Amino acid dipepetide frequency for Actinoplanes philippinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.022AlaAla: 24.022 ± 0.191	0.944AlaCys: 0.944 ± 0.02	8.727AlaAsp: 8.727 ± 0.068	8.206AlaGlu: 8.206 ± 0.07	3.435AlaPhe: 3.435 ± 0.032	15.49AlaGly: 15.49 ± 0.094	2.509AlaHis: 2.509 ± 0.029	4.354AlaIle: 4.354 ± 0.04	2.414AlaLys: 2.414 ± 0.042	13.897AlaLeu: 13.897 ± 0.092	2.541AlaMet: 2.541 ± 0.03	2.186AlaAsn: 2.186 ± 0.028	6.945AlaPro: 6.945 ± 0.068	3.485AlaGln: 3.485 ± 0.038	10.047AlaArg: 10.047 ± 0.083	5.883AlaSer: 5.883 ± 0.049	8.255AlaThr: 8.255 ± 0.073	12.952AlaVal: 12.952 ± 0.088	1.971AlaTrp: 1.971 ± 0.028	2.68AlaTyr: 2.68 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.919CysAla: 0.919 ± 0.02	0.091CysCys: 0.091 ± 0.006	0.456CysAsp: 0.456 ± 0.012	0.304CysGlu: 0.304 ± 0.012	0.199CysPhe: 0.199 ± 0.008	0.837CysGly: 0.837 ± 0.021	0.179CysHis: 0.179 ± 0.009	0.16CysIle: 0.16 ± 0.007	0.09CysLys: 0.09 ± 0.005	0.709CysLeu: 0.709 ± 0.017	0.101CysMet: 0.101 ± 0.006	0.138CysAsn: 0.138 ± 0.007	0.442CysPro: 0.442 ± 0.015	0.142CysGln: 0.142 ± 0.008	0.611CysArg: 0.611 ± 0.016	0.395CysSer: 0.395 ± 0.012	0.446CysThr: 0.446 ± 0.015	0.564CysVal: 0.564 ± 0.014	0.12CysTrp: 0.12 ± 0.011	0.139CysTyr: 0.139 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.252AspAla: 7.252 ± 0.057	0.398AspCys: 0.398 ± 0.013	4.102AspAsp: 4.102 ± 0.056	3.78AspGlu: 3.78 ± 0.041	1.653AspPhe: 1.653 ± 0.023	6.547AspGly: 6.547 ± 0.056	1.333AspHis: 1.333 ± 0.025	1.792AspIle: 1.792 ± 0.024	0.919AspLys: 0.919 ± 0.023	6.675AspLeu: 6.675 ± 0.05	0.785AspMet: 0.785 ± 0.017	1.086AspAsn: 1.086 ± 0.021	4.673AspPro: 4.673 ± 0.042	1.653AspGln: 1.653 ± 0.024	5.343AspArg: 5.343 ± 0.05	2.38AspSer: 2.38 ± 0.031	3.146AspThr: 3.146 ± 0.038	4.961AspVal: 4.961 ± 0.048	0.982AspTrp: 0.982 ± 0.019	1.139AspTyr: 1.139 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.524GluAla: 6.524 ± 0.066	0.293GluCys: 0.293 ± 0.01	2.221GluAsp: 2.221 ± 0.028	2.481GluGlu: 2.481 ± 0.034	1.459GluPhe: 1.459 ± 0.023	3.152GluGly: 3.152 ± 0.035	1.345GluHis: 1.345 ± 0.024	2.437GluIle: 2.437 ± 0.03	1.178GluLys: 1.178 ± 0.021	5.84GluLeu: 5.84 ± 0.053	0.898GluMet: 0.898 ± 0.019	0.937GluAsn: 0.937 ± 0.017	3.373GluPro: 3.373 ± 0.041	2.115GluGln: 2.115 ± 0.031	4.626GluArg: 4.626 ± 0.041	2.39GluSer: 2.39 ± 0.031	2.818GluThr: 2.818 ± 0.034	4.216GluVal: 4.216 ± 0.044	0.732GluTrp: 0.732 ± 0.015	0.962GluTyr: 0.962 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.865PheAla: 3.865 ± 0.037	0.244PheCys: 0.244 ± 0.008	1.975PheAsp: 1.975 ± 0.024	1.295PheGlu: 1.295 ± 0.023	0.814PhePhe: 0.814 ± 0.018	3.031PheGly: 3.031 ± 0.035	0.578PheHis: 0.578 ± 0.016	0.707PheIle: 0.707 ± 0.017	0.475PheLys: 0.475 ± 0.013	2.565PheLeu: 2.565 ± 0.033	0.337PheMet: 0.337 ± 0.011	0.568PheAsn: 0.568 ± 0.013	1.41PhePro: 1.41 ± 0.022	0.693PheGln: 0.693 ± 0.014	1.991PheArg: 1.991 ± 0.025	1.396PheSer: 1.396 ± 0.022	2.144PheThr: 2.144 ± 0.033	2.342PheVal: 2.342 ± 0.028	0.451PheTrp: 0.451 ± 0.014	0.627PheTyr: 0.627 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.125GlyAla: 11.125 ± 0.082	0.804GlyCys: 0.804 ± 0.017	5.777GlyAsp: 5.777 ± 0.051	4.543GlyGlu: 4.543 ± 0.044	3.005GlyPhe: 3.005 ± 0.031	8.753GlyGly: 8.753 ± 0.093	2.231GlyHis: 2.231 ± 0.03	3.386GlyIle: 3.386 ± 0.037	2.024GlyLys: 2.024 ± 0.031	9.594GlyLeu: 9.594 ± 0.066	1.809GlyMet: 1.809 ± 0.023	1.943GlyAsn: 1.943 ± 0.036	5.349GlyPro: 5.349 ± 0.051	2.502GlyGln: 2.502 ± 0.032	7.945GlyArg: 7.945 ± 0.063	5.253GlySer: 5.253 ± 0.044	5.972GlyThr: 5.972 ± 0.067	7.776GlyVal: 7.776 ± 0.058	1.858GlyTrp: 1.858 ± 0.028	2.403GlyTyr: 2.403 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.432HisAla: 2.432 ± 0.032	0.176HisCys: 0.176 ± 0.008	1.427HisAsp: 1.427 ± 0.024	1.071HisGlu: 1.071 ± 0.019	0.578HisPhe: 0.578 ± 0.015	2.142HisGly: 2.142 ± 0.032	0.643HisHis: 0.643 ± 0.016	0.587HisIle: 0.587 ± 0.015	0.242HisLys: 0.242 ± 0.008	2.459HisLeu: 2.459 ± 0.032	0.274HisMet: 0.274 ± 0.009	0.369HisAsn: 0.369 ± 0.011	1.674HisPro: 1.674 ± 0.027	0.607HisGln: 0.607 ± 0.015	2.129HisArg: 2.129 ± 0.031	0.876HisSer: 0.876 ± 0.018	1.163HisThr: 1.163 ± 0.021	1.626HisVal: 1.626 ± 0.022	0.311HisTrp: 0.311 ± 0.01	0.449HisTyr: 0.449 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.5IleAla: 5.5 ± 0.044	0.301IleCys: 0.301 ± 0.01	2.658IleAsp: 2.658 ± 0.03	2.097IleGlu: 2.097 ± 0.031	0.887IlePhe: 0.887 ± 0.018	3.899IleGly: 3.899 ± 0.04	0.605IleHis: 0.605 ± 0.015	1.101IleIle: 1.101 ± 0.02	0.705IleLys: 0.705 ± 0.016	2.878IleLeu: 2.878 ± 0.034	0.488IleMet: 0.488 ± 0.013	0.841IleAsn: 0.841 ± 0.016	1.889IlePro: 1.889 ± 0.026	0.743IleGln: 0.743 ± 0.02	2.7IleArg: 2.7 ± 0.03	1.918IleSer: 1.918 ± 0.026	2.716IleThr: 2.716 ± 0.03	3.175IleVal: 3.175 ± 0.033	0.466IleTrp: 0.466 ± 0.013	0.619IleTyr: 0.619 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	2.389LysAla: 2.389 ± 0.045	0.11LysCys: 0.11 ± 0.007	0.921LysAsp: 0.921 ± 0.023	0.795LysGlu: 0.795 ± 0.019	0.42LysPhe: 0.42 ± 0.013	1.31LysGly: 1.31 ± 0.026	0.358LysHis: 0.358 ± 0.012	0.857LysIle: 0.857 ± 0.018	0.563LysLys: 0.563 ± 0.016	1.777LysLeu: 1.777 ± 0.028	0.3LysMet: 0.3 ± 0.01	0.442LysAsn: 0.442 ± 0.014	1.24LysPro: 1.24 ± 0.023	0.614LysGln: 0.614 ± 0.016	1.26LysArg: 1.26 ± 0.024	1.003LysSer: 1.003 ± 0.019	1.105LysThr: 1.105 ± 0.021	1.575LysVal: 1.575 ± 0.029	0.23LysTrp: 0.23 ± 0.009	0.402LysTyr: 0.402 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.568LeuAla: 15.568 ± 0.098	0.696LeuCys: 0.696 ± 0.018	6.651LeuAsp: 6.651 ± 0.053	4.0LeuGlu: 4.0 ± 0.04	2.62LeuPhe: 2.62 ± 0.037	8.936LeuGly: 8.936 ± 0.06	2.206LeuHis: 2.206 ± 0.026	4.192LeuIle: 4.192 ± 0.041	1.566LeuLys: 1.566 ± 0.03	11.333LeuLeu: 11.333 ± 0.102	1.514LeuMet: 1.514 ± 0.024	1.736LeuAsn: 1.736 ± 0.027	6.443LeuPro: 6.443 ± 0.048	2.213LeuGln: 2.213 ± 0.029	8.72LeuArg: 8.72 ± 0.064	5.409LeuSer: 5.409 ± 0.039	7.417LeuThr: 7.417 ± 0.056	8.576LeuVal: 8.576 ± 0.064	1.328LeuTrp: 1.328 ± 0.026	1.7LeuTyr: 1.7 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.153MetAla: 2.153 ± 0.029	0.105MetCys: 0.105 ± 0.005	0.734MetAsp: 0.734 ± 0.016	0.584MetGlu: 0.584 ± 0.014	0.45MetPhe: 0.45 ± 0.013	1.083MetGly: 1.083 ± 0.022	0.332MetHis: 0.332 ± 0.011	0.862MetIle: 0.862 ± 0.017	0.351MetLys: 0.351 ± 0.013	1.811MetLeu: 1.811 ± 0.027	0.303MetMet: 0.303 ± 0.012	0.38MetAsn: 0.38 ± 0.01	1.155MetPro: 1.155 ± 0.021	0.415MetGln: 0.415 ± 0.011	1.484MetArg: 1.484 ± 0.021	1.257MetSer: 1.257 ± 0.021	1.619MetThr: 1.619 ± 0.021	1.252MetVal: 1.252 ± 0.021	0.21MetTrp: 0.21 ± 0.008	0.282MetTyr: 0.282 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.322AsnAla: 2.322 ± 0.031	0.155AsnCys: 0.155 ± 0.008	1.059AsnAsp: 1.059 ± 0.024	0.801AsnGlu: 0.801 ± 0.016	0.488AsnPhe: 0.488 ± 0.012	2.11AsnGly: 2.11 ± 0.038	0.383AsnHis: 0.383 ± 0.012	0.626AsnIle: 0.626 ± 0.016	0.344AsnLys: 0.344 ± 0.013	1.838AsnLeu: 1.838 ± 0.028	0.283AsnMet: 0.283 ± 0.011	0.518AsnAsn: 0.518 ± 0.02	1.441AsnPro: 1.441 ± 0.023	0.557AsnGln: 0.557 ± 0.014	1.491AsnArg: 1.491 ± 0.023	0.953AsnSer: 0.953 ± 0.021	1.182AsnThr: 1.182 ± 0.025	1.479AsnVal: 1.479 ± 0.026	0.33AsnTrp: 0.33 ± 0.012	0.434AsnTyr: 0.434 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.247ProAla: 10.247 ± 0.083	0.286ProCys: 0.286 ± 0.01	4.496ProAsp: 4.496 ± 0.045	3.725ProGlu: 3.725 ± 0.038	1.506ProPhe: 1.506 ± 0.024	6.941ProGly: 6.941 ± 0.063	1.184ProHis: 1.184 ± 0.021	1.824ProIle: 1.824 ± 0.025	0.935ProLys: 0.935 ± 0.02	5.053ProLeu: 5.053 ± 0.046	0.99ProMet: 0.99 ± 0.02	0.974ProAsn: 0.974 ± 0.022	3.942ProPro: 3.942 ± 0.06	1.512ProGln: 1.512 ± 0.025	3.798ProArg: 3.798 ± 0.043	3.471ProSer: 3.471 ± 0.049	3.03ProThr: 3.03 ± 0.039	5.686ProVal: 5.686 ± 0.05	0.948ProTrp: 0.948 ± 0.019	1.223ProTyr: 1.223 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.646GlnAla: 3.646 ± 0.044	0.136GlnCys: 0.136 ± 0.006	1.134GlnAsp: 1.134 ± 0.018	1.163GlnGlu: 1.163 ± 0.02	0.738GlnPhe: 0.738 ± 0.015	1.835GlnGly: 1.835 ± 0.028	0.629GlnHis: 0.629 ± 0.015	1.204GlnIle: 1.204 ± 0.02	0.535GlnLys: 0.535 ± 0.014	2.91GlnLeu: 2.91 ± 0.037	0.491GlnMet: 0.491 ± 0.014	0.538GlnAsn: 0.538 ± 0.017	1.718GlnPro: 1.718 ± 0.027	1.216GlnGln: 1.216 ± 0.031	2.573GlnArg: 2.573 ± 0.031	1.253GlnSer: 1.253 ± 0.02	1.41GlnThr: 1.41 ± 0.029	2.473GlnVal: 2.473 ± 0.028	0.506GlnTrp: 0.506 ± 0.014	0.536GlnTyr: 0.536 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	9.921ArgAla: 9.921 ± 0.077	0.56ArgCys: 0.56 ± 0.015	4.703ArgAsp: 4.703 ± 0.044	4.15ArgGlu: 4.15 ± 0.04	2.518ArgPhe: 2.518 ± 0.027	5.401ArgGly: 5.401 ± 0.047	2.145ArgHis: 2.145 ± 0.026	3.558ArgIle: 3.558 ± 0.037	1.378ArgLys: 1.378 ± 0.024	9.255ArgLeu: 9.255 ± 0.07	1.819ArgMet: 1.819 ± 0.021	1.475ArgAsn: 1.475 ± 0.024	5.17ArgPro: 5.17 ± 0.055	2.402ArgGln: 2.402 ± 0.032	8.19ArgArg: 8.19 ± 0.067	4.202ArgSer: 4.202 ± 0.043	4.871ArgThr: 4.871 ± 0.042	6.033ArgVal: 6.033 ± 0.051	1.527ArgTrp: 1.527 ± 0.02	1.86ArgTyr: 1.86 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	7.03SerAla: 7.03 ± 0.061	0.362SerCys: 0.362 ± 0.012	2.587SerAsp: 2.587 ± 0.037	2.148SerGlu: 2.148 ± 0.026	1.475SerPhe: 1.475 ± 0.025	6.07SerGly: 6.07 ± 0.059	0.914SerHis: 0.914 ± 0.019	1.766SerIle: 1.766 ± 0.023	0.818SerLys: 0.818 ± 0.019	4.581SerLeu: 4.581 ± 0.04	1.07SerMet: 1.07 ± 0.016	0.922SerAsn: 0.922 ± 0.019	3.447SerPro: 3.447 ± 0.047	1.147SerGln: 1.147 ± 0.021	3.941SerArg: 3.941 ± 0.04	2.915SerSer: 2.915 ± 0.04	3.163SerThr: 3.163 ± 0.039	4.124SerVal: 4.124 ± 0.042	0.987SerTrp: 0.987 ± 0.016	1.129SerTyr: 1.129 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	9.449ThrAla: 9.449 ± 0.082	0.445ThrCys: 0.445 ± 0.015	3.575ThrAsp: 3.575 ± 0.04	2.953ThrGlu: 2.953 ± 0.034	1.779ThrPhe: 1.779 ± 0.027	7.22ThrGly: 7.22 ± 0.066	1.04ThrHis: 1.04 ± 0.019	2.346ThrIle: 2.346 ± 0.038	1.015ThrLys: 1.015 ± 0.024	5.983ThrLeu: 5.983 ± 0.056	1.03ThrMet: 1.03 ± 0.018	1.127ThrAsn: 1.127 ± 0.02	4.178ThrPro: 4.178 ± 0.047	1.192ThrGln: 1.192 ± 0.021	3.989ThrArg: 3.989 ± 0.041	3.182ThrSer: 3.182 ± 0.038	4.191ThrThr: 4.191 ± 0.058	6.788ThrVal: 6.788 ± 0.072	0.983ThrTrp: 0.983 ± 0.019	1.28ThrTyr: 1.28 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	12.138ValAla: 12.138 ± 0.088	0.635ValCys: 0.635 ± 0.014	5.235ValAsp: 5.235 ± 0.042	4.257ValGlu: 4.257 ± 0.044	2.336ValPhe: 2.336 ± 0.029	6.277ValGly: 6.277 ± 0.053	1.785ValHis: 1.785 ± 0.025	3.328ValIle: 3.328 ± 0.034	1.519ValLys: 1.519 ± 0.029	9.547ValLeu: 9.547 ± 0.069	1.281ValMet: 1.281 ± 0.02	1.78ValAsn: 1.78 ± 0.032	5.254ValPro: 5.254 ± 0.05	2.06ValGln: 2.06 ± 0.028	6.898ValArg: 6.898 ± 0.049	4.503ValSer: 4.503 ± 0.039	6.74ValThr: 6.74 ± 0.069	8.138ValVal: 8.138 ± 0.059	1.18ValTrp: 1.18 ± 0.021	1.497ValTyr: 1.497 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.823TrpAla: 1.823 ± 0.028	0.138TrpCys: 0.138 ± 0.009	0.818TrpAsp: 0.818 ± 0.017	0.635TrpGlu: 0.635 ± 0.016	0.521TrpPhe: 0.521 ± 0.015	1.007TrpGly: 1.007 ± 0.022	0.409TrpHis: 0.409 ± 0.012	0.649TrpIle: 0.649 ± 0.017	0.299TrpLys: 0.299 ± 0.011	1.85TrpLeu: 1.85 ± 0.029	0.298TrpMet: 0.298 ± 0.01	0.433TrpAsn: 0.433 ± 0.014	0.904TrpPro: 0.904 ± 0.018	0.656TrpGln: 0.656 ± 0.015	1.482TrpArg: 1.482 ± 0.021	1.042TrpSer: 1.042 ± 0.018	1.108TrpThr: 1.108 ± 0.02	1.035TrpVal: 1.035 ± 0.022	0.391TrpTrp: 0.391 ± 0.013	0.36TrpTyr: 0.36 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.615TyrAla: 2.615 ± 0.026	0.163TyrCys: 0.163 ± 0.007	1.34TyrAsp: 1.34 ± 0.023	1.008TyrGlu: 1.008 ± 0.019	0.633TyrPhe: 0.633 ± 0.016	2.011TyrGly: 2.011 ± 0.027	0.428TyrHis: 0.428 ± 0.013	0.455TyrIle: 0.455 ± 0.012	0.303TyrLys: 0.303 ± 0.01	2.267TyrLeu: 2.267 ± 0.026	0.209TyrMet: 0.209 ± 0.009	0.401TyrAsn: 0.401 ± 0.015	1.122TyrPro: 1.122 ± 0.02	0.719TyrGln: 0.719 ± 0.017	1.92TyrArg: 1.92 ± 0.028	0.912TyrSer: 0.912 ± 0.02	1.25TyrThr: 1.25 ± 0.023	1.618TyrVal: 1.618 ± 0.024	0.348TyrTrp: 0.348 ± 0.01	0.465TyrTyr: 0.465 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9412 proteins (3122312 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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