGlu: 4.715 ± 0.08
2.872AlaPhe: 2.872 ± 0.051
4.778AlaGly: 4.778 ± 0.088
1.125AlaHis: 1.125 ± 0.036
6.879AlaIle: 6.879 ± 0.109
4.173AlaLys: 4.173 ± 0.078
7.831AlaLeu: 7.831 ± 0.122
1.497AlaMet: 1.497 ± 0.045
3.399AlaAsn: 3.399 ± 0.081
2.484AlaPro: 2.484 ± 0.065
3.322AlaGln: 3.322 ± 0.066
3.439AlaArg: 3.439 ± 0.07
4.234AlaSer: 4.234 ± 0.086
4.368AlaThr: 4.368 ± 0.113
4.88AlaVal: 4.88 ± 0.065
1.001AlaTrp: 1.001 ± 0.046
2.295AlaTyr: 2.295 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.553CysAla: 0.553 ± 0.022
0.152CysCys: 0.152 ± 0.013
0.522CysAsp: 0.522 ± 0.022
0.538CysGlu: 0.538 ± 0.021
0.444CysPhe: 0.444 ± 0.025
0.813CysGly: 0.813 ± 0.031
0.307CysHis: 0.307 ± 0.018
0.526CysIle: 0.526 ± 0.025
0.362CysLys: 0.362 ± 0.015
1.4CysLeu: 1.4 ± 0.04
0.141CysMet: 0.141 ± 0.011
0.357CysAsn: 0.357 ± 0.02
0.616CysPro: 0.616 ± 0.032
0.796CysGln: 0.796 ± 0.028
0.612CysArg: 0.612 ± 0.026
0.661CysSer: 0.661 ± 0.028
0.413CysThr: 0.413 ± 0.021
0.537CysVal: 0.537 ± 0.022
0.185CysTrp: 0.185 ± 0.016
0.364CysTyr: 0.364 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.062AspAla: 3.062 ± 0.057
0.59AspCys: 0.59 ± 0.024
2.263AspAsp: 2.263 ± 0.064
2.833AspGlu: 2.833 ± 0.058
2.675AspPhe: 2.675 ± 0.058
3.203AspGly: 3.203 ± 0.082
0.869AspHis: 0.869 ± 0.039
3.558AspIle: 3.558 ± 0.068
2.706AspLys: 2.706 ± 0.073
6.037AspLeu: 6.037 ± 0.083
0.679AspMet: 0.679 ± 0.026
2.625AspAsn: 2.625 ± 0.058
2.281AspPro: 2.281 ± 0.053
1.913AspGln: 1.913 ± 0.054
3.341AspArg: 3.341 ± 0.061
3.251AspSer: 3.251 ± 0.066
2.363AspThr: 2.363 ± 0.069
2.505AspVal: 2.505 ± 0.052
1.074AspTrp: 1.074 ± 0.037
2.262AspTyr: 2.262 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
4.961GluAla: 4.961 ± 0.089
0.439GluCys: 0.439 ± 0.023
3.02GluAsp: 3.02 ± 0.062
4.708GluGlu: 4.708 ± 0.103
2.386GluPhe: 2.386 ± 0.05
3.365GluGly: 3.365 ± 0.062
0.91GluHis: 0.91 ± 0.032
5.823GluIle: 5.823 ± 0.087
4.767GluLys: 4.767 ± 0.088
6.763GluLeu: 6.763 ± 0.107
1.391GluMet: 1.391 ± 0.041
3.422GluAsn: 3.422 ± 0.069
2.164GluPro: 2.164 ± 0.053
3.385GluGln: 3.385 ± 0.064
3.602GluArg: 3.602 ± 0.074
3.834GluSer: 3.834 ± 0.073
3.841GluThr: 3.841 ± 0.079
4.006GluVal: 4.006 ± 0.078
0.77GluTrp: 0.77 ± 0.03
1.99GluTyr: 1.99 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
2.976PheAla: 2.976 ± 0.061
0.588PheCys: 0.588 ± 0.023
2.309PheAsp: 2.309 ± 0.059
2.173PheGlu: 2.173 ± 0.047
1.913PhePhe: 1.913 ± 0.06
2.758PheGly: 2.758 ± 0.06
0.769PheHis: 0.769 ± 0.031
2.628PheIle: 2.628 ± 0.059
1.678PheLys: 1.678 ± 0.043
4.824PheLeu: 4.824 ± 0.089
0.638PheMet: 0.638 ± 0.025
2.115PheAsn: 2.115 ± 0.054
2.079PhePro: 2.079 ± 0.052
2.03PheGln: 2.03 ± 0.048
1.922PheArg: 1.922 ± 0.044
3.238PheSer: 3.238 ± 0.061
2.278PheThr: 2.278 ± 0.057
2.262PheVal: 2.262 ± 0.054
0.765PheTrp: 0.765 ± 0.035
1.637PheTyr: 1.637 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.056GlyAla: 4.056 ± 0.094
0.791GlyCys: 0.791 ± 0.03
3.31GlyAsp: 3.31 ± 0.07
4.445GlyGlu: 4.445 ± 0.074
2.963GlyPhe: 2.963 ± 0.058
4.59GlyGly: 4.59 ± 0.121
1.135GlyHis: 1.135 ± 0.041
5.092GlyIle: 5.092 ± 0.096
4.291GlyLys: 4.291 ± 0.081
6.818GlyLeu: 6.818 ± 0.107
1.414GlyMet: 1.414 ± 0.041
3.037GlyAsn: 3.037 ± 0.085
1.166GlyPro: 1.166 ± 0.041
3.131GlyGln: 3.131 ± 0.072
3.084GlyArg: 3.084 ± 0.075
3.949GlySer: 3.949 ± 0.095
3.694GlyThr: 3.694 ± 0.134
4.299GlyVal: 4.299 ± 0.079
1.083GlyTrp: 1.083 ± 0.036
2.27GlyTyr: 2.27 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
0.871HisAla: 0.871 ± 0.035
0.282HisCys: 0.282 ± 0.019
0.751HisAsp: 0.751 ± 0.03
0.775HisGlu: 0.775 ± 0.031
0.865HisPhe: 0.865 ± 0.026
1.034HisGly: 1.034 ± 0.034
0.591HisHis: 0.591 ± 0.034
1.021HisIle: 1.021 ± 0.036
0.643HisLys: 0.643 ± 0.029
2.442HisLeu: 2.442 ± 0.062
0.171HisMet: 0.171 ± 0.014
0.71HisAsn: 0.71 ± 0.026
1.386HisPro: 1.386 ± 0.046
1.116HisGln: 1.116 ± 0.035
1.067HisArg: 1.067 ± 0.043
1.12HisSer: 1.12 ± 0.036
0.772HisThr: 0.772 ± 0.028
0.665HisVal: 0.665 ± 0.026
0.359HisTrp: 0.359 ± 0.022
0.681HisTyr: 0.681 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.8IleAla: 6.8 ± 0.104
0.794IleCys: 0.794 ± 0.031
4.328IleAsp: 4.328 ± 0.074
5.067IleGlu: 5.067 ± 0.085
2.983IlePhe: 2.983 ± 0.067
4.572IleGly: 4.572 ± 0.079
1.194IleHis: 1.194 ± 0.038
5.154IleIle: 5.154 ± 0.096
3.724IleLys: 3.724 ± 0.08
7.527IleLeu: 7.527 ± 0.104
0.913IleMet: 0.913 ± 0.032
3.553IleAsn: 3.553 ± 0.067
3.86IlePro: 3.86 ± 0.077
2.771IleGln: 2.771 ± 0.061
3.192IleArg: 3.192 ± 0.059
4.853IleSer: 4.853 ± 0.068
4.214IleThr: 4.214 ± 0.082
4.18IleVal: 4.18 ± 0.068
0.894IleTrp: 0.894 ± 0.034
2.373IleTyr: 2.373 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.012LysAla: 4.012 ± 0.086
0.372LysCys: 0.372 ± 0.019
2.485LysAsp: 2.485 ± 0.065
3.418LysGlu: 3.418 ± 0.076
1.898LysPhe: 1.898 ± 0.051
2.879LysGly: 2.879 ± 0.065
0.786LysHis: 0.786 ± 0.033
4.456LysIle: 4.456 ± 0.08
3.092LysLys: 3.092 ± 0.074
5.643LysLeu: 5.643 ± 0.086
1.069LysMet: 1.069 ± 0.038
2.771LysAsn: 2.771 ± 0.068
2.297LysPro: 2.297 ± 0.054
2.666LysGln: 2.666 ± 0.06
2.56LysArg: 2.56 ± 0.056
3.325LysSer: 3.325 ± 0.069
3.416LysThr: 3.416 ± 0.068
3.308LysVal: 3.308 ± 0.065
0.577LysTrp: 0.577 ± 0.026
1.68LysTyr: 1.68 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
9.536LeuAla: 9.536 ± 0.132
1.037LeuCys: 1.037 ± 0.036
5.792LeuAsp: 5.792 ± 0.078
8.451LeuGlu: 8.451 ± 0.125
4.173LeuPhe: 4.173 ± 0.087
7.729LeuGly: 7.729 ± 0.113
1.639LeuHis: 1.639 ± 0.048
7.685LeuIle: 7.685 ± 0.115
6.309LeuLys: 6.309 ± 0.088
11.115LeuLeu: 11.115 ± 0.154
1.911LeuMet: 1.911 ± 0.046
5.003LeuAsn: 5.003 ± 0.076
5.535LeuPro: 5.535 ± 0.081
5.145LeuGln: 5.145 ± 0.089
5.147LeuArg: 5.147 ± 0.082
7.919LeuSer: 7.919 ± 0.103
6.845LeuThr: 6.845 ± 0.091
6.722LeuVal: 6.722 ± 0.093
1.444LeuTrp: 1.444 ± 0.045
2.938LeuTyr: 2.938 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
1.639MetAla: 1.639 ± 0.041
0.105MetCys: 0.105 ± 0.011
0.742MetAsp: 0.742 ± 0.029
0.904MetGlu: 0.904 ± 0.032
0.504MetPhe: 0.504 ± 0.023
1.316MetGly: 1.316 ± 0.049
0.172MetHis: 0.172 ± 0.015
1.238MetIle: 1.238 ± 0.037
0.984MetLys: 0.984 ± 0.034
1.702MetLeu: 1.702 ± 0.043
0.389MetMet: 0.389 ± 0.021
0.816MetAsn: 0.816 ± 0.029
0.749MetPro: 0.749 ± 0.031
0.661MetGln: 0.661 ± 0.03
0.902MetArg: 0.902 ± 0.032
1.253MetSer: 1.253 ± 0.037
1.344MetThr: 1.344 ± 0.035
1.168MetVal: 1.168 ± 0.035
0.138MetTrp: 0.138 ± 0.013
0.341MetTyr: 0.341 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.861AsnAla: 2.861 ± 0.076
0.605AsnCys: 0.605 ± 0.028
1.891AsnAsp: 1.891 ± 0.056
1.936AsnGlu: 1.936 ± 0.053
2.222AsnPhe: 2.222 ± 0.052
2.663AsnGly: 2.663 ± 0.098
1.059AsnHis: 1.059 ± 0.037
3.122AsnIle: 3.122 ± 0.072
1.903AsnLys: 1.903 ± 0.051
6.308AsnLeu: 6.308 ± 0.112
0.59AsnMet: 0.59 ± 0.027
2.653AsnAsn: 2.653 ± 0.084
3.392AsnPro: 3.392 ± 0.067
2.952AsnGln: 2.952 ± 0.067
2.605AsnArg: 2.605 ± 0.058
3.291AsnSer: 3.291 ± 0.086
2.276AsnThr: 2.276 ± 0.066
2.072AsnVal: 2.072 ± 0.054
0.834AsnTrp: 0.834 ± 0.032
1.962AsnTyr: 1.962 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
2.897ProAla: 2.897 ± 0.063
0.389ProCys: 0.389 ± 0.022
3.122ProAsp: 3.122 ± 0.061
3.886ProGlu: 3.886 ± 0.075
1.814ProPhe: 1.814 ± 0.044
2.341ProGly: 2.341 ± 0.056
0.922ProHis: 0.922 ± 0.032
3.121ProIle: 3.121 ± 0.052
2.16ProLys: 2.16 ± 0.054
4.924ProLeu: 4.924 ± 0.09
0.776ProMet: 0.776 ± 0.027
2.263ProAsn: 2.263 ± 0.055
2.266ProPro: 2.266 ± 0.068
2.577ProGln: 2.577 ± 0.064
1.849ProArg: 1.849 ± 0.047
3.085ProSer: 3.085 ± 0.068
2.557ProThr: 2.557 ± 0.064
2.958ProVal: 2.958 ± 0.063
0.585ProTrp: 0.585 ± 0.025
1.394ProTyr: 1.394 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.165GlnAla: 4.165 ± 0.087
0.351GlnCys: 0.351 ± 0.019
2.242GlnAsp: 2.242 ± 0.047
4.075GlnGlu: 4.075 ± 0.084
1.811GlnPhe: 1.811 ± 0.046
3.446GlnGly: 3.446 ± 0.066
0.676GlnHis: 0.676 ± 0.028
3.656GlnIle: 3.656 ± 0.066
3.388GlnLys: 3.388 ± 0.073
5.609GlnLeu: 5.609 ± 0.092
0.844GlnMet: 0.844 ± 0.028
2.051GlnAsn: 2.051 ± 0.05
2.132GlnPro: 2.132 ± 0.055
3.087GlnGln: 3.087 ± 0.08
2.592GlnArg: 2.592 ± 0.059
2.948GlnSer: 2.948 ± 0.067
2.617GlnThr: 2.617 ± 0.058
3.143GlnVal: 3.143 ± 0.065
0.764GlnTrp: 0.764 ± 0.029
1.376GlnTyr: 1.376 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.871ArgAla: 2.871 ± 0.066
0.548ArgCys: 0.548 ± 0.024
2.532ArgAsp: 2.532 ± 0.062
3.774ArgGlu: 3.774 ± 0.061
2.192ArgPhe: 2.192 ± 0.046
3.229ArgGly: 3.229 ± 0.072
0.95ArgHis: 0.95 ± 0.032
3.347ArgIle: 3.347 ± 0.064
2.306ArgLys: 2.306 ± 0.06
6.147ArgLeu: 6.147 ± 0.089
0.906ArgMet: 0.906 ± 0.032
2.085ArgAsn: 2.085 ± 0.047
2.066ArgPro: 2.066 ± 0.053
3.354ArgGln: 3.354 ± 0.062
2.775ArgArg: 2.775 ± 0.071
3.095ArgSer: 3.095 ± 0.07
2.196ArgThr: 2.196 ± 0.051
3.112ArgVal: 3.112 ± 0.06
0.829ArgTrp: 0.829 ± 0.034
1.902ArgTyr: 1.902 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.117SerAla: 4.117 ± 0.076
0.771SerCys: 0.771 ± 0.03
3.281SerAsp: 3.281 ± 0.062
3.852SerGlu: 3.852 ± 0.072
2.729SerPhe: 2.729 ± 0.058
4.382SerGly: 4.382 ± 0.113
1.264SerHis: 1.264 ± 0.046
4.073SerIle: 4.073 ± 0.055
2.715SerLys: 2.715 ± 0.059
8.59SerLeu: 8.59 ± 0.12
1.112SerMet: 1.112 ± 0.035
2.868SerAsn: 2.868 ± 0.076
3.694SerPro: 3.694 ± 0.068
3.774SerGln: 3.774 ± 0.072
3.197SerArg: 3.197 ± 0.06
4.553SerSer: 4.553 ± 0.095
3.059SerThr: 3.059 ± 0.076
3.715SerVal: 3.715 ± 0.071
0.996SerTrp: 0.996 ± 0.034
2.151SerTyr: 2.151 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
4.769ThrAla: 4.769 ± 0.112
0.481ThrCys: 0.481 ± 0.023
2.622ThrAsp: 2.622 ± 0.068
3.393ThrGlu: 3.393 ± 0.066
2.223ThrPhe: 2.223 ± 0.061
4.383ThrGly: 4.383 ± 0.12
0.968ThrHis: 0.968 ± 0.031
4.165ThrIle: 4.165 ± 0.089
2.248ThrLys: 2.248 ± 0.054
6.257ThrLeu: 6.257 ± 0.114
0.801ThrMet: 0.801 ± 0.028
2.344ThrAsn: 2.344 ± 0.073
3.157ThrPro: 3.157 ± 0.063
2.219ThrGln: 2.219 ± 0.055
2.449ThrArg: 2.449 ± 0.054
3.327ThrSer: 3.327 ± 0.084
3.191ThrThr: 3.191 ± 0.106
4.02ThrVal: 4.02 ± 0.096
0.712ThrTrp: 0.712 ± 0.032
1.721ThrTyr: 1.721 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
4.85ValAla: 4.85 ± 0.079
0.645ValCys: 0.645 ± 0.025
2.93ValAsp: 2.93 ± 0.058
3.863ValGlu: 3.863 ± 0.073
2.645ValPhe: 2.645 ± 0.06
4.033ValGly: 4.033 ± 0.081
0.881ValHis: 0.881 ± 0.03
4.72ValIle: 4.72 ± 0.076
3.305ValLys: 3.305 ± 0.06
5.807ValLeu: 5.807 ± 0.086
1.13ValMet: 1.13 ± 0.034
3.089ValAsn: 3.089 ± 0.074
2.404ValPro: 2.404 ± 0.056
2.225ValGln: 2.225 ± 0.049
2.855ValArg: 2.855 ± 0.069
3.961ValSer: 3.961 ± 0.07
3.736ValThr: 3.736 ± 0.089
3.747ValVal: 3.747 ± 0.071
0.798ValTrp: 0.798 ± 0.041
1.863ValTyr: 1.863 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
0.761TrpAla: 0.761 ± 0.038
0.14TrpCys: 0.14 ± 0.013
0.643TrpAsp: 0.643 ± 0.025
0.952TrpGlu: 0.952 ± 0.034
0.618TrpPhe: 0.618 ± 0.029
1.048TrpGly: 1.048 ± 0.044
0.305TrpHis: 0.305 ± 0.018
0.85TrpIle: 0.85 ± 0.034
0.611TrpLys: 0.611 ± 0.029
2.117TrpLeu: 2.117 ± 0.053
0.316TrpMet: 0.316 ± 0.02
0.6TrpAsn: 0.6 ± 0.031
0.332TrpPro: 0.332 ± 0.022
1.409TrpGln: 1.409 ± 0.042
0.905TrpArg: 0.905 ± 0.037
0.858TrpSer: 0.858 ± 0.033
0.714TrpThr: 0.714 ± 0.036
0.791TrpVal: 0.791 ± 0.031
0.209TrpTrp: 0.209 ± 0.016
0.465TrpTyr: 0.465 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.993TyrAla: 1.993 ± 0.046
0.476TyrCys: 0.476 ± 0.023
1.589TyrAsp: 1.589 ± 0.05
1.791TyrGlu: 1.791 ± 0.049
1.648TyrPhe: 1.648 ± 0.044
2.059TyrGly: 2.059 ± 0.055
0.798TyrHis: 0.798 ± 0.029
1.832TyrIle: 1.832 ± 0.049
1.347TyrLys: 1.347 ± 0.046
4.214TyrLeu: 4.214 ± 0.079
0.379TyrMet: 0.379 ± 0.019
1.437TyrAsn: 1.437 ± 0.046
1.827TyrPro: 1.827 ± 0.049
2.437TyrGln: 2.437 ± 0.06
2.119TyrArg: 2.119 ± 0.056
2.138TyrSer: 2.138 ± 0.051
1.557TyrThr: 1.557 ± 0.048
1.4TyrVal: 1.4 ± 0.036
0.625TyrTrp: 0.625 ± 0.029
1.318TyrTyr: 1.318 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3434 proteins (931635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski