Amino acid dipepetide frequency for Hanstruepera neustonica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.923AlaAla: 3.923 ± 0.086
0.626AlaCys: 0.626 ± 0.034
3.259AlaAsp: 3.259 ± 0.064
3.803AlaGlu: 3.803 ± 0.085
3.402AlaPhe: 3.402 ± 0.065
3.9AlaGly: 3.9 ± 0.091
1.151AlaHis: 1.151 ± 0.036
5.457AlaIle: 5.457 ± 0.101
4.307AlaLys: 4.307 ± 0.074
6.088AlaLeu: 6.088 ± 0.107
1.477AlaMet: 1.477 ± 0.043
3.6AlaAsn: 3.6 ± 0.062
1.96AlaPro: 1.96 ± 0.078
2.338AlaGln: 2.338 ± 0.057
1.826AlaArg: 1.826 ± 0.047
4.138AlaSer: 4.138 ± 0.072
3.769AlaThr: 3.769 ± 0.098
3.991AlaVal: 3.991 ± 0.07
0.584AlaTrp: 0.584 ± 0.024
2.449AlaTyr: 2.449 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.509CysAla: 0.509 ± 0.027
0.099CysCys: 0.099 ± 0.011
0.573CysAsp: 0.573 ± 0.05
0.453CysGlu: 0.453 ± 0.028
0.443CysPhe: 0.443 ± 0.023
0.711CysGly: 0.711 ± 0.047
0.229CysHis: 0.229 ± 0.034
0.563CysIle: 0.563 ± 0.03
0.464CysLys: 0.464 ± 0.024
0.682CysLeu: 0.682 ± 0.032
0.15CysMet: 0.15 ± 0.011
0.56CysAsn: 0.56 ± 0.048
0.388CysPro: 0.388 ± 0.031
0.255CysGln: 0.255 ± 0.019
0.168CysArg: 0.168 ± 0.014
0.629CysSer: 0.629 ± 0.038
0.43CysThr: 0.43 ± 0.033
0.486CysVal: 0.486 ± 0.026
0.059CysTrp: 0.059 ± 0.008
0.297CysTyr: 0.297 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.895AspAla: 3.895 ± 0.081
0.567AspCys: 0.567 ± 0.047
3.689AspAsp: 3.689 ± 0.098
3.768AspGlu: 3.768 ± 0.061
3.721AspPhe: 3.721 ± 0.065
3.928AspGly: 3.928 ± 0.111
0.939AspHis: 0.939 ± 0.034
4.966AspIle: 4.966 ± 0.072
3.993AspLys: 3.993 ± 0.083
5.465AspLeu: 5.465 ± 0.087
1.333AspMet: 1.333 ± 0.039
3.838AspAsn: 3.838 ± 0.095
1.78AspPro: 1.78 ± 0.067
1.493AspGln: 1.493 ± 0.048
1.83AspArg: 1.83 ± 0.05
3.786AspSer: 3.786 ± 0.076
3.027AspThr: 3.027 ± 0.071
4.005AspVal: 4.005 ± 0.08
0.727AspTrp: 0.727 ± 0.032
3.095AspTyr: 3.095 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
4.527GluAla: 4.527 ± 0.095
0.339GluCys: 0.339 ± 0.026
3.651GluAsp: 3.651 ± 0.076
4.379GluGlu: 4.379 ± 0.101
3.055GluPhe: 3.055 ± 0.068
3.557GluGly: 3.557 ± 0.06
1.198GluHis: 1.198 ± 0.04
5.093GluIle: 5.093 ± 0.085
4.942GluLys: 4.942 ± 0.106
6.108GluLeu: 6.108 ± 0.093
1.434GluMet: 1.434 ± 0.04
4.507GluAsn: 4.507 ± 0.073
1.777GluPro: 1.777 ± 0.053
2.259GluGln: 2.259 ± 0.06
2.48GluArg: 2.48 ± 0.063
3.711GluSer: 3.711 ± 0.064
3.992GluThr: 3.992 ± 0.068
4.204GluVal: 4.204 ± 0.077
0.586GluTrp: 0.586 ± 0.024
2.308GluTyr: 2.308 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
2.826PheAla: 2.826 ± 0.064
0.435PheCys: 0.435 ± 0.023
3.62PheAsp: 3.62 ± 0.067
3.457PheGlu: 3.457 ± 0.066
2.663PhePhe: 2.663 ± 0.073
3.733PheGly: 3.733 ± 0.067
0.857PheHis: 0.857 ± 0.03
3.986PheIle: 3.986 ± 0.069
3.871PheLys: 3.871 ± 0.073
4.52PheLeu: 4.52 ± 0.091
1.159PheMet: 1.159 ± 0.039
3.539PheAsn: 3.539 ± 0.068
1.638PhePro: 1.638 ± 0.044
1.609PheGln: 1.609 ± 0.041
1.589PheArg: 1.589 ± 0.05
3.889PheSer: 3.889 ± 0.071
3.119PheThr: 3.119 ± 0.08
3.037PheVal: 3.037 ± 0.061
0.57PheTrp: 0.57 ± 0.027
2.185PheTyr: 2.185 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
3.954GlyAla: 3.954 ± 0.091
0.723GlyCys: 0.723 ± 0.071
3.661GlyAsp: 3.661 ± 0.098
3.618GlyGlu: 3.618 ± 0.065
3.707GlyPhe: 3.707 ± 0.067
4.516GlyGly: 4.516 ± 0.106
1.233GlyHis: 1.233 ± 0.039
5.145GlyIle: 5.145 ± 0.078
4.328GlyLys: 4.328 ± 0.079
5.671GlyLeu: 5.671 ± 0.093
1.644GlyMet: 1.644 ± 0.048
3.909GlyAsn: 3.909 ± 0.105
1.416GlyPro: 1.416 ± 0.047
2.03GlyGln: 2.03 ± 0.048
1.99GlyArg: 1.99 ± 0.052
4.162GlySer: 4.162 ± 0.095
4.09GlyThr: 4.09 ± 0.124
4.267GlyVal: 4.267 ± 0.073
0.725GlyTrp: 0.725 ± 0.032
2.903GlyTyr: 2.903 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.018HisAla: 1.018 ± 0.036
0.174HisCys: 0.174 ± 0.013
1.036HisAsp: 1.036 ± 0.036
1.091HisGlu: 1.091 ± 0.038
1.155HisPhe: 1.155 ± 0.034
1.111HisGly: 1.111 ± 0.037
0.468HisHis: 0.468 ± 0.023
1.578HisIle: 1.578 ± 0.046
1.162HisLys: 1.162 ± 0.038
1.78HisLeu: 1.78 ± 0.051
0.335HisMet: 0.335 ± 0.018
1.059HisAsn: 1.059 ± 0.035
0.796HisPro: 0.796 ± 0.033
0.696HisGln: 0.696 ± 0.031
0.611HisArg: 0.611 ± 0.027
1.005HisSer: 1.005 ± 0.032
0.973HisThr: 0.973 ± 0.036
1.134HisVal: 1.134 ± 0.038
0.206HisTrp: 0.206 ± 0.015
0.869HisTyr: 0.869 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.367IleAla: 5.367 ± 0.087
0.652IleCys: 0.652 ± 0.03
5.265IleAsp: 5.265 ± 0.079
5.42IleGlu: 5.42 ± 0.093
3.588IlePhe: 3.588 ± 0.072
5.191IleGly: 5.191 ± 0.09
1.286IleHis: 1.286 ± 0.038
6.144IleIle: 6.144 ± 0.113
5.523IleLys: 5.523 ± 0.09
6.992IleLeu: 6.992 ± 0.112
1.52IleMet: 1.52 ± 0.04
4.943IleAsn: 4.943 ± 0.085
3.233IlePro: 3.233 ± 0.054
2.71IleGln: 2.71 ± 0.051
2.335IleArg: 2.335 ± 0.053
5.744IleSer: 5.744 ± 0.091
5.1IleThr: 5.1 ± 0.095
5.058IleVal: 5.058 ± 0.079
0.697IleTrp: 0.697 ± 0.028
2.799IleTyr: 2.799 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.628LysAla: 4.628 ± 0.094
0.298LysCys: 0.298 ± 0.018
4.179LysAsp: 4.179 ± 0.086
5.148LysGlu: 5.148 ± 0.11
2.697LysPhe: 2.697 ± 0.06
4.05LysGly: 4.05 ± 0.072
1.512LysHis: 1.512 ± 0.044
5.459LysIle: 5.459 ± 0.085
5.967LysLys: 5.967 ± 0.096
6.46LysLeu: 6.46 ± 0.09
1.789LysMet: 1.789 ± 0.047
4.72LysAsn: 4.72 ± 0.082
2.578LysPro: 2.578 ± 0.052
2.922LysGln: 2.922 ± 0.069
2.881LysArg: 2.881 ± 0.054
4.507LysSer: 4.507 ± 0.087
4.581LysThr: 4.581 ± 0.09
4.185LysVal: 4.185 ± 0.09
0.699LysTrp: 0.699 ± 0.031
2.843LysTyr: 2.843 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
5.558LeuAla: 5.558 ± 0.087
0.653LeuCys: 0.653 ± 0.027
5.305LeuAsp: 5.305 ± 0.083
6.105LeuGlu: 6.105 ± 0.09
4.93LeuPhe: 4.93 ± 0.101
5.716LeuGly: 5.716 ± 0.098
1.529LeuHis: 1.529 ± 0.044
7.095LeuIle: 7.095 ± 0.123
7.635LeuLys: 7.635 ± 0.108
8.255LeuLeu: 8.255 ± 0.138
2.093LeuMet: 2.093 ± 0.047
6.053LeuAsn: 6.053 ± 0.097
3.401LeuPro: 3.401 ± 0.064
3.175LeuGln: 3.175 ± 0.062
2.97LeuArg: 2.97 ± 0.063
6.401LeuSer: 6.401 ± 0.085
5.036LeuThr: 5.036 ± 0.089
5.499LeuVal: 5.499 ± 0.091
0.781LeuTrp: 0.781 ± 0.033
3.106LeuTyr: 3.106 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.623MetAla: 1.623 ± 0.05
0.141MetCys: 0.141 ± 0.012
1.25MetAsp: 1.25 ± 0.034
1.346MetGlu: 1.346 ± 0.043
0.935MetPhe: 0.935 ± 0.033
1.373MetGly: 1.373 ± 0.046
0.429MetHis: 0.429 ± 0.02
1.509MetIle: 1.509 ± 0.049
2.037MetLys: 2.037 ± 0.045
2.052MetLeu: 2.052 ± 0.052
0.609MetMet: 0.609 ± 0.029
1.266MetAsn: 1.266 ± 0.039
0.914MetPro: 0.914 ± 0.033
0.855MetGln: 0.855 ± 0.033
0.882MetArg: 0.882 ± 0.034
1.494MetSer: 1.494 ± 0.041
1.28MetThr: 1.28 ± 0.042
1.457MetVal: 1.457 ± 0.043
0.15MetTrp: 0.15 ± 0.014
0.737MetTyr: 0.737 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.915AsnAla: 3.915 ± 0.076
0.622AsnCys: 0.622 ± 0.051
3.926AsnAsp: 3.926 ± 0.071
3.671AsnGlu: 3.671 ± 0.077
2.994AsnPhe: 2.994 ± 0.064
4.353AsnGly: 4.353 ± 0.111
1.214AsnHis: 1.214 ± 0.038
5.031AsnIle: 5.031 ± 0.078
4.164AsnLys: 4.164 ± 0.083
5.51AsnLeu: 5.51 ± 0.09
1.488AsnMet: 1.488 ± 0.043
4.514AsnAsn: 4.514 ± 0.107
3.015AsnPro: 3.015 ± 0.076
2.583AsnGln: 2.583 ± 0.058
2.222AsnArg: 2.222 ± 0.061
4.054AsnSer: 4.054 ± 0.091
3.927AsnThr: 3.927 ± 0.083
3.639AsnVal: 3.639 ± 0.067
0.844AsnTrp: 0.844 ± 0.035
3.004AsnTyr: 3.004 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
1.781ProAla: 1.781 ± 0.063
0.281ProCys: 0.281 ± 0.022
2.121ProAsp: 2.121 ± 0.056
2.871ProGlu: 2.871 ± 0.061
1.936ProPhe: 1.936 ± 0.043
1.913ProGly: 1.913 ± 0.066
0.603ProHis: 0.603 ± 0.024
2.783ProIle: 2.783 ± 0.054
2.559ProLys: 2.559 ± 0.056
2.919ProLeu: 2.919 ± 0.061
0.744ProMet: 0.744 ± 0.034
2.539ProAsn: 2.539 ± 0.058
0.904ProPro: 0.904 ± 0.047
1.169ProGln: 1.169 ± 0.037
0.895ProArg: 0.895 ± 0.029
2.151ProSer: 2.151 ± 0.056
1.99ProThr: 1.99 ± 0.057
2.369ProVal: 2.369 ± 0.061
0.293ProTrp: 0.293 ± 0.018
1.45ProTyr: 1.45 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.253GlnAla: 2.253 ± 0.059
0.2GlnCys: 0.2 ± 0.019
2.026GlnAsp: 2.026 ± 0.059
2.476GlnGlu: 2.476 ± 0.064
1.757GlnPhe: 1.757 ± 0.045
1.881GlnGly: 1.881 ± 0.05
0.586GlnHis: 0.586 ± 0.026
2.752GlnIle: 2.752 ± 0.054
2.507GlnLys: 2.507 ± 0.053
3.366GlnLeu: 3.366 ± 0.057
0.827GlnMet: 0.827 ± 0.032
2.296GlnAsn: 2.296 ± 0.055
1.094GlnPro: 1.094 ± 0.034
1.436GlnGln: 1.436 ± 0.052
1.161GlnArg: 1.161 ± 0.035
2.091GlnSer: 2.091 ± 0.046
2.15GlnThr: 2.15 ± 0.061
2.229GlnVal: 2.229 ± 0.053
0.35GlnTrp: 0.35 ± 0.02
1.396GlnTyr: 1.396 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
1.969ArgAla: 1.969 ± 0.049
0.174ArgCys: 0.174 ± 0.014
1.907ArgAsp: 1.907 ± 0.045
2.077ArgGlu: 2.077 ± 0.052
1.791ArgPhe: 1.791 ± 0.051
1.814ArgGly: 1.814 ± 0.052
0.622ArgHis: 0.622 ± 0.027
2.736ArgIle: 2.736 ± 0.058
2.471ArgLys: 2.471 ± 0.061
3.162ArgLeu: 3.162 ± 0.068
0.857ArgMet: 0.857 ± 0.034
2.012ArgAsn: 2.012 ± 0.044
1.028ArgPro: 1.028 ± 0.036
1.172ArgGln: 1.172 ± 0.036
1.247ArgArg: 1.247 ± 0.049
1.791ArgSer: 1.791 ± 0.048
1.705ArgThr: 1.705 ± 0.048
2.101ArgVal: 2.101 ± 0.05
0.363ArgTrp: 0.363 ± 0.019
1.54ArgTyr: 1.54 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
3.637SerAla: 3.637 ± 0.069
0.675SerCys: 0.675 ± 0.03
3.817SerAsp: 3.817 ± 0.083
4.168SerGlu: 4.168 ± 0.077
3.65SerPhe: 3.65 ± 0.068
4.776SerGly: 4.776 ± 0.103
1.189SerHis: 1.189 ± 0.039
5.266SerIle: 5.266 ± 0.072
4.779SerLys: 4.779 ± 0.081
5.958SerLeu: 5.958 ± 0.098
1.316SerMet: 1.316 ± 0.039
4.343SerAsn: 4.343 ± 0.084
2.075SerPro: 2.075 ± 0.061
2.504SerGln: 2.504 ± 0.051
1.992SerArg: 1.992 ± 0.045
4.171SerSer: 4.171 ± 0.101
3.459SerThr: 3.459 ± 0.078
4.165SerVal: 4.165 ± 0.074
0.708SerTrp: 0.708 ± 0.026
2.723SerTyr: 2.723 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
3.647ThrAla: 3.647 ± 0.092
0.517ThrCys: 0.517 ± 0.042
3.55ThrAsp: 3.55 ± 0.102
3.38ThrGlu: 3.38 ± 0.067
3.312ThrPhe: 3.312 ± 0.078
4.024ThrGly: 4.024 ± 0.096
1.027ThrHis: 1.027 ± 0.038
5.368ThrIle: 5.368 ± 0.089
3.562ThrLys: 3.562 ± 0.07
5.478ThrLeu: 5.478 ± 0.078
1.073ThrMet: 1.073 ± 0.039
3.621ThrAsn: 3.621 ± 0.074
2.374ThrPro: 2.374 ± 0.072
1.876ThrGln: 1.876 ± 0.046
1.584ThrArg: 1.584 ± 0.05
3.755ThrSer: 3.755 ± 0.078
3.741ThrThr: 3.741 ± 0.102
4.329ThrVal: 4.329 ± 0.129
0.709ThrTrp: 0.709 ± 0.06
2.659ThrTyr: 2.659 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
4.116ValAla: 4.116 ± 0.065
0.547ValCys: 0.547 ± 0.028
3.911ValAsp: 3.911 ± 0.077
3.991ValGlu: 3.991 ± 0.076
3.541ValPhe: 3.541 ± 0.073
3.968ValGly: 3.968 ± 0.076
1.02ValHis: 1.02 ± 0.032
5.016ValIle: 5.016 ± 0.076
4.196ValLys: 4.196 ± 0.076
5.993ValLeu: 5.993 ± 0.087
1.407ValMet: 1.407 ± 0.043
3.838ValAsn: 3.838 ± 0.063
2.197ValPro: 2.197 ± 0.055
1.739ValGln: 1.739 ± 0.043
1.972ValArg: 1.972 ± 0.049
4.569ValSer: 4.569 ± 0.085
4.116ValThr: 4.116 ± 0.116
4.498ValVal: 4.498 ± 0.091
0.571ValTrp: 0.571 ± 0.026
2.41ValTyr: 2.41 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.547TrpAla: 0.547 ± 0.025
0.098TrpCys: 0.098 ± 0.011
0.629TrpAsp: 0.629 ± 0.028
0.621TrpGlu: 0.621 ± 0.026
0.599TrpPhe: 0.599 ± 0.026
0.574TrpGly: 0.574 ± 0.03
0.24TrpHis: 0.24 ± 0.016
0.742TrpIle: 0.742 ± 0.028
0.723TrpLys: 0.723 ± 0.031
0.945TrpLeu: 0.945 ± 0.032
0.298TrpMet: 0.298 ± 0.018
0.737TrpAsn: 0.737 ± 0.03
0.225TrpPro: 0.225 ± 0.017
0.412TrpGln: 0.412 ± 0.023
0.379TrpArg: 0.379 ± 0.022
0.63TrpSer: 0.63 ± 0.029
0.644TrpThr: 0.644 ± 0.052
0.609TrpVal: 0.609 ± 0.029
0.136TrpTrp: 0.136 ± 0.013
0.447TrpTyr: 0.447 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.355TyrAla: 2.355 ± 0.053
0.33TyrCys: 0.33 ± 0.02
2.469TyrAsp: 2.469 ± 0.061
2.263TyrGlu: 2.263 ± 0.057
2.427TyrPhe: 2.427 ± 0.058
2.602TyrGly: 2.602 ± 0.06
0.926TyrHis: 0.926 ± 0.03
2.877TyrIle: 2.877 ± 0.061
2.912TyrLys: 2.912 ± 0.061
3.892TyrLeu: 3.892 ± 0.069
0.785TyrMet: 0.785 ± 0.028
2.798TyrAsn: 2.798 ± 0.059
1.475TyrPro: 1.475 ± 0.039
1.601TyrGln: 1.601 ± 0.044
1.525TyrArg: 1.525 ± 0.047
2.694TyrSer: 2.694 ± 0.057
2.458TyrThr: 2.458 ± 0.091
2.354TyrVal: 2.354 ± 0.051
0.475TyrTrp: 0.475 ± 0.024
1.936TyrTyr: 1.936 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2739 proteins (942191 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski