Amino acid dipepetide frequency for Methyloceanibacter caenitepidi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.908AlaAla: 15.908 ± 0.205	1.067AlaCys: 1.067 ± 0.039	6.882AlaAsp: 6.882 ± 0.097	7.864AlaGlu: 7.864 ± 0.105	4.361AlaPhe: 4.361 ± 0.07	9.795AlaGly: 9.795 ± 0.114	2.079AlaHis: 2.079 ± 0.048	5.911AlaIle: 5.911 ± 0.092	4.92AlaLys: 4.92 ± 0.091	12.942AlaLeu: 12.942 ± 0.139	3.186AlaMet: 3.186 ± 0.056	2.992AlaAsn: 2.992 ± 0.057	5.861AlaPro: 5.861 ± 0.116	3.884AlaGln: 3.884 ± 0.085	7.998AlaArg: 7.998 ± 0.104	6.057AlaSer: 6.057 ± 0.093	5.758AlaThr: 5.758 ± 0.081	8.54AlaVal: 8.54 ± 0.1	1.5AlaTrp: 1.5 ± 0.037	2.765AlaTyr: 2.765 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.957CysAla: 0.957 ± 0.035	0.135CysCys: 0.135 ± 0.011	0.561CysAsp: 0.561 ± 0.025	0.479CysGlu: 0.479 ± 0.018	0.331CysPhe: 0.331 ± 0.018	0.929CysGly: 0.929 ± 0.029	0.266CysHis: 0.266 ± 0.02	0.378CysIle: 0.378 ± 0.022	0.252CysLys: 0.252 ± 0.016	0.82CysLeu: 0.82 ± 0.031	0.188CysMet: 0.188 ± 0.013	0.248CysAsn: 0.248 ± 0.017	0.481CysPro: 0.481 ± 0.026	0.211CysGln: 0.211 ± 0.015	0.622CysArg: 0.622 ± 0.027	0.469CysSer: 0.469 ± 0.02	0.402CysThr: 0.402 ± 0.018	0.669CysVal: 0.669 ± 0.025	0.117CysTrp: 0.117 ± 0.012	0.231CysTyr: 0.231 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.168AspAla: 7.168 ± 0.093	0.5AspCys: 0.5 ± 0.022	3.61AspAsp: 3.61 ± 0.091	4.199AspGlu: 4.199 ± 0.073	2.275AspPhe: 2.275 ± 0.052	5.587AspGly: 5.587 ± 0.108	1.124AspHis: 1.124 ± 0.038	3.145AspIle: 3.145 ± 0.052	2.199AspLys: 2.199 ± 0.054	5.886AspLeu: 5.886 ± 0.078	1.321AspMet: 1.321 ± 0.037	1.517AspAsn: 1.517 ± 0.038	3.615AspPro: 3.615 ± 0.064	1.818AspGln: 1.818 ± 0.044	4.032AspArg: 4.032 ± 0.067	2.439AspSer: 2.439 ± 0.061	3.088AspThr: 3.088 ± 0.068	4.609AspVal: 4.609 ± 0.072	0.992AspTrp: 0.992 ± 0.033	1.649AspTyr: 1.649 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.331GluAla: 8.331 ± 0.107	0.407GluCys: 0.407 ± 0.02	3.607GluAsp: 3.607 ± 0.073	3.97GluGlu: 3.97 ± 0.076	1.766GluPhe: 1.766 ± 0.048	4.702GluGly: 4.702 ± 0.06	1.29GluHis: 1.29 ± 0.042	3.563GluIle: 3.563 ± 0.064	2.581GluLys: 2.581 ± 0.058	5.557GluLeu: 5.557 ± 0.08	1.537GluMet: 1.537 ± 0.04	1.737GluAsn: 1.737 ± 0.044	3.251GluPro: 3.251 ± 0.061	2.186GluGln: 2.186 ± 0.046	4.864GluArg: 4.864 ± 0.078	2.883GluSer: 2.883 ± 0.055	3.996GluThr: 3.996 ± 0.069	4.059GluVal: 4.059 ± 0.069	0.738GluTrp: 0.738 ± 0.028	1.112GluTyr: 1.112 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.473PheAla: 4.473 ± 0.061	0.387PheCys: 0.387 ± 0.018	2.747PheAsp: 2.747 ± 0.056	2.386PheGlu: 2.386 ± 0.041	1.475PhePhe: 1.475 ± 0.044	3.745PheGly: 3.745 ± 0.061	0.667PheHis: 0.667 ± 0.026	1.585PheIle: 1.585 ± 0.046	1.219PheLys: 1.219 ± 0.039	3.379PheLeu: 3.379 ± 0.074	0.754PheMet: 0.754 ± 0.024	1.059PheAsn: 1.059 ± 0.039	1.645PhePro: 1.645 ± 0.044	0.96PheGln: 0.96 ± 0.029	2.159PheArg: 2.159 ± 0.053	2.161PheSer: 2.161 ± 0.049	1.877PheThr: 1.877 ± 0.045	3.05PheVal: 3.05 ± 0.064	0.581PheTrp: 0.581 ± 0.023	0.929PheTyr: 0.929 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.151GlyAla: 9.151 ± 0.122	0.811GlyCys: 0.811 ± 0.028	4.84GlyAsp: 4.84 ± 0.105	4.923GlyGlu: 4.923 ± 0.073	3.572GlyPhe: 3.572 ± 0.062	7.217GlyGly: 7.217 ± 0.14	1.875GlyHis: 1.875 ± 0.045	4.334GlyIle: 4.334 ± 0.076	3.49GlyLys: 3.49 ± 0.069	8.837GlyLeu: 8.837 ± 0.106	2.101GlyMet: 2.101 ± 0.049	2.233GlyAsn: 2.233 ± 0.068	3.719GlyPro: 3.719 ± 0.066	2.799GlyGln: 2.799 ± 0.056	5.532GlyArg: 5.532 ± 0.087	4.725GlySer: 4.725 ± 0.081	4.947GlyThr: 4.947 ± 0.102	6.159GlyVal: 6.159 ± 0.08	1.298GlyTrp: 1.298 ± 0.039	2.345GlyTyr: 2.345 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.217HisAla: 2.217 ± 0.049	0.227HisCys: 0.227 ± 0.015	1.236HisAsp: 1.236 ± 0.04	1.1HisGlu: 1.1 ± 0.032	0.795HisPhe: 0.795 ± 0.032	1.868HisGly: 1.868 ± 0.051	0.53HisHis: 0.53 ± 0.029	0.886HisIle: 0.886 ± 0.032	0.599HisLys: 0.599 ± 0.026	1.953HisLeu: 1.953 ± 0.052	0.462HisMet: 0.462 ± 0.02	0.525HisAsn: 0.525 ± 0.022	1.246HisPro: 1.246 ± 0.037	0.534HisGln: 0.534 ± 0.023	1.274HisArg: 1.274 ± 0.039	0.891HisSer: 0.891 ± 0.029	0.905HisThr: 0.905 ± 0.031	1.525HisVal: 1.525 ± 0.044	0.301HisTrp: 0.301 ± 0.017	0.57HisTyr: 0.57 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.814IleAla: 6.814 ± 0.1	0.516IleCys: 0.516 ± 0.024	3.547IleAsp: 3.547 ± 0.066	3.732IleGlu: 3.732 ± 0.063	1.667IlePhe: 1.667 ± 0.045	4.747IleGly: 4.747 ± 0.073	0.845IleHis: 0.845 ± 0.033	2.002IleIle: 2.002 ± 0.055	1.662IleLys: 1.662 ± 0.045	4.261IleLeu: 4.261 ± 0.074	0.923IleMet: 0.923 ± 0.033	1.253IleAsn: 1.253 ± 0.035	2.327IlePro: 2.327 ± 0.051	1.19IleGln: 1.19 ± 0.035	2.69IleArg: 2.69 ± 0.055	2.602IleSer: 2.602 ± 0.052	2.528IleThr: 2.528 ± 0.059	4.388IleVal: 4.388 ± 0.073	0.589IleTrp: 0.589 ± 0.03	1.157IleTyr: 1.157 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.569LysAla: 4.569 ± 0.078	0.252LysCys: 0.252 ± 0.016	2.353LysAsp: 2.353 ± 0.055	2.187LysGlu: 2.187 ± 0.054	1.061LysPhe: 1.061 ± 0.037	2.975LysGly: 2.975 ± 0.066	0.691LysHis: 0.691 ± 0.026	1.824LysIle: 1.824 ± 0.047	1.836LysLys: 1.836 ± 0.068	3.576LysLeu: 3.576 ± 0.064	0.771LysMet: 0.771 ± 0.028	1.124LysAsn: 1.124 ± 0.033	2.358LysPro: 2.358 ± 0.057	1.156LysGln: 1.156 ± 0.039	2.84LysArg: 2.84 ± 0.056	2.242LysSer: 2.242 ± 0.047	2.465LysThr: 2.465 ± 0.06	2.692LysVal: 2.692 ± 0.056	0.408LysTrp: 0.408 ± 0.02	0.733LysTyr: 0.733 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	12.66LeuAla: 12.66 ± 0.152	0.865LeuCys: 0.865 ± 0.027	6.03LeuAsp: 6.03 ± 0.078	5.813LeuGlu: 5.813 ± 0.093	3.661LeuPhe: 3.661 ± 0.071	8.285LeuGly: 8.285 ± 0.111	1.766LeuHis: 1.766 ± 0.044	5.063LeuIle: 5.063 ± 0.085	4.095LeuLys: 4.095 ± 0.062	9.151LeuLeu: 9.151 ± 0.139	2.158LeuMet: 2.158 ± 0.05	2.663LeuAsn: 2.663 ± 0.058	5.231LeuPro: 5.231 ± 0.077	2.688LeuGln: 2.688 ± 0.057	6.261LeuArg: 6.261 ± 0.088	6.128LeuSer: 6.128 ± 0.09	5.582LeuThr: 5.582 ± 0.077	7.313LeuVal: 7.313 ± 0.095	1.17LeuTrp: 1.17 ± 0.039	2.231LeuTyr: 2.231 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.813MetAla: 2.813 ± 0.057	0.179MetCys: 0.179 ± 0.014	1.088MetAsp: 1.088 ± 0.031	1.19MetGlu: 1.19 ± 0.037	0.769MetPhe: 0.769 ± 0.033	1.685MetGly: 1.685 ± 0.041	0.444MetHis: 0.444 ± 0.021	1.189MetIle: 1.189 ± 0.038	0.917MetLys: 0.917 ± 0.03	2.306MetLeu: 2.306 ± 0.051	0.572MetMet: 0.572 ± 0.029	0.678MetAsn: 0.678 ± 0.024	1.462MetPro: 1.462 ± 0.04	0.737MetGln: 0.737 ± 0.03	1.829MetArg: 1.829 ± 0.041	1.563MetSer: 1.563 ± 0.04	1.821MetThr: 1.821 ± 0.041	1.551MetVal: 1.551 ± 0.042	0.22MetTrp: 0.22 ± 0.014	0.341MetTyr: 0.341 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.273AsnAla: 3.273 ± 0.062	0.259AsnCys: 0.259 ± 0.016	1.608AsnAsp: 1.608 ± 0.064	1.511AsnGlu: 1.511 ± 0.039	0.992AsnPhe: 0.992 ± 0.033	2.408AsnGly: 2.408 ± 0.06	0.481AsnHis: 0.481 ± 0.025	1.297AsnIle: 1.297 ± 0.04	0.946AsnLys: 0.946 ± 0.034	2.51AsnLeu: 2.51 ± 0.046	0.619AsnMet: 0.619 ± 0.023	0.786AsnAsn: 0.786 ± 0.033	1.83AsnPro: 1.83 ± 0.041	0.741AsnGln: 0.741 ± 0.028	1.667AsnArg: 1.667 ± 0.048	1.209AsnSer: 1.209 ± 0.045	1.363AsnThr: 1.363 ± 0.039	2.163AsnVal: 2.163 ± 0.052	0.432AsnTrp: 0.432 ± 0.021	0.701AsnTyr: 0.701 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.77ProAla: 5.77 ± 0.093	0.364ProCys: 0.364 ± 0.021	3.977ProAsp: 3.977 ± 0.073	4.132ProGlu: 4.132 ± 0.066	1.991ProPhe: 1.991 ± 0.04	4.543ProGly: 4.543 ± 0.073	1.141ProHis: 1.141 ± 0.034	2.434ProIle: 2.434 ± 0.05	2.162ProLys: 2.162 ± 0.047	4.621ProLeu: 4.621 ± 0.074	1.209ProMet: 1.209 ± 0.036	1.55ProAsn: 1.55 ± 0.047	2.724ProPro: 2.724 ± 0.07	1.839ProGln: 1.839 ± 0.055	2.949ProArg: 2.949 ± 0.063	2.97ProSer: 2.97 ± 0.045	2.493ProThr: 2.493 ± 0.046	3.966ProVal: 3.966 ± 0.066	0.679ProTrp: 0.679 ± 0.03	1.343ProTyr: 1.343 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.817GlnAla: 3.817 ± 0.071	0.218GlnCys: 0.218 ± 0.015	1.67GlnAsp: 1.67 ± 0.042	1.717GlnGlu: 1.717 ± 0.04	1.034GlnPhe: 1.034 ± 0.033	2.478GlnGly: 2.478 ± 0.052	0.617GlnHis: 0.617 ± 0.024	1.565GlnIle: 1.565 ± 0.039	1.121GlnLys: 1.121 ± 0.038	2.805GlnLeu: 2.805 ± 0.056	0.842GlnMet: 0.842 ± 0.027	0.863GlnAsn: 0.863 ± 0.032	1.631GlnPro: 1.631 ± 0.054	1.135GlnGln: 1.135 ± 0.039	2.231GlnArg: 2.231 ± 0.055	1.8GlnSer: 1.8 ± 0.046	1.875GlnThr: 1.875 ± 0.044	2.257GlnVal: 2.257 ± 0.043	0.352GlnTrp: 0.352 ± 0.019	0.622GlnTyr: 0.622 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.243ArgAla: 7.243 ± 0.098	0.485ArgCys: 0.485 ± 0.021	3.996ArgAsp: 3.996 ± 0.07	4.112ArgGlu: 4.112 ± 0.072	2.759ArgPhe: 2.759 ± 0.054	4.706ArgGly: 4.706 ± 0.076	1.503ArgHis: 1.503 ± 0.041	3.535ArgIle: 3.535 ± 0.057	2.505ArgLys: 2.505 ± 0.061	7.202ArgLeu: 7.202 ± 0.09	1.594ArgMet: 1.594 ± 0.039	1.772ArgAsn: 1.772 ± 0.045	3.427ArgPro: 3.427 ± 0.07	2.234ArgGln: 2.234 ± 0.056	5.022ArgArg: 5.022 ± 0.088	3.42ArgSer: 3.42 ± 0.06	3.241ArgThr: 3.241 ± 0.051	4.571ArgVal: 4.571 ± 0.071	0.896ArgTrp: 0.896 ± 0.036	1.899ArgTyr: 1.899 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.202SerAla: 6.202 ± 0.098	0.444SerCys: 0.444 ± 0.025	3.198SerAsp: 3.198 ± 0.057	3.161SerGlu: 3.161 ± 0.059	2.135SerPhe: 2.135 ± 0.043	5.344SerGly: 5.344 ± 0.109	1.083SerHis: 1.083 ± 0.03	2.555SerIle: 2.555 ± 0.051	1.993SerLys: 1.993 ± 0.045	5.403SerLeu: 5.403 ± 0.073	1.381SerMet: 1.381 ± 0.037	1.436SerAsn: 1.436 ± 0.038	2.831SerPro: 2.831 ± 0.053	1.626SerGln: 1.626 ± 0.042	3.311SerArg: 3.311 ± 0.056	2.913SerSer: 2.913 ± 0.061	2.61SerThr: 2.61 ± 0.061	3.943SerVal: 3.943 ± 0.066	0.727SerTrp: 0.727 ± 0.027	1.421SerTyr: 1.421 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.254ThrAla: 6.254 ± 0.108	0.463ThrCys: 0.463 ± 0.024	3.107ThrAsp: 3.107 ± 0.067	2.986ThrGlu: 2.986 ± 0.058	2.146ThrPhe: 2.146 ± 0.052	5.072ThrGly: 5.072 ± 0.093	1.009ThrHis: 1.009 ± 0.034	2.791ThrIle: 2.791 ± 0.056	1.854ThrLys: 1.854 ± 0.043	5.787ThrLeu: 5.787 ± 0.073	1.225ThrMet: 1.225 ± 0.037	1.341ThrAsn: 1.341 ± 0.045	3.273ThrPro: 3.273 ± 0.056	1.548ThrGln: 1.548 ± 0.042	3.072ThrArg: 3.072 ± 0.051	2.806ThrSer: 2.806 ± 0.066	2.896ThrThr: 2.896 ± 0.07	4.529ThrVal: 4.529 ± 0.068	0.703ThrTrp: 0.703 ± 0.031	1.344ThrTyr: 1.344 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.782ValAla: 8.782 ± 0.105	0.72ValCys: 0.72 ± 0.025	4.364ValAsp: 4.364 ± 0.065	4.686ValGlu: 4.686 ± 0.07	2.877ValPhe: 2.877 ± 0.061	5.573ValGly: 5.573 ± 0.089	1.399ValHis: 1.399 ± 0.036	3.779ValIle: 3.779 ± 0.069	2.529ValLys: 2.529 ± 0.045	7.778ValLeu: 7.778 ± 0.104	1.675ValMet: 1.675 ± 0.045	2.008ValAsn: 2.008 ± 0.048	4.125ValPro: 4.125 ± 0.072	2.045ValGln: 2.045 ± 0.046	4.726ValArg: 4.726 ± 0.082	4.497ValSer: 4.497 ± 0.067	4.464ValThr: 4.464 ± 0.08	6.045ValVal: 6.045 ± 0.096	0.971ValTrp: 0.971 ± 0.037	1.681ValTyr: 1.681 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.199TrpAla: 1.199 ± 0.038	0.162TrpCys: 0.162 ± 0.013	0.69TrpAsp: 0.69 ± 0.03	0.577TrpGlu: 0.577 ± 0.023	0.564TrpPhe: 0.564 ± 0.026	0.952TrpGly: 0.952 ± 0.033	0.337TrpHis: 0.337 ± 0.016	0.657TrpIle: 0.657 ± 0.025	0.479TrpLys: 0.479 ± 0.024	1.663TrpLeu: 1.663 ± 0.048	0.327TrpMet: 0.327 ± 0.018	0.393TrpAsn: 0.393 ± 0.021	0.693TrpPro: 0.693 ± 0.026	0.567TrpGln: 0.567 ± 0.021	1.17TrpArg: 1.17 ± 0.034	0.776TrpSer: 0.776 ± 0.029	0.766TrpThr: 0.766 ± 0.029	0.843TrpVal: 0.843 ± 0.031	0.253TrpTrp: 0.253 ± 0.016	0.319TrpTyr: 0.319 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.671TyrAla: 2.671 ± 0.054	0.286TyrCys: 0.286 ± 0.016	1.664TyrAsp: 1.664 ± 0.045	1.413TyrGlu: 1.413 ± 0.042	1.011TyrPhe: 1.011 ± 0.034	2.3TyrGly: 2.3 ± 0.054	0.497TyrHis: 0.497 ± 0.024	0.943TyrIle: 0.943 ± 0.032	0.756TyrLys: 0.756 ± 0.03	2.377TyrLeu: 2.377 ± 0.048	0.509TyrMet: 0.509 ± 0.024	0.62TyrAsn: 0.62 ± 0.028	1.127TyrPro: 1.127 ± 0.037	0.751TyrGln: 0.751 ± 0.031	1.872TyrArg: 1.872 ± 0.044	1.166TyrSer: 1.166 ± 0.033	1.13TyrThr: 1.13 ± 0.036	1.848TyrVal: 1.848 ± 0.047	0.456TyrTrp: 0.456 ± 0.021	0.709TyrTyr: 0.709 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3341 proteins (996689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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