Amino acid dipepetide frequency for Leptotrichia sp. oral taxon 215 str. W9775

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.812AlaAla: 3.812 ± 0.107
0.409AlaCys: 0.409 ± 0.027
2.812AlaAsp: 2.812 ± 0.069
4.266AlaGlu: 4.266 ± 0.092
2.34AlaPhe: 2.34 ± 0.069
4.641AlaGly: 4.641 ± 0.127
0.691AlaHis: 0.691 ± 0.035
4.673AlaIle: 4.673 ± 0.099
4.899AlaLys: 4.899 ± 0.106
4.792AlaLeu: 4.792 ± 0.104
1.455AlaMet: 1.455 ± 0.053
2.547AlaAsn: 2.547 ± 0.069
1.219AlaPro: 1.219 ± 0.041
1.35AlaGln: 1.35 ± 0.045
1.771AlaArg: 1.771 ± 0.047
2.985AlaSer: 2.985 ± 0.076
2.954AlaThr: 2.954 ± 0.103
4.158AlaVal: 4.158 ± 0.094
0.303AlaTrp: 0.303 ± 0.024
2.05AlaTyr: 2.05 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.356CysAla: 0.356 ± 0.025
0.088CysCys: 0.088 ± 0.014
0.342CysAsp: 0.342 ± 0.021
0.475CysGlu: 0.475 ± 0.029
0.346CysPhe: 0.346 ± 0.022
0.659CysGly: 0.659 ± 0.039
0.13CysHis: 0.13 ± 0.015
0.601CysIle: 0.601 ± 0.03
0.548CysLys: 0.548 ± 0.031
0.532CysLeu: 0.532 ± 0.03
0.165CysMet: 0.165 ± 0.016
0.339CysAsn: 0.339 ± 0.022
0.271CysPro: 0.271 ± 0.023
0.139CysGln: 0.139 ± 0.014
0.239CysArg: 0.239 ± 0.019
0.464CysSer: 0.464 ± 0.03
0.349CysThr: 0.349 ± 0.023
0.369CysVal: 0.369 ± 0.024
0.059CysTrp: 0.059 ± 0.009
0.239CysTyr: 0.239 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
2.501AspAla: 2.501 ± 0.071
0.33AspCys: 0.33 ± 0.025
2.483AspAsp: 2.483 ± 0.064
4.855AspGlu: 4.855 ± 0.093
3.022AspPhe: 3.022 ± 0.076
3.246AspGly: 3.246 ± 0.077
0.493AspHis: 0.493 ± 0.028
5.165AspIle: 5.165 ± 0.097
5.283AspLys: 5.283 ± 0.097
4.409AspLeu: 4.409 ± 0.093
1.43AspMet: 1.43 ± 0.045
3.062AspAsn: 3.062 ± 0.08
1.31AspPro: 1.31 ± 0.046
0.716AspGln: 0.716 ± 0.028
2.066AspArg: 2.066 ± 0.062
2.876AspSer: 2.876 ± 0.057
2.579AspThr: 2.579 ± 0.074
3.415AspVal: 3.415 ± 0.076
0.425AspTrp: 0.425 ± 0.026
2.73AspTyr: 2.73 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
4.171GluAla: 4.171 ± 0.087
0.436GluCys: 0.436 ± 0.024
4.157GluAsp: 4.157 ± 0.079
8.146GluGlu: 8.146 ± 0.14
3.651GluPhe: 3.651 ± 0.081
4.354GluGly: 4.354 ± 0.09
0.923GluHis: 0.923 ± 0.037
8.964GluIle: 8.964 ± 0.152
11.785GluLys: 11.785 ± 0.162
7.097GluLeu: 7.097 ± 0.13
2.394GluMet: 2.394 ± 0.068
7.184GluAsn: 7.184 ± 0.13
1.298GluPro: 1.298 ± 0.038
1.639GluGln: 1.639 ± 0.056
2.915GluArg: 2.915 ± 0.074
3.196GluSer: 3.196 ± 0.076
3.777GluThr: 3.777 ± 0.071
5.149GluVal: 5.149 ± 0.086
0.614GluTrp: 0.614 ± 0.032
3.682GluTyr: 3.682 ± 0.086
0.0GluXaa: 0.0 ± 0.0
Phe
2.37PheAla: 2.37 ± 0.072
0.39PheCys: 0.39 ± 0.024
2.756PheAsp: 2.756 ± 0.065
3.747PheGlu: 3.747 ± 0.089
2.641PhePhe: 2.641 ± 0.091
3.219PheGly: 3.219 ± 0.078
0.636PheHis: 0.636 ± 0.031
4.229PheIle: 4.229 ± 0.086
3.838PheLys: 3.838 ± 0.085
4.603PheLeu: 4.603 ± 0.115
1.211PheMet: 1.211 ± 0.049
2.686PheAsn: 2.686 ± 0.067
1.323PhePro: 1.323 ± 0.051
1.168PheGln: 1.168 ± 0.038
1.575PheArg: 1.575 ± 0.054
3.618PheSer: 3.618 ± 0.077
2.412PheThr: 2.412 ± 0.06
2.851PheVal: 2.851 ± 0.074
0.351PheTrp: 0.351 ± 0.026
2.107PheTyr: 2.107 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
3.89GlyAla: 3.89 ± 0.107
0.445GlyCys: 0.445 ± 0.028
3.059GlyAsp: 3.059 ± 0.082
4.603GlyGlu: 4.603 ± 0.078
2.992GlyPhe: 2.992 ± 0.072
4.519GlyGly: 4.519 ± 0.106
1.02GlyHis: 1.02 ± 0.04
6.881GlyIle: 6.881 ± 0.122
7.103GlyLys: 7.103 ± 0.107
5.354GlyLeu: 5.354 ± 0.098
1.898GlyMet: 1.898 ± 0.065
4.258GlyAsn: 4.258 ± 0.126
1.101GlyPro: 1.101 ± 0.042
1.482GlyGln: 1.482 ± 0.054
2.33GlyArg: 2.33 ± 0.075
3.727GlySer: 3.727 ± 0.108
4.163GlyThr: 4.163 ± 0.18
4.69GlyVal: 4.69 ± 0.112
0.497GlyTrp: 0.497 ± 0.029
2.96GlyTyr: 2.96 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
0.682HisAla: 0.682 ± 0.03
0.129HisCys: 0.129 ± 0.012
0.609HisAsp: 0.609 ± 0.033
0.94HisGlu: 0.94 ± 0.037
0.649HisPhe: 0.649 ± 0.032
0.871HisGly: 0.871 ± 0.038
0.256HisHis: 0.256 ± 0.02
1.111HisIle: 1.111 ± 0.038
0.898HisLys: 0.898 ± 0.038
1.074HisLeu: 1.074 ± 0.041
0.34HisMet: 0.34 ± 0.024
0.839HisAsn: 0.839 ± 0.035
0.58HisPro: 0.58 ± 0.032
0.342HisGln: 0.342 ± 0.024
0.5HisArg: 0.5 ± 0.029
0.817HisSer: 0.817 ± 0.038
0.695HisThr: 0.695 ± 0.033
0.742HisVal: 0.742 ± 0.031
0.099HisTrp: 0.099 ± 0.013
0.533HisTyr: 0.533 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.012IleAla: 5.012 ± 0.101
0.684IleCys: 0.684 ± 0.036
5.013IleAsp: 5.013 ± 0.096
7.498IleGlu: 7.498 ± 0.135
4.787IlePhe: 4.787 ± 0.114
5.758IleGly: 5.758 ± 0.102
1.108IleHis: 1.108 ± 0.042
8.059IleIle: 8.059 ± 0.143
8.643IleLys: 8.643 ± 0.125
8.614IleLeu: 8.614 ± 0.146
2.192IleMet: 2.192 ± 0.057
5.614IleAsn: 5.614 ± 0.113
2.941IlePro: 2.941 ± 0.072
2.078IleGln: 2.078 ± 0.056
3.064IleArg: 3.064 ± 0.069
5.974IleSer: 5.974 ± 0.084
4.609IleThr: 4.609 ± 0.084
5.586IleVal: 5.586 ± 0.092
0.577IleTrp: 0.577 ± 0.031
3.729IleTyr: 3.729 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
4.806LysAla: 4.806 ± 0.092
0.455LysCys: 0.455 ± 0.03
5.354LysAsp: 5.354 ± 0.118
10.138LysGlu: 10.138 ± 0.173
4.106LysPhe: 4.106 ± 0.085
5.716LysGly: 5.716 ± 0.101
1.021LysHis: 1.021 ± 0.04
10.184LysIle: 10.184 ± 0.15
11.084LysLys: 11.084 ± 0.168
8.017LysLeu: 8.017 ± 0.122
3.101LysMet: 3.101 ± 0.068
7.975LysAsn: 7.975 ± 0.141
1.953LysPro: 1.953 ± 0.056
2.001LysGln: 2.001 ± 0.058
3.382LysArg: 3.382 ± 0.081
4.965LysSer: 4.965 ± 0.091
4.519LysThr: 4.519 ± 0.085
5.878LysVal: 5.878 ± 0.09
0.78LysTrp: 0.78 ± 0.04
4.962LysTyr: 4.962 ± 0.089
0.0LysXaa: 0.0 ± 0.0
Leu
4.76LeuAla: 4.76 ± 0.111
0.61LeuCys: 0.61 ± 0.03
4.642LeuAsp: 4.642 ± 0.091
7.562LeuGlu: 7.562 ± 0.124
4.238LeuPhe: 4.238 ± 0.103
5.797LeuGly: 5.797 ± 0.105
1.124LeuHis: 1.124 ± 0.044
6.936LeuIle: 6.936 ± 0.131
9.438LeuLys: 9.438 ± 0.159
7.617LeuLeu: 7.617 ± 0.134
2.166LeuMet: 2.166 ± 0.063
5.373LeuAsn: 5.373 ± 0.098
2.707LeuPro: 2.707 ± 0.07
2.063LeuGln: 2.063 ± 0.05
2.979LeuArg: 2.979 ± 0.065
5.955LeuSer: 5.955 ± 0.1
4.418LeuThr: 4.418 ± 0.078
4.742LeuVal: 4.742 ± 0.088
0.561LeuTrp: 0.561 ± 0.031
3.014LeuTyr: 3.014 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
1.658MetAla: 1.658 ± 0.048
0.141MetCys: 0.141 ± 0.013
1.303MetAsp: 1.303 ± 0.048
2.368MetGlu: 2.368 ± 0.067
1.04MetPhe: 1.04 ± 0.048
1.597MetGly: 1.597 ± 0.054
0.314MetHis: 0.314 ± 0.018
2.086MetIle: 2.086 ± 0.06
3.16MetLys: 3.16 ± 0.064
2.33MetLeu: 2.33 ± 0.066
0.606MetMet: 0.606 ± 0.034
1.527MetAsn: 1.527 ± 0.049
0.758MetPro: 0.758 ± 0.032
0.562MetGln: 0.562 ± 0.031
0.955MetArg: 0.955 ± 0.036
1.598MetSer: 1.598 ± 0.052
1.269MetThr: 1.269 ± 0.043
1.34MetVal: 1.34 ± 0.042
0.167MetTrp: 0.167 ± 0.015
0.958MetTyr: 0.958 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
2.97AsnAla: 2.97 ± 0.096
0.388AsnCys: 0.388 ± 0.023
3.098AsnAsp: 3.098 ± 0.069
5.073AsnGlu: 5.073 ± 0.106
3.017AsnPhe: 3.017 ± 0.076
4.445AsnGly: 4.445 ± 0.131
0.769AsnHis: 0.769 ± 0.034
6.543AsnIle: 6.543 ± 0.117
5.725AsnLys: 5.725 ± 0.112
5.586AsnLeu: 5.586 ± 0.095
1.588AsnMet: 1.588 ± 0.042
4.226AsnAsn: 4.226 ± 0.117
2.278AsnPro: 2.278 ± 0.055
1.413AsnGln: 1.413 ± 0.052
2.299AsnArg: 2.299 ± 0.071
4.024AsnSer: 4.024 ± 0.104
3.03AsnThr: 3.03 ± 0.093
3.919AsnVal: 3.919 ± 0.094
0.501AsnTrp: 0.501 ± 0.03
2.859AsnTyr: 2.859 ± 0.081
0.0AsnXaa: 0.0 ± 0.0
Pro
1.479ProAla: 1.479 ± 0.049
0.191ProCys: 0.191 ± 0.018
1.513ProAsp: 1.513 ± 0.044
2.815ProGlu: 2.815 ± 0.073
1.371ProPhe: 1.371 ± 0.049
1.601ProGly: 1.601 ± 0.053
0.39ProHis: 0.39 ± 0.02
1.966ProIle: 1.966 ± 0.057
2.175ProLys: 2.175 ± 0.064
2.305ProLeu: 2.305 ± 0.063
0.571ProMet: 0.571 ± 0.027
1.382ProAsn: 1.382 ± 0.05
0.468ProPro: 0.468 ± 0.027
0.758ProGln: 0.758 ± 0.037
0.704ProArg: 0.704 ± 0.03
1.513ProSer: 1.513 ± 0.045
1.394ProThr: 1.394 ± 0.045
2.227ProVal: 2.227 ± 0.058
0.223ProTrp: 0.223 ± 0.016
1.269ProTyr: 1.269 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
1.327GlnAla: 1.327 ± 0.051
0.122GlnCys: 0.122 ± 0.014
1.045GlnAsp: 1.045 ± 0.042
1.884GlnGlu: 1.884 ± 0.058
0.959GlnPhe: 0.959 ± 0.033
1.485GlnGly: 1.485 ± 0.046
0.262GlnHis: 0.262 ± 0.02
1.988GlnIle: 1.988 ± 0.051
2.492GlnLys: 2.492 ± 0.062
1.869GlnLeu: 1.869 ± 0.055
0.629GlnMet: 0.629 ± 0.028
1.566GlnAsn: 1.566 ± 0.053
0.501GlnPro: 0.501 ± 0.028
0.635GlnGln: 0.635 ± 0.033
0.871GlnArg: 0.871 ± 0.038
1.142GlnSer: 1.142 ± 0.036
1.075GlnThr: 1.075 ± 0.043
1.316GlnVal: 1.316 ± 0.047
0.209GlnTrp: 0.209 ± 0.016
0.869GlnTyr: 0.869 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
1.708ArgAla: 1.708 ± 0.054
0.214ArgCys: 0.214 ± 0.021
1.736ArgAsp: 1.736 ± 0.056
3.396ArgGlu: 3.396 ± 0.081
1.43ArgPhe: 1.43 ± 0.044
2.173ArgGly: 2.173 ± 0.056
0.474ArgHis: 0.474 ± 0.028
3.359ArgIle: 3.359 ± 0.071
4.051ArgLys: 4.051 ± 0.086
2.779ArgLeu: 2.779 ± 0.055
0.929ArgMet: 0.929 ± 0.035
2.388ArgAsn: 2.388 ± 0.064
0.793ArgPro: 0.793 ± 0.032
0.877ArgGln: 0.877 ± 0.033
1.443ArgArg: 1.443 ± 0.05
1.543ArgSer: 1.543 ± 0.044
1.659ArgThr: 1.659 ± 0.058
2.105ArgVal: 2.105 ± 0.057
0.241ArgTrp: 0.241 ± 0.016
1.469ArgTyr: 1.469 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.054SerAla: 3.054 ± 0.076
0.488SerCys: 0.488 ± 0.028
3.386SerAsp: 3.386 ± 0.072
4.871SerGlu: 4.871 ± 0.095
3.025SerPhe: 3.025 ± 0.073
4.629SerGly: 4.629 ± 0.114
0.791SerHis: 0.791 ± 0.032
4.99SerIle: 4.99 ± 0.096
5.241SerLys: 5.241 ± 0.101
4.981SerLeu: 4.981 ± 0.087
1.288SerMet: 1.288 ± 0.041
3.257SerAsn: 3.257 ± 0.085
1.668SerPro: 1.668 ± 0.044
1.491SerGln: 1.491 ± 0.043
2.11SerArg: 2.11 ± 0.052
3.49SerSer: 3.49 ± 0.087
2.834SerThr: 2.834 ± 0.089
3.848SerVal: 3.848 ± 0.08
0.464SerTrp: 0.464 ± 0.026
2.421SerTyr: 2.421 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
3.361ThrAla: 3.361 ± 0.103
0.277ThrCys: 0.277 ± 0.021
2.911ThrAsp: 2.911 ± 0.066
4.025ThrGlu: 4.025 ± 0.076
2.195ThrPhe: 2.195 ± 0.072
4.784ThrGly: 4.784 ± 0.149
0.746ThrHis: 0.746 ± 0.032
3.966ThrIle: 3.966 ± 0.099
3.728ThrLys: 3.728 ± 0.075
4.539ThrLeu: 4.539 ± 0.088
1.103ThrMet: 1.103 ± 0.049
2.469ThrAsn: 2.469 ± 0.109
1.817ThrPro: 1.817 ± 0.059
1.045ThrGln: 1.045 ± 0.043
1.523ThrArg: 1.523 ± 0.047
2.912ThrSer: 2.912 ± 0.084
2.608ThrThr: 2.608 ± 0.101
4.161ThrVal: 4.161 ± 0.092
0.355ThrTrp: 0.355 ± 0.025
1.894ThrTyr: 1.894 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
3.832ValAla: 3.832 ± 0.092
0.49ValCys: 0.49 ± 0.029
3.263ValAsp: 3.263 ± 0.07
4.99ValGlu: 4.99 ± 0.083
3.135ValPhe: 3.135 ± 0.074
4.024ValGly: 4.024 ± 0.118
0.839ValHis: 0.839 ± 0.037
5.693ValIle: 5.693 ± 0.092
5.972ValLys: 5.972 ± 0.103
5.678ValLeu: 5.678 ± 0.099
1.484ValMet: 1.484 ± 0.049
3.709ValAsn: 3.709 ± 0.088
1.881ValPro: 1.881 ± 0.053
1.333ValGln: 1.333 ± 0.047
2.056ValArg: 2.056 ± 0.05
4.196ValSer: 4.196 ± 0.074
3.519ValThr: 3.519 ± 0.079
4.247ValVal: 4.247 ± 0.092
0.396ValTrp: 0.396 ± 0.025
2.72ValTyr: 2.72 ± 0.075
0.0ValXaa: 0.0 ± 0.0
Trp
0.385TrpAla: 0.385 ± 0.025
0.045TrpCys: 0.045 ± 0.009
0.411TrpAsp: 0.411 ± 0.023
0.632TrpGlu: 0.632 ± 0.031
0.34TrpPhe: 0.34 ± 0.026
0.445TrpGly: 0.445 ± 0.025
0.149TrpHis: 0.149 ± 0.017
0.619TrpIle: 0.619 ± 0.031
0.617TrpLys: 0.617 ± 0.029
0.613TrpLeu: 0.613 ± 0.034
0.22TrpMet: 0.22 ± 0.017
0.514TrpAsn: 0.514 ± 0.03
0.145TrpPro: 0.145 ± 0.014
0.23TrpGln: 0.23 ± 0.018
0.268TrpArg: 0.268 ± 0.02
0.367TrpSer: 0.367 ± 0.021
0.381TrpThr: 0.381 ± 0.022
0.369TrpVal: 0.369 ± 0.022
0.091TrpTrp: 0.091 ± 0.011
0.359TrpTyr: 0.359 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.988TyrAla: 1.988 ± 0.061
0.381TyrCys: 0.381 ± 0.025
2.504TyrAsp: 2.504 ± 0.066
3.251TyrGlu: 3.251 ± 0.076
2.446TyrPhe: 2.446 ± 0.071
3.008TyrGly: 3.008 ± 0.093
0.568TyrHis: 0.568 ± 0.028
3.527TyrIle: 3.527 ± 0.078
3.718TyrLys: 3.718 ± 0.089
3.913TyrLeu: 3.913 ± 0.074
0.965TyrMet: 0.965 ± 0.035
2.834TyrAsn: 2.834 ± 0.067
1.305TyrPro: 1.305 ± 0.048
0.924TyrGln: 0.924 ± 0.038
1.717TyrArg: 1.717 ± 0.058
2.967TyrSer: 2.967 ± 0.078
2.173TyrThr: 2.173 ± 0.065
2.341TyrVal: 2.341 ± 0.055
0.293TyrTrp: 0.293 ± 0.02
2.143TyrTyr: 2.143 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2260 proteins (690179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski