Amino acid dipepetide frequency for Streptococcus satellite phage Javan469

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.847AlaAla: 0.847 ± 0.486
0.847AlaCys: 0.847 ± 0.513
4.515AlaAsp: 4.515 ± 1.358
3.668AlaGlu: 3.668 ± 0.853
3.95AlaPhe: 3.95 ± 0.851
2.257AlaGly: 2.257 ± 0.905
0.0AlaHis: 0.0 ± 0.0
4.515AlaIle: 4.515 ± 0.943
5.079AlaLys: 5.079 ± 1.215
4.233AlaLeu: 4.233 ± 0.922
1.129AlaMet: 1.129 ± 0.523
4.233AlaAsn: 4.233 ± 0.792
0.564AlaPro: 0.564 ± 0.318
2.822AlaGln: 2.822 ± 0.675
2.54AlaArg: 2.54 ± 0.757
3.104AlaSer: 3.104 ± 1.297
3.95AlaThr: 3.95 ± 0.611
3.668AlaVal: 3.668 ± 1.001
0.564AlaTrp: 0.564 ± 0.512
1.975AlaTyr: 1.975 ± 0.578
0.0AlaXaa: 0.0 ± 0.0
Cys
0.847CysAla: 0.847 ± 0.375
0.282CysCys: 0.282 ± 0.291
0.847CysAsp: 0.847 ± 0.495
0.282CysGlu: 0.282 ± 0.291
0.0CysPhe: 0.0 ± 0.0
1.411CysGly: 1.411 ± 0.798
0.282CysHis: 0.282 ± 0.34
0.282CysIle: 0.282 ± 0.251
0.564CysLys: 0.564 ± 0.378
1.411CysLeu: 1.411 ± 0.535
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.282CysPro: 0.282 ± 0.291
0.282CysGln: 0.282 ± 0.291
0.564CysArg: 0.564 ± 0.377
0.564CysSer: 0.564 ± 0.39
0.0CysThr: 0.0 ± 0.0
0.282CysVal: 0.282 ± 0.251
0.0CysTrp: 0.0 ± 0.0
0.282CysTyr: 0.282 ± 0.291
0.0CysXaa: 0.0 ± 0.0
Asp
1.975AspAla: 1.975 ± 0.827
1.693AspCys: 1.693 ± 0.841
2.822AspAsp: 2.822 ± 0.822
4.233AspGlu: 4.233 ± 1.242
2.54AspPhe: 2.54 ± 1.099
2.257AspGly: 2.257 ± 0.84
1.129AspHis: 1.129 ± 0.508
7.054AspIle: 7.054 ± 1.312
6.208AspLys: 6.208 ± 1.335
6.208AspLeu: 6.208 ± 1.033
1.129AspMet: 1.129 ± 0.812
2.54AspAsn: 2.54 ± 1.023
1.411AspPro: 1.411 ± 0.583
1.975AspGln: 1.975 ± 0.617
2.54AspArg: 2.54 ± 0.776
4.797AspSer: 4.797 ± 1.659
2.822AspThr: 2.822 ± 1.032
1.693AspVal: 1.693 ± 0.656
0.282AspTrp: 0.282 ± 0.273
5.361AspTyr: 5.361 ± 1.248
0.0AspXaa: 0.0 ± 0.0
Glu
5.079GluAla: 5.079 ± 1.155
0.564GluCys: 0.564 ± 0.369
4.233GluAsp: 4.233 ± 1.237
5.361GluGlu: 5.361 ± 1.687
1.975GluPhe: 1.975 ± 1.044
2.54GluGly: 2.54 ± 0.805
2.257GluHis: 2.257 ± 0.733
5.643GluIle: 5.643 ± 1.264
5.643GluLys: 5.643 ± 0.812
8.465GluLeu: 8.465 ± 1.038
1.411GluMet: 1.411 ± 0.773
1.975GluAsn: 1.975 ± 0.623
2.257GluPro: 2.257 ± 0.783
5.079GluGln: 5.079 ± 1.634
3.95GluArg: 3.95 ± 1.208
1.129GluSer: 1.129 ± 0.547
5.361GluThr: 5.361 ± 1.13
4.797GluVal: 4.797 ± 1.104
0.564GluTrp: 0.564 ± 0.387
2.822GluTyr: 2.822 ± 0.899
0.0GluXaa: 0.0 ± 0.0
Phe
1.693PheAla: 1.693 ± 0.575
0.0PheCys: 0.0 ± 0.0
2.257PheAsp: 2.257 ± 0.723
2.822PheGlu: 2.822 ± 0.867
1.693PhePhe: 1.693 ± 0.612
1.693PheGly: 1.693 ± 0.469
1.411PheHis: 1.411 ± 0.574
3.104PheIle: 3.104 ± 0.844
3.386PheLys: 3.386 ± 1.166
3.668PheLeu: 3.668 ± 1.097
0.0PheMet: 0.0 ± 0.0
3.104PheAsn: 3.104 ± 0.751
0.564PhePro: 0.564 ± 0.369
1.129PheGln: 1.129 ± 0.517
3.104PheArg: 3.104 ± 0.829
2.257PheSer: 2.257 ± 0.853
2.54PheThr: 2.54 ± 0.655
1.975PheVal: 1.975 ± 0.654
0.0PheTrp: 0.0 ± 0.0
1.693PheTyr: 1.693 ± 0.818
0.0PheXaa: 0.0 ± 0.0
Gly
3.104GlyAla: 3.104 ± 1.138
0.282GlyCys: 0.282 ± 0.251
4.797GlyAsp: 4.797 ± 1.205
2.822GlyGlu: 2.822 ± 0.908
2.257GlyPhe: 2.257 ± 0.634
2.54GlyGly: 2.54 ± 0.889
1.129GlyHis: 1.129 ± 0.687
3.104GlyIle: 3.104 ± 0.866
3.668GlyLys: 3.668 ± 1.252
6.772GlyLeu: 6.772 ± 1.277
1.129GlyMet: 1.129 ± 0.516
1.975GlyAsn: 1.975 ± 0.758
0.564GlyPro: 0.564 ± 0.348
2.257GlyGln: 2.257 ± 0.905
1.693GlyArg: 1.693 ± 0.43
1.975GlySer: 1.975 ± 0.759
3.95GlyThr: 3.95 ± 0.839
2.54GlyVal: 2.54 ± 0.825
0.847GlyTrp: 0.847 ± 0.566
3.668GlyTyr: 3.668 ± 0.96
0.0GlyXaa: 0.0 ± 0.0
His
2.257HisAla: 2.257 ± 1.252
0.282HisCys: 0.282 ± 0.251
0.282HisAsp: 0.282 ± 0.316
0.564HisGlu: 0.564 ± 0.381
0.0HisPhe: 0.0 ± 0.0
1.693HisGly: 1.693 ± 0.813
0.0HisHis: 0.0 ± 0.0
1.411HisIle: 1.411 ± 0.575
1.129HisLys: 1.129 ± 0.565
1.975HisLeu: 1.975 ± 0.957
0.282HisMet: 0.282 ± 0.256
1.129HisAsn: 1.129 ± 0.807
0.847HisPro: 0.847 ± 0.754
0.847HisGln: 0.847 ± 0.616
0.282HisArg: 0.282 ± 0.302
0.564HisSer: 0.564 ± 0.546
1.129HisThr: 1.129 ± 0.438
0.282HisVal: 0.282 ± 0.278
0.282HisTrp: 0.282 ± 0.291
1.693HisTyr: 1.693 ± 0.777
0.0HisXaa: 0.0 ± 0.0
Ile
5.361IleAla: 5.361 ± 1.137
0.282IleCys: 0.282 ± 0.34
6.49IleAsp: 6.49 ± 1.05
4.797IleGlu: 4.797 ± 1.339
1.975IlePhe: 1.975 ± 0.584
2.257IleGly: 2.257 ± 0.78
1.129IleHis: 1.129 ± 0.669
4.233IleIle: 4.233 ± 0.993
8.465IleLys: 8.465 ± 1.447
4.233IleLeu: 4.233 ± 0.944
0.847IleMet: 0.847 ± 0.477
3.386IleAsn: 3.386 ± 1.018
2.54IlePro: 2.54 ± 0.993
1.975IleGln: 1.975 ± 0.636
2.54IleArg: 2.54 ± 0.747
5.079IleSer: 5.079 ± 1.3
4.797IleThr: 4.797 ± 1.077
1.693IleVal: 1.693 ± 0.541
0.0IleTrp: 0.0 ± 0.0
2.822IleTyr: 2.822 ± 0.779
0.0IleXaa: 0.0 ± 0.0
Lys
7.054LysAla: 7.054 ± 1.513
0.282LysCys: 0.282 ± 0.316
3.668LysAsp: 3.668 ± 1.125
10.722LysGlu: 10.722 ± 1.465
2.822LysPhe: 2.822 ± 0.633
4.515LysGly: 4.515 ± 1.259
1.693LysHis: 1.693 ± 0.505
2.54LysIle: 2.54 ± 0.726
6.772LysLys: 6.772 ± 1.642
6.772LysLeu: 6.772 ± 1.498
2.54LysMet: 2.54 ± 0.872
5.643LysAsn: 5.643 ± 0.803
3.95LysPro: 3.95 ± 1.425
3.95LysGln: 3.95 ± 0.887
6.208LysArg: 6.208 ± 1.041
3.95LysSer: 3.95 ± 1.002
5.926LysThr: 5.926 ± 1.691
7.054LysVal: 7.054 ± 1.108
1.411LysTrp: 1.411 ± 0.584
3.668LysTyr: 3.668 ± 0.84
0.0LysXaa: 0.0 ± 0.0
Leu
5.361LeuAla: 5.361 ± 1.478
0.847LeuCys: 0.847 ± 0.471
6.49LeuAsp: 6.49 ± 0.922
7.901LeuGlu: 7.901 ± 1.582
4.233LeuPhe: 4.233 ± 1.085
5.643LeuGly: 5.643 ± 1.344
1.129LeuHis: 1.129 ± 0.582
7.901LeuIle: 7.901 ± 1.333
8.465LeuLys: 8.465 ± 1.36
7.054LeuLeu: 7.054 ± 1.629
3.386LeuMet: 3.386 ± 1.03
5.079LeuAsn: 5.079 ± 1.064
4.233LeuPro: 4.233 ± 1.105
2.822LeuGln: 2.822 ± 0.666
2.54LeuArg: 2.54 ± 0.727
9.029LeuSer: 9.029 ± 1.717
4.233LeuThr: 4.233 ± 0.914
3.95LeuVal: 3.95 ± 1.37
1.129LeuTrp: 1.129 ± 0.388
5.079LeuTyr: 5.079 ± 1.212
0.0LeuXaa: 0.0 ± 0.0
Met
1.693MetAla: 1.693 ± 0.635
0.282MetCys: 0.282 ± 0.273
1.129MetAsp: 1.129 ± 0.574
0.847MetGlu: 0.847 ± 0.474
0.564MetPhe: 0.564 ± 0.385
0.282MetGly: 0.282 ± 0.286
0.0MetHis: 0.0 ± 0.0
1.411MetIle: 1.411 ± 0.64
3.104MetLys: 3.104 ± 0.721
2.257MetLeu: 2.257 ± 0.726
0.282MetMet: 0.282 ± 0.313
2.257MetAsn: 2.257 ± 0.713
0.282MetPro: 0.282 ± 0.274
0.847MetGln: 0.847 ± 0.658
1.693MetArg: 1.693 ± 0.619
1.411MetSer: 1.411 ± 0.706
3.386MetThr: 3.386 ± 1.145
0.564MetVal: 0.564 ± 0.47
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.668AsnAla: 3.668 ± 0.897
0.0AsnCys: 0.0 ± 0.0
3.104AsnAsp: 3.104 ± 1.042
2.54AsnGlu: 2.54 ± 0.932
1.693AsnPhe: 1.693 ± 0.784
4.233AsnGly: 4.233 ± 1.194
1.693AsnHis: 1.693 ± 0.607
2.822AsnIle: 2.822 ± 0.949
4.515AsnLys: 4.515 ± 0.866
3.95AsnLeu: 3.95 ± 0.953
1.975AsnMet: 1.975 ± 0.887
2.257AsnAsn: 2.257 ± 0.593
2.54AsnPro: 2.54 ± 0.628
2.822AsnGln: 2.822 ± 1.08
3.95AsnArg: 3.95 ± 0.81
2.257AsnSer: 2.257 ± 0.652
3.386AsnThr: 3.386 ± 0.946
3.104AsnVal: 3.104 ± 0.919
0.564AsnTrp: 0.564 ± 0.382
2.822AsnTyr: 2.822 ± 0.852
0.0AsnXaa: 0.0 ± 0.0
Pro
0.847ProAla: 0.847 ± 0.553
0.282ProCys: 0.282 ± 0.256
0.564ProAsp: 0.564 ± 0.372
3.668ProGlu: 3.668 ± 1.153
0.847ProPhe: 0.847 ± 0.521
0.847ProGly: 0.847 ± 0.474
0.282ProHis: 0.282 ± 0.251
1.975ProIle: 1.975 ± 0.89
4.233ProLys: 4.233 ± 1.207
2.822ProLeu: 2.822 ± 1.079
0.564ProMet: 0.564 ± 0.41
2.257ProAsn: 2.257 ± 0.988
0.847ProPro: 0.847 ± 0.432
1.411ProGln: 1.411 ± 0.62
2.54ProArg: 2.54 ± 0.741
2.822ProSer: 2.822 ± 0.746
2.257ProThr: 2.257 ± 0.529
2.257ProVal: 2.257 ± 0.825
0.282ProTrp: 0.282 ± 0.251
1.975ProTyr: 1.975 ± 0.985
0.0ProXaa: 0.0 ± 0.0
Gln
2.822GlnAla: 2.822 ± 0.787
0.282GlnCys: 0.282 ± 0.291
1.693GlnAsp: 1.693 ± 0.755
3.95GlnGlu: 3.95 ± 1.04
0.564GlnPhe: 0.564 ± 0.384
4.233GlnGly: 4.233 ± 0.999
0.847GlnHis: 0.847 ± 0.564
1.693GlnIle: 1.693 ± 0.583
5.361GlnLys: 5.361 ± 0.966
6.772GlnLeu: 6.772 ± 1.4
1.129GlnMet: 1.129 ± 0.852
2.257GlnAsn: 2.257 ± 0.816
2.54GlnPro: 2.54 ± 0.83
3.104GlnGln: 3.104 ± 1.091
2.822GlnArg: 2.822 ± 0.577
1.693GlnSer: 1.693 ± 0.666
1.693GlnThr: 1.693 ± 0.592
3.95GlnVal: 3.95 ± 1.039
0.282GlnTrp: 0.282 ± 0.273
1.411GlnTyr: 1.411 ± 0.511
0.0GlnXaa: 0.0 ± 0.0
Arg
1.411ArgAla: 1.411 ± 0.517
0.564ArgCys: 0.564 ± 0.427
3.668ArgAsp: 3.668 ± 0.866
1.693ArgGlu: 1.693 ± 0.686
1.975ArgPhe: 1.975 ± 0.555
2.257ArgGly: 2.257 ± 0.796
1.411ArgHis: 1.411 ± 0.691
2.54ArgIle: 2.54 ± 0.766
6.49ArgLys: 6.49 ± 1.414
5.643ArgLeu: 5.643 ± 0.985
0.564ArgMet: 0.564 ± 0.399
2.257ArgAsn: 2.257 ± 0.881
1.975ArgPro: 1.975 ± 0.855
3.668ArgGln: 3.668 ± 0.788
2.257ArgArg: 2.257 ± 0.983
3.386ArgSer: 3.386 ± 1.074
1.975ArgThr: 1.975 ± 0.535
3.95ArgVal: 3.95 ± 0.859
0.564ArgTrp: 0.564 ± 0.435
3.668ArgTyr: 3.668 ± 1.08
0.0ArgXaa: 0.0 ± 0.0
Ser
2.822SerAla: 2.822 ± 0.817
0.564SerCys: 0.564 ± 0.417
5.079SerAsp: 5.079 ± 0.928
3.104SerGlu: 3.104 ± 1.222
2.822SerPhe: 2.822 ± 0.917
2.54SerGly: 2.54 ± 0.694
0.564SerHis: 0.564 ± 0.427
3.104SerIle: 3.104 ± 0.915
4.797SerLys: 4.797 ± 0.95
6.49SerLeu: 6.49 ± 1.164
1.693SerMet: 1.693 ± 0.744
1.975SerAsn: 1.975 ± 0.76
1.693SerPro: 1.693 ± 0.714
3.95SerGln: 3.95 ± 1.084
1.693SerArg: 1.693 ± 0.628
1.975SerSer: 1.975 ± 0.805
3.95SerThr: 3.95 ± 1.252
3.104SerVal: 3.104 ± 1.11
0.564SerTrp: 0.564 ± 0.443
3.104SerTyr: 3.104 ± 1.102
0.0SerXaa: 0.0 ± 0.0
Thr
4.233ThrAla: 4.233 ± 1.191
0.0ThrCys: 0.0 ± 0.0
1.975ThrAsp: 1.975 ± 0.743
2.54ThrGlu: 2.54 ± 0.752
2.54ThrPhe: 2.54 ± 1.416
4.515ThrGly: 4.515 ± 0.695
0.282ThrHis: 0.282 ± 0.274
5.079ThrIle: 5.079 ± 1.344
3.95ThrLys: 3.95 ± 1.21
7.336ThrLeu: 7.336 ± 1.579
0.564ThrMet: 0.564 ± 0.38
2.257ThrAsn: 2.257 ± 0.743
3.668ThrPro: 3.668 ± 1.005
4.515ThrGln: 4.515 ± 0.81
3.668ThrArg: 3.668 ± 1.185
3.386ThrSer: 3.386 ± 0.862
3.668ThrThr: 3.668 ± 1.583
2.257ThrVal: 2.257 ± 0.622
0.847ThrTrp: 0.847 ± 0.413
4.797ThrTyr: 4.797 ± 0.973
0.0ThrXaa: 0.0 ± 0.0
Val
2.257ValAla: 2.257 ± 0.621
0.847ValCys: 0.847 ± 0.448
2.822ValAsp: 2.822 ± 0.82
3.668ValGlu: 3.668 ± 1.167
3.386ValPhe: 3.386 ± 0.958
1.975ValGly: 1.975 ± 0.685
0.282ValHis: 0.282 ± 0.291
4.233ValIle: 4.233 ± 1.048
4.797ValLys: 4.797 ± 0.842
6.49ValLeu: 6.49 ± 1.048
1.693ValMet: 1.693 ± 0.633
3.668ValAsn: 3.668 ± 0.946
1.693ValPro: 1.693 ± 0.685
2.257ValGln: 2.257 ± 1.164
1.975ValArg: 1.975 ± 0.848
3.668ValSer: 3.668 ± 1.297
3.668ValThr: 3.668 ± 0.885
2.54ValVal: 2.54 ± 0.831
0.847ValTrp: 0.847 ± 0.58
1.411ValTyr: 1.411 ± 0.485
0.0ValXaa: 0.0 ± 0.0
Trp
0.282TrpAla: 0.282 ± 0.278
0.0TrpCys: 0.0 ± 0.0
1.129TrpAsp: 1.129 ± 0.574
0.564TrpGlu: 0.564 ± 0.376
0.564TrpPhe: 0.564 ± 0.392
0.564TrpGly: 0.564 ± 0.345
0.0TrpHis: 0.0 ± 0.0
0.282TrpIle: 0.282 ± 0.291
0.564TrpLys: 0.564 ± 0.331
1.411TrpLeu: 1.411 ± 0.505
0.0TrpMet: 0.0 ± 0.0
0.564TrpAsn: 0.564 ± 0.374
0.0TrpPro: 0.0 ± 0.0
0.282TrpGln: 0.282 ± 0.291
0.282TrpArg: 0.282 ± 0.291
0.564TrpSer: 0.564 ± 0.318
0.282TrpThr: 0.282 ± 0.251
1.693TrpVal: 1.693 ± 0.559
0.847TrpTrp: 0.847 ± 0.593
0.564TrpTyr: 0.564 ± 0.418
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.847TyrAla: 0.847 ± 0.464
0.282TyrCys: 0.282 ± 0.246
3.104TyrAsp: 3.104 ± 1.028
5.361TyrGlu: 5.361 ± 1.258
1.693TyrPhe: 1.693 ± 0.753
2.822TyrGly: 2.822 ± 0.82
1.411TyrHis: 1.411 ± 0.568
1.975TyrIle: 1.975 ± 0.72
3.95TyrLys: 3.95 ± 1.208
2.54TyrLeu: 2.54 ± 0.605
1.693TyrMet: 1.693 ± 0.724
5.079TyrAsn: 5.079 ± 1.019
1.411TyrPro: 1.411 ± 0.739
3.104TyrGln: 3.104 ± 0.787
5.079TyrArg: 5.079 ± 1.302
1.975TyrSer: 1.975 ± 0.742
3.104TyrThr: 3.104 ± 0.666
2.822TyrVal: 2.822 ± 0.698
0.564TyrTrp: 0.564 ± 0.582
4.797TyrTyr: 4.797 ± 1.153
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 24 proteins (3545 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski