Amino acid dipepetide frequency for Vibrio sp. 10N.286.49.C2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.238AlaAla: 7.238 ± 0.107
0.905AlaCys: 0.905 ± 0.027
4.398AlaAsp: 4.398 ± 0.06
4.944AlaGlu: 4.944 ± 0.068
3.475AlaPhe: 3.475 ± 0.05
5.832AlaGly: 5.832 ± 0.08
1.674AlaHis: 1.674 ± 0.038
6.163AlaIle: 6.163 ± 0.071
4.717AlaLys: 4.717 ± 0.067
9.753AlaLeu: 9.753 ± 0.084
2.816AlaMet: 2.816 ± 0.051
3.508AlaAsn: 3.508 ± 0.055
2.894AlaPro: 2.894 ± 0.047
3.65AlaGln: 3.65 ± 0.058
3.477AlaArg: 3.477 ± 0.055
5.592AlaSer: 5.592 ± 0.067
4.804AlaThr: 4.804 ± 0.065
5.855AlaVal: 5.855 ± 0.072
0.958AlaTrp: 0.958 ± 0.03
2.364AlaTyr: 2.364 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.787CysAla: 0.787 ± 0.022
0.155CysCys: 0.155 ± 0.011
0.612CysAsp: 0.612 ± 0.021
0.584CysGlu: 0.584 ± 0.021
0.444CysPhe: 0.444 ± 0.017
0.925CysGly: 0.925 ± 0.026
0.392CysHis: 0.392 ± 0.019
0.593CysIle: 0.593 ± 0.02
0.396CysLys: 0.396 ± 0.02
0.924CysLeu: 0.924 ± 0.026
0.245CysMet: 0.245 ± 0.013
0.352CysAsn: 0.352 ± 0.015
0.427CysPro: 0.427 ± 0.018
0.436CysGln: 0.436 ± 0.02
0.471CysArg: 0.471 ± 0.018
0.677CysSer: 0.677 ± 0.021
0.49CysThr: 0.49 ± 0.019
0.692CysVal: 0.692 ± 0.022
0.127CysTrp: 0.127 ± 0.013
0.306CysTyr: 0.306 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.725AspAla: 4.725 ± 0.06
0.528AspCys: 0.528 ± 0.02
3.231AspAsp: 3.231 ± 0.061
3.719AspGlu: 3.719 ± 0.056
2.467AspPhe: 2.467 ± 0.044
3.924AspGly: 3.924 ± 0.075
1.165AspHis: 1.165 ± 0.029
4.227AspIle: 4.227 ± 0.056
3.226AspLys: 3.226 ± 0.054
5.131AspLeu: 5.131 ± 0.069
1.525AspMet: 1.525 ± 0.033
2.725AspAsn: 2.725 ± 0.053
2.038AspPro: 2.038 ± 0.042
1.892AspGln: 1.892 ± 0.039
2.275AspArg: 2.275 ± 0.043
3.461AspSer: 3.461 ± 0.058
2.996AspThr: 2.996 ± 0.058
4.32AspVal: 4.32 ± 0.064
0.891AspTrp: 0.891 ± 0.027
2.089AspTyr: 2.089 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.099GluAla: 5.099 ± 0.077
0.524GluCys: 0.524 ± 0.024
2.82GluAsp: 2.82 ± 0.049
3.577GluGlu: 3.577 ± 0.064
2.459GluPhe: 2.459 ± 0.039
3.622GluGly: 3.622 ± 0.061
1.665GluHis: 1.665 ± 0.035
3.548GluIle: 3.548 ± 0.059
3.576GluLys: 3.576 ± 0.055
6.765GluLeu: 6.765 ± 0.068
1.707GluMet: 1.707 ± 0.039
2.563GluAsn: 2.563 ± 0.045
2.014GluPro: 2.014 ± 0.038
3.602GluGln: 3.602 ± 0.058
3.316GluArg: 3.316 ± 0.054
3.865GluSer: 3.865 ± 0.05
3.188GluThr: 3.188 ± 0.06
4.239GluVal: 4.239 ± 0.063
0.839GluTrp: 0.839 ± 0.026
1.682GluTyr: 1.682 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.496PheAla: 3.496 ± 0.053
0.5PheCys: 0.5 ± 0.019
2.893PheAsp: 2.893 ± 0.043
2.613PheGlu: 2.613 ± 0.039
1.738PhePhe: 1.738 ± 0.04
3.406PheGly: 3.406 ± 0.057
0.854PheHis: 0.854 ± 0.024
2.81PheIle: 2.81 ± 0.053
1.912PheLys: 1.912 ± 0.039
3.382PheLeu: 3.382 ± 0.059
1.103PheMet: 1.103 ± 0.033
2.044PheAsn: 2.044 ± 0.039
1.427PhePro: 1.427 ± 0.035
1.267PheGln: 1.267 ± 0.032
1.453PheArg: 1.453 ± 0.033
3.421PheSer: 3.421 ± 0.053
2.417PheThr: 2.417 ± 0.04
2.971PheVal: 2.971 ± 0.056
0.548PheTrp: 0.548 ± 0.021
1.345PheTyr: 1.345 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.533GlyAla: 5.533 ± 0.074
0.9GlyCys: 0.9 ± 0.026
3.788GlyAsp: 3.788 ± 0.07
4.249GlyGlu: 4.249 ± 0.07
3.344GlyPhe: 3.344 ± 0.05
4.915GlyGly: 4.915 ± 0.08
1.631GlyHis: 1.631 ± 0.037
4.866GlyIle: 4.866 ± 0.064
3.804GlyLys: 3.804 ± 0.05
7.034GlyLeu: 7.034 ± 0.082
2.105GlyMet: 2.105 ± 0.045
2.62GlyAsn: 2.62 ± 0.053
1.686GlyPro: 1.686 ± 0.039
2.968GlyGln: 2.968 ± 0.047
3.073GlyArg: 3.073 ± 0.045
4.213GlySer: 4.213 ± 0.066
3.598GlyThr: 3.598 ± 0.075
5.465GlyVal: 5.465 ± 0.068
0.997GlyTrp: 0.997 ± 0.03
2.623GlyTyr: 2.623 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.693HisAla: 1.693 ± 0.036
0.326HisCys: 0.326 ± 0.015
1.235HisAsp: 1.235 ± 0.031
1.181HisGlu: 1.181 ± 0.028
1.09HisPhe: 1.09 ± 0.03
1.577HisGly: 1.577 ± 0.034
0.78HisHis: 0.78 ± 0.028
1.494HisIle: 1.494 ± 0.034
1.072HisLys: 1.072 ± 0.03
2.228HisLeu: 2.228 ± 0.041
0.486HisMet: 0.486 ± 0.017
0.971HisAsn: 0.971 ± 0.029
1.151HisPro: 1.151 ± 0.026
1.163HisGln: 1.163 ± 0.027
1.071HisArg: 1.071 ± 0.027
1.575HisSer: 1.575 ± 0.033
1.189HisThr: 1.189 ± 0.032
1.461HisVal: 1.461 ± 0.03
0.388HisTrp: 0.388 ± 0.017
0.872HisTyr: 0.872 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.496IleAla: 6.496 ± 0.075
0.658IleCys: 0.658 ± 0.02
4.394IleAsp: 4.394 ± 0.057
4.802IleGlu: 4.802 ± 0.061
2.247IlePhe: 2.247 ± 0.044
4.949IleGly: 4.949 ± 0.068
1.361IleHis: 1.361 ± 0.032
3.826IleIle: 3.826 ± 0.075
3.176IleLys: 3.176 ± 0.049
5.309IleLeu: 5.309 ± 0.08
1.435IleMet: 1.435 ± 0.033
2.954IleAsn: 2.954 ± 0.048
2.74IlePro: 2.74 ± 0.048
2.419IleGln: 2.419 ± 0.043
2.812IleArg: 2.812 ± 0.047
4.46IleSer: 4.46 ± 0.058
3.805IleThr: 3.805 ± 0.06
4.488IleVal: 4.488 ± 0.059
0.664IleTrp: 0.664 ± 0.021
1.712IleTyr: 1.712 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.674LysAla: 4.674 ± 0.061
0.321LysCys: 0.321 ± 0.016
2.701LysAsp: 2.701 ± 0.046
3.239LysGlu: 3.239 ± 0.062
1.478LysPhe: 1.478 ± 0.035
3.386LysGly: 3.386 ± 0.051
1.293LysHis: 1.293 ± 0.032
2.795LysIle: 2.795 ± 0.046
3.004LysLys: 3.004 ± 0.064
5.035LysLeu: 5.035 ± 0.065
1.5LysMet: 1.5 ± 0.034
2.093LysAsn: 2.093 ± 0.043
2.284LysPro: 2.284 ± 0.045
2.889LysGln: 2.889 ± 0.048
2.626LysArg: 2.626 ± 0.048
3.101LysSer: 3.101 ± 0.047
2.929LysThr: 2.929 ± 0.049
3.744LysVal: 3.744 ± 0.054
0.584LysTrp: 0.584 ± 0.02
1.381LysTyr: 1.381 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
9.325LeuAla: 9.325 ± 0.106
1.059LeuCys: 1.059 ± 0.027
5.851LeuAsp: 5.851 ± 0.074
5.956LeuGlu: 5.956 ± 0.078
4.312LeuPhe: 4.312 ± 0.074
7.091LeuGly: 7.091 ± 0.077
1.978LeuHis: 1.978 ± 0.04
6.318LeuIle: 6.318 ± 0.085
5.043LeuLys: 5.043 ± 0.063
9.951LeuLeu: 9.951 ± 0.119
2.774LeuMet: 2.774 ± 0.047
4.585LeuAsn: 4.585 ± 0.059
4.608LeuPro: 4.608 ± 0.057
3.45LeuGln: 3.45 ± 0.055
4.161LeuArg: 4.161 ± 0.067
8.01LeuSer: 8.01 ± 0.081
6.222LeuThr: 6.222 ± 0.071
7.19LeuVal: 7.19 ± 0.077
1.037LeuTrp: 1.037 ± 0.032
2.596LeuTyr: 2.596 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.611MetAla: 2.611 ± 0.048
0.206MetCys: 0.206 ± 0.013
1.374MetAsp: 1.374 ± 0.033
1.286MetGlu: 1.286 ± 0.032
0.988MetPhe: 0.988 ± 0.028
1.885MetGly: 1.885 ± 0.043
0.528MetHis: 0.528 ± 0.02
1.632MetIle: 1.632 ± 0.031
1.571MetLys: 1.571 ± 0.034
2.843MetLeu: 2.843 ± 0.051
0.915MetMet: 0.915 ± 0.03
1.273MetAsn: 1.273 ± 0.032
1.248MetPro: 1.248 ± 0.031
1.096MetGln: 1.096 ± 0.032
1.201MetArg: 1.201 ± 0.031
2.19MetSer: 2.19 ± 0.043
1.884MetThr: 1.884 ± 0.039
2.001MetVal: 2.001 ± 0.042
0.272MetTrp: 0.272 ± 0.014
0.59MetTyr: 0.59 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.517AsnAla: 3.517 ± 0.056
0.366AsnCys: 0.366 ± 0.017
2.645AsnAsp: 2.645 ± 0.068
2.564AsnGlu: 2.564 ± 0.044
1.564AsnPhe: 1.564 ± 0.031
3.11AsnGly: 3.11 ± 0.047
1.064AsnHis: 1.064 ± 0.026
2.838AsnIle: 2.838 ± 0.046
2.25AsnLys: 2.25 ± 0.046
3.881AsnLeu: 3.881 ± 0.054
1.035AsnMet: 1.035 ± 0.029
2.022AsnAsn: 2.022 ± 0.041
2.066AsnPro: 2.066 ± 0.041
2.102AsnGln: 2.102 ± 0.048
1.909AsnArg: 1.909 ± 0.039
2.509AsnSer: 2.509 ± 0.049
2.463AsnThr: 2.463 ± 0.046
2.863AsnVal: 2.863 ± 0.052
0.578AsnTrp: 0.578 ± 0.021
1.381AsnTyr: 1.381 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
2.89ProAla: 2.89 ± 0.048
0.323ProCys: 0.323 ± 0.013
2.356ProAsp: 2.356 ± 0.037
2.987ProGlu: 2.987 ± 0.049
1.792ProPhe: 1.792 ± 0.038
2.167ProGly: 2.167 ± 0.043
0.863ProHis: 0.863 ± 0.024
2.645ProIle: 2.645 ± 0.047
1.909ProLys: 1.909 ± 0.043
3.998ProLeu: 3.998 ± 0.058
1.082ProMet: 1.082 ± 0.03
1.828ProAsn: 1.828 ± 0.038
1.121ProPro: 1.121 ± 0.031
1.54ProGln: 1.54 ± 0.031
1.301ProArg: 1.301 ± 0.033
2.704ProSer: 2.704 ± 0.04
2.315ProThr: 2.315 ± 0.041
3.045ProVal: 3.045 ± 0.044
0.5ProTrp: 0.5 ± 0.02
1.3ProTyr: 1.3 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.01GlnAla: 4.01 ± 0.062
0.42GlnCys: 0.42 ± 0.018
2.158GlnAsp: 2.158 ± 0.046
2.321GlnGlu: 2.321 ± 0.048
1.814GlnPhe: 1.814 ± 0.036
2.942GlnGly: 2.942 ± 0.048
1.245GlnHis: 1.245 ± 0.031
2.438GlnIle: 2.438 ± 0.041
1.986GlnLys: 1.986 ± 0.038
4.778GlnLeu: 4.778 ± 0.07
1.133GlnMet: 1.133 ± 0.024
1.549GlnAsn: 1.549 ± 0.039
1.69GlnPro: 1.69 ± 0.035
2.649GlnGln: 2.649 ± 0.054
2.296GlnArg: 2.296 ± 0.042
2.93GlnSer: 2.93 ± 0.055
2.23GlnThr: 2.23 ± 0.039
3.107GlnVal: 3.107 ± 0.047
0.685GlnTrp: 0.685 ± 0.022
1.492GlnTyr: 1.492 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.263ArgAla: 3.263 ± 0.055
0.453ArgCys: 0.453 ± 0.018
2.439ArgAsp: 2.439 ± 0.046
2.819ArgGlu: 2.819 ± 0.05
2.209ArgPhe: 2.209 ± 0.042
2.481ArgGly: 2.481 ± 0.043
1.128ArgHis: 1.128 ± 0.031
2.931ArgIle: 2.931 ± 0.045
2.167ArgLys: 2.167 ± 0.047
4.744ArgLeu: 4.744 ± 0.061
1.219ArgMet: 1.219 ± 0.031
1.821ArgAsn: 1.821 ± 0.034
1.524ArgPro: 1.524 ± 0.037
2.092ArgGln: 2.092 ± 0.043
2.178ArgArg: 2.178 ± 0.056
2.688ArgSer: 2.688 ± 0.043
2.275ArgThr: 2.275 ± 0.038
3.216ArgVal: 3.216 ± 0.053
0.642ArgTrp: 0.642 ± 0.022
1.725ArgTyr: 1.725 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
5.464SerAla: 5.464 ± 0.062
0.6SerCys: 0.6 ± 0.021
3.842SerAsp: 3.842 ± 0.061
4.06SerGlu: 4.06 ± 0.062
2.928SerPhe: 2.928 ± 0.044
5.054SerGly: 5.054 ± 0.068
1.569SerHis: 1.569 ± 0.033
4.568SerIle: 4.568 ± 0.061
3.257SerLys: 3.257 ± 0.048
7.116SerLeu: 7.116 ± 0.082
1.932SerMet: 1.932 ± 0.045
2.901SerAsn: 2.901 ± 0.047
2.531SerPro: 2.531 ± 0.048
3.061SerGln: 3.061 ± 0.054
2.859SerArg: 2.859 ± 0.041
4.602SerSer: 4.602 ± 0.07
3.68SerThr: 3.68 ± 0.052
4.923SerVal: 4.923 ± 0.059
0.877SerTrp: 0.877 ± 0.028
2.048SerTyr: 2.048 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.542ThrAla: 4.542 ± 0.06
0.494ThrCys: 0.494 ± 0.021
3.032ThrAsp: 3.032 ± 0.069
3.072ThrGlu: 3.072 ± 0.052
2.27ThrPhe: 2.27 ± 0.045
4.13ThrGly: 4.13 ± 0.06
1.34ThrHis: 1.34 ± 0.028
3.715ThrIle: 3.715 ± 0.054
2.554ThrLys: 2.554 ± 0.041
6.616ThrLeu: 6.616 ± 0.075
1.41ThrMet: 1.41 ± 0.035
2.156ThrAsn: 2.156 ± 0.042
2.769ThrPro: 2.769 ± 0.05
2.619ThrGln: 2.619 ± 0.048
2.28ThrArg: 2.28 ± 0.045
3.737ThrSer: 3.737 ± 0.055
3.271ThrThr: 3.271 ± 0.066
4.058ThrVal: 4.058 ± 0.063
0.699ThrTrp: 0.699 ± 0.024
1.529ThrTyr: 1.529 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
6.444ValAla: 6.444 ± 0.07
0.78ValCys: 0.78 ± 0.024
4.393ValAsp: 4.393 ± 0.063
4.636ValGlu: 4.636 ± 0.064
2.935ValPhe: 2.935 ± 0.052
4.983ValGly: 4.983 ± 0.067
1.3ValHis: 1.3 ± 0.034
4.934ValIle: 4.934 ± 0.066
3.537ValLys: 3.537 ± 0.062
7.059ValLeu: 7.059 ± 0.087
2.109ValMet: 2.109 ± 0.038
3.054ValAsn: 3.054 ± 0.046
2.691ValPro: 2.691 ± 0.045
2.314ValGln: 2.314 ± 0.045
2.921ValArg: 2.921 ± 0.052
5.236ValSer: 5.236 ± 0.06
4.386ValThr: 4.386 ± 0.066
5.767ValVal: 5.767 ± 0.069
0.806ValTrp: 0.806 ± 0.026
1.931ValTyr: 1.931 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.912TrpAla: 0.912 ± 0.027
0.157TrpCys: 0.157 ± 0.011
0.616TrpAsp: 0.616 ± 0.023
0.529TrpGlu: 0.529 ± 0.019
0.633TrpPhe: 0.633 ± 0.022
0.868TrpGly: 0.868 ± 0.03
0.369TrpHis: 0.369 ± 0.018
0.708TrpIle: 0.708 ± 0.026
0.579TrpLys: 0.579 ± 0.022
1.726TrpLeu: 1.726 ± 0.039
0.389TrpMet: 0.389 ± 0.017
0.519TrpAsn: 0.519 ± 0.021
0.45TrpPro: 0.45 ± 0.02
0.802TrpGln: 0.802 ± 0.022
0.647TrpArg: 0.647 ± 0.022
0.812TrpSer: 0.812 ± 0.023
0.59TrpThr: 0.59 ± 0.023
0.879TrpVal: 0.879 ± 0.024
0.203TrpTrp: 0.203 ± 0.013
0.389TrpTyr: 0.389 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.298TyrAla: 2.298 ± 0.042
0.359TyrCys: 0.359 ± 0.013
1.776TyrAsp: 1.776 ± 0.035
1.532TyrGlu: 1.532 ± 0.035
1.411TyrPhe: 1.411 ± 0.037
2.165TyrGly: 2.165 ± 0.047
0.807TyrHis: 0.807 ± 0.024
1.655TyrIle: 1.655 ± 0.03
1.322TyrLys: 1.322 ± 0.031
3.244TyrLeu: 3.244 ± 0.049
0.672TyrMet: 0.672 ± 0.022
1.189TyrAsn: 1.189 ± 0.029
1.312TyrPro: 1.312 ± 0.03
1.861TyrGln: 1.861 ± 0.037
1.69TyrArg: 1.69 ± 0.037
2.09TyrSer: 2.09 ± 0.043
1.563TyrThr: 1.563 ± 0.041
1.931TyrVal: 1.931 ± 0.039
0.481TyrTrp: 0.481 ± 0.02
1.035TyrTyr: 1.035 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4338 proteins (1422617 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski