Amino acid dipepetide frequency for Arthrobacter sp. YC-RL1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.079AlaAla: 18.079 ± 0.191
0.801AlaCys: 0.801 ± 0.027
6.519AlaAsp: 6.519 ± 0.091
7.828AlaGlu: 7.828 ± 0.091
3.704AlaPhe: 3.704 ± 0.069
11.675AlaGly: 11.675 ± 0.131
2.343AlaHis: 2.343 ± 0.049
5.471AlaIle: 5.471 ± 0.082
4.413AlaLys: 4.413 ± 0.076
13.192AlaLeu: 13.192 ± 0.13
3.07AlaMet: 3.07 ± 0.052
2.993AlaAsn: 2.993 ± 0.061
5.283AlaPro: 5.283 ± 0.085
5.255AlaGln: 5.255 ± 0.086
7.207AlaArg: 7.207 ± 0.089
7.176AlaSer: 7.176 ± 0.098
6.599AlaThr: 6.599 ± 0.079
9.733AlaVal: 9.733 ± 0.102
1.632AlaTrp: 1.632 ± 0.041
2.314AlaTyr: 2.314 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.794CysAla: 0.794 ± 0.03
0.071CysCys: 0.071 ± 0.009
0.339CysAsp: 0.339 ± 0.017
0.34CysGlu: 0.34 ± 0.018
0.231CysPhe: 0.231 ± 0.015
0.683CysGly: 0.683 ± 0.027
0.146CysHis: 0.146 ± 0.012
0.293CysIle: 0.293 ± 0.016
0.149CysLys: 0.149 ± 0.011
0.603CysLeu: 0.603 ± 0.025
0.119CysMet: 0.119 ± 0.011
0.143CysAsn: 0.143 ± 0.012
0.353CysPro: 0.353 ± 0.018
0.207CysGln: 0.207 ± 0.014
0.352CysArg: 0.352 ± 0.02
0.444CysSer: 0.444 ± 0.021
0.446CysThr: 0.446 ± 0.025
0.454CysVal: 0.454 ± 0.022
0.095CysTrp: 0.095 ± 0.01
0.143CysTyr: 0.143 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.961AspAla: 6.961 ± 0.078
0.295AspCys: 0.295 ± 0.016
2.721AspAsp: 2.721 ± 0.053
4.021AspGlu: 4.021 ± 0.075
2.052AspPhe: 2.052 ± 0.046
4.748AspGly: 4.748 ± 0.084
1.11AspHis: 1.11 ± 0.035
2.317AspIle: 2.317 ± 0.054
1.621AspLys: 1.621 ± 0.048
5.717AspLeu: 5.717 ± 0.079
1.072AspMet: 1.072 ± 0.034
1.059AspAsn: 1.059 ± 0.032
3.644AspPro: 3.644 ± 0.066
1.879AspGln: 1.879 ± 0.046
3.144AspArg: 3.144 ± 0.054
3.129AspSer: 3.129 ± 0.062
2.803AspThr: 2.803 ± 0.063
4.007AspVal: 4.007 ± 0.06
0.811AspTrp: 0.811 ± 0.027
1.426AspTyr: 1.426 ± 0.033
0.001AspXaa: 0.001 ± 0.001
Glu
7.04GluAla: 7.04 ± 0.096
0.291GluCys: 0.291 ± 0.017
3.389GluAsp: 3.389 ± 0.068
3.466GluGlu: 3.466 ± 0.076
2.042GluPhe: 2.042 ± 0.039
3.911GluGly: 3.911 ± 0.068
1.878GluHis: 1.878 ± 0.048
2.974GluIle: 2.974 ± 0.065
2.051GluLys: 2.051 ± 0.056
7.313GluLeu: 7.313 ± 0.101
1.127GluMet: 1.127 ± 0.034
1.911GluAsn: 1.911 ± 0.038
2.781GluPro: 2.781 ± 0.063
3.08GluGln: 3.08 ± 0.06
4.184GluArg: 4.184 ± 0.068
3.294GluSer: 3.294 ± 0.059
2.9GluThr: 2.9 ± 0.058
4.447GluVal: 4.447 ± 0.071
0.622GluTrp: 0.622 ± 0.025
1.253GluTyr: 1.253 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
4.326PheAla: 4.326 ± 0.076
0.256PheCys: 0.256 ± 0.015
2.143PheAsp: 2.143 ± 0.049
1.996PheGlu: 1.996 ± 0.047
1.267PhePhe: 1.267 ± 0.036
3.43PheGly: 3.43 ± 0.063
0.61PheHis: 0.61 ± 0.024
1.603PheIle: 1.603 ± 0.041
0.872PheLys: 0.872 ± 0.031
2.96PheLeu: 2.96 ± 0.066
0.715PheMet: 0.715 ± 0.024
1.013PheAsn: 1.013 ± 0.037
1.378PhePro: 1.378 ± 0.037
0.862PheGln: 0.862 ± 0.029
1.524PheArg: 1.524 ± 0.037
2.302PheSer: 2.302 ± 0.047
2.372PheThr: 2.372 ± 0.055
2.46PheVal: 2.46 ± 0.054
0.491PheTrp: 0.491 ± 0.022
0.744PheTyr: 0.744 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.503GlyAla: 9.503 ± 0.104
0.673GlyCys: 0.673 ± 0.025
3.813GlyAsp: 3.813 ± 0.074
4.719GlyGlu: 4.719 ± 0.072
3.373GlyPhe: 3.373 ± 0.062
6.807GlyGly: 6.807 ± 0.1
1.898GlyHis: 1.898 ± 0.047
4.909GlyIle: 4.909 ± 0.08
3.199GlyLys: 3.199 ± 0.059
8.781GlyLeu: 8.781 ± 0.112
2.266GlyMet: 2.266 ± 0.052
2.293GlyAsn: 2.293 ± 0.049
3.332GlyPro: 3.332 ± 0.06
3.275GlyGln: 3.275 ± 0.054
5.245GlyArg: 5.245 ± 0.086
5.497GlySer: 5.497 ± 0.087
5.519GlyThr: 5.519 ± 0.096
6.391GlyVal: 6.391 ± 0.088
1.547GlyTrp: 1.547 ± 0.047
2.41GlyTyr: 2.41 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.336HisAla: 2.336 ± 0.052
0.159HisCys: 0.159 ± 0.013
1.089HisAsp: 1.089 ± 0.038
1.371HisGlu: 1.371 ± 0.037
0.742HisPhe: 0.742 ± 0.028
2.045HisGly: 2.045 ± 0.045
0.641HisHis: 0.641 ± 0.025
0.815HisIle: 0.815 ± 0.027
0.482HisLys: 0.482 ± 0.025
2.216HisLeu: 2.216 ± 0.048
0.393HisMet: 0.393 ± 0.018
0.487HisAsn: 0.487 ± 0.021
1.388HisPro: 1.388 ± 0.039
0.771HisGln: 0.771 ± 0.03
1.568HisArg: 1.568 ± 0.038
1.144HisSer: 1.144 ± 0.033
1.111HisThr: 1.111 ± 0.034
1.562HisVal: 1.562 ± 0.042
0.329HisTrp: 0.329 ± 0.017
0.497HisTyr: 0.497 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.529IleAla: 6.529 ± 0.082
0.403IleCys: 0.403 ± 0.022
3.175IleAsp: 3.175 ± 0.056
3.012IleGlu: 3.012 ± 0.056
1.573IlePhe: 1.573 ± 0.04
4.469IleGly: 4.469 ± 0.076
0.905IleHis: 0.905 ± 0.029
2.276IleIle: 2.276 ± 0.057
1.398IleLys: 1.398 ± 0.039
4.215IleLeu: 4.215 ± 0.071
0.98IleMet: 0.98 ± 0.032
1.375IleAsn: 1.375 ± 0.04
2.537IlePro: 2.537 ± 0.047
1.373IleGln: 1.373 ± 0.036
2.575IleArg: 2.575 ± 0.052
3.34IleSer: 3.34 ± 0.061
3.055IleThr: 3.055 ± 0.051
3.913IleVal: 3.913 ± 0.069
0.563IleTrp: 0.563 ± 0.023
1.005IleTyr: 1.005 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.705LysAla: 3.705 ± 0.06
0.125LysCys: 0.125 ± 0.011
1.908LysAsp: 1.908 ± 0.051
1.511LysGlu: 1.511 ± 0.042
0.977LysPhe: 0.977 ± 0.031
1.949LysGly: 1.949 ± 0.047
0.73LysHis: 0.73 ± 0.025
1.802LysIle: 1.802 ± 0.038
1.335LysLys: 1.335 ± 0.049
3.466LysLeu: 3.466 ± 0.069
0.845LysMet: 0.845 ± 0.028
1.054LysAsn: 1.054 ± 0.037
1.822LysPro: 1.822 ± 0.05
1.118LysGln: 1.118 ± 0.035
1.863LysArg: 1.863 ± 0.043
1.882LysSer: 1.882 ± 0.053
1.843LysThr: 1.843 ± 0.042
2.541LysVal: 2.541 ± 0.055
0.313LysTrp: 0.313 ± 0.017
0.777LysTyr: 0.777 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
14.423LeuAla: 14.423 ± 0.14
0.757LeuCys: 0.757 ± 0.028
6.472LeuAsp: 6.472 ± 0.089
5.978LeuGlu: 5.978 ± 0.084
3.072LeuPhe: 3.072 ± 0.057
9.719LeuGly: 9.719 ± 0.106
2.004LeuHis: 2.004 ± 0.046
4.751LeuIle: 4.751 ± 0.081
2.868LeuLys: 2.868 ± 0.054
10.848LeuLeu: 10.848 ± 0.158
2.252LeuMet: 2.252 ± 0.05
2.684LeuAsn: 2.684 ± 0.054
5.449LeuPro: 5.449 ± 0.075
3.267LeuGln: 3.267 ± 0.061
6.814LeuArg: 6.814 ± 0.092
6.643LeuSer: 6.643 ± 0.077
5.569LeuThr: 5.569 ± 0.072
8.641LeuVal: 8.641 ± 0.101
1.265LeuTrp: 1.265 ± 0.039
1.781LeuTyr: 1.781 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.799MetAla: 2.799 ± 0.058
0.14MetCys: 0.14 ± 0.011
1.209MetAsp: 1.209 ± 0.032
1.076MetGlu: 1.076 ± 0.032
0.693MetPhe: 0.693 ± 0.026
1.839MetGly: 1.839 ± 0.049
0.489MetHis: 0.489 ± 0.022
1.203MetIle: 1.203 ± 0.033
0.726MetLys: 0.726 ± 0.027
2.475MetLeu: 2.475 ± 0.05
0.442MetMet: 0.442 ± 0.022
0.776MetAsn: 0.776 ± 0.027
1.149MetPro: 1.149 ± 0.036
0.718MetGln: 0.718 ± 0.023
1.27MetArg: 1.27 ± 0.035
1.75MetSer: 1.75 ± 0.04
1.516MetThr: 1.516 ± 0.039
1.756MetVal: 1.756 ± 0.042
0.219MetTrp: 0.219 ± 0.015
0.373MetTyr: 0.373 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.053AsnAla: 3.053 ± 0.055
0.186AsnCys: 0.186 ± 0.016
1.426AsnAsp: 1.426 ± 0.043
1.515AsnGlu: 1.515 ± 0.035
0.955AsnPhe: 0.955 ± 0.03
2.291AsnGly: 2.291 ± 0.05
0.564AsnHis: 0.564 ± 0.024
1.272AsnIle: 1.272 ± 0.035
0.811AsnLys: 0.811 ± 0.03
2.747AsnLeu: 2.747 ± 0.057
0.577AsnMet: 0.577 ± 0.026
0.788AsnAsn: 0.788 ± 0.027
1.943AsnPro: 1.943 ± 0.044
0.966AsnGln: 0.966 ± 0.032
1.591AsnArg: 1.591 ± 0.041
1.571AsnSer: 1.571 ± 0.04
1.554AsnThr: 1.554 ± 0.04
1.941AsnVal: 1.941 ± 0.049
0.406AsnTrp: 0.406 ± 0.023
0.648AsnTyr: 0.648 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
6.565ProAla: 6.565 ± 0.106
0.176ProCys: 0.176 ± 0.014
2.821ProAsp: 2.821 ± 0.051
3.978ProGlu: 3.978 ± 0.067
1.497ProPhe: 1.497 ± 0.04
4.532ProGly: 4.532 ± 0.072
0.964ProHis: 0.964 ± 0.028
1.83ProIle: 1.83 ± 0.037
1.539ProLys: 1.539 ± 0.042
4.478ProLeu: 4.478 ± 0.071
1.075ProMet: 1.075 ± 0.031
1.244ProAsn: 1.244 ± 0.034
1.57ProPro: 1.57 ± 0.044
2.108ProGln: 2.108 ± 0.044
2.662ProArg: 2.662 ± 0.055
2.798ProSer: 2.798 ± 0.057
2.652ProThr: 2.652 ± 0.056
4.362ProVal: 4.362 ± 0.065
0.732ProTrp: 0.732 ± 0.028
0.999ProTyr: 0.999 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.735GlnAla: 4.735 ± 0.076
0.191GlnCys: 0.191 ± 0.013
1.839GlnAsp: 1.839 ± 0.049
1.867GlnGlu: 1.867 ± 0.043
1.062GlnPhe: 1.062 ± 0.027
2.557GlnGly: 2.557 ± 0.05
0.827GlnHis: 0.827 ± 0.028
2.047GlnIle: 2.047 ± 0.044
1.001GlnLys: 1.001 ± 0.035
4.727GlnLeu: 4.727 ± 0.072
0.812GlnMet: 0.812 ± 0.027
0.876GlnAsn: 0.876 ± 0.032
1.711GlnPro: 1.711 ± 0.046
1.654GlnGln: 1.654 ± 0.056
2.806GlnArg: 2.806 ± 0.055
1.9GlnSer: 1.9 ± 0.047
1.746GlnThr: 1.746 ± 0.044
3.085GlnVal: 3.085 ± 0.057
0.553GlnTrp: 0.553 ± 0.02
0.697GlnTyr: 0.697 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
6.748ArgAla: 6.748 ± 0.1
0.336ArgCys: 0.336 ± 0.017
3.152ArgAsp: 3.152 ± 0.054
4.209ArgGlu: 4.209 ± 0.064
2.073ArgPhe: 2.073 ± 0.046
4.522ArgGly: 4.522 ± 0.07
1.332ArgHis: 1.332 ± 0.036
3.408ArgIle: 3.408 ± 0.059
2.094ArgLys: 2.094 ± 0.044
6.116ArgLeu: 6.116 ± 0.08
1.571ArgMet: 1.571 ± 0.039
1.724ArgAsn: 1.724 ± 0.053
2.702ArgPro: 2.702 ± 0.061
2.379ArgGln: 2.379 ± 0.054
4.717ArgArg: 4.717 ± 0.083
3.73ArgSer: 3.73 ± 0.06
3.684ArgThr: 3.684 ± 0.065
4.344ArgVal: 4.344 ± 0.061
1.005ArgTrp: 1.005 ± 0.03
1.52ArgTyr: 1.52 ± 0.041
0.001ArgXaa: 0.001 ± 0.001
Ser
7.292SerAla: 7.292 ± 0.095
0.38SerCys: 0.38 ± 0.019
2.885SerAsp: 2.885 ± 0.056
3.506SerGlu: 3.506 ± 0.071
2.061SerPhe: 2.061 ± 0.047
5.876SerGly: 5.876 ± 0.088
1.171SerHis: 1.171 ± 0.033
2.942SerIle: 2.942 ± 0.053
2.021SerLys: 2.021 ± 0.058
6.092SerLeu: 6.092 ± 0.073
1.649SerMet: 1.649 ± 0.04
1.654SerAsn: 1.654 ± 0.041
2.746SerPro: 2.746 ± 0.051
2.069SerGln: 2.069 ± 0.045
3.634SerArg: 3.634 ± 0.062
3.97SerSer: 3.97 ± 0.062
3.923SerThr: 3.923 ± 0.061
4.683SerVal: 4.683 ± 0.067
1.004SerTrp: 1.004 ± 0.032
1.516SerTyr: 1.516 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
7.1ThrAla: 7.1 ± 0.087
0.345ThrCys: 0.345 ± 0.018
3.036ThrAsp: 3.036 ± 0.051
3.342ThrGlu: 3.342 ± 0.053
1.704ThrPhe: 1.704 ± 0.04
5.663ThrGly: 5.663 ± 0.076
1.185ThrHis: 1.185 ± 0.034
2.649ThrIle: 2.649 ± 0.048
1.642ThrLys: 1.642 ± 0.04
5.908ThrLeu: 5.908 ± 0.074
1.173ThrMet: 1.173 ± 0.032
1.411ThrAsn: 1.411 ± 0.036
3.102ThrPro: 3.102 ± 0.056
1.748ThrGln: 1.748 ± 0.045
3.121ThrArg: 3.121 ± 0.057
3.497ThrSer: 3.497 ± 0.07
3.296ThrThr: 3.296 ± 0.065
5.062ThrVal: 5.062 ± 0.077
0.777ThrTrp: 0.777 ± 0.028
1.236ThrTyr: 1.236 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
9.449ValAla: 9.449 ± 0.103
0.526ValCys: 0.526 ± 0.021
4.57ValAsp: 4.57 ± 0.06
4.295ValGlu: 4.295 ± 0.069
2.804ValPhe: 2.804 ± 0.049
5.861ValGly: 5.861 ± 0.081
1.643ValHis: 1.643 ± 0.04
4.456ValIle: 4.456 ± 0.072
2.304ValLys: 2.304 ± 0.053
9.272ValLeu: 9.272 ± 0.107
1.712ValMet: 1.712 ± 0.045
2.29ValAsn: 2.29 ± 0.043
4.021ValPro: 4.021 ± 0.065
2.647ValGln: 2.647 ± 0.043
4.587ValArg: 4.587 ± 0.07
4.872ValSer: 4.872 ± 0.065
4.404ValThr: 4.404 ± 0.071
6.681ValVal: 6.681 ± 0.097
0.853ValTrp: 0.853 ± 0.028
1.476ValTyr: 1.476 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.44TrpAla: 1.44 ± 0.043
0.115TrpCys: 0.115 ± 0.011
0.784TrpAsp: 0.784 ± 0.03
0.703TrpGlu: 0.703 ± 0.027
0.536TrpPhe: 0.536 ± 0.024
0.903TrpGly: 0.903 ± 0.031
0.314TrpHis: 0.314 ± 0.019
0.835TrpIle: 0.835 ± 0.03
0.46TrpLys: 0.46 ± 0.025
1.676TrpLeu: 1.676 ± 0.038
0.375TrpMet: 0.375 ± 0.015
0.476TrpAsn: 0.476 ± 0.022
0.614TrpPro: 0.614 ± 0.029
0.571TrpGln: 0.571 ± 0.026
0.922TrpArg: 0.922 ± 0.027
0.795TrpSer: 0.795 ± 0.034
0.71TrpThr: 0.71 ± 0.026
1.085TrpVal: 1.085 ± 0.032
0.306TrpTrp: 0.306 ± 0.019
0.286TrpTyr: 0.286 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.408TyrAla: 2.408 ± 0.048
0.178TyrCys: 0.178 ± 0.014
1.25TyrAsp: 1.25 ± 0.04
1.221TyrGlu: 1.221 ± 0.038
0.903TyrPhe: 0.903 ± 0.029
1.968TyrGly: 1.968 ± 0.042
0.389TyrHis: 0.389 ± 0.017
0.817TyrIle: 0.817 ± 0.025
0.585TyrLys: 0.585 ± 0.025
2.454TyrLeu: 2.454 ± 0.048
0.394TyrMet: 0.394 ± 0.02
0.555TyrAsn: 0.555 ± 0.026
1.06TyrPro: 1.06 ± 0.03
0.744TyrGln: 0.744 ± 0.025
1.582TyrArg: 1.582 ± 0.045
1.34TyrSer: 1.34 ± 0.038
1.294TyrThr: 1.294 ± 0.031
1.573TyrVal: 1.573 ± 0.039
0.385TyrTrp: 0.385 ± 0.021
0.516TyrTyr: 0.516 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.02XaaXaa: 0.02 ± 0.014
Statistics based on 3439 proteins (1069183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski