Amino acid dipepetide frequency for Streptomyces monashensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.788AlaAla: 21.788 ± 0.134	1.144AlaCys: 1.144 ± 0.02	8.541AlaAsp: 8.541 ± 0.059	8.768AlaGlu: 8.768 ± 0.087	3.603AlaPhe: 3.603 ± 0.038	13.288AlaGly: 13.288 ± 0.088	3.202AlaHis: 3.202 ± 0.038	3.273AlaIle: 3.273 ± 0.04	2.676AlaLys: 2.676 ± 0.041	15.034AlaLeu: 15.034 ± 0.106	2.434AlaMet: 2.434 ± 0.03	1.903AlaAsn: 1.903 ± 0.032	7.229AlaPro: 7.229 ± 0.072	3.972AlaGln: 3.972 ± 0.038	10.899AlaArg: 10.899 ± 0.079	5.906AlaSer: 5.906 ± 0.059	7.001AlaThr: 7.001 ± 0.059	12.588AlaVal: 12.588 ± 0.081	1.931AlaTrp: 1.931 ± 0.031	2.827AlaTyr: 2.827 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.178CysAla: 1.178 ± 0.02	0.103CysCys: 0.103 ± 0.007	0.493CysAsp: 0.493 ± 0.013	0.402CysGlu: 0.402 ± 0.011	0.225CysPhe: 0.225 ± 0.01	1.001CysGly: 1.001 ± 0.021	0.209CysHis: 0.209 ± 0.009	0.159CysIle: 0.159 ± 0.008	0.113CysLys: 0.113 ± 0.007	0.799CysLeu: 0.799 ± 0.017	0.124CysMet: 0.124 ± 0.007	0.15CysAsn: 0.15 ± 0.008	0.508CysPro: 0.508 ± 0.015	0.175CysGln: 0.175 ± 0.008	0.639CysArg: 0.639 ± 0.015	0.451CysSer: 0.451 ± 0.012	0.55CysThr: 0.55 ± 0.014	0.678CysVal: 0.678 ± 0.017	0.137CysTrp: 0.137 ± 0.008	0.149CysTyr: 0.149 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.702AspAla: 7.702 ± 0.066	0.439AspCys: 0.439 ± 0.014	3.459AspAsp: 3.459 ± 0.043	3.582AspGlu: 3.582 ± 0.043	1.641AspPhe: 1.641 ± 0.031	6.319AspGly: 6.319 ± 0.059	1.498AspHis: 1.498 ± 0.023	1.818AspIle: 1.818 ± 0.025	1.086AspLys: 1.086 ± 0.024	6.271AspLeu: 6.271 ± 0.046	0.817AspMet: 0.817 ± 0.018	0.947AspAsn: 0.947 ± 0.022	4.455AspPro: 4.455 ± 0.039	1.542AspGln: 1.542 ± 0.027	4.91AspArg: 4.91 ± 0.045	2.52AspSer: 2.52 ± 0.034	3.36AspThr: 3.36 ± 0.034	4.696AspVal: 4.696 ± 0.043	1.036AspTrp: 1.036 ± 0.021	1.126AspTyr: 1.126 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.147GluAla: 7.147 ± 0.072	0.368GluCys: 0.368 ± 0.011	2.709GluAsp: 2.709 ± 0.04	3.373GluGlu: 3.373 ± 0.049	1.427GluPhe: 1.427 ± 0.024	4.037GluGly: 4.037 ± 0.042	1.56GluHis: 1.56 ± 0.023	2.09GluIle: 2.09 ± 0.03	1.291GluLys: 1.291 ± 0.025	6.705GluLeu: 6.705 ± 0.058	0.839GluMet: 0.839 ± 0.018	0.95GluAsn: 0.95 ± 0.02	3.281GluPro: 3.281 ± 0.034	2.228GluGln: 2.228 ± 0.03	5.429GluArg: 5.429 ± 0.056	2.404GluSer: 2.404 ± 0.03	2.764GluThr: 2.764 ± 0.035	4.231GluVal: 4.231 ± 0.042	0.729GluTrp: 0.729 ± 0.018	1.049GluTyr: 1.049 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.805PheAla: 3.805 ± 0.039	0.274PheCys: 0.274 ± 0.011	1.913PheAsp: 1.913 ± 0.033	1.363PheGlu: 1.363 ± 0.024	0.882PhePhe: 0.882 ± 0.022	2.96PheGly: 2.96 ± 0.039	0.64PheHis: 0.64 ± 0.014	0.639PheIle: 0.639 ± 0.018	0.471PheLys: 0.471 ± 0.013	2.647PheLeu: 2.647 ± 0.04	0.395PheMet: 0.395 ± 0.015	0.554PheAsn: 0.554 ± 0.017	1.39PhePro: 1.39 ± 0.023	0.688PheGln: 0.688 ± 0.015	1.843PheArg: 1.843 ± 0.027	1.479PheSer: 1.479 ± 0.024	2.065PheThr: 2.065 ± 0.031	2.198PheVal: 2.198 ± 0.029	0.411PheTrp: 0.411 ± 0.013	0.589PheTyr: 0.589 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.272GlyAla: 11.272 ± 0.073	0.854GlyCys: 0.854 ± 0.02	5.027GlyAsp: 5.027 ± 0.04	4.892GlyGlu: 4.892 ± 0.048	2.837GlyPhe: 2.837 ± 0.033	8.637GlyGly: 8.637 ± 0.082	2.539GlyHis: 2.539 ± 0.032	3.435GlyIle: 3.435 ± 0.036	2.226GlyLys: 2.226 ± 0.035	9.558GlyLeu: 9.558 ± 0.074	1.973GlyMet: 1.973 ± 0.031	1.693GlyAsn: 1.693 ± 0.025	5.192GlyPro: 5.192 ± 0.049	2.663GlyGln: 2.663 ± 0.031	7.953GlyArg: 7.953 ± 0.064	5.289GlySer: 5.289 ± 0.049	6.663GlyThr: 6.663 ± 0.055	7.456GlyVal: 7.456 ± 0.052	1.703GlyTrp: 1.703 ± 0.025	2.319GlyTyr: 2.319 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.926HisAla: 2.926 ± 0.032	0.243HisCys: 0.243 ± 0.009	1.412HisAsp: 1.412 ± 0.023	1.263HisGlu: 1.263 ± 0.023	0.667HisPhe: 0.667 ± 0.016	2.621HisGly: 2.621 ± 0.037	0.778HisHis: 0.778 ± 0.017	0.704HisIle: 0.704 ± 0.018	0.372HisLys: 0.372 ± 0.012	2.574HisLeu: 2.574 ± 0.035	0.337HisMet: 0.337 ± 0.011	0.376HisAsn: 0.376 ± 0.013	1.916HisPro: 1.916 ± 0.031	0.659HisGln: 0.659 ± 0.017	2.197HisArg: 2.197 ± 0.03	1.074HisSer: 1.074 ± 0.019	1.521HisThr: 1.521 ± 0.027	1.865HisVal: 1.865 ± 0.027	0.401HisTrp: 0.401 ± 0.012	0.518HisTyr: 0.518 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.627IleAla: 4.627 ± 0.047	0.27IleCys: 0.27 ± 0.01	2.133IleAsp: 2.133 ± 0.028	1.845IleGlu: 1.845 ± 0.027	0.639IlePhe: 0.639 ± 0.017	3.425IleGly: 3.425 ± 0.041	0.607IleHis: 0.607 ± 0.015	0.815IleIle: 0.815 ± 0.017	0.676IleLys: 0.676 ± 0.015	2.345IleLeu: 2.345 ± 0.03	0.427IleMet: 0.427 ± 0.013	0.634IleAsn: 0.634 ± 0.019	1.738IlePro: 1.738 ± 0.029	0.719IleGln: 0.719 ± 0.018	2.255IleArg: 2.255 ± 0.031	1.626IleSer: 1.626 ± 0.027	2.204IleThr: 2.204 ± 0.028	2.609IleVal: 2.609 ± 0.031	0.366IleTrp: 0.366 ± 0.012	0.506IleTyr: 0.506 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.807LysAla: 2.807 ± 0.045	0.105LysCys: 0.105 ± 0.007	1.271LysAsp: 1.271 ± 0.026	1.073LysGlu: 1.073 ± 0.023	0.418LysPhe: 0.418 ± 0.015	1.717LysGly: 1.717 ± 0.027	0.415LysHis: 0.415 ± 0.013	0.816LysIle: 0.816 ± 0.018	0.801LysLys: 0.801 ± 0.023	1.884LysLeu: 1.884 ± 0.029	0.354LysMet: 0.354 ± 0.013	0.523LysAsn: 0.523 ± 0.016	1.21LysPro: 1.21 ± 0.024	0.693LysGln: 0.693 ± 0.016	1.341LysArg: 1.341 ± 0.022	1.06LysSer: 1.06 ± 0.022	1.22LysThr: 1.22 ± 0.024	1.771LysVal: 1.771 ± 0.033	0.243LysTrp: 0.243 ± 0.009	0.43LysTyr: 0.43 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.64LeuAla: 15.64 ± 0.091	0.868LeuCys: 0.868 ± 0.019	6.799LeuAsp: 6.799 ± 0.052	4.575LeuGlu: 4.575 ± 0.048	2.638LeuPhe: 2.638 ± 0.039	9.394LeuGly: 9.394 ± 0.063	2.5LeuHis: 2.5 ± 0.03	3.193LeuIle: 3.193 ± 0.042	1.976LeuLys: 1.976 ± 0.033	11.711LeuLeu: 11.711 ± 0.098	1.565LeuMet: 1.565 ± 0.023	1.695LeuAsn: 1.695 ± 0.024	6.746LeuPro: 6.746 ± 0.055	2.227LeuGln: 2.227 ± 0.028	8.902LeuArg: 8.902 ± 0.08	5.311LeuSer: 5.311 ± 0.045	7.096LeuThr: 7.096 ± 0.054	8.896LeuVal: 8.896 ± 0.067	1.331LeuTrp: 1.331 ± 0.023	1.923LeuTyr: 1.923 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.186MetAla: 2.186 ± 0.032	0.149MetCys: 0.149 ± 0.008	0.872MetAsp: 0.872 ± 0.019	0.703MetGlu: 0.703 ± 0.017	0.455MetPhe: 0.455 ± 0.012	1.229MetGly: 1.229 ± 0.024	0.357MetHis: 0.357 ± 0.012	0.652MetIle: 0.652 ± 0.016	0.387MetLys: 0.387 ± 0.013	1.635MetLeu: 1.635 ± 0.026	0.275MetMet: 0.275 ± 0.012	0.436MetAsn: 0.436 ± 0.013	1.091MetPro: 1.091 ± 0.023	0.442MetGln: 0.442 ± 0.012	1.399MetArg: 1.399 ± 0.022	1.295MetSer: 1.295 ± 0.022	1.542MetThr: 1.542 ± 0.024	1.229MetVal: 1.229 ± 0.025	0.217MetTrp: 0.217 ± 0.009	0.32MetTyr: 0.32 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.13AsnAla: 2.13 ± 0.028	0.164AsnCys: 0.164 ± 0.007	0.951AsnAsp: 0.951 ± 0.023	0.76AsnGlu: 0.76 ± 0.019	0.463AsnPhe: 0.463 ± 0.015	1.893AsnGly: 1.893 ± 0.03	0.408AsnHis: 0.408 ± 0.014	0.629AsnIle: 0.629 ± 0.016	0.389AsnLys: 0.389 ± 0.015	1.599AsnLeu: 1.599 ± 0.027	0.293AsnMet: 0.293 ± 0.011	0.414AsnAsn: 0.414 ± 0.014	1.331AsnPro: 1.331 ± 0.024	0.532AsnGln: 0.532 ± 0.017	1.243AsnArg: 1.243 ± 0.021	0.948AsnSer: 0.948 ± 0.019	1.096AsnThr: 1.096 ± 0.025	1.341AsnVal: 1.341 ± 0.026	0.293AsnTrp: 0.293 ± 0.011	0.407AsnTyr: 0.407 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.985ProAla: 8.985 ± 0.074	0.396ProCys: 0.396 ± 0.014	4.536ProAsp: 4.536 ± 0.04	4.14ProGlu: 4.14 ± 0.044	1.54ProPhe: 1.54 ± 0.022	6.72ProGly: 6.72 ± 0.066	1.51ProHis: 1.51 ± 0.03	1.202ProIle: 1.202 ± 0.025	1.12ProLys: 1.12 ± 0.023	5.432ProLeu: 5.432 ± 0.049	0.966ProMet: 0.966 ± 0.017	0.891ProAsn: 0.891 ± 0.019	3.456ProPro: 3.456 ± 0.055	1.853ProGln: 1.853 ± 0.036	4.087ProArg: 4.087 ± 0.041	3.097ProSer: 3.097 ± 0.04	3.118ProThr: 3.118 ± 0.038	5.646ProVal: 5.646 ± 0.055	0.913ProTrp: 0.913 ± 0.019	1.458ProTyr: 1.458 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.865GlnAla: 3.865 ± 0.045	0.19GlnCys: 0.19 ± 0.008	1.431GlnAsp: 1.431 ± 0.023	1.454GlnGlu: 1.454 ± 0.024	0.687GlnPhe: 0.687 ± 0.017	2.359GlnGly: 2.359 ± 0.035	0.713GlnHis: 0.713 ± 0.017	1.062GlnIle: 1.062 ± 0.021	0.628GlnLys: 0.628 ± 0.018	3.13GlnLeu: 3.13 ± 0.033	0.506GlnMet: 0.506 ± 0.014	0.506GlnAsn: 0.506 ± 0.015	1.733GlnPro: 1.733 ± 0.034	1.275GlnGln: 1.275 ± 0.028	2.374GlnArg: 2.374 ± 0.03	1.309GlnSer: 1.309 ± 0.022	1.392GlnThr: 1.392 ± 0.023	2.384GlnVal: 2.384 ± 0.028	0.498GlnTrp: 0.498 ± 0.013	0.614GlnTyr: 0.614 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.353ArgAla: 10.353 ± 0.083	0.633ArgCys: 0.633 ± 0.016	4.221ArgAsp: 4.221 ± 0.036	4.723ArgGlu: 4.723 ± 0.051	2.346ArgPhe: 2.346 ± 0.031	5.792ArgGly: 5.792 ± 0.052	2.299ArgHis: 2.299 ± 0.031	3.241ArgIle: 3.241 ± 0.034	1.49ArgLys: 1.49 ± 0.029	9.278ArgLeu: 9.278 ± 0.072	1.687ArgMet: 1.687 ± 0.023	1.302ArgAsn: 1.302 ± 0.023	5.196ArgPro: 5.196 ± 0.042	2.412ArgGln: 2.412 ± 0.028	7.95ArgArg: 7.95 ± 0.076	4.018ArgSer: 4.018 ± 0.035	5.613ArgThr: 5.613 ± 0.05	5.923ArgVal: 5.923 ± 0.049	1.389ArgTrp: 1.389 ± 0.023	1.855ArgTyr: 1.855 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	7.011SerAla: 7.011 ± 0.055	0.425SerCys: 0.425 ± 0.011	2.593SerAsp: 2.593 ± 0.034	2.161SerGlu: 2.161 ± 0.029	1.506SerPhe: 1.506 ± 0.025	5.987SerGly: 5.987 ± 0.06	1.037SerHis: 1.037 ± 0.019	1.331SerIle: 1.331 ± 0.025	0.951SerLys: 0.951 ± 0.021	4.91SerLeu: 4.91 ± 0.046	1.067SerMet: 1.067 ± 0.02	0.854SerAsn: 0.854 ± 0.02	3.127SerPro: 3.127 ± 0.037	1.221SerGln: 1.221 ± 0.021	3.589SerArg: 3.589 ± 0.037	2.841SerSer: 2.841 ± 0.043	3.053SerThr: 3.053 ± 0.045	4.304SerVal: 4.304 ± 0.042	0.921SerTrp: 0.921 ± 0.019	1.254SerTyr: 1.254 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	9.259ThrAla: 9.259 ± 0.065	0.465ThrCys: 0.465 ± 0.011	3.708ThrAsp: 3.708 ± 0.039	3.154ThrGlu: 3.154 ± 0.036	1.587ThrPhe: 1.587 ± 0.028	6.954ThrGly: 6.954 ± 0.051	1.281ThrHis: 1.281 ± 0.022	1.644ThrIle: 1.644 ± 0.024	1.114ThrLys: 1.114 ± 0.024	5.894ThrLeu: 5.894 ± 0.046	0.92ThrMet: 0.92 ± 0.02	0.994ThrAsn: 0.994 ± 0.021	4.2ThrPro: 4.2 ± 0.039	1.36ThrGln: 1.36 ± 0.025	4.073ThrArg: 4.073 ± 0.044	3.206ThrSer: 3.206 ± 0.036	3.928ThrThr: 3.928 ± 0.043	6.171ThrVal: 6.171 ± 0.055	0.92ThrTrp: 0.92 ± 0.021	1.397ThrTyr: 1.397 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.725ValAla: 10.725 ± 0.061	0.814ValCys: 0.814 ± 0.019	4.717ValAsp: 4.717 ± 0.047	4.457ValGlu: 4.457 ± 0.042	2.472ValPhe: 2.472 ± 0.034	6.43ValGly: 6.43 ± 0.05	2.042ValHis: 2.042 ± 0.029	2.746ValIle: 2.746 ± 0.037	1.644ValLys: 1.644 ± 0.031	9.676ValLeu: 9.676 ± 0.066	1.376ValMet: 1.376 ± 0.023	1.649ValAsn: 1.649 ± 0.029	5.373ValPro: 5.373 ± 0.043	2.173ValGln: 2.173 ± 0.029	7.43ValArg: 7.43 ± 0.051	4.378ValSer: 4.378 ± 0.041	5.745ValThr: 5.745 ± 0.053	7.907ValVal: 7.907 ± 0.068	1.186ValTrp: 1.186 ± 0.02	1.617ValTyr: 1.617 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.713TrpAla: 1.713 ± 0.027	0.16TrpCys: 0.16 ± 0.007	0.833TrpAsp: 0.833 ± 0.017	0.705TrpGlu: 0.705 ± 0.017	0.509TrpPhe: 0.509 ± 0.013	1.06TrpGly: 1.06 ± 0.021	0.405TrpHis: 0.405 ± 0.012	0.549TrpIle: 0.549 ± 0.015	0.358TrpLys: 0.358 ± 0.013	1.832TrpLeu: 1.832 ± 0.025	0.266TrpMet: 0.266 ± 0.01	0.411TrpAsn: 0.411 ± 0.014	0.795TrpPro: 0.795 ± 0.021	0.667TrpGln: 0.667 ± 0.016	1.347TrpArg: 1.347 ± 0.019	0.981TrpSer: 0.981 ± 0.022	1.067TrpThr: 1.067 ± 0.019	0.963TrpVal: 0.963 ± 0.02	0.346TrpTrp: 0.346 ± 0.012	0.366TrpTyr: 0.366 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.887TyrAla: 2.887 ± 0.03	0.179TyrCys: 0.179 ± 0.008	1.608TyrAsp: 1.608 ± 0.031	1.219TyrGlu: 1.219 ± 0.024	0.66TyrPhe: 0.66 ± 0.016	2.357TyrGly: 2.357 ± 0.03	0.426TyrHis: 0.426 ± 0.014	0.468TyrIle: 0.468 ± 0.012	0.383TyrLys: 0.383 ± 0.011	2.068TyrLeu: 2.068 ± 0.03	0.249TyrMet: 0.249 ± 0.01	0.398TyrAsn: 0.398 ± 0.012	1.1TyrPro: 1.1 ± 0.021	0.612TyrGln: 0.612 ± 0.015	1.863TyrArg: 1.863 ± 0.028	0.95TyrSer: 0.95 ± 0.019	1.233TyrThr: 1.233 ± 0.023	1.701TyrVal: 1.701 ± 0.027	0.363TyrTrp: 0.363 ± 0.012	0.468TyrTyr: 0.468 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8549 proteins (2756139 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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