Amino acid dipepetide frequency for Morus notabilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.518AlaAla: 6.518 ± 0.034	1.275AlaCys: 1.275 ± 0.014	3.126AlaAsp: 3.126 ± 0.019	4.314AlaGlu: 4.314 ± 0.027	2.847AlaPhe: 2.847 ± 0.019	4.157AlaGly: 4.157 ± 0.023	1.332AlaHis: 1.332 ± 0.014	3.828AlaIle: 3.828 ± 0.022	4.002AlaLys: 4.002 ± 0.022	6.784AlaLeu: 6.784 ± 0.03	1.77AlaMet: 1.77 ± 0.015	2.643AlaAsn: 2.643 ± 0.019	2.83AlaPro: 2.83 ± 0.021	2.159AlaGln: 2.159 ± 0.016	3.586AlaArg: 3.586 ± 0.019	6.061AlaSer: 6.061 ± 0.026	3.585AlaThr: 3.585 ± 0.022	4.935AlaVal: 4.935 ± 0.026	0.79AlaTrp: 0.79 ± 0.009	1.793AlaTyr: 1.793 ± 0.014	0.0AlaXaa: 0.0 ± 0.0
Cys	1.027CysAla: 1.027 ± 0.01	0.515CysCys: 0.515 ± 0.007	0.876CysAsp: 0.876 ± 0.009	0.893CysGlu: 0.893 ± 0.01	0.905CysPhe: 0.905 ± 0.011	1.453CysGly: 1.453 ± 0.013	0.484CysHis: 0.484 ± 0.007	0.916CysIle: 0.916 ± 0.011	1.086CysLys: 1.086 ± 0.013	1.868CysLeu: 1.868 ± 0.014	0.409CysMet: 0.409 ± 0.007	0.795CysAsn: 0.795 ± 0.008	0.93CysPro: 0.93 ± 0.011	0.585CysGln: 0.585 ± 0.008	1.138CysArg: 1.138 ± 0.011	1.802CysSer: 1.802 ± 0.015	0.836CysThr: 0.836 ± 0.009	1.068CysVal: 1.068 ± 0.011	0.253CysTrp: 0.253 ± 0.006	0.516CysTyr: 0.516 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.366AspAla: 3.366 ± 0.023	0.963AspCys: 0.963 ± 0.011	3.738AspAsp: 3.738 ± 0.029	3.963AspGlu: 3.963 ± 0.027	2.4AspPhe: 2.4 ± 0.016	3.87AspGly: 3.87 ± 0.023	1.456AspHis: 1.456 ± 0.013	2.879AspIle: 2.879 ± 0.019	2.626AspLys: 2.626 ± 0.017	5.122AspLeu: 5.122 ± 0.026	1.284AspMet: 1.284 ± 0.012	2.096AspAsn: 2.096 ± 0.016	2.58AspPro: 2.58 ± 0.017	1.865AspGln: 1.865 ± 0.016	2.557AspArg: 2.557 ± 0.02	4.204AspSer: 4.204 ± 0.02	2.09AspThr: 2.09 ± 0.014	3.657AspVal: 3.657 ± 0.02	0.708AspTrp: 0.708 ± 0.009	1.535AspTyr: 1.535 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.876GluAla: 4.876 ± 0.027	0.882GluCys: 0.882 ± 0.01	3.953GluAsp: 3.953 ± 0.025	6.5GluGlu: 6.5 ± 0.043	2.402GluPhe: 2.402 ± 0.017	3.749GluGly: 3.749 ± 0.023	1.197GluHis: 1.197 ± 0.011	3.846GluIle: 3.846 ± 0.02	4.895GluLys: 4.895 ± 0.034	5.919GluLeu: 5.919 ± 0.034	1.748GluMet: 1.748 ± 0.014	3.22GluAsn: 3.22 ± 0.023	2.173GluPro: 2.173 ± 0.016	2.103GluGln: 2.103 ± 0.018	3.695GluArg: 3.695 ± 0.025	4.664GluSer: 4.664 ± 0.026	3.118GluThr: 3.118 ± 0.02	4.103GluVal: 4.103 ± 0.023	0.746GluTrp: 0.746 ± 0.008	1.593GluTyr: 1.593 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	2.618PheAla: 2.618 ± 0.017	0.923PheCys: 0.923 ± 0.011	2.422PheAsp: 2.422 ± 0.015	2.364PheGlu: 2.364 ± 0.018	2.032PhePhe: 2.032 ± 0.018	3.183PheGly: 3.183 ± 0.023	1.111PheHis: 1.111 ± 0.012	1.976PheIle: 1.976 ± 0.017	2.057PheLys: 2.057 ± 0.014	4.405PheLeu: 4.405 ± 0.024	0.962PheMet: 0.962 ± 0.009	1.691PheAsn: 1.691 ± 0.013	2.131PhePro: 2.131 ± 0.017	1.496PheGln: 1.496 ± 0.012	2.194PheArg: 2.194 ± 0.014	4.255PheSer: 4.255 ± 0.022	1.921PheThr: 1.921 ± 0.017	2.889PheVal: 2.889 ± 0.017	0.58PheTrp: 0.58 ± 0.008	1.249PheTyr: 1.249 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	3.964GlyAla: 3.964 ± 0.025	1.321GlyCys: 1.321 ± 0.014	3.545GlyAsp: 3.545 ± 0.021	3.811GlyGlu: 3.811 ± 0.021	3.27GlyPhe: 3.27 ± 0.02	5.555GlyGly: 5.555 ± 0.046	1.518GlyHis: 1.518 ± 0.015	3.542GlyIle: 3.542 ± 0.022	4.112GlyLys: 4.112 ± 0.026	6.06GlyLeu: 6.06 ± 0.029	1.438GlyMet: 1.438 ± 0.013	3.094GlyAsn: 3.094 ± 0.022	2.555GlyPro: 2.555 ± 0.018	2.058GlyGln: 2.058 ± 0.016	3.846GlyArg: 3.846 ± 0.022	5.943GlySer: 5.943 ± 0.032	3.173GlyThr: 3.173 ± 0.02	4.302GlyVal: 4.302 ± 0.027	0.931GlyTrp: 0.931 ± 0.01	1.979GlyTyr: 1.979 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.363HisAla: 1.363 ± 0.011	0.513HisCys: 0.513 ± 0.006	1.269HisAsp: 1.269 ± 0.012	1.302HisGlu: 1.302 ± 0.014	1.09HisPhe: 1.09 ± 0.011	1.746HisGly: 1.746 ± 0.016	1.141HisHis: 1.141 ± 0.019	1.143HisIle: 1.143 ± 0.011	1.173HisLys: 1.173 ± 0.011	2.332HisLeu: 2.332 ± 0.017	0.539HisMet: 0.539 ± 0.007	1.002HisAsn: 1.002 ± 0.01	1.307HisPro: 1.307 ± 0.012	1.021HisGln: 1.021 ± 0.011	1.442HisArg: 1.442 ± 0.013	1.915HisSer: 1.915 ± 0.016	0.931HisThr: 0.931 ± 0.01	1.572HisVal: 1.572 ± 0.012	0.304HisTrp: 0.304 ± 0.006	0.708HisTyr: 0.708 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.58IleAla: 3.58 ± 0.022	1.062IleCys: 1.062 ± 0.011	2.775IleAsp: 2.775 ± 0.018	3.144IleGlu: 3.144 ± 0.021	2.257IlePhe: 2.257 ± 0.017	3.37IleGly: 3.37 ± 0.02	1.252IleHis: 1.252 ± 0.011	2.679IleIle: 2.679 ± 0.02	2.816IleLys: 2.816 ± 0.019	5.096IleLeu: 5.096 ± 0.026	1.12IleMet: 1.12 ± 0.011	2.13IleAsn: 2.13 ± 0.016	2.864IlePro: 2.864 ± 0.022	1.823IleGln: 1.823 ± 0.016	2.743IleArg: 2.743 ± 0.018	4.954IleSer: 4.954 ± 0.026	2.569IleThr: 2.569 ± 0.019	3.437IleVal: 3.437 ± 0.022	0.7IleTrp: 0.7 ± 0.009	1.418IleTyr: 1.418 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.118LysAla: 4.118 ± 0.024	0.965LysCys: 0.965 ± 0.011	3.222LysAsp: 3.222 ± 0.021	4.667LysGlu: 4.667 ± 0.035	2.18LysPhe: 2.18 ± 0.014	3.581LysGly: 3.581 ± 0.021	1.282LysHis: 1.282 ± 0.011	3.19LysIle: 3.19 ± 0.019	4.731LysLys: 4.731 ± 0.033	5.894LysLeu: 5.894 ± 0.028	1.446LysMet: 1.446 ± 0.015	2.664LysAsn: 2.664 ± 0.018	2.798LysPro: 2.798 ± 0.016	2.17LysGln: 2.17 ± 0.016	3.764LysArg: 3.764 ± 0.021	4.701LysSer: 4.701 ± 0.025	2.919LysThr: 2.919 ± 0.016	3.796LysVal: 3.796 ± 0.024	0.804LysTrp: 0.804 ± 0.009	1.571LysTyr: 1.571 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	6.602LeuAla: 6.602 ± 0.034	1.851LeuCys: 1.851 ± 0.014	5.033LeuAsp: 5.033 ± 0.026	6.379LeuGlu: 6.379 ± 0.033	3.913LeuPhe: 3.913 ± 0.023	5.934LeuGly: 5.934 ± 0.029	2.537LeuHis: 2.537 ± 0.018	4.597LeuIle: 4.597 ± 0.027	6.051LeuLys: 6.051 ± 0.031	9.855LeuLeu: 9.855 ± 0.049	2.105LeuMet: 2.105 ± 0.017	3.871LeuAsn: 3.871 ± 0.022	5.076LeuPro: 5.076 ± 0.028	4.095LeuGln: 4.095 ± 0.022	5.756LeuArg: 5.756 ± 0.029	8.712LeuSer: 8.712 ± 0.04	4.329LeuThr: 4.329 ± 0.024	6.499LeuVal: 6.499 ± 0.03	1.165LeuTrp: 1.165 ± 0.012	2.468LeuTyr: 2.468 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.194MetAla: 2.194 ± 0.017	0.32MetCys: 0.32 ± 0.005	1.316MetAsp: 1.316 ± 0.011	1.953MetGlu: 1.953 ± 0.014	0.784MetPhe: 0.784 ± 0.009	1.559MetGly: 1.559 ± 0.014	0.486MetHis: 0.486 ± 0.006	1.172MetIle: 1.172 ± 0.012	1.572MetLys: 1.572 ± 0.013	2.055MetLeu: 2.055 ± 0.014	0.629MetMet: 0.629 ± 0.009	0.954MetAsn: 0.954 ± 0.011	1.024MetPro: 1.024 ± 0.011	0.837MetGln: 0.837 ± 0.011	1.243MetArg: 1.243 ± 0.012	1.74MetSer: 1.74 ± 0.013	1.026MetThr: 1.026 ± 0.012	1.587MetVal: 1.587 ± 0.014	0.271MetTrp: 0.271 ± 0.005	0.558MetTyr: 0.558 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.667AsnAla: 2.667 ± 0.018	0.849AsnCys: 0.849 ± 0.011	2.169AsnAsp: 2.169 ± 0.016	2.455AsnGlu: 2.455 ± 0.016	1.943AsnPhe: 1.943 ± 0.015	3.325AsnGly: 3.325 ± 0.019	1.108AsnHis: 1.108 ± 0.012	2.389AsnIle: 2.389 ± 0.017	2.401AsnLys: 2.401 ± 0.017	4.547AsnLeu: 4.547 ± 0.029	1.044AsnMet: 1.044 ± 0.01	2.514AsnAsn: 2.514 ± 0.024	2.375AsnPro: 2.375 ± 0.017	1.626AsnGln: 1.626 ± 0.015	2.104AsnArg: 2.104 ± 0.017	4.038AsnSer: 4.038 ± 0.022	1.932AsnThr: 1.932 ± 0.015	2.771AsnVal: 2.771 ± 0.017	0.57AsnTrp: 0.57 ± 0.008	1.296AsnTyr: 1.296 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	3.028ProAla: 3.028 ± 0.022	0.763ProCys: 0.763 ± 0.009	2.422ProAsp: 2.422 ± 0.014	3.11ProGlu: 3.11 ± 0.019	2.049ProPhe: 2.049 ± 0.017	2.652ProGly: 2.652 ± 0.023	1.128ProHis: 1.128 ± 0.011	2.365ProIle: 2.365 ± 0.018	2.809ProLys: 2.809 ± 0.019	4.368ProLeu: 4.368 ± 0.024	0.95ProMet: 0.95 ± 0.01	2.432ProAsn: 2.432 ± 0.018	3.967ProPro: 3.967 ± 0.053	1.798ProGln: 1.798 ± 0.017	2.559ProArg: 2.559 ± 0.021	5.231ProSer: 5.231 ± 0.033	2.733ProThr: 2.733 ± 0.018	3.069ProVal: 3.069 ± 0.021	0.612ProTrp: 0.612 ± 0.009	1.297ProTyr: 1.297 ± 0.011	0.0ProXaa: 0.0 ± 0.0
Gln	2.366GlnAla: 2.366 ± 0.017	0.547GlnCys: 0.547 ± 0.008	1.606GlnAsp: 1.606 ± 0.014	2.301GlnGlu: 2.301 ± 0.019	1.345GlnPhe: 1.345 ± 0.01	1.997GlnGly: 1.997 ± 0.016	0.893GlnHis: 0.893 ± 0.012	1.987GlnIle: 1.987 ± 0.015	2.311GlnLys: 2.311 ± 0.018	3.422GlnLeu: 3.422 ± 0.019	0.897GlnMet: 0.897 ± 0.011	1.795GlnAsn: 1.795 ± 0.015	1.755GlnPro: 1.755 ± 0.02	1.991GlnGln: 1.991 ± 0.038	2.17GlnArg: 2.17 ± 0.016	2.807GlnSer: 2.807 ± 0.019	1.719GlnThr: 1.719 ± 0.015	2.271GlnVal: 2.271 ± 0.014	0.454GlnTrp: 0.454 ± 0.007	0.899GlnTyr: 0.899 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	3.494ArgAla: 3.494 ± 0.025	1.008ArgCys: 1.008 ± 0.011	2.809ArgAsp: 2.809 ± 0.023	3.67ArgGlu: 3.67 ± 0.023	2.327ArgPhe: 2.327 ± 0.015	3.417ArgGly: 3.417 ± 0.025	1.369ArgHis: 1.369 ± 0.014	2.997ArgIle: 2.997 ± 0.018	3.893ArgLys: 3.893 ± 0.023	5.308ArgLeu: 5.308 ± 0.025	1.324ArgMet: 1.324 ± 0.011	2.581ArgAsn: 2.581 ± 0.016	2.584ArgPro: 2.584 ± 0.017	1.907ArgGln: 1.907 ± 0.016	4.563ArgArg: 4.563 ± 0.03	4.717ArgSer: 4.717 ± 0.025	2.578ArgThr: 2.578 ± 0.017	3.445ArgVal: 3.445 ± 0.019	0.791ArgTrp: 0.791 ± 0.011	1.44ArgTyr: 1.44 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	5.572SerAla: 5.572 ± 0.027	1.695SerCys: 1.695 ± 0.014	4.513SerAsp: 4.513 ± 0.023	5.005SerGlu: 5.005 ± 0.027	4.074SerPhe: 4.074 ± 0.023	6.035SerGly: 6.035 ± 0.035	2.066SerHis: 2.066 ± 0.017	4.286SerIle: 4.286 ± 0.023	4.89SerLys: 4.89 ± 0.024	8.891SerLeu: 8.891 ± 0.033	2.002SerMet: 2.002 ± 0.014	4.002SerAsn: 4.002 ± 0.024	4.833SerPro: 4.833 ± 0.033	3.0SerGln: 3.0 ± 0.02	4.687SerArg: 4.687 ± 0.024	11.582SerSer: 11.582 ± 0.055	4.777SerThr: 4.777 ± 0.025	5.341SerVal: 5.341 ± 0.027	1.2SerTrp: 1.2 ± 0.013	2.245SerTyr: 2.245 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	3.502ThrAla: 3.502 ± 0.021	0.897ThrCys: 0.897 ± 0.009	2.214ThrAsp: 2.214 ± 0.017	2.762ThrGlu: 2.762 ± 0.019	2.034ThrPhe: 2.034 ± 0.016	3.221ThrGly: 3.221 ± 0.019	1.007ThrHis: 1.007 ± 0.01	2.661ThrIle: 2.661 ± 0.018	2.727ThrLys: 2.727 ± 0.018	4.546ThrLeu: 4.546 ± 0.023	1.124ThrMet: 1.124 ± 0.012	2.113ThrAsn: 2.113 ± 0.015	2.601ThrPro: 2.601 ± 0.021	1.485ThrGln: 1.485 ± 0.013	2.487ThrArg: 2.487 ± 0.014	4.623ThrSer: 4.623 ± 0.025	3.246ThrThr: 3.246 ± 0.023	3.29ThrVal: 3.29 ± 0.02	0.654ThrTrp: 0.654 ± 0.01	1.325ThrTyr: 1.325 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	4.911ValAla: 4.911 ± 0.024	1.144ValCys: 1.144 ± 0.011	3.732ValAsp: 3.732 ± 0.021	4.48ValGlu: 4.48 ± 0.026	2.8ValPhe: 2.8 ± 0.018	4.347ValGly: 4.347 ± 0.023	1.49ValHis: 1.49 ± 0.012	3.288ValIle: 3.288 ± 0.022	3.882ValLys: 3.882 ± 0.024	6.442ValLeu: 6.442 ± 0.03	1.489ValMet: 1.489 ± 0.012	2.526ValAsn: 2.526 ± 0.018	3.233ValPro: 3.233 ± 0.02	2.208ValGln: 2.208 ± 0.015	3.335ValArg: 3.335 ± 0.019	5.483ValSer: 5.483 ± 0.026	3.154ValThr: 3.154 ± 0.019	5.259ValVal: 5.259 ± 0.029	0.795ValTrp: 0.795 ± 0.01	1.86ValTyr: 1.86 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.799TrpAla: 0.799 ± 0.009	0.245TrpCys: 0.245 ± 0.005	0.691TrpAsp: 0.691 ± 0.009	0.774TrpGlu: 0.774 ± 0.008	0.551TrpPhe: 0.551 ± 0.008	0.776TrpGly: 0.776 ± 0.01	0.29TrpHis: 0.29 ± 0.006	0.712TrpIle: 0.712 ± 0.009	0.929TrpLys: 0.929 ± 0.01	1.254TrpLeu: 1.254 ± 0.012	0.326TrpMet: 0.326 ± 0.006	0.707TrpAsn: 0.707 ± 0.009	0.531TrpPro: 0.531 ± 0.008	0.435TrpGln: 0.435 ± 0.007	0.898TrpArg: 0.898 ± 0.009	1.004TrpSer: 1.004 ± 0.01	0.651TrpThr: 0.651 ± 0.008	0.812TrpVal: 0.812 ± 0.011	0.264TrpTrp: 0.264 ± 0.006	0.342TrpTyr: 0.342 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.773TyrAla: 1.773 ± 0.015	0.619TyrCys: 0.619 ± 0.008	1.528TyrAsp: 1.528 ± 0.012	1.532TyrGlu: 1.532 ± 0.014	1.252TyrPhe: 1.252 ± 0.012	2.09TyrGly: 2.09 ± 0.016	0.667TyrHis: 0.667 ± 0.008	1.336TyrIle: 1.336 ± 0.013	1.498TyrLys: 1.498 ± 0.013	2.661TyrLeu: 2.661 ± 0.018	0.672TyrMet: 0.672 ± 0.009	1.295TyrAsn: 1.295 ± 0.012	1.19TyrPro: 1.19 ± 0.013	0.872TyrGln: 0.872 ± 0.011	1.457TyrArg: 1.457 ± 0.014	2.259TyrSer: 2.259 ± 0.017	1.235TyrThr: 1.235 ± 0.013	1.754TyrVal: 1.754 ± 0.015	0.401TyrTrp: 0.401 ± 0.006	0.944TyrTyr: 0.944 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 26760 proteins (9697202 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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