Amino acid dipepetide frequency for Ekpoma virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.711AlaAla: 1.711 ± 1.112
1.222AlaCys: 1.222 ± 0.499
1.711AlaAsp: 1.711 ± 0.605
1.222AlaGlu: 1.222 ± 0.487
1.956AlaPhe: 1.956 ± 0.428
1.222AlaGly: 1.222 ± 0.626
0.733AlaHis: 0.733 ± 0.404
2.689AlaIle: 2.689 ± 0.44
1.711AlaLys: 1.711 ± 0.8
5.868AlaLeu: 5.868 ± 1.594
0.489AlaMet: 0.489 ± 0.342
1.956AlaAsn: 1.956 ± 1.289
1.222AlaPro: 1.222 ± 0.331
0.489AlaGln: 0.489 ± 0.269
1.956AlaArg: 1.956 ± 0.988
4.645AlaSer: 4.645 ± 1.078
3.178AlaThr: 3.178 ± 0.426
1.956AlaVal: 1.956 ± 1.098
0.733AlaTrp: 0.733 ± 0.422
0.733AlaTyr: 0.733 ± 0.325
0.0AlaXaa: 0.0 ± 0.0
Cys
1.222CysAla: 1.222 ± 0.871
0.733CysCys: 0.733 ± 0.584
0.733CysAsp: 0.733 ± 0.76
0.733CysGlu: 0.733 ± 0.422
1.222CysPhe: 1.222 ± 0.362
0.978CysGly: 0.978 ± 0.455
1.956CysHis: 1.956 ± 0.736
1.711CysIle: 1.711 ± 0.578
1.222CysLys: 1.222 ± 0.362
1.956CysLeu: 1.956 ± 0.846
0.489CysMet: 0.489 ± 0.332
0.733CysAsn: 0.733 ± 0.275
1.467CysPro: 1.467 ± 0.446
0.244CysGln: 0.244 ± 0.135
0.978CysArg: 0.978 ± 0.464
2.2CysSer: 2.2 ± 0.57
0.978CysThr: 0.978 ± 0.548
0.489CysVal: 0.489 ± 0.347
0.978CysTrp: 0.978 ± 0.539
0.489CysTyr: 0.489 ± 0.507
0.0CysXaa: 0.0 ± 0.0
Asp
0.733AspAla: 0.733 ± 0.275
2.445AspCys: 2.445 ± 1.182
3.667AspAsp: 3.667 ± 0.912
3.178AspGlu: 3.178 ± 0.757
2.445AspPhe: 2.445 ± 0.766
2.2AspGly: 2.2 ± 0.464
2.689AspHis: 2.689 ± 0.636
5.379AspIle: 5.379 ± 0.749
3.423AspLys: 3.423 ± 0.69
5.379AspLeu: 5.379 ± 0.767
1.467AspMet: 1.467 ± 0.798
3.178AspAsn: 3.178 ± 0.938
3.912AspPro: 3.912 ± 1.056
1.467AspGln: 1.467 ± 0.675
1.222AspArg: 1.222 ± 0.59
3.178AspSer: 3.178 ± 0.792
2.445AspThr: 2.445 ± 0.399
2.445AspVal: 2.445 ± 0.581
1.711AspTrp: 1.711 ± 0.602
2.2AspTyr: 2.2 ± 0.898
0.0AspXaa: 0.0 ± 0.0
Glu
1.711GluAla: 1.711 ± 0.757
1.711GluCys: 1.711 ± 0.754
3.423GluAsp: 3.423 ± 1.014
3.667GluGlu: 3.667 ± 1.333
0.978GluPhe: 0.978 ± 0.459
2.934GluGly: 2.934 ± 0.831
1.222GluHis: 1.222 ± 0.571
6.357GluIle: 6.357 ± 0.839
4.645GluLys: 4.645 ± 0.857
5.134GluLeu: 5.134 ± 0.972
1.711GluMet: 1.711 ± 0.642
2.689GluAsn: 2.689 ± 0.999
1.467GluPro: 1.467 ± 0.477
0.244GluGln: 0.244 ± 0.253
2.689GluArg: 2.689 ± 0.52
4.156GluSer: 4.156 ± 1.078
3.667GluThr: 3.667 ± 0.995
2.689GluVal: 2.689 ± 1.07
0.978GluTrp: 0.978 ± 0.774
1.467GluTyr: 1.467 ± 0.808
0.0GluXaa: 0.0 ± 0.0
Phe
0.978PheAla: 0.978 ± 0.414
0.978PheCys: 0.978 ± 0.544
2.689PheAsp: 2.689 ± 0.519
1.956PheGlu: 1.956 ± 0.559
0.978PhePhe: 0.978 ± 0.404
1.467PheGly: 1.467 ± 0.55
0.978PheHis: 0.978 ± 0.664
1.711PheIle: 1.711 ± 0.616
2.445PheLys: 2.445 ± 0.799
2.934PheLeu: 2.934 ± 1.131
1.467PheMet: 1.467 ± 0.475
2.2PheAsn: 2.2 ± 0.426
3.423PhePro: 3.423 ± 1.083
1.711PheGln: 1.711 ± 0.761
1.467PheArg: 1.467 ± 0.616
3.667PheSer: 3.667 ± 0.609
0.978PheThr: 0.978 ± 0.401
3.178PheVal: 3.178 ± 0.849
0.489PheTrp: 0.489 ± 0.269
0.978PheTyr: 0.978 ± 0.472
0.0PheXaa: 0.0 ± 0.0
Gly
2.445GlyAla: 2.445 ± 0.73
0.733GlyCys: 0.733 ± 0.584
2.934GlyAsp: 2.934 ± 0.595
1.222GlyGlu: 1.222 ± 0.57
2.445GlyPhe: 2.445 ± 0.417
4.156GlyGly: 4.156 ± 1.035
1.711GlyHis: 1.711 ± 0.608
5.379GlyIle: 5.379 ± 0.743
3.423GlyLys: 3.423 ± 1.348
6.357GlyLeu: 6.357 ± 1.241
0.733GlyMet: 0.733 ± 0.605
3.178GlyAsn: 3.178 ± 0.81
1.711GlyPro: 1.711 ± 0.372
2.689GlyGln: 2.689 ± 0.595
2.2GlyArg: 2.2 ± 0.692
4.401GlySer: 4.401 ± 0.724
1.956GlyThr: 1.956 ± 0.344
1.956GlyVal: 1.956 ± 0.66
1.222GlyTrp: 1.222 ± 0.487
2.689GlyTyr: 2.689 ± 0.983
0.0GlyXaa: 0.0 ± 0.0
His
1.956HisAla: 1.956 ± 0.577
0.489HisCys: 0.489 ± 0.357
0.978HisAsp: 0.978 ± 0.566
2.445HisGlu: 2.445 ± 0.942
0.978HisPhe: 0.978 ± 0.691
0.733HisGly: 0.733 ± 0.362
0.244HisHis: 0.244 ± 0.253
3.423HisIle: 3.423 ± 1.049
1.956HisLys: 1.956 ± 0.644
2.934HisLeu: 2.934 ± 0.742
1.222HisMet: 1.222 ± 0.534
1.467HisAsn: 1.467 ± 0.471
3.178HisPro: 3.178 ± 0.82
0.978HisGln: 0.978 ± 0.455
1.222HisArg: 1.222 ± 0.362
1.467HisSer: 1.467 ± 0.609
0.733HisThr: 0.733 ± 0.481
0.489HisVal: 0.489 ± 0.228
0.733HisTrp: 0.733 ± 0.325
2.2HisTyr: 2.2 ± 0.608
0.0HisXaa: 0.0 ± 0.0
Ile
1.711IleAla: 1.711 ± 0.458
1.711IleCys: 1.711 ± 0.452
5.134IleAsp: 5.134 ± 1.496
4.156IleGlu: 4.156 ± 0.731
3.667IlePhe: 3.667 ± 0.671
5.379IleGly: 5.379 ± 1.427
1.711IleHis: 1.711 ± 1.376
5.623IleIle: 5.623 ± 1.144
8.068IleLys: 8.068 ± 0.81
8.068IleLeu: 8.068 ± 1.538
2.445IleMet: 2.445 ± 0.969
6.357IleAsn: 6.357 ± 1.115
6.112IlePro: 6.112 ± 1.282
2.2IleGln: 2.2 ± 0.564
4.401IleArg: 4.401 ± 0.966
8.313IleSer: 8.313 ± 1.064
2.934IleThr: 2.934 ± 0.817
5.134IleVal: 5.134 ± 0.694
0.733IleTrp: 0.733 ± 0.586
3.423IleTyr: 3.423 ± 1.029
0.0IleXaa: 0.0 ± 0.0
Lys
1.711LysAla: 1.711 ± 0.538
1.222LysCys: 1.222 ± 0.428
3.178LysAsp: 3.178 ± 0.965
4.89LysGlu: 4.89 ± 1.398
2.2LysPhe: 2.2 ± 0.95
2.934LysGly: 2.934 ± 0.394
1.956LysHis: 1.956 ± 0.414
7.09LysIle: 7.09 ± 1.361
4.89LysLys: 4.89 ± 2.158
8.802LysLeu: 8.802 ± 1.686
1.956LysMet: 1.956 ± 0.633
3.423LysAsn: 3.423 ± 0.59
3.912LysPro: 3.912 ± 1.227
2.689LysGln: 2.689 ± 1.037
3.423LysArg: 3.423 ± 0.859
4.156LysSer: 4.156 ± 1.362
6.601LysThr: 6.601 ± 2.542
2.934LysVal: 2.934 ± 0.668
1.222LysTrp: 1.222 ± 0.463
2.445LysTyr: 2.445 ± 0.574
0.0LysXaa: 0.0 ± 0.0
Leu
5.379LeuAla: 5.379 ± 0.833
2.689LeuCys: 2.689 ± 0.754
6.112LeuAsp: 6.112 ± 1.301
6.112LeuGlu: 6.112 ± 1.258
4.156LeuPhe: 4.156 ± 1.205
6.112LeuGly: 6.112 ± 1.338
2.689LeuHis: 2.689 ± 0.875
8.802LeuIle: 8.802 ± 2.355
7.09LeuLys: 7.09 ± 0.984
10.024LeuLeu: 10.024 ± 1.592
2.445LeuMet: 2.445 ± 0.439
4.401LeuAsn: 4.401 ± 0.978
3.912LeuPro: 3.912 ± 1.18
2.445LeuGln: 2.445 ± 1.083
6.112LeuArg: 6.112 ± 1.269
7.824LeuSer: 7.824 ± 1.557
7.335LeuThr: 7.335 ± 1.847
4.401LeuVal: 4.401 ± 1.211
0.978LeuTrp: 0.978 ± 0.472
4.645LeuTyr: 4.645 ± 1.136
0.0LeuXaa: 0.0 ± 0.0
Met
1.711MetAla: 1.711 ± 1.15
0.489MetCys: 0.489 ± 0.43
0.978MetAsp: 0.978 ± 0.916
1.711MetGlu: 1.711 ± 1.22
0.733MetPhe: 0.733 ± 0.657
1.222MetGly: 1.222 ± 0.633
0.0MetHis: 0.0 ± 0.0
2.934MetIle: 2.934 ± 0.85
2.934MetLys: 2.934 ± 1.242
2.2MetLeu: 2.2 ± 0.565
0.978MetMet: 0.978 ± 0.539
1.956MetAsn: 1.956 ± 0.589
0.733MetPro: 0.733 ± 0.448
0.978MetGln: 0.978 ± 0.368
1.222MetArg: 1.222 ± 0.499
1.467MetSer: 1.467 ± 0.446
1.467MetThr: 1.467 ± 0.472
0.733MetVal: 0.733 ± 0.325
0.733MetTrp: 0.733 ± 0.404
1.222MetTyr: 1.222 ± 0.738
0.0MetXaa: 0.0 ± 0.0
Asn
1.467AsnAla: 1.467 ± 0.863
0.733AsnCys: 0.733 ± 0.337
1.956AsnAsp: 1.956 ± 0.833
2.2AsnGlu: 2.2 ± 0.72
1.711AsnPhe: 1.711 ± 0.393
2.934AsnGly: 2.934 ± 1.096
0.733AsnHis: 0.733 ± 0.35
5.868AsnIle: 5.868 ± 1.462
3.667AsnLys: 3.667 ± 1.92
6.112AsnLeu: 6.112 ± 1.439
1.956AsnMet: 1.956 ± 0.726
4.645AsnAsn: 4.645 ± 1.367
4.645AsnPro: 4.645 ± 0.964
1.711AsnGln: 1.711 ± 1.116
1.222AsnArg: 1.222 ± 0.571
5.379AsnSer: 5.379 ± 1.074
3.912AsnThr: 3.912 ± 0.855
1.467AsnVal: 1.467 ± 0.375
0.733AsnTrp: 0.733 ± 0.462
1.956AsnTyr: 1.956 ± 0.637
0.0AsnXaa: 0.0 ± 0.0
Pro
3.423ProAla: 3.423 ± 0.599
0.244ProCys: 0.244 ± 0.135
4.401ProAsp: 4.401 ± 1.383
2.689ProGlu: 2.689 ± 0.893
0.733ProPhe: 0.733 ± 0.404
2.934ProGly: 2.934 ± 1.142
1.222ProHis: 1.222 ± 0.327
4.156ProIle: 4.156 ± 1.277
3.178ProLys: 3.178 ± 0.756
5.868ProLeu: 5.868 ± 0.824
0.978ProMet: 0.978 ± 0.538
1.956ProAsn: 1.956 ± 1.136
1.711ProPro: 1.711 ± 0.601
2.2ProGln: 2.2 ± 1.219
1.711ProArg: 1.711 ± 0.578
4.89ProSer: 4.89 ± 1.252
2.445ProThr: 2.445 ± 0.98
2.934ProVal: 2.934 ± 0.748
0.978ProTrp: 0.978 ± 0.404
2.445ProTyr: 2.445 ± 0.8
0.0ProXaa: 0.0 ± 0.0
Gln
0.978GlnAla: 0.978 ± 0.86
0.244GlnCys: 0.244 ± 0.135
2.2GlnAsp: 2.2 ± 0.521
1.222GlnGlu: 1.222 ± 0.388
0.733GlnPhe: 0.733 ± 0.275
2.445GlnGly: 2.445 ± 0.9
0.733GlnHis: 0.733 ± 0.462
2.934GlnIle: 2.934 ± 0.82
2.2GlnLys: 2.2 ± 0.659
3.423GlnLeu: 3.423 ± 1.127
0.733GlnMet: 0.733 ± 0.567
1.222GlnAsn: 1.222 ± 0.71
0.978GlnPro: 0.978 ± 0.414
0.733GlnGln: 0.733 ± 0.432
2.2GlnArg: 2.2 ± 0.72
2.689GlnSer: 2.689 ± 0.796
1.956GlnThr: 1.956 ± 0.64
0.489GlnVal: 0.489 ± 0.269
0.244GlnTrp: 0.244 ± 0.135
0.733GlnTyr: 0.733 ± 0.709
0.0GlnXaa: 0.0 ± 0.0
Arg
2.2ArgAla: 2.2 ± 0.68
1.467ArgCys: 1.467 ± 0.468
3.178ArgAsp: 3.178 ± 0.651
3.423ArgGlu: 3.423 ± 0.347
1.467ArgPhe: 1.467 ± 0.615
1.711ArgGly: 1.711 ± 0.537
2.689ArgHis: 2.689 ± 1.036
4.401ArgIle: 4.401 ± 1.143
1.956ArgLys: 1.956 ± 0.831
1.956ArgLeu: 1.956 ± 1.021
0.489ArgMet: 0.489 ± 0.228
1.956ArgAsn: 1.956 ± 0.664
2.689ArgPro: 2.689 ± 0.556
0.489ArgGln: 0.489 ± 0.332
1.711ArgArg: 1.711 ± 0.631
4.156ArgSer: 4.156 ± 0.723
3.178ArgThr: 3.178 ± 0.851
2.689ArgVal: 2.689 ± 0.773
0.978ArgTrp: 0.978 ± 0.45
0.733ArgTyr: 0.733 ± 0.337
0.0ArgXaa: 0.0 ± 0.0
Ser
3.178SerAla: 3.178 ± 1.281
1.222SerCys: 1.222 ± 0.567
3.423SerAsp: 3.423 ± 0.723
3.667SerGlu: 3.667 ± 1.59
3.667SerPhe: 3.667 ± 0.747
3.912SerGly: 3.912 ± 1.096
3.423SerHis: 3.423 ± 0.84
6.112SerIle: 6.112 ± 1.673
5.868SerLys: 5.868 ± 1.431
10.269SerLeu: 10.269 ± 1.347
3.178SerMet: 3.178 ± 1.142
5.868SerAsn: 5.868 ± 0.984
3.912SerPro: 3.912 ± 1.364
2.689SerGln: 2.689 ± 0.71
3.423SerArg: 3.423 ± 0.794
7.335SerSer: 7.335 ± 1.677
5.379SerThr: 5.379 ± 1.457
3.178SerVal: 3.178 ± 0.949
1.467SerTrp: 1.467 ± 0.55
2.934SerTyr: 2.934 ± 1.016
0.0SerXaa: 0.0 ± 0.0
Thr
1.711ThrAla: 1.711 ± 0.564
0.978ThrCys: 0.978 ± 0.475
1.711ThrAsp: 1.711 ± 0.608
3.667ThrGlu: 3.667 ± 1.395
1.956ThrPhe: 1.956 ± 0.413
4.156ThrGly: 4.156 ± 1.007
1.711ThrHis: 1.711 ± 0.463
6.357ThrIle: 6.357 ± 1.198
4.89ThrLys: 4.89 ± 1.048
8.068ThrLeu: 8.068 ± 1.496
1.956ThrMet: 1.956 ± 0.723
1.956ThrAsn: 1.956 ± 1.264
1.467ThrPro: 1.467 ± 0.893
1.956ThrGln: 1.956 ± 1.194
1.956ThrArg: 1.956 ± 1.011
3.912ThrSer: 3.912 ± 1.618
3.912ThrThr: 3.912 ± 2.268
3.667ThrVal: 3.667 ± 0.858
0.978ThrTrp: 0.978 ± 0.368
2.689ThrTyr: 2.689 ± 0.355
0.0ThrXaa: 0.0 ± 0.0
Val
1.467ValAla: 1.467 ± 0.571
1.222ValCys: 1.222 ± 0.428
3.423ValAsp: 3.423 ± 0.924
2.445ValGlu: 2.445 ± 0.674
1.222ValPhe: 1.222 ± 0.547
3.667ValGly: 3.667 ± 1.285
1.956ValHis: 1.956 ± 0.728
2.934ValIle: 2.934 ± 0.576
3.667ValLys: 3.667 ± 0.835
4.156ValLeu: 4.156 ± 0.875
0.733ValMet: 0.733 ± 0.314
3.178ValAsn: 3.178 ± 0.835
2.2ValPro: 2.2 ± 0.588
0.733ValGln: 0.733 ± 0.429
1.467ValArg: 1.467 ± 0.611
4.401ValSer: 4.401 ± 1.501
2.689ValThr: 2.689 ± 0.877
2.445ValVal: 2.445 ± 0.908
0.978ValTrp: 0.978 ± 0.455
0.733ValTyr: 0.733 ± 0.275
0.0ValXaa: 0.0 ± 0.0
Trp
0.733TrpAla: 0.733 ± 0.275
0.0TrpCys: 0.0 ± 0.0
0.489TrpAsp: 0.489 ± 0.41
1.467TrpGlu: 1.467 ± 0.519
0.978TrpPhe: 0.978 ± 0.297
0.733TrpGly: 0.733 ± 0.325
0.244TrpHis: 0.244 ± 0.135
1.222TrpIle: 1.222 ± 0.708
1.711TrpLys: 1.711 ± 0.736
0.978TrpLeu: 0.978 ± 0.368
0.244TrpMet: 0.244 ± 0.135
1.222TrpAsn: 1.222 ± 0.487
0.489TrpPro: 0.489 ± 0.269
0.489TrpGln: 0.489 ± 0.228
0.978TrpArg: 0.978 ± 0.404
1.956TrpSer: 1.956 ± 0.86
1.467TrpThr: 1.467 ± 0.631
1.467TrpVal: 1.467 ± 0.482
0.244TrpTrp: 0.244 ± 0.253
0.489TrpTyr: 0.489 ± 0.399
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.978TyrAla: 0.978 ± 0.389
0.978TyrCys: 0.978 ± 0.404
2.445TyrAsp: 2.445 ± 0.471
1.467TyrGlu: 1.467 ± 1.06
2.445TyrPhe: 2.445 ± 0.629
1.711TyrGly: 1.711 ± 0.474
1.222TyrHis: 1.222 ± 0.327
2.2TyrIle: 2.2 ± 0.538
2.689TyrLys: 2.689 ± 0.897
3.178TyrLeu: 3.178 ± 1.056
0.489TyrMet: 0.489 ± 0.317
1.467TyrAsn: 1.467 ± 0.604
1.956TyrPro: 1.956 ± 0.492
1.956TyrGln: 1.956 ± 0.605
1.956TyrArg: 1.956 ± 0.625
3.912TyrSer: 3.912 ± 0.539
2.689TyrThr: 2.689 ± 1.241
0.978TyrVal: 0.978 ± 0.439
0.489TyrTrp: 0.489 ± 0.507
2.689TyrTyr: 2.689 ± 0.857
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (4091 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski