Amino acid dipepetide frequency for Chryseobacterium sp. FH1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.822AlaAla: 2.822 ± 0.092	0.454AlaCys: 0.454 ± 0.021	3.369AlaAsp: 3.369 ± 0.061	4.253AlaGlu: 4.253 ± 0.085	3.165AlaPhe: 3.165 ± 0.063	4.256AlaGly: 4.256 ± 0.081	0.918AlaHis: 0.918 ± 0.031	4.653AlaIle: 4.653 ± 0.066	4.898AlaLys: 4.898 ± 0.076	5.57AlaLeu: 5.57 ± 0.073	1.499AlaMet: 1.499 ± 0.04	3.342AlaAsn: 3.342 ± 0.061	1.683AlaPro: 1.683 ± 0.046	2.326AlaGln: 2.326 ± 0.052	1.801AlaArg: 1.801 ± 0.045	4.059AlaSer: 4.059 ± 0.057	3.55AlaThr: 3.55 ± 0.071	3.922AlaVal: 3.922 ± 0.073	0.581AlaTrp: 0.581 ± 0.025	2.32AlaTyr: 2.32 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.38CysAla: 0.38 ± 0.021	0.081CysCys: 0.081 ± 0.008	0.403CysAsp: 0.403 ± 0.02	0.425CysGlu: 0.425 ± 0.022	0.416CysPhe: 0.416 ± 0.019	0.6CysGly: 0.6 ± 0.026	0.143CysHis: 0.143 ± 0.013	0.529CysIle: 0.529 ± 0.021	0.493CysLys: 0.493 ± 0.024	0.614CysLeu: 0.614 ± 0.023	0.128CysMet: 0.128 ± 0.011	0.388CysAsn: 0.388 ± 0.022	0.256CysPro: 0.256 ± 0.019	0.172CysGln: 0.172 ± 0.013	0.177CysArg: 0.177 ± 0.013	0.472CysSer: 0.472 ± 0.024	0.346CysThr: 0.346 ± 0.019	0.412CysVal: 0.412 ± 0.02	0.055CysTrp: 0.055 ± 0.007	0.276CysTyr: 0.276 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.259AspAla: 3.259 ± 0.054	0.382AspCys: 0.382 ± 0.02	3.005AspAsp: 3.005 ± 0.056	4.189AspGlu: 4.189 ± 0.068	4.187AspPhe: 4.187 ± 0.067	3.47AspGly: 3.47 ± 0.068	0.879AspHis: 0.879 ± 0.033	4.292AspIle: 4.292 ± 0.06	4.622AspLys: 4.622 ± 0.078	5.315AspLeu: 5.315 ± 0.077	1.031AspMet: 1.031 ± 0.031	3.261AspAsn: 3.261 ± 0.061	1.628AspPro: 1.628 ± 0.042	1.621AspGln: 1.621 ± 0.048	1.758AspArg: 1.758 ± 0.039	3.45AspSer: 3.45 ± 0.068	2.159AspThr: 2.159 ± 0.054	3.48AspVal: 3.48 ± 0.059	0.779AspTrp: 0.779 ± 0.028	2.98AspTyr: 2.98 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	3.876GluAla: 3.876 ± 0.067	0.304GluCys: 0.304 ± 0.016	3.549GluAsp: 3.549 ± 0.053	4.847GluGlu: 4.847 ± 0.1	3.43GluPhe: 3.43 ± 0.058	3.285GluGly: 3.285 ± 0.06	0.947GluHis: 0.947 ± 0.033	6.199GluIle: 6.199 ± 0.088	7.202GluLys: 7.202 ± 0.114	6.1GluLeu: 6.1 ± 0.099	1.754GluMet: 1.754 ± 0.041	5.855GluAsn: 5.855 ± 0.09	1.431GluPro: 1.431 ± 0.036	2.167GluGln: 2.167 ± 0.046	2.304GluArg: 2.304 ± 0.055	3.748GluSer: 3.748 ± 0.061	3.771GluThr: 3.771 ± 0.071	4.047GluVal: 4.047 ± 0.077	0.63GluTrp: 0.63 ± 0.029	2.359GluTyr: 2.359 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.374PheAla: 3.374 ± 0.061	0.497PheCys: 0.497 ± 0.02	3.446PheAsp: 3.446 ± 0.055	3.628PheGlu: 3.628 ± 0.061	3.009PhePhe: 3.009 ± 0.075	3.889PheGly: 3.889 ± 0.065	0.924PheHis: 0.924 ± 0.029	3.996PheIle: 3.996 ± 0.067	3.844PheLys: 3.844 ± 0.062	5.169PheLeu: 5.169 ± 0.086	1.058PheMet: 1.058 ± 0.028	3.181PheAsn: 3.181 ± 0.059	1.979PhePro: 1.979 ± 0.041	1.809PheGln: 1.809 ± 0.042	1.872PheArg: 1.872 ± 0.039	4.5PheSer: 4.5 ± 0.065	3.042PheThr: 3.042 ± 0.054	3.419PheVal: 3.419 ± 0.064	0.659PheTrp: 0.659 ± 0.026	2.547PheTyr: 2.547 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	3.746GlyAla: 3.746 ± 0.078	0.499GlyCys: 0.499 ± 0.024	2.999GlyAsp: 2.999 ± 0.06	3.498GlyGlu: 3.498 ± 0.065	3.772GlyPhe: 3.772 ± 0.066	4.282GlyGly: 4.282 ± 0.101	0.954GlyHis: 0.954 ± 0.029	5.331GlyIle: 5.331 ± 0.07	5.633GlyLys: 5.633 ± 0.074	5.451GlyLeu: 5.451 ± 0.079	1.492GlyMet: 1.492 ± 0.042	4.013GlyAsn: 4.013 ± 0.081	1.097GlyPro: 1.097 ± 0.036	2.016GlyGln: 2.016 ± 0.045	2.004GlyArg: 2.004 ± 0.045	3.959GlySer: 3.959 ± 0.076	3.745GlyThr: 3.745 ± 0.079	3.872GlyVal: 3.872 ± 0.065	0.748GlyTrp: 0.748 ± 0.029	2.655GlyTyr: 2.655 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.799HisAla: 0.799 ± 0.029	0.14HisCys: 0.14 ± 0.012	0.695HisAsp: 0.695 ± 0.027	0.805HisGlu: 0.805 ± 0.029	1.113HisPhe: 1.113 ± 0.035	0.882HisGly: 0.882 ± 0.033	0.466HisHis: 0.466 ± 0.026	1.208HisIle: 1.208 ± 0.034	1.089HisLys: 1.089 ± 0.026	1.668HisLeu: 1.668 ± 0.044	0.259HisMet: 0.259 ± 0.017	0.906HisAsn: 0.906 ± 0.031	0.843HisPro: 0.843 ± 0.025	0.762HisGln: 0.762 ± 0.031	0.608HisArg: 0.608 ± 0.024	1.073HisSer: 1.073 ± 0.031	0.796HisThr: 0.796 ± 0.026	0.653HisVal: 0.653 ± 0.024	0.201HisTrp: 0.201 ± 0.015	0.835HisTyr: 0.835 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.029IleAla: 5.029 ± 0.085	0.634IleCys: 0.634 ± 0.026	4.861IleAsp: 4.861 ± 0.07	5.195IleGlu: 5.195 ± 0.08	4.394IlePhe: 4.394 ± 0.073	4.866IleGly: 4.866 ± 0.082	1.283IleHis: 1.283 ± 0.035	6.403IleIle: 6.403 ± 0.108	6.142IleLys: 6.142 ± 0.084	7.684IleLeu: 7.684 ± 0.096	1.309IleMet: 1.309 ± 0.04	5.201IleAsn: 5.201 ± 0.084	3.212IlePro: 3.212 ± 0.057	2.626IleGln: 2.626 ± 0.049	2.428IleArg: 2.428 ± 0.046	6.445IleSer: 6.445 ± 0.078	4.349IleThr: 4.349 ± 0.079	4.583IleVal: 4.583 ± 0.065	0.71IleTrp: 0.71 ± 0.023	3.172IleTyr: 3.172 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.927LysAla: 4.927 ± 0.078	0.346LysCys: 0.346 ± 0.016	5.04LysAsp: 5.04 ± 0.071	6.252LysGlu: 6.252 ± 0.091	3.784LysPhe: 3.784 ± 0.067	4.328LysGly: 4.328 ± 0.069	1.229LysHis: 1.229 ± 0.033	7.707LysIle: 7.707 ± 0.091	7.549LysLys: 7.549 ± 0.11	7.1LysLeu: 7.1 ± 0.092	2.348LysMet: 2.348 ± 0.048	6.514LysAsn: 6.514 ± 0.095	2.618LysPro: 2.618 ± 0.053	2.743LysGln: 2.743 ± 0.059	2.583LysArg: 2.583 ± 0.056	5.343LysSer: 5.343 ± 0.086	5.075LysThr: 5.075 ± 0.076	4.929LysVal: 4.929 ± 0.071	0.776LysTrp: 0.776 ± 0.026	3.239LysTyr: 3.239 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	5.611LeuAla: 5.611 ± 0.076	0.651LeuCys: 0.651 ± 0.027	5.009LeuAsp: 5.009 ± 0.079	6.239LeuGlu: 6.239 ± 0.09	4.694LeuPhe: 4.694 ± 0.071	5.863LeuGly: 5.863 ± 0.081	1.368LeuHis: 1.368 ± 0.041	7.184LeuIle: 7.184 ± 0.108	8.225LeuLys: 8.225 ± 0.083	8.159LeuLeu: 8.159 ± 0.111	2.286LeuMet: 2.286 ± 0.041	5.633LeuAsn: 5.633 ± 0.075	3.47LeuPro: 3.47 ± 0.057	3.194LeuGln: 3.194 ± 0.062	3.044LeuArg: 3.044 ± 0.062	6.772LeuSer: 6.772 ± 0.076	4.853LeuThr: 4.853 ± 0.078	5.144LeuVal: 5.144 ± 0.073	0.788LeuTrp: 0.788 ± 0.026	3.169LeuTyr: 3.169 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.405MetAla: 1.405 ± 0.031	0.111MetCys: 0.111 ± 0.009	1.133MetAsp: 1.133 ± 0.036	1.487MetGlu: 1.487 ± 0.04	0.939MetPhe: 0.939 ± 0.032	1.322MetGly: 1.322 ± 0.037	0.316MetHis: 0.316 ± 0.016	1.789MetIle: 1.789 ± 0.046	2.555MetLys: 2.555 ± 0.051	1.84MetLeu: 1.84 ± 0.045	0.686MetMet: 0.686 ± 0.029	1.456MetAsn: 1.456 ± 0.035	0.853MetPro: 0.853 ± 0.028	0.746MetGln: 0.746 ± 0.03	0.842MetArg: 0.842 ± 0.029	1.427MetSer: 1.427 ± 0.039	1.226MetThr: 1.226 ± 0.04	1.248MetVal: 1.248 ± 0.039	0.172MetTrp: 0.172 ± 0.014	0.614MetTyr: 0.614 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.786AsnAla: 3.786 ± 0.059	0.419AsnCys: 0.419 ± 0.023	3.378AsnAsp: 3.378 ± 0.063	3.893AsnGlu: 3.893 ± 0.054	3.872AsnPhe: 3.872 ± 0.067	4.164AsnGly: 4.164 ± 0.077	1.115AsnHis: 1.115 ± 0.031	5.439AsnIle: 5.439 ± 0.082	4.488AsnLys: 4.488 ± 0.072	6.242AsnLeu: 6.242 ± 0.088	1.247AsnMet: 1.247 ± 0.032	4.032AsnAsn: 4.032 ± 0.069	3.049AsnPro: 3.049 ± 0.053	2.75AsnGln: 2.75 ± 0.055	2.14AsnArg: 2.14 ± 0.052	4.371AsnSer: 4.371 ± 0.075	3.12AsnThr: 3.12 ± 0.059	3.891AsnVal: 3.891 ± 0.069	0.809AsnTrp: 0.809 ± 0.028	3.178AsnTyr: 3.178 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	2.055ProAla: 2.055 ± 0.048	0.175ProCys: 0.175 ± 0.013	2.095ProAsp: 2.095 ± 0.046	2.9ProGlu: 2.9 ± 0.057	1.779ProPhe: 1.779 ± 0.044	1.729ProGly: 1.729 ± 0.047	0.528ProHis: 0.528 ± 0.022	2.58ProIle: 2.58 ± 0.052	2.781ProLys: 2.781 ± 0.048	2.694ProLeu: 2.694 ± 0.058	0.753ProMet: 0.753 ± 0.028	2.22ProAsn: 2.22 ± 0.054	0.722ProPro: 0.722 ± 0.033	1.157ProGln: 1.157 ± 0.034	0.927ProArg: 0.927 ± 0.025	2.052ProSer: 2.052 ± 0.053	2.031ProThr: 2.031 ± 0.044	2.19ProVal: 2.19 ± 0.052	0.309ProTrp: 0.309 ± 0.017	1.319ProTyr: 1.319 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.875GlnAla: 1.875 ± 0.043	0.156GlnCys: 0.156 ± 0.011	1.722GlnAsp: 1.722 ± 0.037	2.272GlnGlu: 2.272 ± 0.05	1.85GlnPhe: 1.85 ± 0.047	1.731GlnGly: 1.731 ± 0.044	0.521GlnHis: 0.521 ± 0.02	3.011GlnIle: 3.011 ± 0.051	3.452GlnLys: 3.452 ± 0.06	3.304GlnLeu: 3.304 ± 0.069	0.875GlnMet: 0.875 ± 0.029	2.857GlnAsn: 2.857 ± 0.056	1.07GlnPro: 1.07 ± 0.034	1.431GlnGln: 1.431 ± 0.046	1.192GlnArg: 1.192 ± 0.038	2.122GlnSer: 2.122 ± 0.038	2.026GlnThr: 2.026 ± 0.04	1.795GlnVal: 1.795 ± 0.039	0.343GlnTrp: 0.343 ± 0.019	1.416GlnTyr: 1.416 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	1.744ArgAla: 1.744 ± 0.046	0.186ArgCys: 0.186 ± 0.015	1.721ArgAsp: 1.721 ± 0.041	2.186ArgGlu: 2.186 ± 0.05	1.88ArgPhe: 1.88 ± 0.041	1.644ArgGly: 1.644 ± 0.043	0.517ArgHis: 0.517 ± 0.02	2.817ArgIle: 2.817 ± 0.055	2.96ArgLys: 2.96 ± 0.047	2.991ArgLeu: 2.991 ± 0.059	0.871ArgMet: 0.871 ± 0.034	2.328ArgAsn: 2.328 ± 0.042	1.019ArgPro: 1.019 ± 0.036	1.144ArgGln: 1.144 ± 0.038	1.203ArgArg: 1.203 ± 0.034	1.852ArgSer: 1.852 ± 0.047	1.74ArgThr: 1.74 ± 0.042	1.786ArgVal: 1.786 ± 0.045	0.329ArgTrp: 0.329 ± 0.017	1.341ArgTyr: 1.341 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.242SerAla: 4.242 ± 0.069	0.568SerCys: 0.568 ± 0.023	3.749SerAsp: 3.749 ± 0.057	4.791SerGlu: 4.791 ± 0.077	3.903SerPhe: 3.903 ± 0.056	4.821SerGly: 4.821 ± 0.079	1.079SerHis: 1.079 ± 0.029	5.082SerIle: 5.082 ± 0.067	5.447SerLys: 5.447 ± 0.081	6.257SerLeu: 6.257 ± 0.073	1.248SerMet: 1.248 ± 0.036	3.977SerAsn: 3.977 ± 0.069	2.205SerPro: 2.205 ± 0.047	2.578SerGln: 2.578 ± 0.045	2.045SerArg: 2.045 ± 0.042	4.323SerSer: 4.323 ± 0.087	3.568SerThr: 3.568 ± 0.069	4.246SerVal: 4.246 ± 0.063	0.681SerTrp: 0.681 ± 0.025	2.741SerTyr: 2.741 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.667ThrAla: 3.667 ± 0.066	0.309ThrCys: 0.309 ± 0.018	3.238ThrAsp: 3.238 ± 0.059	3.752ThrGlu: 3.752 ± 0.065	2.956ThrPhe: 2.956 ± 0.056	3.871ThrGly: 3.871 ± 0.073	0.789ThrHis: 0.789 ± 0.029	4.227ThrIle: 4.227 ± 0.068	4.075ThrLys: 4.075 ± 0.063	4.932ThrLeu: 4.932 ± 0.075	0.943ThrMet: 0.943 ± 0.029	3.175ThrAsn: 3.175 ± 0.068	2.15ThrPro: 2.15 ± 0.048	1.808ThrGln: 1.808 ± 0.043	1.558ThrArg: 1.558 ± 0.035	3.688ThrSer: 3.688 ± 0.066	3.157ThrThr: 3.157 ± 0.071	3.363ThrVal: 3.363 ± 0.066	0.509ThrTrp: 0.509 ± 0.025	2.222ThrTyr: 2.222 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.035ValAla: 4.035 ± 0.07	0.47ValCys: 0.47 ± 0.024	3.35ValAsp: 3.35 ± 0.055	3.963ValGlu: 3.963 ± 0.07	3.388ValPhe: 3.388 ± 0.064	3.643ValGly: 3.643 ± 0.065	0.851ValHis: 0.851 ± 0.03	4.507ValIle: 4.507 ± 0.061	4.741ValLys: 4.741 ± 0.067	5.492ValLeu: 5.492 ± 0.076	1.369ValMet: 1.369 ± 0.04	3.607ValAsn: 3.607 ± 0.062	2.018ValPro: 2.018 ± 0.051	1.718ValGln: 1.718 ± 0.04	1.898ValArg: 1.898 ± 0.042	4.371ValSer: 4.371 ± 0.062	3.201ValThr: 3.201 ± 0.065	3.896ValVal: 3.896 ± 0.073	0.592ValTrp: 0.592 ± 0.025	2.344ValTyr: 2.344 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.558TrpAla: 0.558 ± 0.024	0.077TrpCys: 0.077 ± 0.009	0.58TrpAsp: 0.58 ± 0.027	0.734TrpGlu: 0.734 ± 0.028	0.596TrpPhe: 0.596 ± 0.026	0.634TrpGly: 0.634 ± 0.031	0.186TrpHis: 0.186 ± 0.014	0.756TrpIle: 0.756 ± 0.025	1.027TrpLys: 1.027 ± 0.035	0.862TrpLeu: 0.862 ± 0.031	0.315TrpMet: 0.315 ± 0.018	0.764TrpAsn: 0.764 ± 0.026	0.19TrpPro: 0.19 ± 0.014	0.412TrpGln: 0.412 ± 0.02	0.339TrpArg: 0.339 ± 0.017	0.631TrpSer: 0.631 ± 0.024	0.55TrpThr: 0.55 ± 0.024	0.539TrpVal: 0.539 ± 0.023	0.138TrpTrp: 0.138 ± 0.012	0.373TrpTyr: 0.373 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.25TyrAla: 2.25 ± 0.045	0.31TyrCys: 0.31 ± 0.017	2.403TyrAsp: 2.403 ± 0.041	2.493TyrGlu: 2.493 ± 0.052	2.717TyrPhe: 2.717 ± 0.055	2.483TyrGly: 2.483 ± 0.052	0.788TyrHis: 0.788 ± 0.029	2.814TyrIle: 2.814 ± 0.053	3.207TyrLys: 3.207 ± 0.062	3.915TyrLeu: 3.915 ± 0.069	0.695TyrMet: 0.695 ± 0.023	2.671TyrAsn: 2.671 ± 0.059	1.503TyrPro: 1.503 ± 0.036	1.837TyrGln: 1.837 ± 0.043	1.537TyrArg: 1.537 ± 0.043	2.893TyrSer: 2.893 ± 0.046	2.09TyrThr: 2.09 ± 0.046	2.041TyrVal: 2.041 ± 0.046	0.452TyrTrp: 0.452 ± 0.023	1.935TyrTyr: 1.935 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3367 proteins (1084421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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