Amino acid dipepetide frequency for Pseudoalteromonas luteoviolacea DSM 6061

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.784AlaAla: 6.784 ± 0.083	1.009AlaCys: 1.009 ± 0.025	4.221AlaAsp: 4.221 ± 0.056	4.839AlaGlu: 4.839 ± 0.067	3.411AlaPhe: 3.411 ± 0.05	5.395AlaGly: 5.395 ± 0.067	1.907AlaHis: 1.907 ± 0.035	5.643AlaIle: 5.643 ± 0.066	5.164AlaLys: 5.164 ± 0.059	9.722AlaLeu: 9.722 ± 0.087	2.267AlaMet: 2.267 ± 0.044	3.857AlaAsn: 3.857 ± 0.052	2.906AlaPro: 2.906 ± 0.048	4.739AlaGln: 4.739 ± 0.068	3.243AlaArg: 3.243 ± 0.048	5.353AlaSer: 5.353 ± 0.063	4.313AlaThr: 4.313 ± 0.064	5.305AlaVal: 5.305 ± 0.065	0.882AlaTrp: 0.882 ± 0.027	2.61AlaTyr: 2.61 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.838CysAla: 0.838 ± 0.025	0.162CysCys: 0.162 ± 0.01	0.671CysAsp: 0.671 ± 0.022	0.684CysGlu: 0.684 ± 0.018	0.495CysPhe: 0.495 ± 0.017	0.792CysGly: 0.792 ± 0.022	0.316CysHis: 0.316 ± 0.013	0.683CysIle: 0.683 ± 0.022	0.502CysLys: 0.502 ± 0.016	1.007CysLeu: 1.007 ± 0.026	0.225CysMet: 0.225 ± 0.013	0.46CysAsn: 0.46 ± 0.017	0.408CysPro: 0.408 ± 0.016	0.52CysGln: 0.52 ± 0.021	0.429CysArg: 0.429 ± 0.014	0.741CysSer: 0.741 ± 0.02	0.527CysThr: 0.527 ± 0.02	0.657CysVal: 0.657 ± 0.022	0.113CysTrp: 0.113 ± 0.008	0.365CysTyr: 0.365 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.263AspAla: 4.263 ± 0.062	0.546AspCys: 0.546 ± 0.018	3.012AspAsp: 3.012 ± 0.052	3.769AspGlu: 3.769 ± 0.054	2.566AspPhe: 2.566 ± 0.048	3.814AspGly: 3.814 ± 0.076	1.072AspHis: 1.072 ± 0.026	4.17AspIle: 4.17 ± 0.045	3.505AspLys: 3.505 ± 0.05	5.168AspLeu: 5.168 ± 0.057	1.315AspMet: 1.315 ± 0.028	2.657AspAsn: 2.657 ± 0.044	2.0AspPro: 2.0 ± 0.039	1.882AspGln: 1.882 ± 0.031	1.879AspArg: 1.879 ± 0.037	3.488AspSer: 3.488 ± 0.054	2.92AspThr: 2.92 ± 0.053	3.811AspVal: 3.811 ± 0.044	0.794AspTrp: 0.794 ± 0.023	2.164AspTyr: 2.164 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	4.907GluAla: 4.907 ± 0.063	0.488GluCys: 0.488 ± 0.016	2.751GluAsp: 2.751 ± 0.05	3.618GluGlu: 3.618 ± 0.061	2.777GluPhe: 2.777 ± 0.046	3.427GluGly: 3.427 ± 0.056	1.842GluHis: 1.842 ± 0.036	3.871GluIle: 3.871 ± 0.051	3.742GluLys: 3.742 ± 0.059	7.531GluLeu: 7.531 ± 0.081	1.393GluMet: 1.393 ± 0.03	2.745GluAsn: 2.745 ± 0.048	1.905GluPro: 1.905 ± 0.034	4.746GluGln: 4.746 ± 0.066	3.117GluArg: 3.117 ± 0.048	3.957GluSer: 3.957 ± 0.052	2.907GluThr: 2.907 ± 0.05	4.465GluVal: 4.465 ± 0.058	0.606GluTrp: 0.606 ± 0.019	1.993GluTyr: 1.993 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.716PheAla: 3.716 ± 0.056	0.532PheCys: 0.532 ± 0.018	3.046PheAsp: 3.046 ± 0.051	3.036PheGlu: 3.036 ± 0.045	1.696PhePhe: 1.696 ± 0.036	3.032PheGly: 3.032 ± 0.046	0.79PheHis: 0.79 ± 0.018	2.877PheIle: 2.877 ± 0.049	2.5PheLys: 2.5 ± 0.042	3.321PheLeu: 3.321 ± 0.058	0.946PheMet: 0.946 ± 0.024	2.377PheAsn: 2.377 ± 0.037	1.266PhePro: 1.266 ± 0.027	1.194PheGln: 1.194 ± 0.027	1.376PheArg: 1.376 ± 0.03	3.704PheSer: 3.704 ± 0.048	2.457PheThr: 2.457 ± 0.042	2.97PheVal: 2.97 ± 0.047	0.544PheTrp: 0.544 ± 0.017	1.501PheTyr: 1.501 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	4.959GlyAla: 4.959 ± 0.065	0.84GlyCys: 0.84 ± 0.024	3.548GlyAsp: 3.548 ± 0.067	4.21GlyGlu: 4.21 ± 0.052	3.268GlyPhe: 3.268 ± 0.044	4.396GlyGly: 4.396 ± 0.077	1.578GlyHis: 1.578 ± 0.031	4.172GlyIle: 4.172 ± 0.057	3.886GlyLys: 3.886 ± 0.06	6.416GlyLeu: 6.416 ± 0.071	1.589GlyMet: 1.589 ± 0.036	2.896GlyAsn: 2.896 ± 0.065	1.594GlyPro: 1.594 ± 0.03	2.927GlyGln: 2.927 ± 0.047	2.71GlyArg: 2.71 ± 0.049	4.037GlySer: 4.037 ± 0.069	3.385GlyThr: 3.385 ± 0.053	4.876GlyVal: 4.876 ± 0.064	0.832GlyTrp: 0.832 ± 0.021	2.515GlyTyr: 2.515 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.694HisAla: 1.694 ± 0.032	0.352HisCys: 0.352 ± 0.013	1.194HisAsp: 1.194 ± 0.026	1.271HisGlu: 1.271 ± 0.028	1.213HisPhe: 1.213 ± 0.027	1.569HisGly: 1.569 ± 0.034	0.729HisHis: 0.729 ± 0.025	1.622HisIle: 1.622 ± 0.03	1.213HisLys: 1.213 ± 0.03	2.322HisLeu: 2.322 ± 0.04	0.498HisMet: 0.498 ± 0.018	1.085HisAsn: 1.085 ± 0.023	1.046HisPro: 1.046 ± 0.024	1.271HisGln: 1.271 ± 0.033	0.942HisArg: 0.942 ± 0.026	1.628HisSer: 1.628 ± 0.03	1.257HisThr: 1.257 ± 0.034	1.387HisVal: 1.387 ± 0.033	0.345HisTrp: 0.345 ± 0.016	0.985HisTyr: 0.985 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.145IleAla: 6.145 ± 0.07	0.709IleCys: 0.709 ± 0.019	4.186IleAsp: 4.186 ± 0.056	5.031IleGlu: 5.031 ± 0.067	2.237IlePhe: 2.237 ± 0.045	4.262IleGly: 4.262 ± 0.059	1.255IleHis: 1.255 ± 0.029	3.23IleIle: 3.23 ± 0.049	3.682IleLys: 3.682 ± 0.051	5.024IleLeu: 5.024 ± 0.071	1.154IleMet: 1.154 ± 0.028	3.296IleAsn: 3.296 ± 0.042	2.275IlePro: 2.275 ± 0.041	2.259IleGln: 2.259 ± 0.034	2.507IleArg: 2.507 ± 0.04	4.861IleSer: 4.861 ± 0.055	3.621IleThr: 3.621 ± 0.05	3.987IleVal: 3.987 ± 0.058	0.674IleTrp: 0.674 ± 0.021	1.836IleTyr: 1.836 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.949LysAla: 4.949 ± 0.055	0.405LysCys: 0.405 ± 0.018	2.846LysAsp: 2.846 ± 0.042	3.48LysGlu: 3.48 ± 0.051	1.832LysPhe: 1.832 ± 0.033	3.395LysGly: 3.395 ± 0.045	1.51LysHis: 1.51 ± 0.028	3.025LysIle: 3.025 ± 0.044	3.057LysLys: 3.057 ± 0.059	6.201LysLeu: 6.201 ± 0.062	1.241LysMet: 1.241 ± 0.029	2.463LysAsn: 2.463 ± 0.04	2.379LysPro: 2.379 ± 0.036	3.385LysGln: 3.385 ± 0.047	2.858LysArg: 2.858 ± 0.044	3.906LysSer: 3.906 ± 0.054	2.971LysThr: 2.971 ± 0.046	4.192LysVal: 4.192 ± 0.054	0.625LysTrp: 0.625 ± 0.017	1.761LysTyr: 1.761 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	9.462LeuAla: 9.462 ± 0.102	1.191LeuCys: 1.191 ± 0.028	5.812LeuAsp: 5.812 ± 0.069	6.386LeuGlu: 6.386 ± 0.076	4.291LeuPhe: 4.291 ± 0.07	6.491LeuGly: 6.491 ± 0.077	2.113LeuHis: 2.113 ± 0.037	5.97LeuIle: 5.97 ± 0.067	5.904LeuLys: 5.904 ± 0.062	10.186LeuLeu: 10.186 ± 0.137	2.354LeuMet: 2.354 ± 0.035	5.265LeuAsn: 5.265 ± 0.063	4.551LeuPro: 4.551 ± 0.052	4.107LeuGln: 4.107 ± 0.059	3.893LeuArg: 3.893 ± 0.055	8.469LeuSer: 8.469 ± 0.087	5.989LeuThr: 5.989 ± 0.067	6.808LeuVal: 6.808 ± 0.072	0.998LeuTrp: 0.998 ± 0.031	2.888LeuTyr: 2.888 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.166MetAla: 2.166 ± 0.04	0.191MetCys: 0.191 ± 0.011	1.08MetAsp: 1.08 ± 0.025	1.046MetGlu: 1.046 ± 0.025	0.795MetPhe: 0.795 ± 0.021	1.382MetGly: 1.382 ± 0.033	0.502MetHis: 0.502 ± 0.016	1.254MetIle: 1.254 ± 0.026	1.329MetLys: 1.329 ± 0.025	2.581MetLeu: 2.581 ± 0.04	0.611MetMet: 0.611 ± 0.02	0.974MetAsn: 0.974 ± 0.022	1.084MetPro: 1.084 ± 0.025	1.188MetGln: 1.188 ± 0.027	1.099MetArg: 1.099 ± 0.025	1.864MetSer: 1.864 ± 0.035	1.406MetThr: 1.406 ± 0.033	1.452MetVal: 1.452 ± 0.03	0.21MetTrp: 0.21 ± 0.011	0.573MetTyr: 0.573 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.806AsnAla: 3.806 ± 0.047	0.513AsnCys: 0.513 ± 0.019	2.559AsnAsp: 2.559 ± 0.06	2.847AsnGlu: 2.847 ± 0.044	1.79AsnPhe: 1.79 ± 0.037	3.242AsnGly: 3.242 ± 0.055	1.067AsnHis: 1.067 ± 0.022	2.948AsnIle: 2.948 ± 0.041	2.772AsnLys: 2.772 ± 0.044	4.369AsnLeu: 4.369 ± 0.046	1.104AsnMet: 1.104 ± 0.026	2.37AsnAsn: 2.37 ± 0.036	1.962AsnPro: 1.962 ± 0.033	2.416AsnGln: 2.416 ± 0.04	2.007AsnArg: 2.007 ± 0.033	3.06AsnSer: 3.06 ± 0.047	2.776AsnThr: 2.776 ± 0.049	2.881AsnVal: 2.881 ± 0.042	0.694AsnTrp: 0.694 ± 0.02	1.633AsnTyr: 1.633 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	2.764ProAla: 2.764 ± 0.045	0.321ProCys: 0.321 ± 0.014	2.234ProAsp: 2.234 ± 0.039	2.82ProGlu: 2.82 ± 0.042	1.706ProPhe: 1.706 ± 0.03	1.95ProGly: 1.95 ± 0.039	0.885ProHis: 0.885 ± 0.019	2.498ProIle: 2.498 ± 0.037	2.133ProLys: 2.133 ± 0.037	3.699ProLeu: 3.699 ± 0.055	0.799ProMet: 0.799 ± 0.023	1.918ProAsn: 1.918 ± 0.038	1.011ProPro: 1.011 ± 0.026	1.703ProGln: 1.703 ± 0.03	1.171ProArg: 1.171 ± 0.03	2.664ProSer: 2.664 ± 0.042	2.023ProThr: 2.023 ± 0.036	2.747ProVal: 2.747 ± 0.043	0.492ProTrp: 0.492 ± 0.018	1.265ProTyr: 1.265 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.481GlnAla: 4.481 ± 0.063	0.441GlnCys: 0.441 ± 0.016	2.257GlnAsp: 2.257 ± 0.04	2.421GlnGlu: 2.421 ± 0.042	2.163GlnPhe: 2.163 ± 0.037	3.259GlnGly: 3.259 ± 0.055	1.273GlnHis: 1.273 ± 0.031	2.889GlnIle: 2.889 ± 0.04	2.449GlnLys: 2.449 ± 0.041	5.784GlnLeu: 5.784 ± 0.084	1.006GlnMet: 1.006 ± 0.025	2.03GlnAsn: 2.03 ± 0.038	1.725GlnPro: 1.725 ± 0.031	3.317GlnGln: 3.317 ± 0.07	2.062GlnArg: 2.062 ± 0.039	3.689GlnSer: 3.689 ± 0.052	2.567GlnThr: 2.567 ± 0.04	3.526GlnVal: 3.526 ± 0.053	0.633GlnTrp: 0.633 ± 0.02	1.616GlnTyr: 1.616 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.342ArgAla: 3.342 ± 0.048	0.395ArgCys: 0.395 ± 0.016	2.175ArgAsp: 2.175 ± 0.044	2.496ArgGlu: 2.496 ± 0.046	2.131ArgPhe: 2.131 ± 0.037	2.398ArgGly: 2.398 ± 0.038	1.01ArgHis: 1.01 ± 0.023	2.678ArgIle: 2.678 ± 0.038	2.201ArgLys: 2.201 ± 0.039	4.558ArgLeu: 4.558 ± 0.06	0.931ArgMet: 0.931 ± 0.023	1.799ArgAsn: 1.799 ± 0.037	1.372ArgPro: 1.372 ± 0.028	1.969ArgGln: 1.969 ± 0.035	1.839ArgArg: 1.839 ± 0.039	2.446ArgSer: 2.446 ± 0.036	2.018ArgThr: 2.018 ± 0.037	3.034ArgVal: 3.034 ± 0.047	0.541ArgTrp: 0.541 ± 0.018	1.671ArgTyr: 1.671 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.855SerAla: 5.855 ± 0.064	0.672SerCys: 0.672 ± 0.02	3.975SerAsp: 3.975 ± 0.057	4.578SerGlu: 4.578 ± 0.062	3.135SerPhe: 3.135 ± 0.051	5.136SerGly: 5.136 ± 0.081	1.773SerHis: 1.773 ± 0.034	4.421SerIle: 4.421 ± 0.055	3.799SerLys: 3.799 ± 0.053	7.275SerLeu: 7.275 ± 0.072	1.61SerMet: 1.61 ± 0.031	3.315SerAsn: 3.315 ± 0.046	2.453SerPro: 2.453 ± 0.039	3.488SerGln: 3.488 ± 0.049	2.755SerArg: 2.755 ± 0.042	4.849SerSer: 4.849 ± 0.067	3.647SerThr: 3.647 ± 0.055	4.777SerVal: 4.777 ± 0.059	0.861SerTrp: 0.861 ± 0.024	2.371SerTyr: 2.371 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.309ThrAla: 4.309 ± 0.064	0.515ThrCys: 0.515 ± 0.018	2.888ThrAsp: 2.888 ± 0.05	3.233ThrGlu: 3.233 ± 0.045	2.214ThrPhe: 2.214 ± 0.039	3.8ThrGly: 3.8 ± 0.056	1.403ThrHis: 1.403 ± 0.028	3.312ThrIle: 3.312 ± 0.048	2.622ThrLys: 2.622 ± 0.043	6.237ThrLeu: 6.237 ± 0.074	1.109ThrMet: 1.109 ± 0.024	2.227ThrAsn: 2.227 ± 0.041	2.665ThrPro: 2.665 ± 0.046	2.86ThrGln: 2.86 ± 0.048	2.1ThrArg: 2.1 ± 0.035	3.597ThrSer: 3.597 ± 0.047	2.936ThrThr: 2.936 ± 0.052	3.676ThrVal: 3.676 ± 0.063	0.66ThrTrp: 0.66 ± 0.02	1.743ThrTyr: 1.743 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	5.945ValAla: 5.945 ± 0.069	0.774ValCys: 0.774 ± 0.021	3.941ValAsp: 3.941 ± 0.054	4.663ValGlu: 4.663 ± 0.055	2.936ValPhe: 2.936 ± 0.045	4.063ValGly: 4.063 ± 0.05	1.307ValHis: 1.307 ± 0.028	4.508ValIle: 4.508 ± 0.06	3.907ValLys: 3.907 ± 0.05	6.617ValLeu: 6.617 ± 0.074	1.689ValMet: 1.689 ± 0.033	3.296ValAsn: 3.296 ± 0.047	2.449ValPro: 2.449 ± 0.039	2.421ValGln: 2.421 ± 0.035	2.622ValArg: 2.622 ± 0.043	5.325ValSer: 5.325 ± 0.064	4.136ValThr: 4.136 ± 0.059	4.855ValVal: 4.855 ± 0.06	0.745ValTrp: 0.745 ± 0.021	2.113ValTyr: 2.113 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.725TrpAla: 0.725 ± 0.02	0.115TrpCys: 0.115 ± 0.008	0.552TrpAsp: 0.552 ± 0.019	0.538TrpGlu: 0.538 ± 0.02	0.57TrpPhe: 0.57 ± 0.02	0.683TrpGly: 0.683 ± 0.021	0.426TrpHis: 0.426 ± 0.016	0.551TrpIle: 0.551 ± 0.016	0.426TrpLys: 0.426 ± 0.015	1.622TrpLeu: 1.622 ± 0.037	0.303TrpMet: 0.303 ± 0.013	0.403TrpAsn: 0.403 ± 0.015	0.445TrpPro: 0.445 ± 0.017	1.204TrpGln: 1.204 ± 0.034	0.658TrpArg: 0.658 ± 0.019	0.79TrpSer: 0.79 ± 0.023	0.477TrpThr: 0.477 ± 0.018	0.832TrpVal: 0.832 ± 0.021	0.179TrpTrp: 0.179 ± 0.011	0.417TrpTyr: 0.417 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.462TyrAla: 2.462 ± 0.038	0.424TyrCys: 0.424 ± 0.018	1.848TyrAsp: 1.848 ± 0.04	1.822TyrGlu: 1.822 ± 0.033	1.653TyrPhe: 1.653 ± 0.033	2.148TyrGly: 2.148 ± 0.036	0.867TyrHis: 0.867 ± 0.024	1.909TyrIle: 1.909 ± 0.034	1.685TyrLys: 1.685 ± 0.033	3.491TyrLeu: 3.491 ± 0.049	0.64TyrMet: 0.64 ± 0.021	1.382TyrAsn: 1.382 ± 0.031	1.307TyrPro: 1.307 ± 0.031	1.992TyrGln: 1.992 ± 0.03	1.738TyrArg: 1.738 ± 0.033	2.318TyrSer: 2.318 ± 0.041	1.771TyrThr: 1.771 ± 0.034	2.075TyrVal: 2.075 ± 0.041	0.486TyrTrp: 0.486 ± 0.018	1.17TyrTyr: 1.17 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5008 proteins (1708250 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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