Amino acid dipepetide frequency for Streptococcus phage Javan477

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.721AlaAla: 3.721 ± 0.827
0.26AlaCys: 0.26 ± 0.131
4.326AlaAsp: 4.326 ± 0.644
5.451AlaGlu: 5.451 ± 0.799
2.769AlaPhe: 2.769 ± 0.598
4.067AlaGly: 4.067 ± 0.855
0.865AlaHis: 0.865 ± 0.326
5.797AlaIle: 5.797 ± 0.71
7.355AlaLys: 7.355 ± 1.007
6.143AlaLeu: 6.143 ± 1.461
1.471AlaMet: 1.471 ± 0.306
4.153AlaAsn: 4.153 ± 0.721
0.952AlaPro: 0.952 ± 0.32
3.548AlaGln: 3.548 ± 0.804
2.423AlaArg: 2.423 ± 0.452
4.846AlaSer: 4.846 ± 1.266
3.461AlaThr: 3.461 ± 0.691
4.067AlaVal: 4.067 ± 0.705
0.779AlaTrp: 0.779 ± 0.21
1.211AlaTyr: 1.211 ± 0.321
0.0AlaXaa: 0.0 ± 0.0
Cys
0.173CysAla: 0.173 ± 0.123
0.0CysCys: 0.0 ± 0.0
0.087CysAsp: 0.087 ± 0.106
0.952CysGlu: 0.952 ± 0.278
0.173CysPhe: 0.173 ± 0.131
0.087CysGly: 0.087 ± 0.09
0.087CysHis: 0.087 ± 0.092
0.519CysIle: 0.519 ± 0.218
0.692CysLys: 0.692 ± 0.222
0.346CysLeu: 0.346 ± 0.213
0.173CysMet: 0.173 ± 0.126
0.087CysAsn: 0.087 ± 0.079
0.087CysPro: 0.087 ± 0.092
0.087CysGln: 0.087 ± 0.092
0.26CysArg: 0.26 ± 0.131
0.433CysSer: 0.433 ± 0.199
0.173CysThr: 0.173 ± 0.12
0.26CysVal: 0.26 ± 0.152
0.087CysTrp: 0.087 ± 0.084
0.346CysTyr: 0.346 ± 0.207
0.0CysXaa: 0.0 ± 0.0
Asp
3.721AspAla: 3.721 ± 0.511
0.433AspCys: 0.433 ± 0.205
3.634AspAsp: 3.634 ± 0.621
5.97AspGlu: 5.97 ± 0.715
3.807AspPhe: 3.807 ± 0.592
3.721AspGly: 3.721 ± 0.736
0.433AspHis: 0.433 ± 0.198
4.932AspIle: 4.932 ± 0.788
7.268AspLys: 7.268 ± 0.656
5.192AspLeu: 5.192 ± 0.714
2.25AspMet: 2.25 ± 0.379
3.548AspAsn: 3.548 ± 0.653
1.817AspPro: 1.817 ± 0.43
2.077AspGln: 2.077 ± 0.279
1.125AspArg: 1.125 ± 0.351
3.98AspSer: 3.98 ± 0.447
2.509AspThr: 2.509 ± 0.451
3.028AspVal: 3.028 ± 0.52
1.557AspTrp: 1.557 ± 0.384
3.202AspTyr: 3.202 ± 0.747
0.0AspXaa: 0.0 ± 0.0
Glu
5.278GluAla: 5.278 ± 1.371
0.519GluCys: 0.519 ± 0.223
3.375GluAsp: 3.375 ± 0.493
7.095GluGlu: 7.095 ± 0.982
3.028GluPhe: 3.028 ± 0.633
3.894GluGly: 3.894 ± 0.541
0.952GluHis: 0.952 ± 0.222
6.49GluIle: 6.49 ± 0.834
6.576GluLys: 6.576 ± 0.86
9.605GluLeu: 9.605 ± 0.82
1.644GluMet: 1.644 ± 0.358
3.202GluAsn: 3.202 ± 0.592
1.904GluPro: 1.904 ± 0.475
3.721GluGln: 3.721 ± 0.73
3.028GluArg: 3.028 ± 0.409
5.365GluSer: 5.365 ± 0.568
4.413GluThr: 4.413 ± 0.582
5.624GluVal: 5.624 ± 0.886
1.125GluTrp: 1.125 ± 0.288
2.682GluTyr: 2.682 ± 0.456
0.0GluXaa: 0.0 ± 0.0
Phe
1.817PheAla: 1.817 ± 0.356
0.0PheCys: 0.0 ± 0.0
3.115PheAsp: 3.115 ± 0.515
2.682PheGlu: 2.682 ± 0.62
1.298PhePhe: 1.298 ± 0.386
2.596PheGly: 2.596 ± 0.519
0.692PheHis: 0.692 ± 0.287
2.855PheIle: 2.855 ± 0.365
5.192PheLys: 5.192 ± 0.596
2.509PheLeu: 2.509 ± 0.444
1.125PheMet: 1.125 ± 0.277
2.769PheAsn: 2.769 ± 0.54
0.692PhePro: 0.692 ± 0.287
1.125PheGln: 1.125 ± 0.28
1.817PheArg: 1.817 ± 0.401
2.596PheSer: 2.596 ± 0.403
2.596PheThr: 2.596 ± 0.516
2.596PheVal: 2.596 ± 0.543
0.26PheTrp: 0.26 ± 0.13
1.471PheTyr: 1.471 ± 0.365
0.0PheXaa: 0.0 ± 0.0
Gly
2.855GlyAla: 2.855 ± 0.637
0.346GlyCys: 0.346 ± 0.161
3.288GlyAsp: 3.288 ± 0.612
3.375GlyGlu: 3.375 ± 0.559
2.855GlyPhe: 2.855 ± 0.517
3.807GlyGly: 3.807 ± 0.594
1.125GlyHis: 1.125 ± 0.299
4.846GlyIle: 4.846 ± 0.565
5.451GlyLys: 5.451 ± 0.53
6.749GlyLeu: 6.749 ± 0.818
1.384GlyMet: 1.384 ± 0.304
3.721GlyAsn: 3.721 ± 0.518
1.731GlyPro: 1.731 ± 0.551
2.855GlyGln: 2.855 ± 0.572
2.596GlyArg: 2.596 ± 0.487
2.769GlySer: 2.769 ± 0.588
3.634GlyThr: 3.634 ± 0.879
2.769GlyVal: 2.769 ± 0.614
1.038GlyTrp: 1.038 ± 0.277
2.423GlyTyr: 2.423 ± 0.578
0.0GlyXaa: 0.0 ± 0.0
His
0.779HisAla: 0.779 ± 0.255
0.087HisCys: 0.087 ± 0.079
1.211HisAsp: 1.211 ± 0.402
1.644HisGlu: 1.644 ± 0.405
0.952HisPhe: 0.952 ± 0.256
1.471HisGly: 1.471 ± 0.275
0.519HisHis: 0.519 ± 0.193
0.692HisIle: 0.692 ± 0.235
0.692HisLys: 0.692 ± 0.313
1.038HisLeu: 1.038 ± 0.28
0.346HisMet: 0.346 ± 0.141
0.692HisAsn: 0.692 ± 0.263
0.519HisPro: 0.519 ± 0.268
0.779HisGln: 0.779 ± 0.327
0.606HisArg: 0.606 ± 0.229
0.606HisSer: 0.606 ± 0.269
0.865HisThr: 0.865 ± 0.289
0.606HisVal: 0.606 ± 0.247
0.173HisTrp: 0.173 ± 0.123
0.692HisTyr: 0.692 ± 0.264
0.0HisXaa: 0.0 ± 0.0
Ile
5.884IleAla: 5.884 ± 1.017
0.433IleCys: 0.433 ± 0.197
6.749IleAsp: 6.749 ± 0.867
5.711IleGlu: 5.711 ± 0.604
2.682IlePhe: 2.682 ± 0.616
4.326IleGly: 4.326 ± 0.465
1.211IleHis: 1.211 ± 0.346
4.067IleIle: 4.067 ± 0.621
7.961IleLys: 7.961 ± 0.972
4.672IleLeu: 4.672 ± 0.775
1.211IleMet: 1.211 ± 0.346
4.846IleAsn: 4.846 ± 0.649
2.163IlePro: 2.163 ± 0.377
1.557IleGln: 1.557 ± 0.329
2.855IleArg: 2.855 ± 0.515
4.153IleSer: 4.153 ± 0.593
3.894IleThr: 3.894 ± 0.566
3.721IleVal: 3.721 ± 0.71
0.346IleTrp: 0.346 ± 0.15
3.028IleTyr: 3.028 ± 0.547
0.0IleXaa: 0.0 ± 0.0
Lys
6.576LysAla: 6.576 ± 0.916
0.519LysCys: 0.519 ± 0.194
7.009LysAsp: 7.009 ± 0.803
8.22LysGlu: 8.22 ± 0.74
2.682LysPhe: 2.682 ± 0.468
4.846LysGly: 4.846 ± 0.703
1.211LysHis: 1.211 ± 0.283
7.701LysIle: 7.701 ± 0.888
8.134LysLys: 8.134 ± 0.834
7.787LysLeu: 7.787 ± 0.772
2.769LysMet: 2.769 ± 0.48
6.23LysAsn: 6.23 ± 0.874
1.99LysPro: 1.99 ± 0.353
3.894LysGln: 3.894 ± 0.702
3.721LysArg: 3.721 ± 0.621
6.23LysSer: 6.23 ± 0.634
4.932LysThr: 4.932 ± 0.625
6.143LysVal: 6.143 ± 0.799
1.125LysTrp: 1.125 ± 0.339
2.942LysTyr: 2.942 ± 0.501
0.0LysXaa: 0.0 ± 0.0
Leu
6.143LeuAla: 6.143 ± 0.866
0.692LeuCys: 0.692 ± 0.254
5.278LeuAsp: 5.278 ± 0.723
7.528LeuGlu: 7.528 ± 0.875
2.25LeuPhe: 2.25 ± 0.542
6.143LeuGly: 6.143 ± 0.839
0.692LeuHis: 0.692 ± 0.263
5.538LeuIle: 5.538 ± 0.667
9.951LeuLys: 9.951 ± 0.908
7.787LeuLeu: 7.787 ± 0.841
2.163LeuMet: 2.163 ± 0.446
4.846LeuAsn: 4.846 ± 0.879
2.423LeuPro: 2.423 ± 0.422
3.461LeuGln: 3.461 ± 0.662
2.942LeuArg: 2.942 ± 0.508
7.182LeuSer: 7.182 ± 0.707
6.836LeuThr: 6.836 ± 0.796
4.499LeuVal: 4.499 ± 0.499
0.519LeuTrp: 0.519 ± 0.18
2.423LeuTyr: 2.423 ± 0.504
0.0LeuXaa: 0.0 ± 0.0
Met
1.298MetAla: 1.298 ± 0.361
0.087MetCys: 0.087 ± 0.089
1.644MetAsp: 1.644 ± 0.437
1.99MetGlu: 1.99 ± 0.322
1.211MetPhe: 1.211 ± 0.328
0.779MetGly: 0.779 ± 0.237
0.26MetHis: 0.26 ± 0.174
2.25MetIle: 2.25 ± 0.427
1.817MetLys: 1.817 ± 0.387
2.509MetLeu: 2.509 ± 0.566
0.606MetMet: 0.606 ± 0.279
0.865MetAsn: 0.865 ± 0.228
0.692MetPro: 0.692 ± 0.234
0.606MetGln: 0.606 ± 0.245
1.557MetArg: 1.557 ± 0.451
1.99MetSer: 1.99 ± 0.409
2.25MetThr: 2.25 ± 0.409
1.471MetVal: 1.471 ± 0.389
0.173MetTrp: 0.173 ± 0.126
0.865MetTyr: 0.865 ± 0.301
0.0MetXaa: 0.0 ± 0.0
Asn
4.153AsnAla: 4.153 ± 0.752
0.433AsnCys: 0.433 ± 0.169
2.509AsnAsp: 2.509 ± 0.486
2.682AsnGlu: 2.682 ± 0.481
2.077AsnPhe: 2.077 ± 0.439
4.067AsnGly: 4.067 ± 0.658
1.298AsnHis: 1.298 ± 0.279
3.028AsnIle: 3.028 ± 0.582
4.672AsnLys: 4.672 ± 0.743
5.192AsnLeu: 5.192 ± 0.715
1.731AsnMet: 1.731 ± 0.344
2.942AsnAsn: 2.942 ± 0.673
2.25AsnPro: 2.25 ± 0.411
2.769AsnGln: 2.769 ± 0.598
3.461AsnArg: 3.461 ± 0.445
3.634AsnSer: 3.634 ± 0.806
3.028AsnThr: 3.028 ± 0.609
2.942AsnVal: 2.942 ± 0.429
0.606AsnTrp: 0.606 ± 0.187
2.596AsnTyr: 2.596 ± 0.448
0.0AsnXaa: 0.0 ± 0.0
Pro
1.644ProAla: 1.644 ± 0.371
0.173ProCys: 0.173 ± 0.138
1.731ProAsp: 1.731 ± 0.428
2.163ProGlu: 2.163 ± 0.448
1.211ProPhe: 1.211 ± 0.352
0.952ProGly: 0.952 ± 0.252
0.346ProHis: 0.346 ± 0.154
2.336ProIle: 2.336 ± 0.495
3.028ProLys: 3.028 ± 0.53
1.384ProLeu: 1.384 ± 0.367
0.606ProMet: 0.606 ± 0.27
1.384ProAsn: 1.384 ± 0.371
0.346ProPro: 0.346 ± 0.141
1.125ProGln: 1.125 ± 0.358
1.038ProArg: 1.038 ± 0.351
1.99ProSer: 1.99 ± 0.5
1.125ProThr: 1.125 ± 0.25
1.384ProVal: 1.384 ± 0.347
0.26ProTrp: 0.26 ± 0.155
0.346ProTyr: 0.346 ± 0.167
0.0ProXaa: 0.0 ± 0.0
Gln
3.028GlnAla: 3.028 ± 0.574
0.346GlnCys: 0.346 ± 0.176
2.336GlnAsp: 2.336 ± 0.498
3.028GlnGlu: 3.028 ± 0.403
1.731GlnPhe: 1.731 ± 0.465
1.731GlnGly: 1.731 ± 0.407
0.433GlnHis: 0.433 ± 0.204
2.509GlnIle: 2.509 ± 0.421
4.413GlnLys: 4.413 ± 0.69
5.105GlnLeu: 5.105 ± 0.908
0.779GlnMet: 0.779 ± 0.263
2.336GlnAsn: 2.336 ± 0.538
1.038GlnPro: 1.038 ± 0.317
1.817GlnGln: 1.817 ± 0.494
1.644GlnArg: 1.644 ± 0.381
3.375GlnSer: 3.375 ± 0.605
2.163GlnThr: 2.163 ± 0.476
2.336GlnVal: 2.336 ± 0.505
0.173GlnTrp: 0.173 ± 0.12
0.952GlnTyr: 0.952 ± 0.379
0.0GlnXaa: 0.0 ± 0.0
Arg
2.855ArgAla: 2.855 ± 0.456
0.346ArgCys: 0.346 ± 0.167
2.336ArgAsp: 2.336 ± 0.439
3.634ArgGlu: 3.634 ± 0.587
1.644ArgPhe: 1.644 ± 0.323
2.163ArgGly: 2.163 ± 0.451
0.865ArgHis: 0.865 ± 0.329
2.855ArgIle: 2.855 ± 0.486
3.028ArgLys: 3.028 ± 0.494
3.375ArgLeu: 3.375 ± 0.518
1.038ArgMet: 1.038 ± 0.277
1.644ArgAsn: 1.644 ± 0.403
1.125ArgPro: 1.125 ± 0.354
2.423ArgGln: 2.423 ± 0.349
1.904ArgArg: 1.904 ± 0.458
2.163ArgSer: 2.163 ± 0.485
2.25ArgThr: 2.25 ± 0.418
2.077ArgVal: 2.077 ± 0.338
0.865ArgTrp: 0.865 ± 0.287
2.336ArgTyr: 2.336 ± 0.387
0.0ArgXaa: 0.0 ± 0.0
Ser
5.538SerAla: 5.538 ± 0.961
0.0SerCys: 0.0 ± 0.0
4.24SerAsp: 4.24 ± 0.835
4.499SerGlu: 4.499 ± 0.622
2.855SerPhe: 2.855 ± 0.519
4.326SerGly: 4.326 ± 0.779
1.125SerHis: 1.125 ± 0.348
4.759SerIle: 4.759 ± 0.645
4.846SerLys: 4.846 ± 0.837
5.451SerLeu: 5.451 ± 0.577
1.125SerMet: 1.125 ± 0.307
3.98SerAsn: 3.98 ± 0.828
1.298SerPro: 1.298 ± 0.387
3.028SerGln: 3.028 ± 0.558
3.115SerArg: 3.115 ± 0.502
3.894SerSer: 3.894 ± 0.706
3.202SerThr: 3.202 ± 0.607
4.153SerVal: 4.153 ± 0.608
0.26SerTrp: 0.26 ± 0.164
2.336SerTyr: 2.336 ± 0.587
0.0SerXaa: 0.0 ± 0.0
Thr
4.586ThrAla: 4.586 ± 0.992
0.173ThrCys: 0.173 ± 0.163
3.288ThrAsp: 3.288 ± 0.577
3.807ThrGlu: 3.807 ± 0.572
2.336ThrPhe: 2.336 ± 0.405
5.192ThrGly: 5.192 ± 0.613
0.519ThrHis: 0.519 ± 0.203
3.634ThrIle: 3.634 ± 0.54
5.451ThrLys: 5.451 ± 0.739
4.932ThrLeu: 4.932 ± 0.584
1.125ThrMet: 1.125 ± 0.298
3.548ThrAsn: 3.548 ± 0.601
1.298ThrPro: 1.298 ± 0.344
1.817ThrGln: 1.817 ± 0.281
1.817ThrArg: 1.817 ± 0.361
3.375ThrSer: 3.375 ± 0.471
3.202ThrThr: 3.202 ± 0.594
4.153ThrVal: 4.153 ± 0.637
0.519ThrTrp: 0.519 ± 0.233
2.077ThrTyr: 2.077 ± 0.359
0.0ThrXaa: 0.0 ± 0.0
Val
4.24ValAla: 4.24 ± 0.693
0.173ValCys: 0.173 ± 0.177
3.98ValAsp: 3.98 ± 0.707
5.019ValGlu: 5.019 ± 0.748
2.423ValPhe: 2.423 ± 0.413
3.028ValGly: 3.028 ± 0.461
1.125ValHis: 1.125 ± 0.349
3.634ValIle: 3.634 ± 0.6
4.932ValLys: 4.932 ± 0.651
4.586ValLeu: 4.586 ± 0.668
1.731ValMet: 1.731 ± 0.374
2.769ValAsn: 2.769 ± 0.436
1.125ValPro: 1.125 ± 0.29
2.596ValGln: 2.596 ± 0.519
3.028ValArg: 3.028 ± 0.53
3.548ValSer: 3.548 ± 0.514
4.067ValThr: 4.067 ± 0.608
3.98ValVal: 3.98 ± 0.579
0.346ValTrp: 0.346 ± 0.18
1.904ValTyr: 1.904 ± 0.409
0.0ValXaa: 0.0 ± 0.0
Trp
0.433TrpAla: 0.433 ± 0.223
0.0TrpCys: 0.0 ± 0.0
0.606TrpAsp: 0.606 ± 0.192
0.952TrpGlu: 0.952 ± 0.254
0.692TrpPhe: 0.692 ± 0.251
0.692TrpGly: 0.692 ± 0.258
0.346TrpHis: 0.346 ± 0.153
0.692TrpIle: 0.692 ± 0.237
0.779TrpLys: 0.779 ± 0.246
1.211TrpLeu: 1.211 ± 0.344
0.519TrpMet: 0.519 ± 0.219
0.692TrpAsn: 0.692 ± 0.243
0.0TrpPro: 0.0 ± 0.0
0.519TrpGln: 0.519 ± 0.181
0.433TrpArg: 0.433 ± 0.171
0.433TrpSer: 0.433 ± 0.209
0.606TrpThr: 0.606 ± 0.197
0.346TrpVal: 0.346 ± 0.192
0.087TrpTrp: 0.087 ± 0.099
0.692TrpTyr: 0.692 ± 0.281
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.942TyrAla: 2.942 ± 0.632
0.087TyrCys: 0.087 ± 0.109
3.461TyrAsp: 3.461 ± 0.444
3.115TyrGlu: 3.115 ± 0.546
1.125TyrPhe: 1.125 ± 0.3
1.731TyrGly: 1.731 ± 0.349
0.865TyrHis: 0.865 ± 0.259
2.336TyrIle: 2.336 ± 0.587
2.423TyrLys: 2.423 ± 0.466
3.721TyrLeu: 3.721 ± 0.66
1.038TyrMet: 1.038 ± 0.343
1.817TyrAsn: 1.817 ± 0.313
1.125TyrPro: 1.125 ± 0.322
1.557TyrGln: 1.557 ± 0.338
1.557TyrArg: 1.557 ± 0.374
1.471TyrSer: 1.471 ± 0.327
1.644TyrThr: 1.644 ± 0.386
2.077TyrVal: 2.077 ± 0.461
0.433TyrTrp: 0.433 ± 0.214
1.557TyrTyr: 1.557 ± 0.36
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11558 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski