Amino acid dipepetide frequency for Marinimicrobium koreense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.199AlaAla: 9.199 ± 0.129	0.954AlaCys: 0.954 ± 0.032	5.762AlaAsp: 5.762 ± 0.07	7.193AlaGlu: 7.193 ± 0.09	3.563AlaPhe: 3.563 ± 0.062	7.417AlaGly: 7.417 ± 0.083	1.944AlaHis: 1.944 ± 0.044	4.726AlaIle: 4.726 ± 0.065	2.967AlaLys: 2.967 ± 0.078	11.948AlaLeu: 11.948 ± 0.162	2.542AlaMet: 2.542 ± 0.049	2.925AlaAsn: 2.925 ± 0.056	4.171AlaPro: 4.171 ± 0.068	4.441AlaGln: 4.441 ± 0.073	6.434AlaArg: 6.434 ± 0.093	5.632AlaSer: 5.632 ± 0.082	4.508AlaThr: 4.508 ± 0.082	6.623AlaVal: 6.623 ± 0.084	1.264AlaTrp: 1.264 ± 0.034	2.434AlaTyr: 2.434 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.807CysAla: 0.807 ± 0.025	0.119CysCys: 0.119 ± 0.01	0.556CysAsp: 0.556 ± 0.024	0.527CysGlu: 0.527 ± 0.022	0.307CysPhe: 0.307 ± 0.017	0.856CysGly: 0.856 ± 0.031	0.31CysHis: 0.31 ± 0.022	0.418CysIle: 0.418 ± 0.02	0.253CysLys: 0.253 ± 0.015	0.92CysLeu: 0.92 ± 0.032	0.146CysMet: 0.146 ± 0.011	0.229CysAsn: 0.229 ± 0.015	0.448CysPro: 0.448 ± 0.024	0.375CysGln: 0.375 ± 0.017	0.574CysArg: 0.574 ± 0.027	0.55CysSer: 0.55 ± 0.025	0.422CysThr: 0.422 ± 0.021	0.563CysVal: 0.563 ± 0.022	0.13CysTrp: 0.13 ± 0.009	0.257CysTyr: 0.257 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.584AspAla: 5.584 ± 0.078	0.528AspCys: 0.528 ± 0.022	3.915AspAsp: 3.915 ± 0.083	4.278AspGlu: 4.278 ± 0.074	2.471AspPhe: 2.471 ± 0.053	4.886AspGly: 4.886 ± 0.104	1.412AspHis: 1.412 ± 0.035	3.369AspIle: 3.369 ± 0.057	1.922AspLys: 1.922 ± 0.045	5.847AspLeu: 5.847 ± 0.069	1.321AspMet: 1.321 ± 0.04	2.255AspAsn: 2.255 ± 0.056	3.139AspPro: 3.139 ± 0.057	2.705AspGln: 2.705 ± 0.052	3.9AspArg: 3.9 ± 0.06	3.556AspSer: 3.556 ± 0.067	3.165AspThr: 3.165 ± 0.063	3.945AspVal: 3.945 ± 0.067	1.229AspTrp: 1.229 ± 0.038	2.29AspTyr: 2.29 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	7.147GluAla: 7.147 ± 0.096	0.44GluCys: 0.44 ± 0.021	3.656GluAsp: 3.656 ± 0.061	4.173GluGlu: 4.173 ± 0.077	2.248GluPhe: 2.248 ± 0.052	4.855GluGly: 4.855 ± 0.079	1.71GluHis: 1.71 ± 0.04	2.866GluIle: 2.866 ± 0.053	2.455GluLys: 2.455 ± 0.059	7.209GluLeu: 7.209 ± 0.102	1.438GluMet: 1.438 ± 0.038	2.088GluAsn: 2.088 ± 0.041	3.398GluPro: 3.398 ± 0.061	4.154GluGln: 4.154 ± 0.076	5.472GluArg: 5.472 ± 0.09	3.668GluSer: 3.668 ± 0.064	3.419GluThr: 3.419 ± 0.057	4.683GluVal: 4.683 ± 0.065	0.942GluTrp: 0.942 ± 0.033	1.786GluTyr: 1.786 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.334PheAla: 3.334 ± 0.056	0.365PheCys: 0.365 ± 0.019	2.7PheAsp: 2.7 ± 0.056	2.476PheGlu: 2.476 ± 0.048	1.477PhePhe: 1.477 ± 0.043	3.14PheGly: 3.14 ± 0.06	0.803PheHis: 0.803 ± 0.027	1.855PheIle: 1.855 ± 0.045	1.191PheLys: 1.191 ± 0.037	3.269PheLeu: 3.269 ± 0.066	0.871PheMet: 0.871 ± 0.028	1.451PheAsn: 1.451 ± 0.04	1.486PhePro: 1.486 ± 0.036	1.241PheGln: 1.241 ± 0.034	2.04PheArg: 2.04 ± 0.041	2.679PheSer: 2.679 ± 0.052	2.143PheThr: 2.143 ± 0.054	2.509PheVal: 2.509 ± 0.055	0.616PheTrp: 0.616 ± 0.025	1.232PheTyr: 1.232 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.657GlyAla: 6.657 ± 0.093	0.859GlyCys: 0.859 ± 0.029	4.87GlyAsp: 4.87 ± 0.088	5.526GlyGlu: 5.526 ± 0.079	3.312GlyPhe: 3.312 ± 0.058	6.071GlyGly: 6.071 ± 0.117	1.843GlyHis: 1.843 ± 0.045	3.963GlyIle: 3.963 ± 0.062	2.938GlyLys: 2.938 ± 0.062	7.94GlyLeu: 7.94 ± 0.097	1.938GlyMet: 1.938 ± 0.047	2.525GlyAsn: 2.525 ± 0.067	2.642GlyPro: 2.642 ± 0.045	3.386GlyGln: 3.386 ± 0.057	4.721GlyArg: 4.721 ± 0.064	4.472GlySer: 4.472 ± 0.092	3.926GlyThr: 3.926 ± 0.074	5.85GlyVal: 5.85 ± 0.071	1.374GlyTrp: 1.374 ± 0.038	2.563GlyTyr: 2.563 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.673HisAla: 1.673 ± 0.038	0.319HisCys: 0.319 ± 0.017	1.134HisAsp: 1.134 ± 0.034	1.206HisGlu: 1.206 ± 0.032	1.014HisPhe: 1.014 ± 0.029	1.606HisGly: 1.606 ± 0.045	0.753HisHis: 0.753 ± 0.03	1.162HisIle: 1.162 ± 0.033	0.734HisLys: 0.734 ± 0.026	2.458HisLeu: 2.458 ± 0.043	0.514HisMet: 0.514 ± 0.021	0.789HisAsn: 0.789 ± 0.028	1.519HisPro: 1.519 ± 0.037	1.122HisGln: 1.122 ± 0.034	1.694HisArg: 1.694 ± 0.045	1.356HisSer: 1.356 ± 0.035	1.159HisThr: 1.159 ± 0.034	1.152HisVal: 1.152 ± 0.029	0.559HisTrp: 0.559 ± 0.021	1.032HisTyr: 1.032 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.08IleAla: 5.08 ± 0.069	0.404IleCys: 0.404 ± 0.02	3.552IleAsp: 3.552 ± 0.065	3.649IleGlu: 3.649 ± 0.064	1.532IlePhe: 1.532 ± 0.039	3.918IleGly: 3.918 ± 0.064	1.096IleHis: 1.096 ± 0.033	2.175IleIle: 2.175 ± 0.051	1.767IleLys: 1.767 ± 0.046	4.051IleLeu: 4.051 ± 0.071	0.919IleMet: 0.919 ± 0.029	2.023IleAsn: 2.023 ± 0.047	2.359IlePro: 2.359 ± 0.044	1.809IleGln: 1.809 ± 0.038	2.939IleArg: 2.939 ± 0.056	2.861IleSer: 2.861 ± 0.056	2.785IleThr: 2.785 ± 0.057	3.195IleVal: 3.195 ± 0.055	0.555IleTrp: 0.555 ± 0.022	1.307IleTyr: 1.307 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.558LysAla: 3.558 ± 0.077	0.186LysCys: 0.186 ± 0.014	1.901LysAsp: 1.901 ± 0.049	1.871LysGlu: 1.871 ± 0.043	0.852LysPhe: 0.852 ± 0.03	2.467LysGly: 2.467 ± 0.05	0.76LysHis: 0.76 ± 0.027	1.53LysIle: 1.53 ± 0.045	1.433LysLys: 1.433 ± 0.05	3.18LysLeu: 3.18 ± 0.059	0.698LysMet: 0.698 ± 0.025	1.119LysAsn: 1.119 ± 0.036	1.924LysPro: 1.924 ± 0.044	1.449LysGln: 1.449 ± 0.04	2.299LysArg: 2.299 ± 0.051	1.839LysSer: 1.839 ± 0.044	1.938LysThr: 1.938 ± 0.041	2.642LysVal: 2.642 ± 0.069	0.339LysTrp: 0.339 ± 0.017	0.788LysTyr: 0.788 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.273LeuAla: 11.273 ± 0.155	0.979LeuCys: 0.979 ± 0.037	6.402LeuAsp: 6.402 ± 0.084	6.973LeuGlu: 6.973 ± 0.093	3.728LeuPhe: 3.728 ± 0.073	7.843LeuGly: 7.843 ± 0.105	2.148LeuHis: 2.148 ± 0.051	5.056LeuIle: 5.056 ± 0.075	4.033LeuLys: 4.033 ± 0.061	11.053LeuLeu: 11.053 ± 0.179	2.562LeuMet: 2.562 ± 0.056	3.768LeuAsn: 3.768 ± 0.059	5.367LeuPro: 5.367 ± 0.081	3.818LeuGln: 3.818 ± 0.057	6.307LeuArg: 6.307 ± 0.09	7.289LeuSer: 7.289 ± 0.09	6.01LeuThr: 6.01 ± 0.085	7.462LeuVal: 7.462 ± 0.098	1.58LeuTrp: 1.58 ± 0.045	2.79LeuTyr: 2.79 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.655MetAla: 2.655 ± 0.053	0.137MetCys: 0.137 ± 0.011	1.26MetAsp: 1.26 ± 0.035	1.274MetGlu: 1.274 ± 0.037	0.632MetPhe: 0.632 ± 0.025	1.684MetGly: 1.684 ± 0.046	0.45MetHis: 0.45 ± 0.018	1.145MetIle: 1.145 ± 0.033	0.912MetLys: 0.912 ± 0.031	2.197MetLeu: 2.197 ± 0.056	0.557MetMet: 0.557 ± 0.021	0.897MetAsn: 0.897 ± 0.03	1.25MetPro: 1.25 ± 0.03	0.834MetGln: 0.834 ± 0.028	1.359MetArg: 1.359 ± 0.038	1.55MetSer: 1.55 ± 0.036	1.633MetThr: 1.633 ± 0.039	1.602MetVal: 1.602 ± 0.041	0.181MetTrp: 0.181 ± 0.012	0.42MetTyr: 0.42 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.119AsnAla: 3.119 ± 0.057	0.28AsnCys: 0.28 ± 0.019	2.028AsnAsp: 2.028 ± 0.051	1.926AsnGlu: 1.926 ± 0.038	1.229AsnPhe: 1.229 ± 0.031	2.801AsnGly: 2.801 ± 0.074	0.788AsnHis: 0.788 ± 0.029	1.75AsnIle: 1.75 ± 0.044	0.957AsnLys: 0.957 ± 0.033	3.337AsnLeu: 3.337 ± 0.053	0.645AsnMet: 0.645 ± 0.027	1.266AsnAsn: 1.266 ± 0.042	2.209AsnPro: 2.209 ± 0.047	1.463AsnGln: 1.463 ± 0.038	2.413AsnArg: 2.413 ± 0.05	1.765AsnSer: 1.765 ± 0.047	1.862AsnThr: 1.862 ± 0.041	2.063AsnVal: 2.063 ± 0.047	0.533AsnTrp: 0.533 ± 0.023	1.002AsnTyr: 1.002 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.557ProAla: 4.557 ± 0.071	0.312ProCys: 0.312 ± 0.017	3.67ProAsp: 3.67 ± 0.059	4.88ProGlu: 4.88 ± 0.075	1.685ProPhe: 1.685 ± 0.04	3.973ProGly: 3.973 ± 0.063	1.03ProHis: 1.03 ± 0.033	1.997ProIle: 1.997 ± 0.047	1.471ProLys: 1.471 ± 0.042	5.0ProLeu: 5.0 ± 0.065	1.145ProMet: 1.145 ± 0.033	1.56ProAsn: 1.56 ± 0.04	1.89ProPro: 1.89 ± 0.048	1.737ProGln: 1.737 ± 0.042	2.329ProArg: 2.329 ± 0.05	2.648ProSer: 2.648 ± 0.051	2.334ProThr: 2.334 ± 0.047	3.785ProVal: 3.785 ± 0.062	0.722ProTrp: 0.722 ± 0.025	1.294ProTyr: 1.294 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.703GlnAla: 4.703 ± 0.077	0.349GlnCys: 0.349 ± 0.017	2.017GlnAsp: 2.017 ± 0.043	2.417GlnGlu: 2.417 ± 0.054	1.54GlnPhe: 1.54 ± 0.036	3.21GlnGly: 3.21 ± 0.052	1.004GlnHis: 1.004 ± 0.033	1.866GlnIle: 1.866 ± 0.046	1.328GlnLys: 1.328 ± 0.034	4.831GlnLeu: 4.831 ± 0.089	0.989GlnMet: 0.989 ± 0.03	1.156GlnAsn: 1.156 ± 0.033	2.286GlnPro: 2.286 ± 0.047	2.302GlnGln: 2.302 ± 0.062	3.336GlnArg: 3.336 ± 0.065	2.702GlnSer: 2.702 ± 0.054	2.24GlnThr: 2.24 ± 0.038	3.236GlnVal: 3.236 ± 0.057	0.96GlnTrp: 0.96 ± 0.031	1.1GlnTyr: 1.1 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.947ArgAla: 5.947 ± 0.089	0.532ArgCys: 0.532 ± 0.027	3.946ArgAsp: 3.946 ± 0.063	4.764ArgGlu: 4.764 ± 0.076	2.723ArgPhe: 2.723 ± 0.054	3.94ArgGly: 3.94 ± 0.059	1.715ArgHis: 1.715 ± 0.039	3.333ArgIle: 3.333 ± 0.055	2.129ArgLys: 2.129 ± 0.041	7.341ArgLeu: 7.341 ± 0.111	1.524ArgMet: 1.524 ± 0.04	2.09ArgAsn: 2.09 ± 0.043	2.879ArgPro: 2.879 ± 0.053	3.305ArgGln: 3.305 ± 0.063	4.476ArgArg: 4.476 ± 0.081	3.481ArgSer: 3.481 ± 0.063	2.867ArgThr: 2.867 ± 0.049	4.517ArgVal: 4.517 ± 0.072	1.256ArgTrp: 1.256 ± 0.035	2.28ArgTyr: 2.28 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.954SerAla: 5.954 ± 0.088	0.445SerCys: 0.445 ± 0.022	3.885SerAsp: 3.885 ± 0.07	4.156SerGlu: 4.156 ± 0.07	2.189SerPhe: 2.189 ± 0.046	5.591SerGly: 5.591 ± 0.092	1.346SerHis: 1.346 ± 0.034	2.701SerIle: 2.701 ± 0.051	1.566SerLys: 1.566 ± 0.041	6.539SerLeu: 6.539 ± 0.087	1.301SerMet: 1.301 ± 0.036	1.866SerAsn: 1.866 ± 0.05	2.73SerPro: 2.73 ± 0.048	2.267SerGln: 2.267 ± 0.048	3.604SerArg: 3.604 ± 0.055	4.121SerSer: 4.121 ± 0.175	2.996SerThr: 2.996 ± 0.052	4.606SerVal: 4.606 ± 0.07	0.802SerTrp: 0.802 ± 0.027	1.657SerTyr: 1.657 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.805ThrAla: 4.805 ± 0.072	0.43ThrCys: 0.43 ± 0.023	3.337ThrAsp: 3.337 ± 0.06	3.315ThrGlu: 3.315 ± 0.058	1.954ThrPhe: 1.954 ± 0.046	4.739ThrGly: 4.739 ± 0.079	1.162ThrHis: 1.162 ± 0.034	2.432ThrIle: 2.432 ± 0.055	1.181ThrLys: 1.181 ± 0.033	6.889ThrLeu: 6.889 ± 0.089	0.934ThrMet: 0.934 ± 0.029	1.48ThrAsn: 1.48 ± 0.039	3.062ThrPro: 3.062 ± 0.058	1.988ThrGln: 1.988 ± 0.042	3.274ThrArg: 3.274 ± 0.046	2.778ThrSer: 2.778 ± 0.057	2.636ThrThr: 2.636 ± 0.052	3.853ThrVal: 3.853 ± 0.082	0.74ThrTrp: 0.74 ± 0.023	1.404ThrTyr: 1.404 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	7.022ValAla: 7.022 ± 0.076	0.642ValCys: 0.642 ± 0.023	4.539ValAsp: 4.539 ± 0.068	4.677ValGlu: 4.677 ± 0.065	2.639ValPhe: 2.639 ± 0.054	5.057ValGly: 5.057 ± 0.069	1.475ValHis: 1.475 ± 0.036	3.771ValIle: 3.771 ± 0.067	2.315ValLys: 2.315 ± 0.051	7.135ValLeu: 7.135 ± 0.118	1.706ValMet: 1.706 ± 0.041	2.536ValAsn: 2.536 ± 0.054	3.142ValPro: 3.142 ± 0.062	2.562ValGln: 2.562 ± 0.046	4.196ValArg: 4.196 ± 0.064	4.746ValSer: 4.746 ± 0.073	4.123ValThr: 4.123 ± 0.075	5.531ValVal: 5.531 ± 0.084	0.904ValTrp: 0.904 ± 0.029	1.956ValTyr: 1.956 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.201TrpAla: 1.201 ± 0.038	0.152TrpCys: 0.152 ± 0.012	0.775TrpAsp: 0.775 ± 0.026	0.825TrpGlu: 0.825 ± 0.031	0.594TrpPhe: 0.594 ± 0.026	1.097TrpGly: 1.097 ± 0.033	0.444TrpHis: 0.444 ± 0.022	0.65TrpIle: 0.65 ± 0.024	0.411TrpLys: 0.411 ± 0.017	2.112TrpLeu: 2.112 ± 0.052	0.358TrpMet: 0.358 ± 0.02	0.471TrpAsn: 0.471 ± 0.024	0.711TrpPro: 0.711 ± 0.028	1.054TrpGln: 1.054 ± 0.033	1.255TrpArg: 1.255 ± 0.037	0.866TrpSer: 0.866 ± 0.028	0.705TrpThr: 0.705 ± 0.024	1.069TrpVal: 1.069 ± 0.03	0.289TrpTrp: 0.289 ± 0.017	0.457TrpTyr: 0.457 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.37TyrAla: 2.37 ± 0.05	0.336TyrCys: 0.336 ± 0.018	1.815TyrAsp: 1.815 ± 0.055	1.7TyrGlu: 1.7 ± 0.042	1.188TyrPhe: 1.188 ± 0.036	2.221TyrGly: 2.221 ± 0.055	0.762TyrHis: 0.762 ± 0.024	1.208TyrIle: 1.208 ± 0.035	0.812TyrLys: 0.812 ± 0.029	3.184TyrLeu: 3.184 ± 0.056	0.523TyrMet: 0.523 ± 0.023	0.942TyrAsn: 0.942 ± 0.032	1.406TyrPro: 1.406 ± 0.037	1.561TyrGln: 1.561 ± 0.04	2.423TyrArg: 2.423 ± 0.051	1.767TyrSer: 1.767 ± 0.04	1.522TyrThr: 1.522 ± 0.038	1.788TyrVal: 1.788 ± 0.039	0.522TyrTrp: 0.522 ± 0.023	1.025TyrTyr: 1.025 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3203 proteins (1151955 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---