Amino acid dipepetide frequency for Spiribacter curvatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.809AlaAla: 15.809 ± 0.225
1.02AlaCys: 1.02 ± 0.042
8.153AlaAsp: 8.153 ± 0.126
7.624AlaGlu: 7.624 ± 0.121
3.827AlaPhe: 3.827 ± 0.088
11.183AlaGly: 11.183 ± 0.172
2.285AlaHis: 2.285 ± 0.071
6.085AlaIle: 6.085 ± 0.104
1.692AlaLys: 1.692 ± 0.055
14.376AlaLeu: 14.376 ± 0.222
3.321AlaMet: 3.321 ± 0.077
2.476AlaAsn: 2.476 ± 0.06
4.837AlaPro: 4.837 ± 0.094
3.849AlaGln: 3.849 ± 0.088
9.356AlaArg: 9.356 ± 0.146
5.652AlaSer: 5.652 ± 0.101
5.649AlaThr: 5.649 ± 0.106
9.331AlaVal: 9.331 ± 0.157
1.651AlaTrp: 1.651 ± 0.056
2.473AlaTyr: 2.473 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.785CysAla: 0.785 ± 0.039
0.101CysCys: 0.101 ± 0.012
0.474CysAsp: 0.474 ± 0.029
0.498CysGlu: 0.498 ± 0.027
0.265CysPhe: 0.265 ± 0.021
0.827CysGly: 0.827 ± 0.039
0.295CysHis: 0.295 ± 0.024
0.439CysIle: 0.439 ± 0.029
0.103CysLys: 0.103 ± 0.012
0.935CysLeu: 0.935 ± 0.038
0.175CysMet: 0.175 ± 0.017
0.211CysAsn: 0.211 ± 0.022
0.502CysPro: 0.502 ± 0.035
0.304CysGln: 0.304 ± 0.024
0.724CysArg: 0.724 ± 0.035
0.426CysSer: 0.426 ± 0.027
0.391CysThr: 0.391 ± 0.025
0.599CysVal: 0.599 ± 0.03
0.101CysTrp: 0.101 ± 0.013
0.233CysTyr: 0.233 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
8.083AspAla: 8.083 ± 0.141
0.669AspCys: 0.669 ± 0.039
4.163AspAsp: 4.163 ± 0.097
4.213AspGlu: 4.213 ± 0.084
2.095AspPhe: 2.095 ± 0.064
5.542AspGly: 5.542 ± 0.101
1.596AspHis: 1.596 ± 0.058
2.978AspIle: 2.978 ± 0.074
1.03AspLys: 1.03 ± 0.053
6.053AspLeu: 6.053 ± 0.106
1.336AspMet: 1.336 ± 0.046
1.514AspAsn: 1.514 ± 0.053
3.789AspPro: 3.789 ± 0.082
2.529AspGln: 2.529 ± 0.069
5.446AspArg: 5.446 ± 0.107
2.764AspSer: 2.764 ± 0.068
3.313AspThr: 3.313 ± 0.083
4.07AspVal: 4.07 ± 0.082
1.226AspTrp: 1.226 ± 0.053
1.835AspTyr: 1.835 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
8.634GluAla: 8.634 ± 0.126
0.468GluCys: 0.468 ± 0.027
2.925GluAsp: 2.925 ± 0.075
2.785GluGlu: 2.785 ± 0.093
1.562GluPhe: 1.562 ± 0.052
4.469GluGly: 4.469 ± 0.098
1.384GluHis: 1.384 ± 0.06
2.9GluIle: 2.9 ± 0.082
1.388GluLys: 1.388 ± 0.062
5.542GluLeu: 5.542 ± 0.118
1.473GluMet: 1.473 ± 0.056
1.29GluAsn: 1.29 ± 0.048
3.023GluPro: 3.023 ± 0.074
2.937GluGln: 2.937 ± 0.081
6.516GluArg: 6.516 ± 0.12
3.566GluSer: 3.566 ± 0.091
3.627GluThr: 3.627 ± 0.084
4.193GluVal: 4.193 ± 0.096
0.879GluTrp: 0.879 ± 0.038
1.178GluTyr: 1.178 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.511PheAla: 3.511 ± 0.082
0.326PheCys: 0.326 ± 0.021
2.236PheAsp: 2.236 ± 0.064
2.285PheGlu: 2.285 ± 0.07
1.231PhePhe: 1.231 ± 0.058
3.027PheGly: 3.027 ± 0.083
0.672PheHis: 0.672 ± 0.034
1.629PheIle: 1.629 ± 0.065
0.591PheLys: 0.591 ± 0.03
2.995PheLeu: 2.995 ± 0.08
0.787PheMet: 0.787 ± 0.036
0.99PheAsn: 0.99 ± 0.04
1.479PhePro: 1.479 ± 0.05
1.108PheGln: 1.108 ± 0.042
2.07PheArg: 2.07 ± 0.062
1.922PheSer: 1.922 ± 0.067
1.757PheThr: 1.757 ± 0.053
2.283PheVal: 2.283 ± 0.065
0.441PheTrp: 0.441 ± 0.029
0.81PheTyr: 0.81 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
8.384GlyAla: 8.384 ± 0.149
0.855GlyCys: 0.855 ± 0.04
5.343GlyAsp: 5.343 ± 0.102
5.689GlyGlu: 5.689 ± 0.112
3.346GlyPhe: 3.346 ± 0.079
7.153GlyGly: 7.153 ± 0.135
2.281GlyHis: 2.281 ± 0.064
4.795GlyIle: 4.795 ± 0.095
1.957GlyLys: 1.957 ± 0.077
9.722GlyLeu: 9.722 ± 0.176
2.418GlyMet: 2.418 ± 0.063
1.978GlyAsn: 1.978 ± 0.064
3.255GlyPro: 3.255 ± 0.078
3.21GlyGln: 3.21 ± 0.084
6.87GlyArg: 6.87 ± 0.108
4.318GlySer: 4.318 ± 0.094
4.2GlyThr: 4.2 ± 0.092
6.963GlyVal: 6.963 ± 0.113
1.311GlyTrp: 1.311 ± 0.052
2.436GlyTyr: 2.436 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
2.441HisAla: 2.441 ± 0.053
0.293HisCys: 0.293 ± 0.025
1.466HisAsp: 1.466 ± 0.058
1.226HisGlu: 1.226 ± 0.041
0.779HisPhe: 0.779 ± 0.042
2.063HisGly: 2.063 ± 0.056
0.784HisHis: 0.784 ± 0.045
1.052HisIle: 1.052 ± 0.042
0.379HisLys: 0.379 ± 0.027
2.3HisLeu: 2.3 ± 0.061
0.479HisMet: 0.479 ± 0.032
0.527HisAsn: 0.527 ± 0.03
1.564HisPro: 1.564 ± 0.05
0.915HisGln: 0.915 ± 0.038
2.045HisArg: 2.045 ± 0.074
1.082HisSer: 1.082 ± 0.044
1.03HisThr: 1.03 ± 0.043
1.479HisVal: 1.479 ± 0.053
0.461HisTrp: 0.461 ± 0.03
0.724HisTyr: 0.724 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.594IleAla: 6.594 ± 0.117
0.391IleCys: 0.391 ± 0.024
4.273IleAsp: 4.273 ± 0.084
3.745IleGlu: 3.745 ± 0.087
1.316IlePhe: 1.316 ± 0.052
4.958IleGly: 4.958 ± 0.107
1.286IleHis: 1.286 ± 0.048
2.203IleIle: 2.203 ± 0.064
1.048IleLys: 1.048 ± 0.047
4.023IleLeu: 4.023 ± 0.093
0.915IleMet: 0.915 ± 0.04
1.644IleAsn: 1.644 ± 0.053
2.376IlePro: 2.376 ± 0.069
1.524IleGln: 1.524 ± 0.048
3.847IleArg: 3.847 ± 0.085
2.564IleSer: 2.564 ± 0.07
2.785IleThr: 2.785 ± 0.065
3.451IleVal: 3.451 ± 0.08
0.491IleTrp: 0.491 ± 0.027
0.997IleTyr: 0.997 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
2.323LysAla: 2.323 ± 0.077
0.092LysCys: 0.092 ± 0.013
0.987LysAsp: 0.987 ± 0.049
0.812LysGlu: 0.812 ± 0.047
0.398LysPhe: 0.398 ± 0.029
1.652LysGly: 1.652 ± 0.06
0.354LysHis: 0.354 ± 0.026
0.805LysIle: 0.805 ± 0.038
0.596LysLys: 0.596 ± 0.039
1.717LysLeu: 1.717 ± 0.063
0.376LysMet: 0.376 ± 0.027
0.426LysAsn: 0.426 ± 0.03
1.063LysPro: 1.063 ± 0.046
0.724LysGln: 0.724 ± 0.038
1.807LysArg: 1.807 ± 0.059
1.045LysSer: 1.045 ± 0.045
1.2LysThr: 1.2 ± 0.044
1.285LysVal: 1.285 ± 0.06
0.171LysTrp: 0.171 ± 0.018
0.404LysTyr: 0.404 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
13.358LeuAla: 13.358 ± 0.181
0.845LeuCys: 0.845 ± 0.043
6.919LeuAsp: 6.919 ± 0.127
6.716LeuGlu: 6.716 ± 0.119
3.419LeuPhe: 3.419 ± 0.105
8.945LeuGly: 8.945 ± 0.156
2.273LeuHis: 2.273 ± 0.059
5.696LeuIle: 5.696 ± 0.115
2.193LeuLys: 2.193 ± 0.078
10.275LeuLeu: 10.275 ± 0.224
2.489LeuMet: 2.489 ± 0.064
2.554LeuAsn: 2.554 ± 0.061
5.774LeuPro: 5.774 ± 0.119
3.715LeuGln: 3.715 ± 0.085
8.221LeuArg: 8.221 ± 0.139
6.063LeuSer: 6.063 ± 0.11
5.842LeuThr: 5.842 ± 0.093
7.491LeuVal: 7.491 ± 0.117
1.063LeuTrp: 1.063 ± 0.042
2.191LeuTyr: 2.191 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
3.419MetAla: 3.419 ± 0.083
0.111MetCys: 0.111 ± 0.011
1.403MetAsp: 1.403 ± 0.052
1.261MetGlu: 1.261 ± 0.048
0.522MetPhe: 0.522 ± 0.029
1.992MetGly: 1.992 ± 0.06
0.461MetHis: 0.461 ± 0.034
1.273MetIle: 1.273 ± 0.047
0.651MetLys: 0.651 ± 0.035
2.443MetLeu: 2.443 ± 0.07
0.589MetMet: 0.589 ± 0.034
0.742MetAsn: 0.742 ± 0.026
1.416MetPro: 1.416 ± 0.053
0.918MetGln: 0.918 ± 0.042
1.8MetArg: 1.8 ± 0.058
1.418MetSer: 1.418 ± 0.045
1.666MetThr: 1.666 ± 0.056
1.666MetVal: 1.666 ± 0.052
0.153MetTrp: 0.153 ± 0.015
0.275MetTyr: 0.275 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.148AsnAla: 3.148 ± 0.083
0.23AsnCys: 0.23 ± 0.021
1.471AsnAsp: 1.471 ± 0.056
1.304AsnGlu: 1.304 ± 0.047
0.687AsnPhe: 0.687 ± 0.03
2.128AsnGly: 2.128 ± 0.063
0.554AsnHis: 0.554 ± 0.03
1.225AsnIle: 1.225 ± 0.05
0.434AsnLys: 0.434 ± 0.031
2.398AsnLeu: 2.398 ± 0.057
0.496AsnMet: 0.496 ± 0.032
0.632AsnAsn: 0.632 ± 0.036
1.606AsnPro: 1.606 ± 0.055
0.805AsnGln: 0.805 ± 0.037
2.0AsnArg: 2.0 ± 0.061
0.947AsnSer: 0.947 ± 0.046
1.25AsnThr: 1.25 ± 0.047
1.611AsnVal: 1.611 ± 0.064
0.328AsnTrp: 0.328 ± 0.028
0.541AsnTyr: 0.541 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
6.609ProAla: 6.609 ± 0.128
0.311ProCys: 0.311 ± 0.025
3.762ProAsp: 3.762 ± 0.092
3.514ProGlu: 3.514 ± 0.085
1.532ProPhe: 1.532 ± 0.046
4.689ProGly: 4.689 ± 0.106
0.97ProHis: 0.97 ± 0.036
2.208ProIle: 2.208 ± 0.06
0.775ProLys: 0.775 ± 0.036
5.201ProLeu: 5.201 ± 0.101
1.271ProMet: 1.271 ± 0.043
1.068ProAsn: 1.068 ± 0.045
2.459ProPro: 2.459 ± 0.074
1.571ProGln: 1.571 ± 0.057
3.185ProArg: 3.185 ± 0.074
2.516ProSer: 2.516 ± 0.058
2.557ProThr: 2.557 ± 0.07
4.424ProVal: 4.424 ± 0.084
0.76ProTrp: 0.76 ± 0.036
1.017ProTyr: 1.017 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.97GlnAla: 4.97 ± 0.086
0.276GlnCys: 0.276 ± 0.02
1.454GlnAsp: 1.454 ± 0.052
1.404GlnGlu: 1.404 ± 0.053
1.002GlnPhe: 1.002 ± 0.046
2.734GlnGly: 2.734 ± 0.07
0.784GlnHis: 0.784 ± 0.039
1.722GlnIle: 1.722 ± 0.051
0.639GlnLys: 0.639 ± 0.038
3.702GlnLeu: 3.702 ± 0.081
0.832GlnMet: 0.832 ± 0.039
0.636GlnAsn: 0.636 ± 0.031
2.176GlnPro: 2.176 ± 0.061
1.626GlnGln: 1.626 ± 0.059
3.93GlnArg: 3.93 ± 0.086
2.271GlnSer: 2.271 ± 0.069
2.067GlnThr: 2.067 ± 0.059
2.544GlnVal: 2.544 ± 0.068
0.561GlnTrp: 0.561 ± 0.03
0.75GlnTyr: 0.75 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
7.968ArgAla: 7.968 ± 0.125
0.697ArgCys: 0.697 ± 0.031
5.196ArgAsp: 5.196 ± 0.107
5.225ArgGlu: 5.225 ± 0.108
3.241ArgPhe: 3.241 ± 0.082
5.656ArgGly: 5.656 ± 0.096
2.3ArgHis: 2.3 ± 0.069
4.439ArgIle: 4.439 ± 0.097
1.283ArgLys: 1.283 ± 0.05
9.958ArgLeu: 9.958 ± 0.167
2.042ArgMet: 2.042 ± 0.057
1.825ArgAsn: 1.825 ± 0.06
3.98ArgPro: 3.98 ± 0.094
3.463ArgGln: 3.463 ± 0.079
7.488ArgArg: 7.488 ± 0.139
3.877ArgSer: 3.877 ± 0.085
3.434ArgThr: 3.434 ± 0.088
6.047ArgVal: 6.047 ± 0.099
1.228ArgTrp: 1.228 ± 0.053
2.351ArgTyr: 2.351 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
6.236SerAla: 6.236 ± 0.095
0.301SerCys: 0.301 ± 0.027
3.283SerAsp: 3.283 ± 0.077
2.912SerGlu: 2.912 ± 0.074
1.622SerPhe: 1.622 ± 0.057
5.364SerGly: 5.364 ± 0.108
1.131SerHis: 1.131 ± 0.05
2.486SerIle: 2.486 ± 0.072
0.799SerLys: 0.799 ± 0.043
5.717SerLeu: 5.717 ± 0.109
1.273SerMet: 1.273 ± 0.048
1.235SerAsn: 1.235 ± 0.042
2.498SerPro: 2.498 ± 0.063
1.616SerGln: 1.616 ± 0.053
3.907SerArg: 3.907 ± 0.083
2.478SerSer: 2.478 ± 0.071
2.579SerThr: 2.579 ± 0.075
4.08SerVal: 4.08 ± 0.088
0.614SerTrp: 0.614 ± 0.032
0.973SerTyr: 0.973 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
6.448ThrAla: 6.448 ± 0.117
0.361ThrCys: 0.361 ± 0.027
3.632ThrAsp: 3.632 ± 0.078
2.907ThrGlu: 2.907 ± 0.076
1.448ThrPhe: 1.448 ± 0.053
5.363ThrGly: 5.363 ± 0.106
1.201ThrHis: 1.201 ± 0.043
2.343ThrIle: 2.343 ± 0.068
0.681ThrLys: 0.681 ± 0.042
6.531ThrLeu: 6.531 ± 0.101
1.025ThrMet: 1.025 ± 0.044
1.073ThrAsn: 1.073 ± 0.046
3.27ThrPro: 3.27 ± 0.079
1.519ThrGln: 1.519 ± 0.045
3.782ThrArg: 3.782 ± 0.09
2.178ThrSer: 2.178 ± 0.067
2.794ThrThr: 2.794 ± 0.067
4.193ThrVal: 4.193 ± 0.078
0.556ThrTrp: 0.556 ± 0.031
0.955ThrTyr: 0.955 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
8.364ValAla: 8.364 ± 0.127
0.644ValCys: 0.644 ± 0.029
5.19ValAsp: 5.19 ± 0.102
4.785ValGlu: 4.785 ± 0.099
2.536ValPhe: 2.536 ± 0.067
5.87ValGly: 5.87 ± 0.112
1.587ValHis: 1.587 ± 0.05
4.554ValIle: 4.554 ± 0.087
1.393ValLys: 1.393 ± 0.056
7.404ValLeu: 7.404 ± 0.121
2.078ValMet: 2.078 ± 0.061
2.057ValAsn: 2.057 ± 0.059
3.494ValPro: 3.494 ± 0.085
2.015ValGln: 2.015 ± 0.063
5.168ValArg: 5.168 ± 0.097
4.198ValSer: 4.198 ± 0.087
4.404ValThr: 4.404 ± 0.087
5.938ValVal: 5.938 ± 0.128
0.849ValTrp: 0.849 ± 0.04
1.507ValTyr: 1.507 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
1.203TrpAla: 1.203 ± 0.047
0.126TrpCys: 0.126 ± 0.014
0.564TrpAsp: 0.564 ± 0.03
0.537TrpGlu: 0.537 ± 0.031
0.531TrpPhe: 0.531 ± 0.027
0.79TrpGly: 0.79 ± 0.032
0.353TrpHis: 0.353 ± 0.025
0.696TrpIle: 0.696 ± 0.041
0.23TrpLys: 0.23 ± 0.021
2.198TrpLeu: 2.198 ± 0.068
0.421TrpMet: 0.421 ± 0.028
0.309TrpAsn: 0.309 ± 0.024
0.677TrpPro: 0.677 ± 0.037
0.795TrpGln: 0.795 ± 0.041
1.339TrpArg: 1.339 ± 0.053
0.679TrpSer: 0.679 ± 0.035
0.597TrpThr: 0.597 ± 0.033
0.923TrpVal: 0.923 ± 0.037
0.208TrpTrp: 0.208 ± 0.018
0.276TrpTyr: 0.276 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.359TyrAla: 2.359 ± 0.069
0.271TyrCys: 0.271 ± 0.019
1.353TyrAsp: 1.353 ± 0.049
1.296TyrGlu: 1.296 ± 0.057
0.79TyrPhe: 0.79 ± 0.036
2.078TyrGly: 2.078 ± 0.058
0.537TyrHis: 0.537 ± 0.033
0.905TyrIle: 0.905 ± 0.04
0.376TyrLys: 0.376 ± 0.029
2.551TyrLeu: 2.551 ± 0.075
0.381TyrMet: 0.381 ± 0.028
0.606TyrAsn: 0.606 ± 0.032
1.163TyrPro: 1.163 ± 0.05
0.937TyrGln: 0.937 ± 0.042
2.196TyrArg: 2.196 ± 0.061
1.141TyrSer: 1.141 ± 0.043
1.116TyrThr: 1.116 ± 0.045
1.466TyrVal: 1.466 ± 0.052
0.403TyrTrp: 0.403 ± 0.027
0.614TyrTyr: 0.614 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1861 proteins (600998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski