Amino acid dipepetide frequency for Rhizoclosmatium globosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.342AlaAla: 8.342 ± 0.064	1.055AlaCys: 1.055 ± 0.016	3.504AlaAsp: 3.504 ± 0.028	4.272AlaGlu: 4.272 ± 0.031	3.297AlaPhe: 3.297 ± 0.026	4.618AlaGly: 4.618 ± 0.036	1.459AlaHis: 1.459 ± 0.015	4.343AlaIle: 4.343 ± 0.026	4.398AlaLys: 4.398 ± 0.032	7.384AlaLeu: 7.384 ± 0.04	1.741AlaMet: 1.741 ± 0.018	3.167AlaAsn: 3.167 ± 0.022	4.008AlaPro: 4.008 ± 0.037	2.903AlaGln: 2.903 ± 0.024	3.372AlaArg: 3.372 ± 0.029	7.035AlaSer: 7.035 ± 0.046	5.372AlaThr: 5.372 ± 0.043	5.745AlaVal: 5.745 ± 0.039	0.825AlaTrp: 0.825 ± 0.013	1.905AlaTyr: 1.905 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.989CysAla: 0.989 ± 0.014	0.361CysCys: 0.361 ± 0.008	0.703CysAsp: 0.703 ± 0.012	0.657CysGlu: 0.657 ± 0.011	0.757CysPhe: 0.757 ± 0.013	1.116CysGly: 1.116 ± 0.017	0.348CysHis: 0.348 ± 0.008	0.879CysIle: 0.879 ± 0.013	0.706CysLys: 0.706 ± 0.013	1.517CysLeu: 1.517 ± 0.018	0.336CysMet: 0.336 ± 0.007	0.594CysAsn: 0.594 ± 0.012	0.736CysPro: 0.736 ± 0.013	0.539CysGln: 0.539 ± 0.011	0.706CysArg: 0.706 ± 0.012	1.14CysSer: 1.14 ± 0.017	0.836CysThr: 0.836 ± 0.011	1.086CysVal: 1.086 ± 0.015	0.229CysTrp: 0.229 ± 0.007	0.446CysTyr: 0.446 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.356AspAla: 4.356 ± 0.032	0.751AspCys: 0.751 ± 0.012	3.653AspAsp: 3.653 ± 0.044	3.833AspGlu: 3.833 ± 0.031	2.278AspPhe: 2.278 ± 0.02	3.515AspGly: 3.515 ± 0.027	0.953AspHis: 0.953 ± 0.013	2.859AspIle: 2.859 ± 0.021	2.379AspLys: 2.379 ± 0.019	4.88AspLeu: 4.88 ± 0.031	1.106AspMet: 1.106 ± 0.015	1.801AspAsn: 1.801 ± 0.02	2.732AspPro: 2.732 ± 0.024	1.649AspGln: 1.649 ± 0.017	2.189AspArg: 2.189 ± 0.024	4.313AspSer: 4.313 ± 0.03	2.648AspThr: 2.648 ± 0.023	3.8AspVal: 3.8 ± 0.03	0.757AspTrp: 0.757 ± 0.012	1.489AspTyr: 1.489 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	4.535GluAla: 4.535 ± 0.033	0.782GluCys: 0.782 ± 0.011	3.384GluAsp: 3.384 ± 0.028	4.825GluGlu: 4.825 ± 0.052	2.392GluPhe: 2.392 ± 0.019	3.109GluGly: 3.109 ± 0.023	1.061GluHis: 1.061 ± 0.015	3.133GluIle: 3.133 ± 0.029	3.721GluLys: 3.721 ± 0.027	5.221GluLeu: 5.221 ± 0.04	1.503GluMet: 1.503 ± 0.017	2.415GluAsn: 2.415 ± 0.022	2.105GluPro: 2.105 ± 0.019	2.031GluGln: 2.031 ± 0.021	3.208GluArg: 3.208 ± 0.028	4.658GluSer: 4.658 ± 0.034	3.621GluThr: 3.621 ± 0.031	3.696GluVal: 3.696 ± 0.035	0.783GluTrp: 0.783 ± 0.014	1.725GluTyr: 1.725 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.127PheAla: 3.127 ± 0.025	0.685PheCys: 0.685 ± 0.011	2.465PheAsp: 2.465 ± 0.022	2.418PheGlu: 2.418 ± 0.022	1.795PhePhe: 1.795 ± 0.022	3.203PheGly: 3.203 ± 0.027	1.042PheHis: 1.042 ± 0.013	2.145PheIle: 2.145 ± 0.021	2.155PheLys: 2.155 ± 0.02	4.063PheLeu: 4.063 ± 0.034	1.001PheMet: 1.001 ± 0.013	1.876PheAsn: 1.876 ± 0.02	1.933PhePro: 1.933 ± 0.021	1.648PheGln: 1.648 ± 0.016	1.841PheArg: 1.841 ± 0.018	3.369PheSer: 3.369 ± 0.027	2.401PheThr: 2.401 ± 0.02	3.043PheVal: 3.043 ± 0.024	0.615PheTrp: 0.615 ± 0.012	1.303PheTyr: 1.303 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.316GlyAla: 4.316 ± 0.032	0.955GlyCys: 0.955 ± 0.013	3.012GlyAsp: 3.012 ± 0.026	2.949GlyGlu: 2.949 ± 0.025	2.902GlyPhe: 2.902 ± 0.024	5.229GlyGly: 5.229 ± 0.049	1.304GlyHis: 1.304 ± 0.017	3.49GlyIle: 3.49 ± 0.028	3.407GlyLys: 3.407 ± 0.028	5.499GlyLeu: 5.499 ± 0.034	1.449GlyMet: 1.449 ± 0.016	2.642GlyAsn: 2.642 ± 0.022	2.42GlyPro: 2.42 ± 0.02	1.88GlyGln: 1.88 ± 0.019	2.925GlyArg: 2.925 ± 0.027	5.469GlySer: 5.469 ± 0.039	3.653GlyThr: 3.653 ± 0.029	4.578GlyVal: 4.578 ± 0.03	0.877GlyTrp: 0.877 ± 0.013	1.887GlyTyr: 1.887 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.456HisAla: 1.456 ± 0.015	0.374HisCys: 0.374 ± 0.009	0.975HisAsp: 0.975 ± 0.012	1.14HisGlu: 1.14 ± 0.013	0.998HisPhe: 0.998 ± 0.013	1.258HisGly: 1.258 ± 0.016	0.835HisHis: 0.835 ± 0.016	1.295HisIle: 1.295 ± 0.013	1.014HisLys: 1.014 ± 0.014	2.295HisLeu: 2.295 ± 0.021	0.461HisMet: 0.461 ± 0.009	0.886HisAsn: 0.886 ± 0.012	1.451HisPro: 1.451 ± 0.016	1.129HisGln: 1.129 ± 0.018	1.15HisArg: 1.15 ± 0.016	1.905HisSer: 1.905 ± 0.021	1.216HisThr: 1.216 ± 0.016	1.396HisVal: 1.396 ± 0.015	0.318HisTrp: 0.318 ± 0.011	0.655HisTyr: 0.655 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.311IleAla: 4.311 ± 0.029	0.891IleCys: 0.891 ± 0.012	2.949IleAsp: 2.949 ± 0.02	3.032IleGlu: 3.032 ± 0.022	2.049IlePhe: 2.049 ± 0.022	3.267IleGly: 3.267 ± 0.026	1.349IleHis: 1.349 ± 0.015	2.737IleIle: 2.737 ± 0.026	2.825IleLys: 2.825 ± 0.021	5.205IleLeu: 5.205 ± 0.029	1.163IleMet: 1.163 ± 0.014	2.192IleAsn: 2.192 ± 0.019	3.447IlePro: 3.447 ± 0.026	2.448IleGln: 2.448 ± 0.019	2.599IleArg: 2.599 ± 0.022	4.326IleSer: 4.326 ± 0.028	3.119IleThr: 3.119 ± 0.021	3.805IleVal: 3.805 ± 0.025	0.625IleTrp: 0.625 ± 0.01	1.491IleTyr: 1.491 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.251LysAla: 4.251 ± 0.032	0.743LysCys: 0.743 ± 0.012	2.976LysAsp: 2.976 ± 0.025	3.937LysGlu: 3.937 ± 0.027	1.87LysPhe: 1.87 ± 0.016	2.967LysGly: 2.967 ± 0.023	1.26LysHis: 1.26 ± 0.012	2.651LysIle: 2.651 ± 0.022	4.221LysLys: 4.221 ± 0.036	5.093LysLeu: 5.093 ± 0.029	1.31LysMet: 1.31 ± 0.014	2.357LysAsn: 2.357 ± 0.02	2.755LysPro: 2.755 ± 0.027	2.285LysGln: 2.285 ± 0.021	3.304LysArg: 3.304 ± 0.023	4.351LysSer: 4.351 ± 0.028	3.429LysThr: 3.429 ± 0.026	3.494LysVal: 3.494 ± 0.028	0.694LysTrp: 0.694 ± 0.012	1.674LysTyr: 1.674 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.373LeuAla: 7.373 ± 0.039	1.462LeuCys: 1.462 ± 0.016	5.105LeuAsp: 5.105 ± 0.029	5.729LeuGlu: 5.729 ± 0.042	4.243LeuPhe: 4.243 ± 0.033	5.341LeuGly: 5.341 ± 0.033	2.198LeuHis: 2.198 ± 0.019	4.714LeuIle: 4.714 ± 0.03	5.608LeuLys: 5.608 ± 0.038	9.363LeuLeu: 9.363 ± 0.058	2.133LeuMet: 2.133 ± 0.017	4.197LeuAsn: 4.197 ± 0.03	5.028LeuPro: 5.028 ± 0.033	3.999LeuGln: 3.999 ± 0.029	4.723LeuArg: 4.723 ± 0.029	7.88LeuSer: 7.88 ± 0.041	5.325LeuThr: 5.325 ± 0.029	6.352LeuVal: 6.352 ± 0.034	1.103LeuTrp: 1.103 ± 0.016	2.58LeuTyr: 2.58 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.802MetAla: 1.802 ± 0.017	0.286MetCys: 0.286 ± 0.007	1.401MetAsp: 1.401 ± 0.014	1.462MetGlu: 1.462 ± 0.016	0.911MetPhe: 0.911 ± 0.013	1.331MetGly: 1.331 ± 0.014	0.485MetHis: 0.485 ± 0.009	1.159MetIle: 1.159 ± 0.013	1.393MetLys: 1.393 ± 0.013	1.883MetLeu: 1.883 ± 0.017	0.649MetMet: 0.649 ± 0.011	1.106MetAsn: 1.106 ± 0.013	1.011MetPro: 1.011 ± 0.012	0.916MetGln: 0.916 ± 0.013	1.067MetArg: 1.067 ± 0.013	1.791MetSer: 1.791 ± 0.016	1.395MetThr: 1.395 ± 0.014	1.311MetVal: 1.311 ± 0.015	0.24MetTrp: 0.24 ± 0.007	0.632MetTyr: 0.632 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.445AsnAla: 3.445 ± 0.023	0.647AsnCys: 0.647 ± 0.008	2.135AsnAsp: 2.135 ± 0.021	2.37AsnGlu: 2.37 ± 0.023	1.529AsnPhe: 1.529 ± 0.015	2.914AsnGly: 2.914 ± 0.025	1.013AsnHis: 1.013 ± 0.012	2.36AsnIle: 2.36 ± 0.02	2.028AsnLys: 2.028 ± 0.02	4.145AsnLeu: 4.145 ± 0.03	0.979AsnMet: 0.979 ± 0.012	2.249AsnAsn: 2.249 ± 0.028	2.678AsnPro: 2.678 ± 0.02	1.947AsnGln: 1.947 ± 0.021	1.899AsnArg: 1.899 ± 0.018	3.602AsnSer: 3.602 ± 0.024	2.679AsnThr: 2.679 ± 0.022	2.891AsnVal: 2.891 ± 0.021	0.554AsnTrp: 0.554 ± 0.01	1.219AsnTyr: 1.219 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.056ProAla: 4.056 ± 0.037	0.563ProCys: 0.563 ± 0.014	2.393ProAsp: 2.393 ± 0.018	2.775ProGlu: 2.775 ± 0.024	2.109ProPhe: 2.109 ± 0.02	2.586ProGly: 2.586 ± 0.021	1.159ProHis: 1.159 ± 0.015	2.807ProIle: 2.807 ± 0.02	2.696ProLys: 2.696 ± 0.026	4.598ProLeu: 4.598 ± 0.032	0.923ProMet: 0.923 ± 0.011	2.345ProAsn: 2.345 ± 0.019	4.473ProPro: 4.473 ± 0.058	2.312ProGln: 2.312 ± 0.029	2.274ProArg: 2.274 ± 0.024	5.577ProSer: 5.577 ± 0.041	4.084ProThr: 4.084 ± 0.029	3.741ProVal: 3.741 ± 0.03	0.516ProTrp: 0.516 ± 0.008	1.314ProTyr: 1.314 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	2.653GlnAla: 2.653 ± 0.024	0.563GlnCys: 0.563 ± 0.014	1.785GlnAsp: 1.785 ± 0.023	2.182GlnGlu: 2.182 ± 0.025	1.59GlnPhe: 1.59 ± 0.016	1.834GlnGly: 1.834 ± 0.017	1.014GlnHis: 1.014 ± 0.015	2.236GlnIle: 2.236 ± 0.018	2.193GlnLys: 2.193 ± 0.019	3.87GlnLeu: 3.87 ± 0.028	0.957GlnMet: 0.957 ± 0.015	1.835GlnAsn: 1.835 ± 0.019	2.312GlnPro: 2.312 ± 0.028	3.23GlnGln: 3.23 ± 0.076	2.161GlnArg: 2.161 ± 0.022	3.343GlnSer: 3.343 ± 0.023	2.603GlnThr: 2.603 ± 0.021	2.41GlnVal: 2.41 ± 0.02	0.456GlnTrp: 0.456 ± 0.009	1.242GlnTyr: 1.242 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	3.354ArgAla: 3.354 ± 0.026	0.655ArgCys: 0.655 ± 0.011	2.542ArgAsp: 2.542 ± 0.025	2.882ArgGlu: 2.882 ± 0.026	2.106ArgPhe: 2.106 ± 0.017	2.667ArgGly: 2.667 ± 0.025	1.149ArgHis: 1.149 ± 0.014	2.928ArgIle: 2.928 ± 0.023	3.159ArgLys: 3.159 ± 0.024	4.687ArgLeu: 4.687 ± 0.033	1.181ArgMet: 1.181 ± 0.014	2.228ArgAsn: 2.228 ± 0.019	2.157ArgPro: 2.157 ± 0.024	1.872ArgGln: 1.872 ± 0.019	3.436ArgArg: 3.436 ± 0.029	3.55ArgSer: 3.55 ± 0.031	2.662ArgThr: 2.662 ± 0.024	3.358ArgVal: 3.358 ± 0.025	0.57ArgTrp: 0.57 ± 0.009	1.342ArgTyr: 1.342 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	6.486SerAla: 6.486 ± 0.046	1.152SerCys: 1.152 ± 0.015	4.132SerAsp: 4.132 ± 0.029	4.082SerGlu: 4.082 ± 0.031	3.638SerPhe: 3.638 ± 0.029	5.221SerGly: 5.221 ± 0.037	1.916SerHis: 1.916 ± 0.023	4.772SerIle: 4.772 ± 0.03	4.543SerLys: 4.543 ± 0.026	8.353SerLeu: 8.353 ± 0.045	1.729SerMet: 1.729 ± 0.018	3.988SerAsn: 3.988 ± 0.032	4.589SerPro: 4.589 ± 0.044	3.28SerGln: 3.28 ± 0.024	3.956SerArg: 3.956 ± 0.027	9.323SerSer: 9.323 ± 0.083	6.591SerThr: 6.591 ± 0.091	5.927SerVal: 5.927 ± 0.036	0.967SerTrp: 0.967 ± 0.012	2.065SerTyr: 2.065 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.258ThrAla: 5.258 ± 0.035	0.924ThrCys: 0.924 ± 0.014	2.817ThrAsp: 2.817 ± 0.027	3.034ThrGlu: 3.034 ± 0.027	2.516ThrPhe: 2.516 ± 0.019	3.739ThrGly: 3.739 ± 0.03	1.346ThrHis: 1.346 ± 0.016	3.449ThrIle: 3.449 ± 0.023	3.17ThrLys: 3.17 ± 0.023	6.004ThrLeu: 6.004 ± 0.029	1.143ThrMet: 1.143 ± 0.015	2.68ThrAsn: 2.68 ± 0.022	4.027ThrPro: 4.027 ± 0.032	2.363ThrGln: 2.363 ± 0.025	2.765ThrArg: 2.765 ± 0.021	6.165ThrSer: 6.165 ± 0.098	5.792ThrThr: 5.792 ± 0.128	4.366ThrVal: 4.366 ± 0.035	0.668ThrTrp: 0.668 ± 0.012	1.585ThrTyr: 1.585 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.801ValAla: 5.801 ± 0.042	1.097ValCys: 1.097 ± 0.016	3.8ValAsp: 3.8 ± 0.029	4.23ValGlu: 4.23 ± 0.036	3.062ValPhe: 3.062 ± 0.026	4.381ValGly: 4.381 ± 0.034	1.409ValHis: 1.409 ± 0.014	3.485ValIle: 3.485 ± 0.031	3.817ValLys: 3.817 ± 0.027	6.56ValLeu: 6.56 ± 0.039	1.472ValMet: 1.472 ± 0.013	2.726ValAsn: 2.726 ± 0.017	3.704ValPro: 3.704 ± 0.027	2.529ValGln: 2.529 ± 0.021	2.911ValArg: 2.911 ± 0.025	5.682ValSer: 5.682 ± 0.031	3.943ValThr: 3.943 ± 0.029	5.611ValVal: 5.611 ± 0.045	0.897ValTrp: 0.897 ± 0.014	1.968ValTyr: 1.968 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.8TrpAla: 0.8 ± 0.012	0.218TrpCys: 0.218 ± 0.007	0.717TrpAsp: 0.717 ± 0.013	0.629TrpGlu: 0.629 ± 0.011	0.643TrpPhe: 0.643 ± 0.012	0.693TrpGly: 0.693 ± 0.012	0.236TrpHis: 0.236 ± 0.006	0.855TrpIle: 0.855 ± 0.011	0.829TrpLys: 0.829 ± 0.013	1.077TrpLeu: 1.077 ± 0.012	0.38TrpMet: 0.38 ± 0.007	0.687TrpAsn: 0.687 ± 0.011	0.414TrpPro: 0.414 ± 0.008	0.359TrpGln: 0.359 ± 0.007	0.669TrpArg: 0.669 ± 0.011	0.958TrpSer: 0.958 ± 0.016	0.815TrpThr: 0.815 ± 0.013	0.737TrpVal: 0.737 ± 0.012	0.239TrpTrp: 0.239 ± 0.007	0.375TrpTyr: 0.375 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.031TyrAla: 2.031 ± 0.018	0.517TyrCys: 0.517 ± 0.009	1.495TyrAsp: 1.495 ± 0.015	1.472TyrGlu: 1.472 ± 0.015	1.444TyrPhe: 1.444 ± 0.015	1.853TyrGly: 1.853 ± 0.019	0.671TyrHis: 0.671 ± 0.011	1.531TyrIle: 1.531 ± 0.018	1.357TyrLys: 1.357 ± 0.015	2.761TyrLeu: 2.761 ± 0.023	0.614TyrMet: 0.614 ± 0.01	1.311TyrAsn: 1.311 ± 0.015	1.32TyrPro: 1.32 ± 0.015	1.15TyrGln: 1.15 ± 0.017	1.331TyrArg: 1.331 ± 0.013	2.271TyrSer: 2.271 ± 0.02	1.628TyrThr: 1.628 ± 0.018	1.74TyrVal: 1.74 ± 0.017	0.399TyrTrp: 0.399 ± 0.009	1.041TyrTyr: 1.041 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 16725 proteins (6640880 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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