Amino acid dipepetide frequency for Muricauda sp. ES.050

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.423AlaAla: 4.423 ± 0.089	0.588AlaCys: 0.588 ± 0.026	3.459AlaAsp: 3.459 ± 0.077	4.32AlaGlu: 4.32 ± 0.076	3.264AlaPhe: 3.264 ± 0.06	4.326AlaGly: 4.326 ± 0.072	1.222AlaHis: 1.222 ± 0.03	5.16AlaIle: 5.16 ± 0.086	4.602AlaLys: 4.602 ± 0.086	6.399AlaLeu: 6.399 ± 0.093	1.746AlaMet: 1.746 ± 0.043	3.336AlaAsn: 3.336 ± 0.072	2.148AlaPro: 2.148 ± 0.057	2.555AlaGln: 2.555 ± 0.049	2.111AlaArg: 2.111 ± 0.047	4.269AlaSer: 4.269 ± 0.085	3.698AlaThr: 3.698 ± 0.143	4.207AlaVal: 4.207 ± 0.078	0.664AlaTrp: 0.664 ± 0.028	2.46AlaTyr: 2.46 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.446CysAla: 0.446 ± 0.023	0.091CysCys: 0.091 ± 0.01	0.435CysAsp: 0.435 ± 0.037	0.452CysGlu: 0.452 ± 0.025	0.393CysPhe: 0.393 ± 0.02	0.594CysGly: 0.594 ± 0.025	0.204CysHis: 0.204 ± 0.032	0.515CysIle: 0.515 ± 0.024	0.46CysLys: 0.46 ± 0.023	0.618CysLeu: 0.618 ± 0.027	0.149CysMet: 0.149 ± 0.013	0.394CysAsn: 0.394 ± 0.018	0.324CysPro: 0.324 ± 0.02	0.201CysGln: 0.201 ± 0.015	0.202CysArg: 0.202 ± 0.015	0.513CysSer: 0.513 ± 0.029	0.432CysThr: 0.432 ± 0.032	0.407CysVal: 0.407 ± 0.022	0.065CysTrp: 0.065 ± 0.008	0.284CysTyr: 0.284 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.874AspAla: 3.874 ± 0.061	0.427AspCys: 0.427 ± 0.028	3.37AspAsp: 3.37 ± 0.08	4.182AspGlu: 4.182 ± 0.063	3.703AspPhe: 3.703 ± 0.064	4.458AspGly: 4.458 ± 0.125	1.027AspHis: 1.027 ± 0.036	4.555AspIle: 4.555 ± 0.146	3.883AspLys: 3.883 ± 0.075	5.296AspLeu: 5.296 ± 0.077	1.387AspMet: 1.387 ± 0.037	3.046AspAsn: 3.046 ± 0.072	1.997AspPro: 1.997 ± 0.06	1.661AspGln: 1.661 ± 0.043	2.061AspArg: 2.061 ± 0.053	3.458AspSer: 3.458 ± 0.063	2.987AspThr: 2.987 ± 0.067	3.818AspVal: 3.818 ± 0.072	0.86AspTrp: 0.86 ± 0.029	2.847AspTyr: 2.847 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.563GluAla: 4.563 ± 0.079	0.342GluCys: 0.342 ± 0.019	4.088GluAsp: 4.088 ± 0.065	5.866GluGlu: 5.866 ± 0.091	2.969GluPhe: 2.969 ± 0.053	4.274GluGly: 4.274 ± 0.077	1.397GluHis: 1.397 ± 0.045	5.211GluIle: 5.211 ± 0.08	5.765GluLys: 5.765 ± 0.099	6.596GluLeu: 6.596 ± 0.094	1.741GluMet: 1.741 ± 0.042	4.362GluAsn: 4.362 ± 0.072	1.953GluPro: 1.953 ± 0.049	2.546GluGln: 2.546 ± 0.053	2.829GluArg: 2.829 ± 0.055	3.583GluSer: 3.583 ± 0.059	3.738GluThr: 3.738 ± 0.057	4.846GluVal: 4.846 ± 0.065	0.708GluTrp: 0.708 ± 0.03	2.473GluTyr: 2.473 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.989PheAla: 2.989 ± 0.05	0.382PheCys: 0.382 ± 0.018	3.463PheAsp: 3.463 ± 0.06	3.519PheGlu: 3.519 ± 0.063	2.689PhePhe: 2.689 ± 0.062	3.782PheGly: 3.782 ± 0.064	0.887PheHis: 0.887 ± 0.03	3.327PheIle: 3.327 ± 0.065	3.366PheLys: 3.366 ± 0.065	4.686PheLeu: 4.686 ± 0.073	1.297PheMet: 1.297 ± 0.036	2.838PheAsn: 2.838 ± 0.057	1.753PhePro: 1.753 ± 0.044	1.654PheGln: 1.654 ± 0.037	1.674PheArg: 1.674 ± 0.037	3.66PheSer: 3.66 ± 0.069	2.916PheThr: 2.916 ± 0.062	3.129PheVal: 3.129 ± 0.058	0.616PheTrp: 0.616 ± 0.026	2.091PheTyr: 2.091 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.545GlyAla: 4.545 ± 0.084	0.664GlyCys: 0.664 ± 0.048	3.901GlyAsp: 3.901 ± 0.079	4.264GlyGlu: 4.264 ± 0.073	3.869GlyPhe: 3.869 ± 0.068	5.022GlyGly: 5.022 ± 0.106	1.289GlyHis: 1.289 ± 0.041	5.449GlyIle: 5.449 ± 0.075	5.044GlyLys: 5.044 ± 0.086	6.33GlyLeu: 6.33 ± 0.078	1.863GlyMet: 1.863 ± 0.045	3.754GlyAsn: 3.754 ± 0.069	1.63GlyPro: 1.63 ± 0.047	2.041GlyGln: 2.041 ± 0.044	2.33GlyArg: 2.33 ± 0.048	4.225GlySer: 4.225 ± 0.087	4.312GlyThr: 4.312 ± 0.101	4.67GlyVal: 4.67 ± 0.078	0.864GlyTrp: 0.864 ± 0.031	2.88GlyTyr: 2.88 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.0HisAla: 1.0 ± 0.029	0.165HisCys: 0.165 ± 0.013	0.858HisAsp: 0.858 ± 0.031	0.998HisGlu: 0.998 ± 0.033	1.129HisPhe: 1.129 ± 0.032	1.204HisGly: 1.204 ± 0.033	0.512HisHis: 0.512 ± 0.028	1.414HisIle: 1.414 ± 0.034	1.216HisLys: 1.216 ± 0.032	1.85HisLeu: 1.85 ± 0.04	0.416HisMet: 0.416 ± 0.016	0.903HisAsn: 0.903 ± 0.03	0.964HisPro: 0.964 ± 0.035	0.808HisGln: 0.808 ± 0.03	0.744HisArg: 0.744 ± 0.029	1.007HisSer: 1.007 ± 0.034	0.987HisThr: 0.987 ± 0.032	1.084HisVal: 1.084 ± 0.037	0.26HisTrp: 0.26 ± 0.017	0.828HisTyr: 0.828 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.483IleAla: 5.483 ± 0.132	0.543IleCys: 0.543 ± 0.025	4.418IleAsp: 4.418 ± 0.068	4.755IleGlu: 4.755 ± 0.071	3.416IlePhe: 3.416 ± 0.063	5.031IleGly: 5.031 ± 0.08	1.208IleHis: 1.208 ± 0.037	4.839IleIle: 4.839 ± 0.082	5.082IleLys: 5.082 ± 0.083	6.668IleLeu: 6.668 ± 0.107	1.487IleMet: 1.487 ± 0.033	4.074IleAsn: 4.074 ± 0.064	3.153IlePro: 3.153 ± 0.055	2.495IleGln: 2.495 ± 0.05	2.572IleArg: 2.572 ± 0.053	5.195IleSer: 5.195 ± 0.074	4.322IleThr: 4.322 ± 0.095	4.601IleVal: 4.601 ± 0.083	0.715IleTrp: 0.715 ± 0.026	2.588IleTyr: 2.588 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.815LysAla: 4.815 ± 0.086	0.3LysCys: 0.3 ± 0.017	4.259LysAsp: 4.259 ± 0.07	6.152LysGlu: 6.152 ± 0.11	2.607LysPhe: 2.607 ± 0.056	4.684LysGly: 4.684 ± 0.08	1.285LysHis: 1.285 ± 0.035	5.282LysIle: 5.282 ± 0.088	6.69LysLys: 6.69 ± 0.109	6.131LysLeu: 6.131 ± 0.09	1.956LysMet: 1.956 ± 0.046	4.51LysAsn: 4.51 ± 0.071	2.388LysPro: 2.388 ± 0.058	2.554LysGln: 2.554 ± 0.053	2.941LysArg: 2.941 ± 0.065	4.329LysSer: 4.329 ± 0.079	4.229LysThr: 4.229 ± 0.076	4.795LysVal: 4.795 ± 0.084	0.76LysTrp: 0.76 ± 0.028	2.719LysTyr: 2.719 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.26LeuAla: 6.26 ± 0.083	0.699LeuCys: 0.699 ± 0.026	5.712LeuAsp: 5.712 ± 0.078	6.708LeuGlu: 6.708 ± 0.106	4.713LeuPhe: 4.713 ± 0.082	6.373LeuGly: 6.373 ± 0.077	1.552LeuHis: 1.552 ± 0.038	6.099LeuIle: 6.099 ± 0.097	7.187LeuLys: 7.187 ± 0.113	8.748LeuLeu: 8.748 ± 0.121	2.407LeuMet: 2.407 ± 0.05	5.087LeuAsn: 5.087 ± 0.077	3.676LeuPro: 3.676 ± 0.06	3.199LeuGln: 3.199 ± 0.057	3.299LeuArg: 3.299 ± 0.06	6.378LeuSer: 6.378 ± 0.091	4.894LeuThr: 4.894 ± 0.077	5.909LeuVal: 5.909 ± 0.076	0.849LeuTrp: 0.849 ± 0.026	3.152LeuTyr: 3.152 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.004MetAla: 2.004 ± 0.044	0.145MetCys: 0.145 ± 0.011	1.666MetAsp: 1.666 ± 0.044	1.957MetGlu: 1.957 ± 0.047	0.963MetPhe: 0.963 ± 0.032	1.805MetGly: 1.805 ± 0.038	0.443MetHis: 0.443 ± 0.02	1.5MetIle: 1.5 ± 0.04	2.081MetLys: 2.081 ± 0.046	2.08MetLeu: 2.08 ± 0.048	0.658MetMet: 0.658 ± 0.027	1.223MetAsn: 1.223 ± 0.033	0.956MetPro: 0.956 ± 0.033	0.875MetGln: 0.875 ± 0.028	0.976MetArg: 0.976 ± 0.03	1.406MetSer: 1.406 ± 0.038	1.179MetThr: 1.179 ± 0.037	1.725MetVal: 1.725 ± 0.045	0.184MetTrp: 0.184 ± 0.015	0.734MetTyr: 0.734 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.604AsnAla: 3.604 ± 0.098	0.425AsnCys: 0.425 ± 0.026	2.913AsnAsp: 2.913 ± 0.061	3.383AsnGlu: 3.383 ± 0.06	2.769AsnPhe: 2.769 ± 0.06	4.159AsnGly: 4.159 ± 0.088	1.043AsnHis: 1.043 ± 0.035	4.263AsnIle: 4.263 ± 0.072	3.615AsnLys: 3.615 ± 0.073	4.963AsnLeu: 4.963 ± 0.079	1.36AsnMet: 1.36 ± 0.033	3.118AsnAsn: 3.118 ± 0.066	2.76AsnPro: 2.76 ± 0.053	2.2AsnGln: 2.2 ± 0.04	2.245AsnArg: 2.245 ± 0.043	3.342AsnSer: 3.342 ± 0.064	3.393AsnThr: 3.393 ± 0.111	3.464AsnVal: 3.464 ± 0.058	0.702AsnTrp: 0.702 ± 0.033	2.412AsnTyr: 2.412 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.928ProAla: 1.928 ± 0.061	0.2ProCys: 0.2 ± 0.017	2.281ProAsp: 2.281 ± 0.056	3.284ProGlu: 3.284 ± 0.063	1.924ProPhe: 1.924 ± 0.045	2.172ProGly: 2.172 ± 0.053	0.647ProHis: 0.647 ± 0.025	2.723ProIle: 2.723 ± 0.053	2.821ProLys: 2.821 ± 0.056	3.174ProLeu: 3.174 ± 0.057	0.897ProMet: 0.897 ± 0.029	2.274ProAsn: 2.274 ± 0.056	0.999ProPro: 0.999 ± 0.036	1.115ProGln: 1.115 ± 0.033	1.055ProArg: 1.055 ± 0.031	2.267ProSer: 2.267 ± 0.05	2.124ProThr: 2.124 ± 0.05	2.382ProVal: 2.382 ± 0.046	0.411ProTrp: 0.411 ± 0.023	1.525ProTyr: 1.525 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.987GlnAla: 1.987 ± 0.048	0.164GlnCys: 0.164 ± 0.012	1.825GlnAsp: 1.825 ± 0.044	2.531GlnGlu: 2.531 ± 0.048	1.713GlnPhe: 1.713 ± 0.035	2.038GlnGly: 2.038 ± 0.048	0.621GlnHis: 0.621 ± 0.023	2.473GlnIle: 2.473 ± 0.052	2.814GlnLys: 2.814 ± 0.065	3.578GlnLeu: 3.578 ± 0.065	0.957GlnMet: 0.957 ± 0.027	2.191GlnAsn: 2.191 ± 0.049	1.15GlnPro: 1.15 ± 0.035	1.417GlnGln: 1.417 ± 0.038	1.415GlnArg: 1.415 ± 0.044	1.92GlnSer: 1.92 ± 0.036	1.814GlnThr: 1.814 ± 0.041	2.076GlnVal: 2.076 ± 0.048	0.401GlnTrp: 0.401 ± 0.021	1.308GlnTyr: 1.308 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.142ArgAla: 2.142 ± 0.048	0.198ArgCys: 0.198 ± 0.013	1.937ArgAsp: 1.937 ± 0.044	2.427ArgGlu: 2.427 ± 0.053	1.983ArgPhe: 1.983 ± 0.046	2.196ArgGly: 2.196 ± 0.049	0.672ArgHis: 0.672 ± 0.024	2.924ArgIle: 2.924 ± 0.061	2.91ArgLys: 2.91 ± 0.059	3.39ArgLeu: 3.39 ± 0.061	0.969ArgMet: 0.969 ± 0.03	2.102ArgAsn: 2.102 ± 0.048	1.266ArgPro: 1.266 ± 0.032	1.155ArgGln: 1.155 ± 0.036	1.438ArgArg: 1.438 ± 0.048	2.062ArgSer: 2.062 ± 0.052	2.019ArgThr: 2.019 ± 0.041	2.195ArgVal: 2.195 ± 0.044	0.404ArgTrp: 0.404 ± 0.023	1.692ArgTyr: 1.692 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.714SerAla: 3.714 ± 0.066	0.601SerCys: 0.601 ± 0.032	3.638SerAsp: 3.638 ± 0.099	4.114SerGlu: 4.114 ± 0.071	3.405SerPhe: 3.405 ± 0.064	4.736SerGly: 4.736 ± 0.088	1.128SerHis: 1.128 ± 0.036	4.935SerIle: 4.935 ± 0.076	4.688SerLys: 4.688 ± 0.074	5.913SerLeu: 5.913 ± 0.083	1.42SerMet: 1.42 ± 0.041	3.579SerAsn: 3.579 ± 0.068	2.253SerPro: 2.253 ± 0.051	2.068SerGln: 2.068 ± 0.043	2.151SerArg: 2.151 ± 0.054	4.002SerSer: 4.002 ± 0.069	3.495SerThr: 3.495 ± 0.064	3.945SerVal: 3.945 ± 0.065	0.664SerTrp: 0.664 ± 0.028	2.641SerTyr: 2.641 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.682ThrAla: 3.682 ± 0.085	0.329ThrCys: 0.329 ± 0.024	3.418ThrAsp: 3.418 ± 0.104	3.504ThrGlu: 3.504 ± 0.056	2.911ThrPhe: 2.911 ± 0.065	4.183ThrGly: 4.183 ± 0.078	0.982ThrHis: 0.982 ± 0.034	4.392ThrIle: 4.392 ± 0.089	3.509ThrLys: 3.509 ± 0.066	5.312ThrLeu: 5.312 ± 0.08	1.16ThrMet: 1.16 ± 0.035	3.04ThrAsn: 3.04 ± 0.178	2.483ThrPro: 2.483 ± 0.06	1.83ThrGln: 1.83 ± 0.048	1.658ThrArg: 1.658 ± 0.044	3.705ThrSer: 3.705 ± 0.072	3.316ThrThr: 3.316 ± 0.099	3.915ThrVal: 3.915 ± 0.101	0.636ThrTrp: 0.636 ± 0.031	2.331ThrTyr: 2.331 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.373ValAla: 4.373 ± 0.081	0.511ValCys: 0.511 ± 0.026	4.235ValAsp: 4.235 ± 0.07	4.318ValGlu: 4.318 ± 0.062	3.414ValPhe: 3.414 ± 0.067	4.313ValGly: 4.313 ± 0.066	1.185ValHis: 1.185 ± 0.038	4.385ValIle: 4.385 ± 0.067	4.218ValLys: 4.218 ± 0.077	6.353ValLeu: 6.353 ± 0.083	1.544ValMet: 1.544 ± 0.043	3.308ValAsn: 3.308 ± 0.054	2.5ValPro: 2.5 ± 0.051	2.011ValGln: 2.011 ± 0.041	2.25ValArg: 2.25 ± 0.043	4.622ValSer: 4.622 ± 0.07	3.645ValThr: 3.645 ± 0.082	4.672ValVal: 4.672 ± 0.084	0.648ValTrp: 0.648 ± 0.027	2.363ValTyr: 2.363 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.649TrpAla: 0.649 ± 0.023	0.097TrpCys: 0.097 ± 0.008	0.699TrpAsp: 0.699 ± 0.029	0.794TrpGlu: 0.794 ± 0.03	0.58TrpPhe: 0.58 ± 0.026	0.748TrpGly: 0.748 ± 0.027	0.237TrpHis: 0.237 ± 0.016	0.705TrpIle: 0.705 ± 0.026	0.823TrpLys: 0.823 ± 0.032	0.997TrpLeu: 0.997 ± 0.034	0.341TrpMet: 0.341 ± 0.018	0.688TrpAsn: 0.688 ± 0.03	0.31TrpPro: 0.31 ± 0.017	0.397TrpGln: 0.397 ± 0.022	0.435TrpArg: 0.435 ± 0.021	0.67TrpSer: 0.67 ± 0.027	0.571TrpThr: 0.571 ± 0.026	0.737TrpVal: 0.737 ± 0.026	0.177TrpTrp: 0.177 ± 0.013	0.439TrpTyr: 0.439 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.479TyrAla: 2.479 ± 0.047	0.306TyrCys: 0.306 ± 0.02	2.325TyrAsp: 2.325 ± 0.046	2.321TyrGlu: 2.321 ± 0.049	2.304TyrPhe: 2.304 ± 0.055	2.845TyrGly: 2.845 ± 0.058	0.808TyrHis: 0.808 ± 0.025	2.494TyrIle: 2.494 ± 0.056	2.61TyrLys: 2.61 ± 0.054	3.819TyrLeu: 3.819 ± 0.059	0.807TyrMet: 0.807 ± 0.026	2.305TyrAsn: 2.305 ± 0.058	1.539TyrPro: 1.539 ± 0.042	1.612TyrGln: 1.612 ± 0.039	1.695TyrArg: 1.695 ± 0.039	2.476TyrSer: 2.476 ± 0.051	2.226TyrThr: 2.226 ± 0.056	2.291TyrVal: 2.291 ± 0.049	0.507TyrTrp: 0.507 ± 0.022	1.675TyrTyr: 1.675 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3184 proteins (1083582 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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